Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate via the use of individual pumps to deposit individual wet film products onto a substrate.

Abstract: The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.

Abstract: The present invention provides a unit assembly for storing and dispensing a film strip. The unit assembly includes a first and second panel each having a perimetrical edge; wherein the first and second panels are substantially opposed to each other; and at least one gusseted side panel disposed between at least a portion of the panels along a common side thereof, the gusseted side panel configured to facilitate access to at least one film strip which is stored in a perimetrically sealed, substantially planar cavity within the unit assembly.

Abstract: The present invention relates to methods and apparatuses for forming films. In particular, the present invention relates to the formation of films on a substrate via the use of individual pumps to deposit individual wet film products onto a substrate. A method of forming film products includes: providing a reservoir housing a film forming matrix, pumps in association with the reservoir, and orifices; feeding the wet film forming matrix from the reservoir to the pumps; dispensing the film forming matrix from each of the pumps through an orifice; and depositing wet film products onto a substrate. An apparatus for forming film strips includes: (a) a reservoir for housing a film forming matrix; (b) pumps associated with the reservoir; (c) a plurality of orifices, with each orifice being associated with a pump; (d) a substrate; and (e) a means for moving the substrate through the apparatus.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.

Abstract: The present invention relates to compositions relating to films containing active pharmaceutical agents. In particular, the present invention relates to methods and systems useful for stabilizing amine-containing actives for dispersion in a film product.

Abstract: The present invention relates to a system and method for dispensing a therapeutically effective amount of dosage containing a medicament including an instrument for inputting data from a user, analyzing the inputted data to determine an appropriate amount of medicament to be administered to the user, and a dispenser for sizing and dispensing a therapeutically effective amount of the medicament. The medicament may be in the form of a continuous roll of oral thin film including the medicament.

Abstract: A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.

Abstract: The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.

Abstract: The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate, the substrate having at least one dam portion.

Abstract: The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of forming a pharmaceutical product directly onto the surface of a substrate.

Abstract: The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.

Abstract: An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.

Abstract: The present invention includes a pharmaceutical-based film system which includes various small-scale forms of pharmaceutically active agents, including testosterone esters, in a film base. Such forms include nanoparticles, microparticles, and combinations thereof. Methods of producing such film and providing a dosage of the pharmaceutical in a film are also provided.

Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.

Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.

Abstract: The invention relates to a process for drying a wet film including the steps of: a) determining a desired loss on drying (LOD) for the wet film; b) determining a relationship between LOD and a rate of temperature rise of the wet film or a rate of change of the rate of temperature rise of the wet film; c) drying a wet film with continuous monitoring of the temperature of the wet film; and d) continuously adjusting one or more drying parameters to maintain the rate of temperature rise of the wet film or the rate of change of the rate of temperature rise of the wet film that produces the desired LOD.

Abstract: The present invention relates to a method of forming a multi-layered film product, including the steps of forming a single-layered film having a length and a width and folding said single-layered film over on itself along said length at least once to form a multi-layered film having at least 2 layers in a face-to-face engagement. The single-layered film includes at least 2 lanes in a side-by-side arrangement along the length of the single layered film, wherein: a) each of said lanes spans the length of said single-layered film; b) each of said lanes spans at least a portion of the width of said single-layered film; c) said lanes that are adjacent to one another meet at a fold line that runs parallel to the length of said single-layered film; and d) at least one of said at least 2 lanes comprises at least one active component.