Patents Assigned to Modern Meadow, Inc.
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Publication number: 20190093116Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: ApplicationFiled: September 7, 2018Publication date: March 28, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin Dai, Kristin Ruebling-Jass, David Thomas Williamson
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Publication number: 20190040400Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. A chimeric collagen DNA sequence, comprising from 10 to 40 percent or 60 to 90 percent of optimized DNA based on the total length of the chimeric collagen DN. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: ApplicationFiled: July 30, 2018Publication date: February 7, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin DAI, Julia BORDEN, Jeffrey NELSON, Kristin RUEBLING-JASS
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Publication number: 20190024303Abstract: The invention herein provides biofabricated leather materials, solutions comprising collagen that can be used to create biofabricated leather materials, articles comprising biofabricated leather materials applied to portions of a substrate in a pattern or a design such a lace like pattern, and/or that serve to join end portions of one or more substrates, e.g., to replace stitching and/or adhesives, and methods thereof.Type: ApplicationFiled: September 22, 2017Publication date: January 24, 2019Applicant: Modern Meadow, Inc.Inventors: Suzanne LEE, Catherine Amy CONGDON, Morgan SCHNEIDER, Brendan Patrick PURCELL, Callie McBride CLAYTON, Natalia KRASNODEBSKA, Nicole MUSE
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Publication number: 20190002893Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: ApplicationFiled: June 29, 2018Publication date: January 3, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin Dai, Julia Borden, Jeffrey Nelson, Kristin Ruebling-Jass
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Publication number: 20180230644Abstract: Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.Type: ApplicationFiled: September 21, 2016Publication date: August 16, 2018Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, Gabor FORGACS
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Patent number: 9752122Abstract: Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD-containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.Type: GrantFiled: September 15, 2014Date of Patent: September 5, 2017Assignee: Modern Meadow, Inc.Inventors: Francoise Suzanne Marga, Brendan Patrick Purcell, Gabor Forgacs, Andras Forgacs
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Publication number: 20170233945Abstract: The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Suzanne LEE, Amy CONGDON
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Publication number: 20170233834Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INCInventors: Brendan Patrick PURCELL, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham, Stephen M. Spinella, Amy Congdon
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Publication number: 20170233536Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham
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Publication number: 20170233944Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Lixin DAI, Darryl Miles CASSINGHAM, Stephen M. SPINELLA, Amy CONGDON
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Publication number: 20170233943Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrilsand provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Publication number: 20170233837Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Publication number: 20170233537Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Publication number: 20170233838Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Lixin DAI, Darryl Miles CASSINGHAM, Stephen M. SPINELLA
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Patent number: 9332779Abstract: Dehydrated, edible, high-protein food products formed of cultured muscle cells that are combined (e.g., mixed) with a hydrogel (e.g., a plant-derived polysaccharide) are described. These food products may be formed into a chip (e.g., snack chip), that has a protein content of greater than 50%. One or more flavorants may also be included.Type: GrantFiled: February 5, 2015Date of Patent: May 10, 2016Assignee: Modern Meadow, Inc.Inventor: Francoise Suzanne Marga