Patents Assigned to Nankai University
  • Patent number: 12383654
    Abstract: An acellular matrix woven material, a preparation method and an application thereof are provided. The acellular matrix woven material is prepared by combining 3D printing with weaving. At the same time, also provided are the acellular matrix woven material prepared by the preparation method and its application in preparing tissue engineering scaffold materials.
    Type: Grant
    Filed: January 9, 2025
    Date of Patent: August 12, 2025
    Assignee: Nankai University
    Inventors: Meifeng Zhu, Guangzhou Song, Wenqian Cong, Wen Li, Kai Wang, Deling Kong
  • Patent number: 12365740
    Abstract: The present invention relates to novel antibodies and antibody fragments that specifically bind to CD40, and compositions, medicaments, combination products and kits comprising the antibodies or antibody fragments. Furthermore, the invention relates to nucleic acids encoding said antibodies or antibody fragments thereof and host cells comprising the same, as well as related uses. Furthermore, the invention relates to therapeutic and diagnostic uses of these antibodies and antibody fragments.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: July 22, 2025
    Assignee: Nankai University
    Inventors: Hongkai Zhang, Yuan Wang
  • Publication number: 20250170627
    Abstract: A magnetization pyrolysis device for organic waste and a using method thereof are provided. During the magnetization pyrolysis of organic waste, the device uses perovskite as a catalyst, and includes a crushing reaction chamber combining a crushing zone with a reaction zone; a crushing mechanism for crushing waste; and a heating mechanism for heating the waste, the crushing mechanism and the heating mechanism are arranged in the crushing reaction chamber. In accordance with the present disclosure, the crushing zone is combined with the reaction zone, which significantly reduces the treatment space and cost. In-situ degradation of household waste can be achieved by the device without leaving the village, and the daily cleaning of everyday rural waste can be effectively achieved.
    Type: Application
    Filed: January 4, 2024
    Publication date: May 29, 2025
    Applicants: Nankai University, Kashi University, Tianjin Sinotech Environmental Technology Development Co., Ltd.
    Inventors: Weizun LI, Mingyan YU, Tao SUN, Zhentong LIU, Xianghao ZHA
  • Publication number: 20250170561
    Abstract: Provided are a perovskite catalyst, and a preparation method and use thereof in electromagnetic degradation of an organic waste. In the preparation method of the perovskite catalyst, the perovskite catalyst is prepared by co-precipitation. A precursor with a higher purity is prepared by limiting types, concentrations, and addition ratios of reaction raw materials as well as controlling a temperature and a pH value of the precipitation reaction, and provides a desirable basis for the preparation of a subsequent catalyst. The precursor is subjected to aging and calcination to obtain the perovskite catalyst.
    Type: Application
    Filed: January 5, 2024
    Publication date: May 29, 2025
    Applicants: Nankai University, Kashi University, Tianjin Sinotech Environmental Technology Development Co., Ltd.
    Inventors: Weizun LI, Mingyan YU, Tao SUN, Zhentong LIU, Xianghao ZHA
  • Patent number: 12312373
    Abstract: The present invention relates to cyclopropane skeleton monophosphine ligands and preparation methods for palladium complexes thereof and an application. Specifically, trans-diaryl substituted cyclopropane skeleton monophosphine ligands are synthesized after trans-1,2-diaryl ethylene undergoing the steps of cyclopropanation reaction, debromination reaction, substitution reaction, and the like. Palladium complexes prepared by coordinating the cyclopropane skeleton monophosphine ligands with a palladium salt show very high activity in catalyzing C—N bond coupling reactions, and have good application prospects.
    Type: Grant
    Filed: July 24, 2024
    Date of Patent: May 27, 2025
    Assignee: Nankai University
    Inventors: Shoufei Zhu, Huawei Liu, Wei Sun, Wentao Li, Ling Dang, Mingyao Huang, Xinyu Zhang
  • Patent number: 12257615
    Abstract: A stacked circulatable microbial electrochemical reactor and a degradation method of petroleum hydrocarbon contaminated soil are provided, which belong to the field of microbial electrochemical soil remediation. The stacked circulatable microbial electrochemical reactor of the present disclosure expands influence range of anodes by a stacked microbial electrochemical system, accelerates the movement of the petroleum hydrocarbon molecules in the contaminated soil by a water circulation system, and improves the mass transfer capacity of soil, thereby increasing the degradation efficiency of petroleum hydrocarbon in the contaminated soil with microbial electrochemical technology from different aspects. The degradation method of petroleum hydrocarbon contaminated soil is provided. The degradation method of the present disclosure is simple in operation and has a high degradation efficiency of petroleum hydrocarbon in contaminated soil.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: March 25, 2025
    Assignee: Nankai University
    Inventors: Qixing Zhou, Tian Li, Xin Wang
  • Patent number: 12237470
    Abstract: The invention belongs to the technical field of batteries, and discloses a phosphate-based flame-retardant electrolyte and a lithium-metal battery, and the phosphate-based flame-retardant electrolyte consists of a lithium salt, a phosphate solvent and a diluent. According to the invention, dimethyl (2-methoxyethoxy)methylphosphonate or diethyl (2-methoxyethoxy)methylphosphonate is used as a novel phosphate solvent, an electrolyte system with local high salt concentration is adopted, most phosphate solvent molecules are complexed with Li+ at the local high salt concentration by adjusting dosages of the lithium salt, the phosphate solvent and the diluent, so almost none of free solvent molecules exist, thus inhibiting irreversible decomposition of phosphate molecules on a surface of a li-anode, and meanwhile, the flame retardancy of the phosphate solvent greatly improves the safety of the lithium-metal battery.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: February 25, 2025
    Assignee: Nankai University
    Inventors: Jun Chen, Chunyu Zheng, Yuankun Wang, Yunpeng Hou, Zhenhua Yan, Haixia Li, Qing Zhao
  • Patent number: 12215279
    Abstract: A method for administering a composition for exploiting natural gas hydrates. The method includes the following steps: injecting the reagent A into the tube A; injecting the reagent B into the tube B; stretching the tube A and the tube B into a hydrate reservoir by using a reagent injection instrument; regulating a flow rate according to a proportion of each component; allowing the reagents to react at a preset reservoir position; and allowing water in the reservoir to participate in the reaction at the same time, wherein a reaction product is used for supporting the reservoir.
    Type: Grant
    Filed: July 21, 2023
    Date of Patent: February 4, 2025
    Assignee: Nankai University
    Inventors: Xiaohang Liu, Annan Guo, Peng Zhao, Xiaoyang Li, Jinqiang Liang, Wei Huang, Yongqin Zhang
  • Publication number: 20250019736
    Abstract: The present disclosure provides a microbial electrolysis cell (MEC) reactor and a rapid test method for a biochemical oxygen demand (BOD) of organic wastewater, and relates to the technical field of analysis and detection. In the present disclosure, an efficient MEC reactor is constructed based on a MEC sensing technology; meanwhile, combined with a continuous short-cycle test method and a supporting data calculation method, a rapid test method is obtained, and can be applied to various types of complex organic wastewater that does not have a biologically toxic substance and is greater than 5 mg BOD/L. After three cycles of test, last two stable cycles are taken to allow calculation; at the same time, a resulting curve is divided into multiple segments according to changes in main components of a degraded organic matter in different periods to allow segmented weighted calculations.
    Type: Application
    Filed: December 11, 2023
    Publication date: January 16, 2025
    Applicant: Nankai University
    Inventors: Xin WANG, Chengmei LIAO, Ziyuan WANG, Nan LI
  • Patent number: 12187811
    Abstract: Provided are a cyclic peptide compound simulating a natural product structure and a method for preparation thereof. The method is: the compound of formula I, a divalent palladium catalyst, and a silver salt undergoing an intramolecular arylation in a solvent under heating and stirring to construct a cyclic peptide, to generate the compound of formula II, in which the arylation sites are diverse, and can be extended to the side chain ?-position methyl or methylene of the majority hydrophobic amino acids to perform intramolecular arylation, thus overcoming the previous defect of the restriction of the types of selectable amino acids, and effectively constructing a novel aromatic ring-supported cyclic peptide compound. The aromatic ring support structure forms a novel 3D structure similar to a natural product, and provide a very favorable support for the subsequent construction of a cyclic peptide molecular library and high-throughput drug screening.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: January 7, 2025
    Assignee: Nankai University
    Inventors: Gong Chen, Bo Li, Xinghua Li, Boyang Han, Gang He
  • Patent number: 12098414
    Abstract: It is provided a monitoring reactor and a method for using the same, belonging to microbiologic electrochemical early-warning technology. The monitoring reactor enriches microorganisms therein before use, and consumes the organic matter. When the organic matter in the monitoring reactor is consumed completely, i.e. the microorganisms are in a starved state, the monitoring reactor is placed in a system to be monitored for monitoring, thereby avoiding the interference of the organic matter in the soil in the monitoring reactor to the electrical signal and improving the monitoring accuracy. Furthermore, since the electrical signal in the monitoring reactor is conducted through the electricigens, the process of generating electricity of the electricigens is a process of growth and propagation of microorganism. This process is less affected by the monitored environment. Therefore, the signal output process is stable, without swell and sag of the electrical signal.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: September 24, 2024
    Assignee: Nankai University
    Inventors: Tian Li, Qixing Zhou
  • Patent number: 12091340
    Abstract: The present disclosure relates to the technical field of microbial electrochemical technology, in particular to a graphene-magnetite conductive skeleton electrode, a preparation method and application thereof, and a method for treating petrochemical wastewater. In the present disclosure, the surface roughness of the graphite rod electrode can be increased by the conductive skeleton modified on the surface of the graphite rod electrode, which is beneficial to the enrichment of microorganisms. The increase in the load of microorganisms will mean the amount of electroactive microorganisms will also increase, which will further improve the electron transfer ability, and because the material of the modified layer is a conductive material, it is also more conducive to the transfer of electrons; at the same time, the conductive skeleton modified on the surface of graphite rod electrode can also further enhance the transmission distance of electrons because of the skeleton constructed.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: September 17, 2024
    Assignee: Nankai University
    Inventors: Qixing Zhou, Ruixiang Li, Tian Li, Xiaolin Zhang
  • Patent number: 11986380
    Abstract: Disclosed is a bending-resistant nerve catheter and a preparation method and application thereof, and relates to the technical field of tissue engineering materials. The catheter of the present application includes an inner layer, a middle layer and an outer layer, and each layer uses raw materials of biodegradable polymers; among them, the inner layer includes a smooth surface inner layer, an oriented microchannel inner layer or a fibrous inner layer, the middle layer is a fibrous middle layer with crossing angles, the middle layer is prepared by entangling micron fibers with a certain angular arrangement, and the outer layer is made of randomly entangled polymer fibers and is tightly bonded to the middle layer.
    Type: Grant
    Filed: May 1, 2023
    Date of Patent: May 21, 2024
    Assignees: Neosheng (Tianjin) Biotechnology Co., Ltd, Nankai University
    Inventors: Meifeng Zhu, Deling Kong, Xianhao Dong, Guangzhou Song
  • Patent number: 11908037
    Abstract: The present disclosure provides a method and system for large-capacity image steganography and recovery based on an invertible neural networks. The method is intended to embed one or more hidden images into a single host image, and recover all the hidden images from a stego image. The method designs an image steganography model that supports bidirectional mapping. The model includes cascaded invertible modules containing a host branch and a hidden branch. A hidden image is embedded into a host image through forward mapping to form a stego image, and the host image and the hidden image are separated and recovered from the single stego image through reverse mapping.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: February 20, 2024
    Assignee: Nankai University
    Inventors: Shaoping Lu, Rong Wang, Tao Zhong
  • Patent number: 11865595
    Abstract: A device for wholly treating urban and rural mixed household refuse at low temperature on site is provided. The device includes a vibration sieving and crushing system, a magnetic separator, conveyor belts, a magnetic pulse mineralization reactor and a tail gas purifying device. By using the device, urban and rural mixed household refuse is continuously fed; the mixed household refuse is sieved by the vibrating sieve according to viscosity, weight and size; nonferrous metal is sieved through a magnetic field; and organic substances are conveyed to the magnetic pulse mineralization mixed household refuse treatment device for terminal treatment. So, efficient reduction and harmlessness of the organic substances in the mixed household refuse are realized, and the pollution of organic wastes on the environment is effectively eliminated.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: January 9, 2024
    Assignees: Nankai University, Chifeng Environmental Science Research Institute, Tianjin Shangyusheng Technology Dev., Co., Ltd.
    Inventors: Weizun Li, Peng Ji, Tianliang Xia, Yuandong Xia, Ruifeng Zhang, Xunwei Wang, Mingyan Yu
  • Publication number: 20240005440
    Abstract: The present disclosure provides a method and system for large-capacity image steganography and recovery based on an invertible neural networks. The method is intended to embed one or more hidden images into a single host image, and recover all the hidden images from a stego image. The method designs an image steganography model that supports bidirectional mapping. The model includes cascaded invertible modules containing a host branch and a hidden branch. A hidden image is embedded into a host image through forward mapping to form a stego image, and the host image and the hidden image are separated and recovered from the single stego image through reverse mapping.
    Type: Application
    Filed: June 18, 2021
    Publication date: January 4, 2024
    Applicant: Nankai University
    Inventors: Shaoping Lu, Rong Wang, Tao Zhong
  • Patent number: 11760923
    Abstract: The present invention relates to a reagent for exploiting natural gas hydrates, which includes a regent A and a regent B. The reagent A is PEG400-polyurethane prepolymer; the reagent B includes PEG400 and an initiator; and a volume ratio of the PEG400-polyurethane prepolymer, the PEG400 and the initiator is (1-3000):(1-1000):(1-2000). The reagent of the present invention has excellent performance and high stability, and can effectively “replace” the “water” of the natural gas hydrate; and moreover, the reaction is exothermic reaction to effectively increase the reaction rate, which reduces the energy loss on the one hand, and reduces the blockage of a gas passage caused by the secondary generation of the natural gas hydrates in a low-temperature high-pressure pipeline during transferring on the other hand.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: September 19, 2023
    Assignees: Nankai University, Guangzhou Marine Geological Survey, Institute of Exploration Technology, Chinese Academy of Geological Sciences
    Inventors: Xiaohang Liu, Annan Guo, Peng Zhao, Xiaoyang Li, Jinqiang Liang, Wei Huang, Yongqin Zhang
  • Publication number: 20230144262
    Abstract: The present disclosure relates to the technical field of terahertz (THz) wave measurement and relates to a photo-thermo-acoustic mechanism-based power measurement apparatus and measurement method for a terahertz wave at room temperature. The apparatus includes a terahertz wave power modulation component, a photo-thermo-acoustic conversion device, and an acoustic wave measurement component. In the present disclosure, the THz absorbing substance having a photo-thermo-acoustic effect is used as the photo-thermo-acoustic conversion device. A power-modulated terahertz wave is converted into an acoustic wave pulse by means of the photo-thermo-acoustic mechanism. The acoustic wave measurement component measures the acoustic wave pulse. A peak-to-peak value of a pulse of the measured acoustic wave is proportional to the power of the terahertz wave, thereby implementing the fast broadband measurement of the terahertz wave power at room temperature.
    Type: Application
    Filed: November 2, 2022
    Publication date: May 11, 2023
    Applicant: Nankai University
    Inventors: Weiwei LIU, Tingyuan WANG, Nan ZHANG, Lanjun GUO
  • Patent number: 11543564
    Abstract: The present disclosure provides a metalens array and a spatial positioning method based on the metalens array. The metalens array includes at least two metalenses, each of the metalenses comprises a plurality of prism cells, each of the prism cells comprises a silicon dioxide substrate and a titanium oxide prism placed on the silicon dioxide substrate, and the plurality of prism cells are arranged periodically.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: January 3, 2023
    Assignee: Nankai University
    Inventors: Shuqi Chen, Wenwei Liu, Dina Ma, Hua Cheng, Jianguo Tian
  • Patent number: 11505800
    Abstract: A method for improving a bio-coupling efficiency between a protein and a nucleic acid based on an ?-helix handle includes the following steps. First, the handle carrying the non-natural amino acid (H-tag) is designed. Then, a recombinant expression plasmid encoding a fusion protein containing the H-tag and the protein to be tested is constructed. Subsequently, the fusion recombinant protein containing the non-natural amino acid in the H-tag is expressed and purified. Finally, the non-natural amino acid in the H-tag-fused protein and the coupling group on the nucleic acid substrate are efficiently connected by click chemistry. Thea-helix handle is used to provide a controllable reaction condition on the protein surface for the non-natural amino acid, avoiding the complex structure, charge and polar nanoenvironment around the surface of the protein to be tested.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 22, 2022
    Assignee: Nankai University
    Inventors: Zhongbo Yu, Xu Li, Xiaofeng Ma, Lihua Qu, Wei Huang