Patents Assigned to NANOFIBER SOLUTIONS, LLC
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Publication number: 20230320998Abstract: A fiber may comprise an electrospun polymer and a pharmaceutical. The pharmaceutical may be dispersed within the electrospun polymer, and may have the form of a crystal, an oil, or a combination thereof. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a pharmaceutical. A method of treating a disorder in a subject may comprise obtaining such a fiber having an effective amount of a pharmaceutical, applying the fiber to an oral region of the subject, and allowing the fiber to disintegrate, thereby delivering the effective amount of the pharmaceutical to the subject.Type: ApplicationFiled: October 28, 2022Publication date: October 12, 2023Applicant: Nanofiber Solutions, LLCInventors: Jed JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
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Patent number: 11576927Abstract: A method of treating a chronic wound may comprise applying to the wound a first scaffold comprising an electrospun polymer fiber. The electrospun fiber may comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactide-co-caprolactone), polylactic acid, polycaprolactone, copolymers thereof, and combinations thereof. The first scaffold may have a thickness from about 50 ?m to about 1 mm, a length from about 1 cm to about 20 cm, and a width from about 1 cm to about 15 cm. The method may further comprise keeping the first scaffold on the chronic wound for a time period of about 3 days to about 21 days. After the time period passes, the chronic wound may have a decreased planimetric area.Type: GrantFiled: December 11, 2019Date of Patent: February 14, 2023Assignee: Nanofiber Solutions, LLCInventors: Jason Chakroff, Ronald Lloyd Bracken, Jed Johnson
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Publication number: 20220395609Abstract: Disclosed herein are methods of controlling a composition of M1/M2 macrophages in a wound of a subject. The method can include applying an electrospun structure to the wound, wherein the electrospun structure comprises a polymer, wherein the polymer comprises an alpha-hydroxy acid, and keeping the electrospun structure on the wound for a time period. The presence of the electrospun structure on the wound causes an increase in presence of M2 macrophages relative to M1 macrophages, which can, in turn, promote healing of the wound.Type: ApplicationFiled: June 15, 2022Publication date: December 15, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Ronald Lloyd Bracken
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Patent number: 11337705Abstract: An embolization device may include a fiber section having a plurality of polymeric electrospun fibers and, optionally, a contrast agent. An embolization device may further include a plurality of fiber sections, wherein each fiber section is separated by a linker. A method of deploying such an embolization device may include inserting the embolization device into a vessel. The method may further include applying an electrical current to one or more of the linkers, applying electrothermal heat to at least a portion of the device, or applying force to at least a portion of a delivery vehicle for the device. A method of manufacturing the device may include electrospinning a fiber section, and processing the fiber section by straining, twisting, heating, or shaping it.Type: GrantFiled: May 23, 2019Date of Patent: May 24, 2022Assignee: NANOFIBER SOLUTIONS, LLCInventors: Jed Johnson, Tyler Groehl, Devan Ohst
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Publication number: 20220133950Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: ApplicationFiled: January 14, 2022Publication date: May 5, 2022Applicant: Nanofiber Solutions, LLCInventor: Jed K. Johnson
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Publication number: 20220133946Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.Type: ApplicationFiled: January 13, 2022Publication date: May 5, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Ross Kayuha
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Patent number: 11311650Abstract: The invention provides devices for supporting regeneration of body tissue and of tubular structures, such as the esophagus or intestine, and methods for making and for using the devices.Type: GrantFiled: September 30, 2016Date of Patent: April 26, 2022Assignees: The Administrators of the Tulane Educational Fund, Nanofiber Solutions, LLCInventors: Derek C. Dashti, Aline M. Betancourt, Jed Johnson, Ruth Waterman
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Publication number: 20220111578Abstract: Systems and methods of fabricating corrugated electrospun fiber assemblies are disclosed herein. The method can include placing an electrospun fiber scaffold on a corrugation rod, wherein the corrugation rod comprises a helical structure; applying a monofilament fiber about the electrospun fiber scaffold and the corrugation rod from a dispenser as the dispenser is translated longitudinally and the corrugation rod is rotated such that the monofilament fiber is wrapped about the electrospun fiber scaffold at a defined threads per inch (TPI) to form a wrapped electrospun fiber assembly; and longitudinally compressing the corrugated electrospun fiber assembly until it has been compressed from a first length to a second length to form the corrugated electrospun fiber assembly. The corrugated electrospun fiber assemblies can be kink-resistant as compared to conventional electrospun fiber scaffolds. The corrugated electrospun fiber assemblies can be used in, for example, biological applications within a subject.Type: ApplicationFiled: October 13, 2021Publication date: April 14, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Kevin Nelson, Tyler Groehl
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Publication number: 20220090299Abstract: Described herein are electrospun nanofiber structures and compositions configured to serve as TNT-based platforms for the delivery of an agent or cargo, such as genetic material. The structures can include a conductive nanofiber comprising a shell electrospun from an insulating polymer, wherein the shell comprises a plurality of nanochannels therethrough, a conductive element, and an agent contained within the shell. The conductive nanofiber can be configured to deliver the agent when exposed to an electric field. The agent can include a therapeutic agent, a prophylactic agent, or a diagnostic agent.Type: ApplicationFiled: September 21, 2021Publication date: March 24, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed JOHNSON, Doug KAYUHA, Devan OHST
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Patent number: 11246959Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: GrantFiled: June 17, 2020Date of Patent: February 15, 2022Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson
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Publication number: 20210259988Abstract: Systems and methods of forming electrospun structures including pharmaceuticals are disclosed. An electrospun structure can include one or more polymers electrospun from a polymer solution comprising a pharmaceutical such that the pharmaceutical is dispersed throughout the one or more electrospun polymers. The pharmaceutical can include a cannabinoid, a phytocannabinoid, a terpene produced by a Cannabis plant, or a combination thereof. The one or more electrospun polymer are configured to degrade over a predetermined time period to deliver the pharmaceutical over the predetermined time period.Type: ApplicationFiled: February 22, 2021Publication date: August 26, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
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Publication number: 20210138108Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: ApplicationFiled: June 17, 2020Publication date: May 13, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventor: Jed K. JOHNSON
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Publication number: 20210138104Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.Type: ApplicationFiled: January 15, 2021Publication date: May 13, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Ross KAYUHA
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Publication number: 20210106720Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST, Jason CHAKROFF, Brian COHEN, Anthony ROMEO
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Patent number: 10953097Abstract: A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.Type: GrantFiled: November 2, 2016Date of Patent: March 23, 2021Assignee: NANOFIBER SOLUTIONS. LLCInventors: Jed Johnson, Devan Ohst, Jason Chakroff
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Patent number: 10941375Abstract: A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.Type: GrantFiled: April 9, 2019Date of Patent: March 9, 2021Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed Johnson
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Patent number: 10898608Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: GrantFiled: February 2, 2018Date of Patent: January 26, 2021Assignee: NANOFIBER SOLUTIONS, LLCInventors: Jed Johnson, Jason Chakroff, Devan Ohst, Brian Cohen, Anthony Romeo
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Patent number: 10895020Abstract: A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.Type: GrantFiled: August 26, 2016Date of Patent: January 19, 2021Assignees: CHILDREN'S NATIONAL MEDICAL CENTER, RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, NANOFIBER SOLUTIONS LLCInventors: Axel Krieger, Narutoshi Hibino, Jed Johnson, Justin Opfermann, Carolyn Cochenour Dorgan, Christopher K. Breuer
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Publication number: 20200245658Abstract: A cultured meat product may comprise a scaffold comprising an electro spun polymer fiber, and a population of cells. The cultured meat product may have a thickness from about 100 ?m to about 500 mm. A method of producing such a cultured meat product may comprise preparing the scaffold, placing the scaffold into a bioreactor, adding the population of cells to the bioreactor, culturing the population of cells in the bioreactor containing the scaffold for a period of time, thereby forming the cultured meat product, and removing the cultured meat product from the bioreactor. The cultured meat product may be configured to mimic the taste, texture, size, shape, and/or topography of a traditional slaughtered meat.Type: ApplicationFiled: February 3, 2020Publication date: August 6, 2020Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST
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Publication number: 20200237680Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: ApplicationFiled: April 10, 2020Publication date: July 30, 2020Applicant: NANOFIBER SOLUTIONS, LLCInventor: Jed K. JOHNSON