Patents Assigned to National Cheng-Kung University
  • Publication number: 20240414931
    Abstract: An organic/inorganic composite structure includes a silicon substrate and a conductive polymer layer. The silicon substrate includes a plurality of microstructures disposed on a surface of the silicon substrate. The conductive polymer layer is disposed on the plurality of microstructures. A spaced distance is between the conductive polymer layer and the surface of the silicon substrate.
    Type: Application
    Filed: July 28, 2023
    Publication date: December 12, 2024
    Applicant: National Cheng Kung University
    Inventors: Chia-Yun Chen, Jheng-Yi Li, Tsung-Yen Wu
  • Patent number: 12163242
    Abstract: A method of manufacturing colorful thermal insulation films is provided. A substrate is connected with a metal adhesion layer and then the metal adhesion layer is connected with a porous anodic aluminum oxide (AAO) layer. A porosity of the AAO layer is changed by pore-widening. Thereby the thermal insulation film produced shows the color by the structure color of the AAO layer. Thus no dyes and organic compounds are required to be added during manufacturing process and environmental pollution caused by these substances can be avoided. The pore-widening changes the porosity of the AAO layer and further provides convenient color adjustment so that the colorful thermal insulation film with different colors can be produced easily. Besides providing attractive appearance, the colorful thermal insulation film filters out light with specific wavelengths.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: December 10, 2024
    Assignee: National Cheng Kung University
    Inventors: Chen-Kuei Chung, Chung-Yu Yu, Tsung-Han Chen
  • Patent number: 12128385
    Abstract: Provided are a catalyst and a method of preparing the same. The catalyst has a ternary Prussian blue analogue having transition metals M1, M2, and M3 and represented by the Formula (1) as defined herein, and can be used as a catalyst for oxygen evolution reaction. The method includes separately dissolving transition metal salts, ferrocyanide of alkali metals, and alkali metal salts in different solutions; adding the first two solutions to the third solution; mixing; precipitating; and drying. The ternary Prussian blue analogue catalyst is prepared by a simple and low-energy-consuming co-precipitation method, and the ternary Prussian blue analogue exhibit excellent electrocatalytic property through the synergistic effect of multiple transition metals.
    Type: Grant
    Filed: November 23, 2022
    Date of Patent: October 29, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Jyh-Ming Ting, Kai-Hasiang Yang
  • Patent number: 12114573
    Abstract: A method for manufacturing a thermoelectric polymer film includes steps as follows. A conductive polymer liquid and a plurality of carbon nanotubes are mixed to form a mixture. The mixture is coated on a substrate to form a film precursor. Two electrode parts are arranged on the film precursor. An electric field is applied to the film precursor through the two electrode parts at a room temperature, so as to change an arrangement of the plurality of carbon nanotubes, such that the thermoelectric polymer film is formed.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: October 8, 2024
    Assignee: National Cheng Kung University
    Inventors: Chia-Yun Chen, Kuan-Yi Kuo, Po-Hsuan Hsiao, Yi-Yin Lin
  • Patent number: 12109317
    Abstract: Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also disclosed herein is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: October 8, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Ping-Ching Wu, Cheng-Hsin Chuang, Po-Heng Chen, Yu-Yi Chiang
  • Patent number: 12100512
    Abstract: The present invention discloses a medical image project management platform comprising a project management module and a radiomic feature extracting module. The project management module comprises a multi-module management interface and a labeling unit. An image is input by the multi-module management interface and received by the labeling unit. A first labeled image and a second labeled image are produced thereafter. The radiomic feature extracting module comprises an analysis unit and a feature extracting module. The analysis unit analyzes the first labeled image and gives the first labeled image a first labeling unit. The analysis unit analyzes the second labeled image and gives the second labeled image a second labeling unit. The radiomic feature extracting unit receives the first and the second labeling units and proceeds radiomic computation to output a radiomic feature.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: September 24, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventor: Yi-Shan Tsai
  • Publication number: 20240307318
    Abstract: Disclosed herein is a composition comprising a lipid nanoparticle and a double-stranded oligodeoxynucleotide (dsODN) encapsulated in the lipid nanoparticle. According to the embodiments of the present disclosure, the dsODN comprises two strands complementary to each other, in which the first strand comprises the nucleotide sequence of SEQ ID NO: 1. Also disclosed herein are methods of treating cancers by using the present composition.
    Type: Application
    Filed: March 17, 2023
    Publication date: September 19, 2024
    Applicant: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Yan-Shen SHAN, Chang-Jung CHEN, Hao-Chen WANG
  • Patent number: 12091677
    Abstract: The present invention provides a carboxylated nanodiamond-mediated CRISPR-Cas9 delivery system for gene editing comprising nanodiamond (ND) particles as the carriers of CRISPR-Cas9 components designed to introduce the mutation in a given gene for repairing a tissue damage.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: September 17, 2024
    Assignees: Taipei Veterans General Hospital, National Chiao Tung University, National Cheng Kung University
    Inventors: Shih-Hwa Chiou, Tien-Chun Yang, Chia-Ching Chang, Yon-Hua Tzeng
  • Patent number: 12086182
    Abstract: A method of building a knowledge graph, performed by a processing device, includes: classifying news articles to a main event associated with sub events, using the main event as a first node of the knowledge graph, using the sub events as second nodes of the knowledge graph respectively, connecting the second nodes to the first node, extracting event summaries from the news articles respectively according to a template, using the event summaries as third nodes of the knowledge graph respectively, and connecting each of the third nodes to one of the second nodes according to association between the event summaries and the sub events, extracting commenter identities from the event summaries, and using the commenter identities as fourth nodes of the knowledge graph, and connecting each of the fourth nodes to one of the third nodes.
    Type: Grant
    Filed: June 9, 2022
    Date of Patent: September 10, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Wen-Hsiang Lu, Cheng-Wei Lin, Bo Yang Huang, Chia-Ming Tung
  • Patent number: 12078542
    Abstract: An optical sensor circuit is provided. In the optical sensor circuit, an output stage circuit transmits a voltage of first and second node to the output line according to a first driving signal. A first sensor is configured to generate a first photocurrent according to a first color light that senses an ambient light, and generate a second photocurrent according to a second color light. A second sensor is configured to generate a third photocurrent according to a third color light, and generate a fourth photocurrent according to the second color light. In a sensing phase, when the first sensor senses the first color light, and the second sensor senses the third color light, the first sensor adjusts a voltage level of the voltage according to the first photocurrent, and the second sensor adjusts the voltage level of the voltage according to the third photocurrent.
    Type: Grant
    Filed: May 11, 2022
    Date of Patent: September 3, 2024
    Assignees: Au Optronics Corporation, National Cheng-Kung University
    Inventors: Chih-Lung Lin, Chia-En Wu, Chia-Lun Lee, Jui-Hung Chang, Jian-Shen Yu
  • Publication number: 20240276934
    Abstract: Disclosed are a leaf vein absorption method and a functional modification material for plant. The functional modification material has a covering with a functional material and a protector with a polymeric stabilizing material. The functional material is a unitary, a multivariate, or a high-entropy compound, or a semiconducting or an optoelectronic material. The covering covers a surface of a plant organ, wherein the covering comprises a stomata expansion material to enable the functional material to be absorbed into a plant through stomata. The protector covers a surface of the covering. The functional material is capable of maintaining its functional presence on a surface of the plant until the plant organ undergoes natural apoptosis. Through an absorption technology of leaf veins on the surface of the plant, special functions can be achieved without modifying or implanting plant genes.
    Type: Application
    Filed: December 10, 2023
    Publication date: August 22, 2024
    Applicant: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: CHEN-PIAO YEN, SHENG-LUNG TU, JYH-MING TING, YEN-HSUN SU
  • Patent number: 12051338
    Abstract: The disclosure provides a human laryngeal model for simulation of endoscopic guided injection laryngoplasty surgery and for an insertion of a syringe containing a fluid. The human laryngeal model includes a laryngeal body, a seat body, and a vocal cord. The seat body is mounted to the laryngeal body. The seat body has an accommodation space. The vocal cord includes a plate and at least one bag body. The plate is stacked on the seat body, the bag body is fixed to the plate and located in the accommodation space of the seat body, and the bag body has a storage space. The vocal cord is configured for the insertion of the syringe to allow the syringe to inject the fluid into the storage space of the bag body. In addition, the disclosure also provides a human head and neck model including the human laryngeal model.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: July 30, 2024
    Assignees: NATIONAL CHENG KUNG UNIVERSITY, NATIONAL CHENG KUNG UNIVERSITY HOSPITAL
    Inventors: Shu Wei Tsai, Chun-Wei Tang, Jenn-Ren Hsiao, Chou-Ching Lin
  • Publication number: 20240220573
    Abstract: A computing in memory accelerator for applying to a neural network includes a memory, a data buffer unit, a pooling unit, a loss computing unit, a first macro circuit, a second macro unit, a third macro unit, and a multiplexer. The memory is used for saving data. The data buffer unit is coupled to the memory and used to buffer data outputted from the memory. The pooling unit is coupled to the memory and used to pool data for acquiring a maximum pooling value. The loss computing unit is coupled to the memory and used to compute output loss. The first macro circuit, the second macro unit, and the third macro unit are coupled to the data buffer unit. The multiplexer is coupled to the pooling unit, the first macro circuit, the second macro unit, and the third macro unit and used to generate output data.
    Type: Application
    Filed: March 7, 2023
    Publication date: July 4, 2024
    Applicant: National Cheng Kung University
    Inventors: Lih-Yih Chiou, Yun-Ru Chen, Tsung-Chi Chen
  • Publication number: 20240201541
    Abstract: The present invention provides a liquid crystal display device, which comprises: cholesteric liquid crystals and polymer fragments. By adding polymer fragments, the upper and lower substrates of the liquid crystal display device of the present invention may control the alignment of the liquid crystals and have excellent electro-optical characteristics without the use of an alignment film; furthermore, the polymer fragments are modified with a vertical alignment agent, DMOAP to form a radial structure so as to improve the contrast. The present invention also provides a method for preparing a liquid crystal display device in a simple way, so that the liquid crystal display device has the electro-optical characteristics of high contrast, low threshold voltage, and fast response time.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 20, 2024
    Applicant: National Cheng Kung University
    Inventors: Chun-Yen Liu, Jui-Hsiang Liu
  • Publication number: 20240191135
    Abstract: A method for reactive ion etching includes multiple steps of: (a) placing a film to be etched in a vacuum chamber; (b) introducing an etching gas into the vacuum chamber; (c) starting a reactive ion etching to etch the film via the etching gas in a first duration; (d) in a second duration, stopping reactive ion etching and extracting the remaining gas in the vacuum chamber to make the vacuum chamber be in a high-clean state; and (e) repeating step (b) to (d) until an etching depth of the film is reached to a predetermined value.
    Type: Application
    Filed: December 7, 2022
    Publication date: June 13, 2024
    Applicant: National Cheng Kung University
    Inventors: Tse-Ming Chen, Chiu-Hua Huang, Ching-Hua Kao, Yu-Chiang Hsieh
  • Publication number: 20240180830
    Abstract: Disclosed herein is drawn to a method for producing a nanoframe of Prussian blue (PB) or an analogue thereof (PBA). The producing method comprises: (a) mixing a nanocube of PB or PBA with an acid solution to form a mixture; and (b) heating the mixture of the step (a) in an oil bath at 80-100° C. for 0.5 hours-1 month to produce the nanoframe of PB or PBA. Also encompassed herein is a method for treating a cancer in a subject in need thereof, which comprises administering an effective amount of a nanocube or a nanoframe of PB or PBA to the subject.
    Type: Application
    Filed: December 2, 2022
    Publication date: June 6, 2024
    Applicant: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Chen-Sheng YEH, Wei-Peng LI, Liu-Chun WANG
  • Patent number: 11999956
    Abstract: The present invention discloses a targeted therapy composition and a method for suppressing breast cancer cell proliferation, migration or invasion by administrating the targeted therapy composition to a subject in need thereof. The composition comprises a type 3 epithelial membrane proteins (EMP3) targeted inhibitor. The breast cancer cells are characterized by upregulation of EMP3, EGFR, HER2, HER3, HR, or downregulation of HER4 gene expression. EMP3-targeting oligonucleotide or nuclease is administrated upon the breast cancer cells so as to degrade EMP3-coding DNA or mRNA, and to suppress breast cancer cell proliferation, migration or invasion.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: June 4, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Nan-Haw Chow, Yi-Wen Wang, Yih-Lin Tuan, Yao-Lung Kuo
  • Patent number: 11993775
    Abstract: The present invention relates to a ubiquitin-specific peptidase 24 inhibitor, a medicinal composition and a method of delaying or reversing multidrug resistance in cancers using the same. The USP24 inhibitor, which includes a shUSP24 RNA and/or a carbonyl substituted phenyl compound, can serve as a chemosensitizing agent for inhibiting the drug pump out, cancer stemness and genomic instability of cancer cells, thereby being applied to a medicinal composition and a method for delaying or reversing multidrug resistance in cancers.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: May 28, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventor: Chien-Chung Hung
  • Patent number: 11996551
    Abstract: A method for the fabrication of an electroless-metal-plated sulfur nanocomposite, an electroless-metal-plated sulfur cathode which is made from the nanocomposite, and a battery that uses the cathode, where the method includes chemically plating a conductive metal nanoshell onto the surface of the insulating sulfur powder to improve the conductivity of the sulfur cathode material, where through enhancing the electrochemical reaction kinetics with metal catalysis capabilities, and performing physical and chemical adsorption of liquid polysulfides with metal activity, the electroless-metal-plated sulfur nanocomposite enables the battery to exhibit high electrochemical utilization and stable cyclability, such that the nanocomposite can achieve a high sulfur content and high metal content, and the cathode demonstrates a high sulfur loading with a low electrolyte-to-sulfur ratio, the lithium-sulfur battery with the cathode exhibiting a high discharge capacity along with high energy density, and maintaining stable a
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: May 28, 2024
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventor: Sheng Heng Chung
  • Publication number: 20240170062
    Abstract: A non-volatile static random access memory includes: a static random access memory, a reading element and a first embedded non-volatile memory. The static random access memory includes a first inverter, a second inverter and two transistors, an output terminal of the first inverter and the input terminal of the second inverter are electrically connected to each other to serve as a Q node, an input terminal of the first inverter and an output terminal of the second inverter are electrically connected to each other to serve as a QB node, and the two transistors are electrically connected to the Q node and the QB node, respectively. The reading element is electrically connected to the Q node. The first embedded non-volatile memory is electrically connected to the QB node.
    Type: Application
    Filed: December 22, 2022
    Publication date: May 23, 2024
    Applicant: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Darsen Duane LU, Mohammed Aftab BAIG, Siao-Shan HUANG, Fu Yuan CHANG