Abstract: A process method for producing a pesticide by using carbon dioxide includes: weighing a 1,3-cyclohexanedione substrate 1(a-e), a catalyst and Cs2CO3 in a Schlenk bottle, degassing, and continuously introducing 1 atm of carbon dioxide; adding a solvent and reacting for 48 h in an oil bath at 50° C. After the reaction was completed, post-treatment was carried out to obtain a 2-carboxyl-1,3-cyclohexanedione compound 2(a-e). The obtained acid is acylated and then added dropwise to a dichloromethane solution containing aniline to react for 2 h at room temperature. After the reaction, column chromatography was performed to obtain a pesticide compound 3(a-e). Adding the pesticide compound 3(a-e) into 50% concentrated sulfuric acid and refluxing at 80° C. for 8 hours. Through separation, a pesticide product compound 4(a-e) was obtained. The process method is simple, with low requirements on equipment, wide sources of raw materials, low cost, low toxicity and easy industrial scale-up production.

Abstract: A system for determining a second-order nonlinear susceptibility of a material includes a laser light source, a polarization modulator, a light collector, a polarization detector and a controller. The controller can obtain the second-order nonlinear susceptibility of the sample to be tested according to the test data. The system for determining the second-order nonlinear susceptibility of a material can directly test a material (block or film) with a thickness of hundreds of nanometers, and draw a second-order nonlinear susceptibility fitting curve of the material according to the test results of the optical system.

Abstract: A highly-dispersed hydrogenation catalyst, a preparation method thereof, and use thereof in the preparation of biofuel from palm oil or other oil are provided. The combination of maleic anhydride-grafted polypropylene (MA-PP) and a silane coupling agent (SCA) is introduced into an aluminum oxide composite carrier through organic amidation to obtain a uniformly-dispersed composite carrier with regular pores. Moreover, through a multi-stage impregnation and roasting process, a particle size of an active component is greatly reduced, and the dispersion of the active component and the number of active sites are improved. A hydrogenation catalyst with high hydrothermal stability, high hydrogenation activity, and long life is prepared based on the composite carrier with regular pores and used in the preparation of biofuel from vegetable oil or other oil through hydrodeoxygenation (HDO), which has great industrial application value.

Abstract: The invention relates to the complex of synthetic polymer and natural extracellular matrix for vascular grafts and their preparation methods. The components of biodegradable synthetic polymer in the preparation process can be chosen with different material proportions. The scaffolds with different fiber diameters, different fiber arrangements, different pore sizes and different pore structures can be prepared by electro-spinning, wet-spinning, melt-spinning, 3D printing, pouring, phase separation, particle leaching and other technologies. Among them, the natural extracellular matrix components come from a wide range of sources such as vascular tissues from different kinds of animals including arteries and veins of pigs and cattle or vascular tissues from human donors including umbilical cord vessels, etc. And its composition and content can be flexibly adjusted according to the demand.

Abstract: The present invention belongs to the technical field of pesticides, particularly relates to sulfonyl-structure-containing triazinone derivatives, their preparation methods, and their uses in insect killing and/or bacterium killing. The sulfonyl-structure-containing triazinone derivatives are compounds represented by formula (Ia) or (Ib). The sulfonyl-structure-containing triazinone derivatives provided in the present invention exhibit outstanding insecticidal activity as well as bactericidal activity.

Abstract: The present disclosure discloses a trusted execution environment (TEE)-based password management method and system. This method assumes a hardware trusted environment on a mobile end. A user authorizes the hardware trusted environment, and an independent operating system in the trusted environment automatically performs password management operations. The TEE registers an independent strong password for each account, and stores a correspondence between accounts and applications (or websites) in a hardware security zone. When an application requests login, an account list corresponding to the application is returned for a user to select. Through point-to-point encrypted transmission, different trusted devices can synchronize stored password information. In addition, a trusted mobile end can manage applications (or websites) on other devices without a TEE such as laptops.

Abstract: The present invention relates to a microbicidal ?-amino acrylic derivative and its preparation method and applications. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of ?-amino acrylic derivatives are designed and synthesized, and in particular, ?-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provide many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to reduce the pesticide application dosage and protect the environment and ecology.

Abstract: A method for improving a bio-coupling efficiency between a protein and a nucleic acid based on an ?-helix handle includes the following steps. First, the handle carrying the non-natural amino acid (H-tag) is designed. Then, a recombinant expression plasmid encoding a fusion protein containing the H-tag and the protein to be tested is constructed. Subsequently, the fusion recombinant protein containing the non-natural amino acid in the H-tag is expressed and purified. Finally, the non-natural amino acid in the H-tag-fused protein and the coupling group on the nucleic acid substrate are efficiently connected by click chemistry. Thea-helix handle is used to provide a controllable reaction condition on the protein surface for the non-natural amino acid, avoiding the complex structure, charge and polar nanoenvironment around the surface of the protein to be tested.

Abstract: The present invention belongs to the technical field of pesticides, particularly relates to sulfonyl-structure-containing triazinone derivatives, their preparation methods, and their uses in insect killing and/or bacterium killing. The sulfonyl-structure-containing triazinone derivatives are compounds represented by formula (Ia) or (Ib). The sulfonyl-structure-containing triazinone derivatives provided in the present invention exhibit outstanding insecticidal activity as well as bactericidal activity.

Abstract: The present invention relates to a new method for successfully inducing the mutation of cell chemokine receptor CCR5 gene into CCR5?32 deletion gene by using the CRISPR-Cas9 genome editing technique. CCR5 is an important co-receptor for entry of Human Immunodeficiency Virus (HIV) into human host cells. CCR5?32 deletion is a 32-bp deletion in CCR5 coding region, which results in change and premature termination in the sequence following the 185th amino acid. Biallelic homozygous deletion of CCR5?32 is naturally resistant to HIV infection, i.e., the people carrying this mutation can't be infected by HIV. The present invention uses both lentiviral packaging system and the CRISPR technique to induce CCR5?32 deletion. Due to the characteristics of a wide range of Lentivirus infection, the invention can be applied to cells such as bone marrow stem cells and CD4+ T cells and can be expected to be the therapeutic drug for HIV/AIDS infection or other diseases.

Abstract: A method for quantitative detection of trace polylactic acid microplastics (PLA MPs) in an environmental sample is disclosed, where the PLA MP in the environmental sample is depolymerized in an alkaline alcohol phase system, and the monomers thereof, i.e., lactic acid molecules were separated and recovered. Mass concentrations of lactic acid before and after reaction are quantitatively detected by HPLC-MS, and the initial mass concentration of PLA MPs in the sample is calculated using a formula. The minimum detectable concentration may be as low as 0.05 mg/kg. This method can quantify the trace PLA in water body, sludge, sediment, dust, and soil samples; no special treatment is required before heating in pentanol; use of such reaction conditions as heating and alkaline alcohol phase reduces reaction time substantially.

Abstract: Provided are a crystal form of a sesquiterpene derivative, a preparation method therefor and the use thereof. In an X-ray powder diffraction pattern of crystal form A, there are characteristic diffraction peaks at positions corresponding to the 2? diffraction angles of 6.840±0.2, 9.390±0.2, 15.980±0.2, 16.830±0.2, 17.780±0.2, 18.760±0.2, 19.340±0.2, 20.400±0.2, 21.910±0.2, 23.280±0.2, 25.520±0.2, 26.680±0.2, 27.490±0.2, 32.110±0.2, 32.300±0.2, 37.980±0.2 and 44.230±0.2. The crystal form A has a high degree of crystallinity and is basically non-hygroscopic; in addition, same shows more favorable dissolution kinetics and has a bioavailability that can reach 85.8%.

Abstract: The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

Abstract: The present invention provides a breeding method for tetraploid ricinus communis. The method comprises: collecting a ricinus communis germplasm resource, performing morphologic character analysis and chromosome ploidy identification, selecting good diploid varieties, carrying out mutagenesis by using colchicine and oryzalin; performing chromosome ploidy identification on F1 generation seeds, selecting homozygous tetraploids, and performing economic character analysis and identification on the F2 generation, so as to breed good tetraploid ricinus communis.

Abstract: A porous chiral material of formula [M(L)1.5(A)]+X? wherein M is a metal ion; L is a nitrogen-containing bidentate ligand; A is the anion of mandelic acid or a related acid; and X? is an anion.

Abstract: This disclosure provides a stress-responsive polypeptide sequence for fusion with a polypeptide to specifically induce stability of the fusion polypeptide under stress conditions, such as drought, high salt and high temperature, in plants. Also disclosed includes an expression vector for expressing a fusion polypeptide comprising the stress-responsive peptide in plants transformed therewith, and a method for generating a transgenic plant with enhanced tolerance to environmental stresses, comprising introducing into the transgenic plant a polynucleotide encoding a fusion polypeptide which comprises the stress-responsive peptide as disclosed and a plant anti-stress gene, such as the plant senescence-associated gene SSPP. A plant expressing the expression vector that have an enhanced stress tolerance, including Arabidopsis and soybean, is also provided.

Abstract: The present invention relates to the uses of sesquiterpene lactone compounds and their derivatives in preparing drugs. It belongs to the field of drug technology, specifically relates to the uses of the compounds of Formula (I) in preparing the drugs, especially the uses in preparing the drugs to treat rheumatoid arthritis and treat cancers through inhibiting cancer stem cells.

Abstract: Provided are a Fourier lens, a method for designing a Fourier lens, and a schlieren apparatus. The Fourier lens includes a substrate and a plurality of cuboid waveguides. The plurality of waveguides are arranged on the substrate in parallel and spaced from each other at a preset interval. The material of the substrate and the material of the waveguides are all transparent to the working waveband of the Fourier lens. The preset interval is smaller than a quotient obtained by dividing a center wavelength of the working waveband by the refractive index of the substrate. The waveguide has a plurality of widths, and the waveguides of different widths correspond to different phase delays. The individual waveguides are arranged on the substrate according to phase delays required at different positions. According to the embodiments, the range of the working angle of the Fourier lens can be increased.

Abstract: The method for orientation of liquid crystals in a micro/nano region on the basis of laser direct writing and a system thereof includes a laser direct writing system employed to build a micro/nano structure. Liquid crystal molecules in a micro/nano structural region perform self-orientation; and the orientation of liquid crystals is generated by fine structures on side walls of polymer strips which form the micro/nano structure. The dimension of the micro/nano region varies from the micrometer magnitude to the nanometer magnitude exceeding the diffraction limit. The orientating direction can be adjusted and controlled in the micro/nano region, which is favorable for the miniaturization of the liquid crystal display devices and the orientation of the complicated three-dimensional liquid crystal structure.

Abstract: The present invention relates to ?-carboline, dihydro-?-carboline and tetrahydro-?-carboline alkaloid derivatives (I) and a method for preparing same and the use in the aspects of preventing and treating plant viruses, fungicides and insecticides. For the meaning of each group in formula (I) see the description. The ?-carboline, dihydro-?-carboline and tetrahydro-?-carboline alkaloid derivatives of the present invention show a particularly ourstanding anti-plant virus activity, and also have fungicidal and insecticidal activities.