Patents Assigned to MODERNA THERAPEUTICS, INC.
  • Publication number: 20180256750
    Abstract: The invention features polynucleotides encoding a polypeptide including a 3?-stabilizing region and having increased stability compared to wild-type polynucleotides.
    Type: Application
    Filed: September 19, 2016
    Publication date: September 13, 2018
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Gabor BUTORA, Andrew W. FRALEY, Edward John MIRACCO, Jennifer NELSON, Amy RHODEN-SMITH, Matthew STANTON
  • Publication number: 20170204152
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized placement, position and percent load of chemical modifications, which improve, alter or optimize certain physicochemical and pharmaceutical properties of the polynucleotides. In one non-limiting embodiment, such chimeric polynucleotides take the form or function as modified mRNA molecules which encode a polypeptide of interest. In one embodiment, such chimeric polynucleotides are substantially noncoding.
    Type: Application
    Filed: July 16, 2015
    Publication date: July 20, 2017
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Jennifer NELSON, Andrew W. FRALEY, Amy RHODEN-SMITH
  • Patent number: 9675668
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 13, 2017
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
  • Publication number: 20170136132
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 18, 2017
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Atanu ROY, Christopher R. CONLEE, Antonin DE FOUGEROLLES, Andrew W. FRALEY
  • Publication number: 20170065675
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 9, 2017
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • Publication number: 20160331828
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
    Type: Application
    Filed: April 5, 2016
    Publication date: November 17, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Giuseppe Ciaramella, Axel Bouchon, Eric Yi-Chun Huang
  • Publication number: 20160317647
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
    Type: Application
    Filed: April 1, 2016
    Publication date: November 3, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Giuseppe Ciaramella, Axel Bouchon, Eric Yi-Chun Huang
  • Patent number: 9464124
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 11, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • Publication number: 20160271272
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: June 6, 2016
    Publication date: September 22, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • Patent number: 9447164
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 20, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan, Kenechi Ejebe
  • Publication number: 20160264614
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.
    Type: Application
    Filed: October 2, 2014
    Publication date: September 15, 2016
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Christopher R. CONLEE, Andrew W. FRALEY, Atanu ROY
  • Patent number: 9428535
    Abstract: The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: August 30, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Antonin de Fougerolles, Atanu Roy, Jason P. Schrum, Suhaib Siddiqi, Paul Hatala, Stephane Bancel
  • Publication number: 20160244501
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
    Type: Application
    Filed: October 3, 2014
    Publication date: August 25, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Jeff Lynn ELLSWORTH, Joseph Beene BOLEN, Francine M. GREGOIRE, Justin GUILD
  • Publication number: 20160243221
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
    Type: Application
    Filed: October 17, 2014
    Publication date: August 25, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. Hoge, Eric Yi-Chun Huang
  • Publication number: 20160194368
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 7, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. HOGE, Antonin DE FOUGEROLLES
  • Publication number: 20160136236
    Abstract: The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules. The present invention also relates to compositions and methods for altering cholesterol levels using polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 19, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephen G. HOGE, Eric Yi-Chun HUANG, Joseph Beene BOLEN, Justin GUILD, Antonin DE FOUGEROLLES, Jeff Lynn ELLSWORTH
  • Patent number: 9334328
    Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: May 10, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Suhaib Siddiqi, Kenechi Ejebe
  • Patent number: 9303079
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: April 5, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Patent number: 9301993
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: April 5, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Tirtha Chakraborty, Antonin de Fougerolles
  • Patent number: 9295689
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Grant
    Filed: May 18, 2013
    Date of Patent: March 29, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Antonin de Fougerolles, Kristy M. Wood, Pedro Valencia