Abstract: The present invention relates to products and methods of making products having a dual taste masked active component. In particular, the present invention relates to film dosage forms including at least one dual taste masked active, where the dual taste masked active includes a coated complexed active composition.
Abstract: The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
Type:
Grant
Filed:
April 14, 2008
Date of Patent:
November 2, 2010
Assignee:
Monosol RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain at least one active agent, which may be administered to a user topically, transmucosally, vaginally, ocularly, aurally, nasally, transdermally or orally.
Abstract: A unit assembly including a plurality of individual film strips, each film strip having an active within a polymer matrix, the film strips having respective perimetrical edges, the plurality of individual film strips being alternatingly positioned next to one another such that a film strip perimetrical edge is at least partially offset from a subsequent film strip perimetrical edge, wherein the respective perimetrical edges of the film strips are directly adjacent to each other.
Abstract: The present invention provides a process for making an edible film having a substantially uniform distribution of components, which includes the steps of combining a water-based film polymer solution and a slurry-type mixture comprising a water-active component and a solvent; mixing the polymer solution and slurry-type mixture for about 10 minutes or less; dispensing the mixed solution and slurry-type mixture to form a film; and drying the film to evaporate the water and solvent. Films made by the process are also provided.
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Type:
Application
Filed:
November 9, 2009
Publication date:
April 15, 2010
Applicant:
MonoSol RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Type:
Grant
Filed:
May 28, 2004
Date of Patent:
February 23, 2010
Assignee:
MonoSol Rx, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Gary L. Myers, Joseph M. Fuisz
Abstract: The present invention relates to a method of making a film composition with an improved uniformity of active composition. The invention includes a method including the steps of forming a flowable film composition comprising an edible water-soluble polymer, a polar solvent and a particulate active suspended therein, where the ratio of solids to liquids is at least about 95 to about 5 and where the composition comprises a mixture having compositional uniformity per unit volume; directing the flowable film composition to a transfer trough, the transfer trough including a first rotating roller and a movable transfer substrate upon which to form the film; and maintaining uniformity of the flowable film composition during the residence time in the trough by maintaining the rate of composition entering the transfer trough and the level of the flowable film composition in the transfer trough at a substantially constant level. Methods of administering the active are also contemplated.
Type:
Application
Filed:
August 18, 2008
Publication date:
February 18, 2010
Applicant:
MONOSOL RX, LLC
Inventors:
Garry L. Myers, Madhusudan Hariharan, Pradeep Sanghvi, Alex Szopinski, Patrick Dailey
Abstract: The invention relates to pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.
Abstract: An aspect of the invention provides a tearable package for a pharmaceutical product including: (i) a first layer including a sheet of flexible material; (ii) a second layer including a sheet of flexible material; the layers being overlaid and fused together at a perimetrical sealing region, the fused layers defining a cavity therebetween for the storage of the pharmaceutical product; wherein one of the layers has a discontinuous region in the sealing region; and wherein the package may be folded through the discontinuous region to be torn such that the pharmaceutical contents may be removed.
Abstract: The invention relates to a pacifier and nipple member for delivery of active ingredients into the oral cavity of an infant or patient. The pacifier includes a porous nipple member and a base member adapted to remain outside the oral cavity of the infant. The porous nipple member includes at least one reservoir or chamber therein for receiving a thin-film containing an active ingredient. The base member may be removably attached to the neck of the nipple member, or the nipple and base members may form a single unit. Reusable and disposable forms are disclosed.
Type:
Application
Filed:
March 6, 2009
Publication date:
September 10, 2009
Applicant:
MONOSOL RX, LLC
Inventors:
Richard C. Fuisz, Joseph M. Fuisz, Tushar Misra, Pradeep Sanghvi
Abstract: The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
Type:
Application
Filed:
March 26, 2009
Publication date:
July 16, 2009
Applicant:
MONOSOL RX, LLC
Inventors:
Roert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
Type:
Application
Filed:
March 26, 2009
Publication date:
July 16, 2009
Applicant:
MONOSOL RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to a pacifier and nipple member for delivery of active ingredients into the oral cavity of an infant or patient. The pacifier includes a porous nipple member and a base member adapted to remain outside the oral cavity of the infant. The porous nipple member includes at least one reservoir or chamber therein for receiving a thin-film containing an active ingredient. The base member may be removably attached to the neck of the nipple member, or the nipple and base members may form a single unit. Reusable and disposable forms are disclosed.
Type:
Grant
Filed:
September 13, 2004
Date of Patent:
March 10, 2009
Assignee:
MonoSol Rx, LLC
Inventors:
Richard C. Fuisz, Joseph M. Fuisz, Tushar Misra, Pradeep Sanghvi
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
Type:
Application
Filed:
July 11, 2008
Publication date:
October 30, 2008
Applicant:
Monosol Rx, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Type:
Application
Filed:
April 22, 2008
Publication date:
October 23, 2008
Applicant:
MONOSOL RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Gary L. Myers, Joseph M. Fuisz
Abstract: The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
Type:
Application
Filed:
April 14, 2008
Publication date:
October 23, 2008
Applicant:
MONOSOL RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: This invention relates to films incorporating high amounts of pharmaceutical agents and methods for the preparation of the same. Moreover, the invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Type:
Application
Filed:
January 14, 2008
Publication date:
September 25, 2008
Applicant:
MONOSOL RX, LLC
Inventors:
Garry L. Myers, Bill J. Boone, Samuel D. Hilbert
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
Type:
Application
Filed:
May 29, 2008
Publication date:
September 18, 2008
Applicant:
MONOSOL RX, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
Type:
Grant
Filed:
February 14, 2002
Date of Patent:
September 16, 2008
Assignee:
MonoSol Rx, LLC
Inventors:
Robert K. Yang, Richard C. Fuisz, Gary L. Myers, Joseph M. Fuisz