Abstract: An angioplasty device may comprise a catheter, a balloon disposed on the catheter, and a scaffold disposed over the balloon. The scaffold may comprise an electrospun polymer fiber and an agent dispersed within the fiber. A method of making such an angioplasty device may comprise obtaining a catheter having a balloon disposed on it, contracting the balloon, and electrospinning a polymer solution onto the surface of the catheter having the balloon, thereby forming a scaffold disposed over the balloon. The polymer solution may comprise a polymer, a solvent, and an agent. A method of performing an angioplasty procedure may comprise inserting such an angioplasty device into a blood vessel, placing the angioplasty device near a lesion within the blood vessel, expanding the balloon, thereby contacting the lesion with the scaffold, contracting the balloon, and removing the angioplasty device from the blood vessel.

Abstract: A method of treating a chronic wound may comprise applying to the wound a first scaffold comprising an electrospun polymer fiber. The electrospun fiber may comprise a polymer selected from the group consisting of polyglycolic acid, poly(lactide-co-caprolactone), polylactic acid, polycaprolactone, copolymers thereof, and combinations thereof. The first scaffold may have a thickness from about 50 ?m to about 1 mm, a length from about 1 cm to about 20 cm, and a width from about 1 cm to about 15 cm. The method may further comprise keeping the first scaffold on the chronic wound for a time period of about 3 days to about 21 days. After the time period passes, the chronic wound may have a decreased planimetric area.

Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.

Abstract: A scaffold may comprise a first polymeric electrospun fiber comprising a first material having a first degradation rate, and a second polymeric electrospun fiber comprising a second material having a second degradation rate different from the first degradation rate. The first degradation rate may substantially correspond to a cell infiltration rate, and the second degradation rate may be slower than the first degradation rate. Such a scaffold may be manufactured by electrospinning a first polymer fiber having a first degradation rate by ejecting a first polymer solution from a first polymer injection system onto a mandrel, and electrospinning a second polymer fiber having a second degradation rate different from the first degradation rate by ejecting a second polymer solution from a second polymer injection system onto a mandrel. Wound healing may be improved by applying such a scaffold to a portion of a wound.

Abstract: The instant disclosure is directed to devices and methods for water filtration. A filter may comprise electrospun polymer fibers comprising an effective amount of an additive. The additive may be configured to react with chlorine. A method of manufacturing such a filter may comprise mixing a homogeneous solution comprising a polymer, a solvent, and an effective amount of an additive. The method may further comprise electrospinning the mixture onto a mandrel to form a scaffold comprising electrospun polymer fibers and the additive, and removing the scaffold from the mandrel to form a filter. A method of filtering a chlorine-containing liquid may comprise exposing the chlorine-containing liquid to such a filter, and exposing the chlorine-containing liquid to the filter may produce a purified liquid. The method may further include collecting the purified liquid. The purified liquid may contain about 85% less chlorine than the chlorine-containing liquid.

Abstract: A system for manufacturing a synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.

Abstract: The instant disclosure is directed to flexible electrospun fiber rods and methods of manufacturing such rods. A scaffold may comprise a flexible rod having a spiral cross-section, the flexible rod comprising electrospun polymer fibers. The electrospun polymer fibers may be substantially aligned or randomly oriented with respect to one another. The flexible rod may further comprise substantially uniformly distributed pores. The flexible rod may have a length and a diameter of a native mammalian tendon or ligament. A method of manufacturing such a scaffold may comprise forming a layer of polymer fibers on a mandrel by electrospinning, rolling the layer from a first end of the mandrel to a second end of the mandrel to form a toroid at the second end of the mandrel, and cutting the toroid off the mandrel to form a flexible rod having a spiral cross-section.

Abstract: A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.

Abstract: The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed.

Abstract: A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.

Abstract: A synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.

Abstract: The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed.

Abstract: The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed.

Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.