Patents Assigned to National Central University
  • Patent number: 11307088
    Abstract: An optical tomography imaging system includes a signal generator, at least one light emitter, at least one light receiver, a signal processor, and an image processor. The signal generator is configured to generate a periodic signal and a reference signal. The light emitter is configured to be activated by the periodic signal to generate an optical signal passing through an object under test. The light receiver is configured to receive and convert the optical signal passing through the object under test into an electrical signal. The signal processor is configured to generate a comparison signal according to the electrical signal and the reference signal. The image processor is configured to acquire a plurality of disassembled sine waves from the comparison signal and generate a reconstructed image according to the disassembled sine waves.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: April 19, 2022
    Assignees: National Central University
    Inventors: Min-Chun Pan, Ya-Fen Hsu, Yan-Yang Hsu
  • Publication number: 20220110682
    Abstract: The present invention relates to a computer-implemented method for a computer-assisted planning of a surgical path. The method includes accessing a data set of a computer-readable three-dimensional visualization medical representation including at least one three-dimensional medical model; loading the data set into and presenting the data set in a three-dimensional surgical path simulator; inserting a virtual three-dimensional object representing for the surgical path and features thereof into the data set; and adjusting a relative position of the virtual three-dimensional object with respect to the at least one three-dimensional medical model.
    Type: Application
    Filed: October 20, 2020
    Publication date: April 14, 2022
    Applicant: National Central University
    Inventors: CHING SHIOW TSENG, JHENG-RUEI YU
  • Publication number: 20220110712
    Abstract: The present invention relates to a surgical instrument holder. The holder includes an assembly of linkages comprising a first line of center and a second line of center, wherein where the first line of center and the second line of center intersect each other forms a stagnation point; a securing module configured to secure a surgical instrument and define a first line of center; and a complex lockable joint configured to define a second line of center, and comprising a turn piece to selectively lock up the assembly of linkages.
    Type: Application
    Filed: October 20, 2020
    Publication date: April 14, 2022
    Applicant: National Central University
    Inventors: CHING SHIOW TSENG, HUNG-JUNG CHEN
  • Publication number: 20220114292
    Abstract: The present invention relates to a structure analyzing method. The method includes dividing a physical structure into a plurality of virtual elements in accordance with a structural geometry of the physical structure and establishing a discrete increment secant iterative model including an equivalent nodal secant mass coefficient and an equivalent nodal secant mass damping coefficient; implementing an increment-secant iterative algorithm to repeatedly compute until convergence a secant mass coefficient slope corresponding to the equivalent nodal secant mass coefficient and a secant mass damping coefficient slope corresponding to the equivalent nodal secant mass damping coefficient; and replacing the equivalent nodal secant mass coefficient and the equivalent nodal secant mass damping coefficient by the converged secant mass coefficient slope and the converged secant mass damping coefficient slope respectively.
    Type: Application
    Filed: October 20, 2020
    Publication date: April 14, 2022
    Applicant: National Central University
    Inventors: TZU-YING LEE, WEN-HSIAO HUNG
  • Publication number: 20220106582
    Abstract: An exosomal nucleic acid extraction method is provided. A substrate is provided, on which antibodies and silicon nanoparticles are disposed, and the antibodies have binding specificity to exosomal surface antigens. After that, based on the binding specificity between the antibodies and the exosomal surface antigens, exosomes in a specimen are separated. Next, the nucleic acids in the separated exosomes are adsorbed by the silicon nanoparticles.
    Type: Application
    Filed: October 28, 2020
    Publication date: April 7, 2022
    Applicant: National Central University
    Inventors: Wen-Yih Chen, Hsin-Yi Lin, Chi-Hung Lai
  • Patent number: 11294362
    Abstract: A yield-rate assessment apparatus for a manufacture system including a plurality of machines, each machine participating in one or more manufacture steps of a batch of products in the manufacture system, performs for each machine: calculating a bad-piece expectation value and a quantity of potential bad pieces at each corresponding manufacture step based on a quantity of bad pieces detected after the last one of the manufacture steps is finished and an initial yield rate of the current machine; calculating a good-piece expectation value based on a quantity of good pieces detected after the last one of the manufacture steps is finished and a summation of all quantities of potential bad pieces calculated for the current machine; and assessing a yield rate according to the good-piece expectation value calculated for the current machine and a summation of the bad-piece expectation value calculated for the current machine at each corresponding step.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: April 5, 2022
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Deron Liang, Chin-Chun Chang
  • Publication number: 20220104310
    Abstract: The present invention relates to a method for building self-organized network. The method including steps of providing a plurality of network nodes and configuring a layer of middleware into the each of the plurality of network nodes; implementing a hop-by-hop transport test to acquire a current status of message exchange among the plurality of network nodes; computing a nodal topology for the plurality of network nodes in accordance with the current status; establishing at least one peer-to-peer communication link among the plurality of network nodes in accordance with the nodal topology; and transmitting messages through the at least one peer-to-peer communication link.
    Type: Application
    Filed: October 20, 2020
    Publication date: March 31, 2022
    Applicant: National Central University
    Inventors: CHIH-LIN HU, CHITRIN BAMRUNG, YING-JIUN LU, WU-MIN SUNG, JIAN-CHIUAN HOU
  • Publication number: 20220089990
    Abstract: The present invention relates to a composite membrane. The composite membrane includes: an elastic polymer substrate having a first surface processed by a surface modification; and a thermosensitive conductive layer formed on the first surface by performing a co-polymerization process, allowing an electrical current to pass through, and altering a hydrophilicity of a membrane surface in response to a change of a temperature.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 24, 2022
    Applicant: National Central University
    Inventors: WEI-WEN HU, CHIA-WEN TSAO
  • Publication number: 20220088603
    Abstract: The present invention relates to a bioreactor. The bioreactor includes a fluidic channel layer including a set of channels configured to generate a suction caused by a negative pressure or a retrieval force caused by a positive pressure; an elastic conductive layer configured with a pair of electrodes, configured on the fluidic channel layer, driven by the suction or the retrieval force to have a deformation toward a deformation direction, and receiving a voltage difference by the pair of the electrodes to form an electrical field along an electrical field direction; and a culture layer configured on the elastic conductive layer and providing for a biological tissue to culture in vitro on the elastic conductive layer.
    Type: Application
    Filed: October 23, 2020
    Publication date: March 24, 2022
    Applicant: National Central University
    Inventors: CHIA-WEN TSAO, WEI-WEN HU
  • Patent number: 11282197
    Abstract: The present disclosure provides an operating method of a system for analyzing brain tissue based on computerized tomographic imaging, and the operation method includes steps as follows. A computed tomography image of a subject is aligned to a predetermined standard brain space image, to obtain a first normalized test computed tomography image. A voxel contrast of the first normalized test computed tomography image is enhanced to obtain an enhanced first normalized test computed tomography image. The enhanced first normalized test computed tomography image is aligned to an average computed tomographic image of a control group to obtain a second normalized test computed tomography image. An analysis based on the second normalized test computed tomography image and a plurality of computerized tomographic images of the control group is performed to obtain a t-score map.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: March 22, 2022
    Assignees: National Central University, Taipei Medical University (TMU)
    Inventors: Syu-Jyun Peng, Yu-Wei Chen, Jing-Yu Yang, Jang-Zern Tsai, Kuo-Wei Wang, Yeh-Lin Kuo
  • Patent number: 11271587
    Abstract: The present invention relates to a compressed sensing apparatus for compressed sensing of a set function consisting of a plurality of input sets containing a group of data. The apparatus includes: a plurality of sensing units acquiring a group of sampling data representing a plurality of sampling sets selected out of the plurality of input sets; a compression and computation unit enabling a compression to the group of data based on the group of sampling data in accordance with a Fourier basis set generated on the basis of the plurality of input sets and sampling sets, and a computation to compute a Fourier coefficient set based on a sparse regression technique which is in relation with the Fourier basis set; and a reconstruction unit predicting the group of data based on the Fourier coefficient set.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: March 8, 2022
    Assignee: National Central University
    Inventor: Kuo-Shih Tseng
  • Patent number: 11261204
    Abstract: The present invention provides a composition for substrate surface modification and a method using the same, and the composition for substrate surface modification is composed of a compound of the general formula structure shown in formula 1: formula 1, wherein n1 is an integer of 1 to 6, and R is a zwitterionic group. The composition for substrate surface modification uses water as a medium to perform modifying reaction over a substrate surface, and at the same time has biological modification characteristics, and abilities of immobilizing biomolecules and anti-biofouling.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: March 1, 2022
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Chen-Han Huang, Wen-Hao Chen
  • Patent number: 11261203
    Abstract: The present invention provides a composition for substrate surface modification and a method using the same, and the composition for substrate surface modification is composed of a compound of the general formula structure shown in formula 1: formula 1, wherein n1 is an integer of 1 to 6, and R is a zwitterionic group. The composition for substrate surface modification uses water as a medium to perform modifying reaction over a substrate surface, and at the same time has biological modification characteristics, and abilities of immobilizing biomolecules and anti-biofouling.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: March 1, 2022
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Chen-Han Huang, Wen-Hao Chen
  • Patent number: 11237313
    Abstract: A reflective electronic display device being pixels or sub-pixels includes: a main substrate; an electromagnetic micro-electromechanical module installed on a side of the main substrate; a shaft coupled to the electromagnetic micro-electromechanical module and the main substrate; a reflector stacked on the other side of the main substrate; a first polarizer stacked on the reflector and configured to be opposite to the main substrate, and the first polarizer defining a first penetration axis; a second polarizer installed on a side of the first polarizer a side, and the second polarizer defining a second penetration axis; an electromagnetic micro-electromechanical module driving the main substrate to drive the reflector, so as to link and rotate the first polarizer and define a bright mode, a dark mode, and a grayscale mode.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: February 1, 2022
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Ko-Ting Cheng, Cheng-Kai Liu
  • Patent number: 11226857
    Abstract: When the inspection unit corresponding to at least one disabled layer of a multilayer system is unavailable, a fault-eliminating device defines the at least one disabled layer and a target layer as a combined layer. The fault dependency of the target layer is the lowest among the fault dependency of the at least one available layer. The inspection unit of the at least one available layer is active and the fault dependency thereof is higher than the disabled layer. Then, the device makes the inspection unit and the fault symptom corresponding to the target layer correspond to the combined layer, so as to update a list of layers and a fault model. After that, the device determines a source of a fault from the layers according to the list of layers and the fault model, and performs a strategy of fault elimination corresponding to the source, to eliminate the fault.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: January 18, 2022
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Deron Liang, Yen-Lin Lee, Wei-Jen Wang
  • Patent number: 11220734
    Abstract: A magnesium-based bulk metallic glass composite includes a magnesium-based bulk metallic glass composite comprising a magnesium-based material and a TiZr alloy.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 11, 2022
    Assignees: NATIONAL CENTRAL UNIVERSITY, TAIPEI MEDICAL UNIVERSITY
    Inventors: Chih-Hwa Chen, Shian-Ching Jang, Hsiang-Ho Chen, Lau-Yuen Woo, Erh-Yuan Chuang
  • Patent number: 11209069
    Abstract: A dynamic balancing apparatus includes a dynamic balancing assembly and a plurality of damping particles. The dynamic balancing assembly includes at least two structural members separately arranged on a rotating shaft connected to a rotor, wherein each structural member includes at least one recess portion. The plurality of damping particles are introduced into at least one recess portion of each structural member, such that a centroid of each structural member deviates from the axis. Accordingly, each structural member generates inertial force and moment of inertia as rotation of the rotor to offset another inertial force and moment of inertia generated by centroid deviation of the rotor while rotating to achieve dynamic balance. The plurality of damping particles can move in the recess portion as rotation of the rotor to induce friction and collision so as to achieve the effects of vibration reduction and noise reduction.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: December 28, 2021
    Assignee: NATIONAL CENTRAL UNIVERSITY
    Inventors: Yu-Ren Wu, Yun-Chi Chung
  • Publication number: 20210388440
    Abstract: A method for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis is provided, including measuring an expression level of at least one microRNA from a sample of the subject, and the microRNA is selected from miR-17, miR-100, miR-155, miR-202, miR-422a, and miR-483; comparing the expression level of the microRNA in the sample to that of a same miRNA of a control, when the expression level of miRNA in the sample is lower than that of the control, the subject is estimated having the risk of encapsulating peritoneal sclerosis. A kit for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis is also provided, including at least one agent for identifying the at least one microRNA as above mentioned from the sample of the subject.
    Type: Application
    Filed: July 9, 2020
    Publication date: December 16, 2021
    Applicant: National Central University
    Inventors: Nian-Han Ma, Chiu-Chin Huang, Jin-Bor Chen, Chin-Chung Tseng, I-Kuan Wang, Chien-Lung Chen, An-Lun Li
  • Publication number: 20210373559
    Abstract: The present invention relates to an environmental coverage oriented motion system. The system includes a rangefinder module configured to measure a distance in real time; an odometry module configured to measure a velocity or a position in real time; a powered vehicle carrying the rangefinder module and the odometry module; and a controller module carried by the powered vehicle, configured to receive one of the distance, the velocity and the position, performing an environmental coverage oriented motion scheme based on one of the distance, the velocity and the position to select a plurality of positions, and commanding the powered vehicle to move among the plurality of positions.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 2, 2021
    Applicant: National Central University
    Inventors: KUO-SHIH TSENG, CHIH-YUAN CHOU
  • Publication number: 20210363494
    Abstract: Universal human induced pluripotent stem cells (universal hiPSCs) and a method of forming the same are provided in the disclosure, including the following steps: providing a first cell group including human stem cells; providing a second cell group including human mononuclear cells; in some embodiments, the second cell group further includes human stem cells, in which the human stem cells of the second cell group are allogenic cells from the first cell group; mixing the first cell group and the second cell group to form cell mixture; maintaining the cell mixture at a temperature below 30° C. for at least one day; reprogramming the human stem cells of the cell mixture to obtain universal hiPSCs. The universal hiPSCs includes human leukocyte antigen-1 (HLA class I) gene and human leukocyte antigen-2 (HLA class II) gene, but no HLA class I and HLA class II expressions.
    Type: Application
    Filed: July 27, 2020
    Publication date: November 25, 2021
    Applicant: National Central University
    Inventors: Akon Higuchi, Tzu-Cheng Sung