Patents Assigned to Nankai University
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Patent number: 12269022Abstract: A highly-dispersed hydrogenation catalyst, a preparation method thereof, and use thereof in the preparation of biofuel from palm oil or other oil are provided. The combination of maleic anhydride-grafted polypropylene (MA-PP) and a silane coupling agent (SCA) is introduced into an aluminum oxide composite carrier through organic amidation to obtain a uniformly-dispersed composite carrier with regular pores. Moreover, through a multi-stage impregnation and roasting process, a particle size of an active component is greatly reduced, and the dispersion of the active component and the number of active sites are improved. A hydrogenation catalyst with high hydrothermal stability, high hydrogenation activity, and long life is prepared based on the composite carrier with regular pores and used in the preparation of biofuel from vegetable oil or other oil through hydrodeoxygenation (HDO), which has great industrial application value.Type: GrantFiled: September 20, 2019Date of Patent: April 8, 2025Assignee: NANKAI UNIVERSITYInventors: Wei Li, Siyang Liu, Qingxin Guan
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Patent number: 12257364Abstract: The present disclosure discloses a preparation method and application of decellularized extracellular matrix tissue paper, and belongs to the technical field of regenerative medicine. The preparation method includes the following steps: (1) preparing decellularized extracellular matrix materials; (2) preparing tissue paper: homogenizing and stirring the prepared decellularized extracellular matrix materials, then, placing the obtained homogenates on a flat-bottom filter screen to filter out water, standing and air-drying the filtered homogenates, and freeze-drying the homogenates to obtain the tissue paper; (3) cross-linking the tissue paper: cross-linking the tissue paper in a cross-linking solution; and (4) freeze-drying or stacking and compacting the cross-linked tissue paper. According to the present disclosure, the decellularized extracellular matrix tissue paper with tissue specificity is prepared by a traditional paper-making technology combined with a freeze-drying technology.Type: GrantFiled: March 15, 2023Date of Patent: March 25, 2025Assignee: NANKAI UNIVERSITYInventors: Meifeng Zhu, Wen Li, Deling Kong, Zhen Zhang
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Patent number: 12257615Abstract: A stacked circulatable microbial electrochemical reactor and a degradation method of petroleum hydrocarbon contaminated soil are provided, which belong to the field of microbial electrochemical soil remediation. The stacked circulatable microbial electrochemical reactor of the present disclosure expands influence range of anodes by a stacked microbial electrochemical system, accelerates the movement of the petroleum hydrocarbon molecules in the contaminated soil by a water circulation system, and improves the mass transfer capacity of soil, thereby increasing the degradation efficiency of petroleum hydrocarbon in the contaminated soil with microbial electrochemical technology from different aspects. The degradation method of petroleum hydrocarbon contaminated soil is provided. The degradation method of the present disclosure is simple in operation and has a high degradation efficiency of petroleum hydrocarbon in contaminated soil.Type: GrantFiled: April 8, 2021Date of Patent: March 25, 2025Assignee: Nankai UniversityInventors: Qixing Zhou, Tian Li, Xin Wang
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Patent number: 12237470Abstract: The invention belongs to the technical field of batteries, and discloses a phosphate-based flame-retardant electrolyte and a lithium-metal battery, and the phosphate-based flame-retardant electrolyte consists of a lithium salt, a phosphate solvent and a diluent. According to the invention, dimethyl (2-methoxyethoxy)methylphosphonate or diethyl (2-methoxyethoxy)methylphosphonate is used as a novel phosphate solvent, an electrolyte system with local high salt concentration is adopted, most phosphate solvent molecules are complexed with Li+ at the local high salt concentration by adjusting dosages of the lithium salt, the phosphate solvent and the diluent, so almost none of free solvent molecules exist, thus inhibiting irreversible decomposition of phosphate molecules on a surface of a li-anode, and meanwhile, the flame retardancy of the phosphate solvent greatly improves the safety of the lithium-metal battery.Type: GrantFiled: July 20, 2023Date of Patent: February 25, 2025Assignee: Nankai UniversityInventors: Jun Chen, Chunyu Zheng, Yuankun Wang, Yunpeng Hou, Zhenhua Yan, Haixia Li, Qing Zhao
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Publication number: 20250042831Abstract: The present disclosure provides a process for preparing 5-chloro-2,3-dihydro-1H-inden-1-one and the 5-chloro-2,3-dihydro-1H-inden-1-one prepared by the process. The present disclosure also provides a process for preparing Indoxacarb and the Indoxacarb prepared by the process.Type: ApplicationFiled: December 7, 2021Publication date: February 6, 2025Applicants: ADAMA MAKHTESHIM LTD., NANKAI UNIVERSITYInventors: Wei LI, Yu ZHAO, Dingwen MIAO, Mannam SREEDEVI, Bijukumar Gopinathan PILLAI
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Publication number: 20250047255Abstract: The present disclosure provides a new broadband balun structure, comprising an inverting transformer and an autotransformer; wherein the inverting transformer is configured to invert an input signal to generate an inverting signal; the autotransformer is configured to divide the input signal to generate an in-phase signal; at least one of one end of the inverting transformer or one end of the autotransformer is connected to an unbalanced end; the inverting transformer is connected to the autotransformer when the one end of the inverting transformer or the autotransformer is connected to the input signal of the unbalanced end; and the other end of the inverting transformer is used as an inverting signal end of a balanced end, and the other end of the autotransformer is used as an in-phase signal end of the balanced end.Type: ApplicationFiled: July 4, 2024Publication date: February 6, 2025Applicant: NANKAI UNIVERSITYInventor: Xudong WANG
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Patent number: 12215279Abstract: A method for administering a composition for exploiting natural gas hydrates. The method includes the following steps: injecting the reagent A into the tube A; injecting the reagent B into the tube B; stretching the tube A and the tube B into a hydrate reservoir by using a reagent injection instrument; regulating a flow rate according to a proportion of each component; allowing the reagents to react at a preset reservoir position; and allowing water in the reservoir to participate in the reaction at the same time, wherein a reaction product is used for supporting the reservoir.Type: GrantFiled: July 21, 2023Date of Patent: February 4, 2025Assignee: Nankai UniversityInventors: Xiaohang Liu, Annan Guo, Peng Zhao, Xiaoyang Li, Jinqiang Liang, Wei Huang, Yongqin Zhang
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Publication number: 20250019736Abstract: The present disclosure provides a microbial electrolysis cell (MEC) reactor and a rapid test method for a biochemical oxygen demand (BOD) of organic wastewater, and relates to the technical field of analysis and detection. In the present disclosure, an efficient MEC reactor is constructed based on a MEC sensing technology; meanwhile, combined with a continuous short-cycle test method and a supporting data calculation method, a rapid test method is obtained, and can be applied to various types of complex organic wastewater that does not have a biologically toxic substance and is greater than 5 mg BOD/L. After three cycles of test, last two stable cycles are taken to allow calculation; at the same time, a resulting curve is divided into multiple segments according to changes in main components of a degraded organic matter in different periods to allow segmented weighted calculations.Type: ApplicationFiled: December 11, 2023Publication date: January 16, 2025Applicant: Nankai UniversityInventors: Xin WANG, Chengmei LIAO, Ziyuan WANG, Nan LI
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Patent number: 12187811Abstract: Provided are a cyclic peptide compound simulating a natural product structure and a method for preparation thereof. The method is: the compound of formula I, a divalent palladium catalyst, and a silver salt undergoing an intramolecular arylation in a solvent under heating and stirring to construct a cyclic peptide, to generate the compound of formula II, in which the arylation sites are diverse, and can be extended to the side chain ?-position methyl or methylene of the majority hydrophobic amino acids to perform intramolecular arylation, thus overcoming the previous defect of the restriction of the types of selectable amino acids, and effectively constructing a novel aromatic ring-supported cyclic peptide compound. The aromatic ring support structure forms a novel 3D structure similar to a natural product, and provide a very favorable support for the subsequent construction of a cyclic peptide molecular library and high-throughput drug screening.Type: GrantFiled: June 21, 2019Date of Patent: January 7, 2025Assignee: Nankai UniversityInventors: Gong Chen, Bo Li, Xinghua Li, Boyang Han, Gang He
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Patent number: 12146163Abstract: A vascularized cardiac organoid with a chamber structure and its preparation method is presented. The cardiac organoids have a unique chamber structure, which includes a myocardium wall. Within the cardiac organoids, a vascular network is developed, enclosed within the myocardium wall. This vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a network of branched tubular structures. The presence of vasculature significantly promotes the arrangement of the myocardium, enhances the organization of the cardiac cytoskeleton, and promotes the consistency and beating frequency of cardiac cells. The vasculature facilitates the growth and size increase of the cardiac organoids.Type: GrantFiled: October 19, 2023Date of Patent: November 19, 2024Assignee: NANKAI UNIVERSITYInventors: Deling Kong, Zhuangzhuang Yang, Songdi Wang
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Patent number: 12098414Abstract: It is provided a monitoring reactor and a method for using the same, belonging to microbiologic electrochemical early-warning technology. The monitoring reactor enriches microorganisms therein before use, and consumes the organic matter. When the organic matter in the monitoring reactor is consumed completely, i.e. the microorganisms are in a starved state, the monitoring reactor is placed in a system to be monitored for monitoring, thereby avoiding the interference of the organic matter in the soil in the monitoring reactor to the electrical signal and improving the monitoring accuracy. Furthermore, since the electrical signal in the monitoring reactor is conducted through the electricigens, the process of generating electricity of the electricigens is a process of growth and propagation of microorganism. This process is less affected by the monitored environment. Therefore, the signal output process is stable, without swell and sag of the electrical signal.Type: GrantFiled: March 30, 2021Date of Patent: September 24, 2024Assignee: Nankai UniversityInventors: Tian Li, Qixing Zhou
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Patent number: 12090254Abstract: The present disclosure discloses a composite tubular material and a preparation method thereof. The tubular material is prepared from extracellular matrix and directionally arranged synthetic polymer fibers through compounding; the synthetic polymer fibers serve as an internal skeleton, a fiber diameter ranges from 1 ?m to 2000 ?m, a fiber angle ranges from 0° to 180°, and a wall thickness ranges from 1 ?m to 1000 ?m; and extracellular matrix components are obtained from human or animal tissue through decellularization. According to the present disclosure, the tubular material with bioactivity and excellent mechanical properties can be prepared from the synthetic polymer and the natural material extracellular matrix through compounding; the synthetic polymer fibers with controllable fiber angle and diameter serve as the internal skeleton of the tubular material, and accordingly the tubular material has the mechanical properties of resistance to bending and squeezing.Type: GrantFiled: February 28, 2023Date of Patent: September 17, 2024Assignee: NANKAI UNIVERSITYInventors: Meifeng Zhu, Yueyue Yang, Wen Li, Deling Kong
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Patent number: 12091340Abstract: The present disclosure relates to the technical field of microbial electrochemical technology, in particular to a graphene-magnetite conductive skeleton electrode, a preparation method and application thereof, and a method for treating petrochemical wastewater. In the present disclosure, the surface roughness of the graphite rod electrode can be increased by the conductive skeleton modified on the surface of the graphite rod electrode, which is beneficial to the enrichment of microorganisms. The increase in the load of microorganisms will mean the amount of electroactive microorganisms will also increase, which will further improve the electron transfer ability, and because the material of the modified layer is a conductive material, it is also more conducive to the transfer of electrons; at the same time, the conductive skeleton modified on the surface of graphite rod electrode can also further enhance the transmission distance of electrons because of the skeleton constructed.Type: GrantFiled: September 13, 2021Date of Patent: September 17, 2024Assignee: Nankai UniversityInventors: Qixing Zhou, Ruixiang Li, Tian Li, Xiaolin Zhang
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Publication number: 20240228967Abstract: A vascularized cardiac organoid with a chamber structure and its preparation method is presented. The cardiac organoids have a unique chamber structure, which includes a myocardium wall. Within the cardiac organoids, a vascular network is developed, enclosed within the myocardium wall. This vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a network of branched tubular structures. The presence of vasculature significantly promotes the arrangement of the myocardium, enhances the organization of the cardiac cytoskeleton, and promotes the consistency and beating frequency of cardiac cells. The vasculature facilitates the growth and size increase of the cardiac organoids.Type: ApplicationFiled: October 19, 2023Publication date: July 11, 2024Applicant: NANKAI UNIVERSITYInventors: Deling KONG, Zhuangzhuang YANG, Songdi WANG
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Publication number: 20240228974Abstract: Vascularized islets and their preparation method is presented. The vascularized islets are comprised of islet spheroids enclosed within a network of blood vessels. The vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a tubular vessel with branched structures. The presence of this vasculature significantly enhances the survival of the islets, improves the efficiency of pancreatic precursor cells, islet progenitor cells and R cells, and the increases the synthesis of insulin precursor C-peptide. The procedures for constructing vascularized islets are suitable for long-term in vitro culture of islets.Type: ApplicationFiled: October 19, 2023Publication date: July 11, 2024Applicant: NANKAI UNIVERSITYInventors: Deling KONG, Hongmeng MA, Zhuangzhuang YANG
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Patent number: 11986380Abstract: Disclosed is a bending-resistant nerve catheter and a preparation method and application thereof, and relates to the technical field of tissue engineering materials. The catheter of the present application includes an inner layer, a middle layer and an outer layer, and each layer uses raw materials of biodegradable polymers; among them, the inner layer includes a smooth surface inner layer, an oriented microchannel inner layer or a fibrous inner layer, the middle layer is a fibrous middle layer with crossing angles, the middle layer is prepared by entangling micron fibers with a certain angular arrangement, and the outer layer is made of randomly entangled polymer fibers and is tightly bonded to the middle layer.Type: GrantFiled: May 1, 2023Date of Patent: May 21, 2024Assignees: Neosheng (Tianjin) Biotechnology Co., Ltd, Nankai UniversityInventors: Meifeng Zhu, Deling Kong, Xianhao Dong, Guangzhou Song
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Publication number: 20240132847Abstract: A vascularized cardiac organoid with a chamber structure and its preparation method is presented. The cardiac organoids have a unique chamber structure, which includes a myocardium wall. Within the cardiac organoids, a vascular network is developed, enclosed within the myocardium wall. This vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a network of branched tubular structures. The presence of vasculature significantly promotes the arrangement of the myocardium, enhances the organization of the cardiac cytoskeleton, and promotes the consistency and beating frequency of cardiac cells. The vasculature facilitates the growth and size increase of the cardiac organoids.Type: ApplicationFiled: October 18, 2023Publication date: April 25, 2024Applicant: NANKAI UNIVERSITYInventors: Deling KONG, Zhuangzhuang YANG, Songdi WANG
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Publication number: 20240132850Abstract: Vascularized islets and their preparation method is presented. The vascularized islets are comprised of islet spheroids enclosed within a network of blood vessels. The vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a tubular vessel with branched structures. The presence of this vasculature significantly enhances the survival of the islets, improves the efficiency of pancreatic precursor cells, islet progenitor cells and R cells, and the increases the synthesis of insulin precursor C-peptide. The procedures for constructing vascularized islets are suitable for long-term in vitro culture of islets.Type: ApplicationFiled: October 18, 2023Publication date: April 25, 2024Applicant: NANKAI UNIVERSITYInventors: Deling KONG, Hongmeng MA, Zhuangzhuang YANG
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Patent number: 11958759Abstract: A ternary oxide based composite cathode material for a lithium-sulfur battery and a preparation method thereof are provided wherein the composite cathode material includes: sulfur and LiNi0.8Co0.15Al0.05O2 or LiNixCoyMn1-x-yO2 (0<x<1, 0<y<1, 0<x+y<1), wherein a sulfur content is 50 wt. %-80 wt. %. The host has adsorption and catalytic effects on polar polysulfides, which can fix sulfur and promote electrochemical reactions, thereby preparing lithium-sulfur battery with high capacity and high stability.Type: GrantFiled: January 19, 2019Date of Patent: April 16, 2024Assignee: NANKAI UNIVERSITYInventors: Xueping Gao, Lu Wang, Guoran Li, Sheng Liu
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Patent number: 11908037Abstract: The present disclosure provides a method and system for large-capacity image steganography and recovery based on an invertible neural networks. The method is intended to embed one or more hidden images into a single host image, and recover all the hidden images from a stego image. The method designs an image steganography model that supports bidirectional mapping. The model includes cascaded invertible modules containing a host branch and a hidden branch. A hidden image is embedded into a host image through forward mapping to form a stego image, and the host image and the hidden image are separated and recovered from the single stego image through reverse mapping.Type: GrantFiled: June 18, 2021Date of Patent: February 20, 2024Assignee: Nankai UniversityInventors: Shaoping Lu, Rong Wang, Tao Zhong