Abstract: The present technology aims at providing a novel type of drug. Specifically, the present technology provides polypeptides comprising at least three immunoglobulin single variable domains (ISVDs), characterized in that at least one ISVD binds to TNF? and at least two ISVDs bind to IL-23. The present technology also provides nucleic acids, vectors and compositions.

Abstract: Systems and methods for automated data visualization are disclosed. According to one embodiment, in an information processing apparatus comprising at least one computer processor, a method for automatically analyzing data from a plurality of data files and producing a visual output may include (1) receiving a plurality of data files from at least one data file source, each data file comprising a plurality of data columns; (2) identifying a number of columns in each of the data files; (3) using column-value matching to identify two matching columns from two different data files; (4) executing one or more machine learning algorithms on data in the data files to enrich the data; and (5) generating a first visualization for the enriched data and outputting the first visualization on a display.

Abstract: The present invention relates to an apparatus (26) and a method for determining a fractional flow reserve. For this purpose, a new personalized hyperemic boundary condition model is provided. The personalized hyperemic boundary condition model is used to condition a parametric model for a simulation of a blood flow in a coronary tree (34) of a human subject. As a basis for the personalized hyperemic boundary condition model, a predefined hyperemic boundary condition model is used, which represents empirical derived hyperemic boundary condition parameters. However, these empirical hyperemic boundary condition parameters are not specific for a human subject under examination. In order to achieve a specification of the respective predefined hyperemic boundary condition model, specific human subject features are derived from a volumetric image of the coronary tree of the human subject.

Abstract: A system and method for tracking and determining characteristics of an inflatable medical instrument that is configured for interventional deployment. The system includes a guidewire that is positioned within a lumen of the inflatable medical instrument. The guidewire includes an optical fiber for a FORS system. The FORS system is configured to measure a shape of the guidewire during the interventional deployment of the inflatable medical instrument. A shape analysis module is configured to analyze the FORS data from the FORS system and determine characteristics of the inflatable medical instrument, including the diameter of the inflatable instrument, the pressurization of the instrument, whether the instrument has ruptured and the position of the inflatable instrument during an interventional procedure.

Abstract: A scintillator layer (206) includes a plurality of scintillator pixels (337), walls of non-scintillation material (336) surrounding each of the plurality of scintillator pixels, and at least one electrically conductive interconnect (224) for a pixel, wherein the at least one electrically conductive interconnect extends within a wall of the pixel along an entire depth of the wall. A multi-energy detector array (114) includes a detector tile (116) with an upper scintillator layer (202), an upper photosensor (204) optically coupled to the upper scintillator layer, a lower scintillator layer (206) electrically coupled to the upper photosensor, and a lower photodetector (208) optically and electrically coupled to the lower scintillator layer.

Abstract: A method (300) for providing feedback to a user of an oral cleaning device (10). The method includes the steps of: (i) receiving (330), from a sensor (28) of the oral cleaning device, data about a plurality of orientations of the oral cleaning device within the user's mouth during a cleaning session; (ii) extracting (340), from the received data, information about one or more stable orientations of the oral cleaning device within the user's mouth during the cleaning session, where a stable orientation is an orientation of the oral cleaning device maintained by the user for a period of time above a threshold; (iii) fitting (350) the information about the one or more stable orientations of the oral cleaning device to one or more expected orientations; and (iv) providing (360) feedback to the user about the cleaning session based on an analysis of the fitted one or more stable orientations.

Abstract: An image processing system (IPS) and a related method. The system comprises an input interface (IN) for receiving two or more input images that include respectively an attenuation signal of an imaged object and a dark-field signal of the object. A combiner (COM) is configured to combine the two or more input images in a linear combination operation to form a combined image. An output (OUT) port configured to output the combined image.

Abstract: A method for modelling a composition of an object of interest comprises segmenting object of interest image data provided by computer tomography image data resulting in a plurality of image segments. A determined Hounsfield density value is then extracted from the object of interest image data for each image segment. A component ratio of at least two component classes is defined for the object of interest, the at least two component classes having different component Hounsfield density values. At least one component class is assigned to each image segment based on the corresponding determined Hounsfield density value resulting in simulated image segments comprising the component Hounsfield density values. The simulated image segments define simulated image data of the object of interest, where a ratio of the assigned component classes corresponds to the component ratio. A deviation between the simulated image data and the object of interest image data is then determined.

Abstract: Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.

Abstract: An X-ray source (10) for generating X-rays (11) is provided. The X-ray source (10) comprises an emitter arrangement (12) for generating electrons or for generating X-rays, at least one feedthrough (38) for supplying electrical power to the emitter arrangement (12), and an insulator (20) configured for isolating an electrical potential of the at least one feedthrough (38) from a ground potential. Therein, the at least one feedthrough (38) extends at least partly through the insulator (20), and at least a part of the insulator (20) is in thermal contact with at least a part of the emitter arrangement (12). Further, the insulator (20) comprises at least one cooling channel (28) formed completely in an interior volume (25) of the insulator (20) and configured to dissipate heat from the emitter arrangement (12), wherein a distance (29) between an outer surface (26) of the insulator (20) and the cooling channel (28) is at least as large as half of a thickness (27) of the cooling channel (20).

Abstract: A pulsed laser skin treatment device is for laser induced optical breakdown of hair or skin tissue. A feedback system is used for detecting a feedback system based on light and/or sound/and/or contact force or pressure. The feedback signal is used to determine whether a pulse was in the tissue or outside the tissue. With these data an effectiveness of the treatment can be determined which can be provided to a user.

Abstract: The present application describes a system for curing moldable material. The system comprises an energy source, a mold, and/or other components. The mold comprises internal mold surfaces forming a mold cavity. The mold is formed from one or more materials configured to absorb electromagnetic radiation emitted by the energy source. The mold has a hot zone and a cold zone. The hot zone and the cold zone have the one or more materials thereof comprising at least one different physical characteristic so that the hot zone and the cold zone absorb the electromagnetic radiation at different rates and/or in different amounts. The hot zone absorbs more electromagnetic radiation than, and/or electromagnetic radiation faster than, the cold zone.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for generating time series. A time series simulator receives information corresponding to a request for time series. The information is formatted into input data by the time series simulator. The input data comprises at least one continuous condition. A generator network of the continuous condition generative adversarial network (CCGAN) generates the time series based directly on a value of the at least one continuous condition. The time series is provided such that the time series is at least one of (a) provided as input to an analysis pipeline or (b) received by a user computing device wherein a representation of at least a portion of the one or more time series is provided via an interactive user interface of the user computing device.

Abstract: Techniques are described for sender authenticated remittance via an automatic teller machine (ATM). The techniques include transferring money between a sender and a recipient via the ATM without the recipient needing a computing device or a bank account with which to receive the money. The disclosed techniques enable a remittance server to interact with both the sender via a sender computing device and the recipient via the ATM to perform a money transfer in which the recipient is at least partially authenticated by the sender. The ATM is configured to take a picture or a video of the recipient to be sent by the remittance server to the sender computing device for approval by the sender prior to allocating the transferred money to the recipient. In this way, the remittance server essentially passes control of the ATM and the remittance of the transferred money to the sender.

Abstract: A system (100) and method for monitoring a recoating mechanism (415A, 415B) in an additive manufacturing environment is provided. Various embodiments involve the use of a control computer (102a-102d) to receive data based on a thermal image of a recoating mechanism (415A, 415B) from an imaging device (436) configured to capture thermal image. The control computer (102a-102d) further determines a value of a property of the thermal image, wherein the property is related to an amount of powder in the recoating mechanism. The control computer (102a-102d) further determines at least one of if the value indicates an error related to the amount of powder in the recoating mechanism (415A, 415B), and an action to take with respect to the recoating mechanism (415A, 415B) that is based on the value.

Abstract: A circuit includes a test data input (TDI) pin receiving a test data input signal, a test data out (TDO) pin outputting a test data output signal, and debugging test access port (TAP) having a test data input coupled to the TDI pin and a bypass register having an input coupled to the test data input of the debugging TAP. A multiplexer has inputs coupled to the TDI pin and the debugging TAP. A testing TAP has a test data input coupled to the output of the multiplexer, and a data register having an input coupled to the test data input of the testing TAP. The multiplexer switches so the test data input signal is selectively coupled to the input of the data register of the testing TAP so the output of the debugging TAP is selectively coupled to the input of the data register of the testing TAP.

Abstract: A computer implemented method for detecting a fall of a user within an internal space of a building, the method comprising receiving a first air-pressure sensor signal indicative of change in air-pressure measured at a device worn by the user; receiving a measurement indicative of change in air-pressure within the internal space of the building; and determining the fall of the user based on the change in air-pressure measured at the device and the measurement indicative of change in air-pressure within the internal space of the building.

Abstract: Disclosed are methods, systems, and devices for facilitating secure and private communications, via a website or application of a third-party computing system (TPCS), between a user device and a service provider computing system (SPCS). The communications may be conducted via a frame in a website served by the TPCS. The TPCS may serve a website that incorporates a customizable SDK component provided by the SPCS. The communications allow the user to, for example, open a new account. The SDK component may be initialized via a script from the SPCS, and authenticated via a session token obtained from the SPCS via the TPCS. The SDK component may provide user information, input into the frame, to the SPCS via API calls to the SPCS. The user does not navigate away from the website while securely engaging the SPCS. The third-party/partner need not develop its own user interface, security protocols, etc.

Abstract: A radio station comprises means for allocating resources for communication with at least one other station, and including means for mapping data to be transmitted from at least the radio station to the at least one other station, and means for applying a cyclic shift to the data mapping, wherein this cyclic shift is adjusted depending on the number of data blocks to be mapped. A possible implementation concerns the mapping of the DVRB (Distributed Virtual Resource Block) in OFDM.