Abstract: The present invention provides a reciprocal-flow-type nucleic acid amplification device comprising: heaters capable of forming a denaturation temperature zone and an extension/annealing temperature zone; a fluorescence detector capable of detecting movement of a sample solution between the two temperature zones; a pair of liquid delivery mechanisms that allow the sample solution to move between the two temperature zones and that are configured to be open to atmospheric pressure when liquid delivery stops; a substrate on which the chip for nucleic acid amplification according to claim 2 can be placed; and a control mechanism that controls driving of each liquid delivery mechanism by receiving an electrical signal from the fluorescence detector relating to movement of the sample solution from the control mechanism; the device being capable of performing real-time PCR by measuring fluorescence intensity for each thermal cycle.

Abstract: In a conventional moiré method, achieving both measurement accuracy and dynamic measurement and balancing field of view and measurement accuracy have been difficult. The present invention makes it possible to handle conventional moiré fringes as a grating for generating phase-shifted second-order moiré fringes, use a spatial phase shift method algorithm to accurately analyze the phases of the second-order moiré fringes before and after deformation, and determine shape from the phase differences between gratings projected onto the surface of an object of measurement and a reference surface and determine deformation and strain from the phase differences between the second-order moiré fringes, before and after deformation, of a repeating pattern on the object surface or a produced grating. As a result, it is possible to measure the three-dimensional shape and deformation distribution of an object accurately and with a wide field of view or dynamically and with a high degree of accuracy.

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2R? receptor and a decreased binding capacity for IL-2R?c receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

Abstract: A phase contrast transmission electron microscope apparatus has a long-life phase modulator, enabling changes in quantity of phase modulation, barely absorbing the electron beams, and not being influenced by irradiation of the electron beams. An electron microscope comprises an electron gun, a first laser beam irradiating process, being positioned between the electron source and an object lens, for irradiating laser beams onto the electron beams radiated from the electron gun, a second laser beam irradiating process, being positioned on a focal plane behind the object lens, for focusing and irradiating the laser beams upon the focus of the electron beams penetrating through a specimen, and a screen or a 2D electron sensor for detecting a specimen image in the form of distribution of intensity of the electron beams by an optical system.

Abstract: The present disclosure relates to a method for manufacturing a coin-type secondary battery. The method includes at least: bonding one or more solid electrolytes to an anode upper case; forming an anode active material layer on an anode current collector; sequentially stacking the anode current collector on which the anode active material layer is formed and the anode upper case to which the one or more solid electrolytes are bonded on an anode bottom case to obtain an anode part; sequentially stacking the anode part, a separator, a cathode current collector, and a second case including one or more openings on a first case; bonding the first case to the second case; and introducing an ion-containing solution containing sodium, lithium, magnesium, and a combination thereof from the outside of the second case into an interior thereof.

Abstract: The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Abstract: Information indicating a shape of a screen, a shape of a viewing area and a relative positional relationship between the viewing area and the screen is acquired. A shared area in which a three-dimensional image presented by a three-dimensional display is to be arranged in order to be observed from any position in the viewing area is created based on the acquired information. Based on the acquired information, a specific area in which a three-dimensional image presented by the three-dimensional display is to be arranged in order to be observed from a specific position in the viewing area is created. The data indicating the created shared area and the data indicating the specific area are generated.

Abstract: The present invention acquires self-tracking information obtained by integrating habit information and biological signal information. Based on personal genome information and the acquired self-tracking information, characteristic information about characteristics of a user is acquired, and the acquired characteristic information is output.

Abstract: The object of the invention is to provide an adsorbent that can adsorb ammonia with no large volume change between absorption and desorption, that has a high ammonia and/or ammonium ion adsorption capacity, and that can have an additional function by gaining proper control of composition, etc. The invention makes it possible to provide an adsorbent that absorbs ammonia and/or ammonium ions through the use of a metal cyanocomplex as an ammonia adsorbent, experiences no or little volume change, exhibits high enough capacity for adsorbing ammonia and/or ammonium ions, and has a function of decomposing ammonia as well as a function of varying optical responses before and after adsorption, etc.

Abstract: A method of manufacturing a ceramic electronic component includes forming a dielectric layer including a plurality of ceramic nanosheets on a first electrode, treating the dielectric layer with an acid, and forming a second electrode on the dielectric layer, a ceramic electronic component, and an electronic device.

Abstract: It is an object of the present invention to provide a method for preparing a water extract of ashwagandha, which comprises increasing the amounts of withanone and withaferin A contained as active ingredients in the water extract of ashwagandha leaves. In addition, it is another object of the present invention to more economically and simply provide a pharmaceutical composition comprising ashwagandha leaves. The present invention relates to a method for preparing a water extract of ashwagandha leaves, which comprises extracting ashwagandha leaves with water in the presence of cyclodextrin, and a method for enhancing the anticancer activity of the water extract of ashwagandha leaves. The present invention also relates to a pharmaceutical composition for treating or preventing cancer, comprising the water extract of ashwagandha leaves. The present invention further relates to a pharmaceutical composition comprising dry powders of ashwagandha leaves and cyclodextrin.

Abstract: A Ga2O3-based semiconductor device includes a Ga2O3-based crystal layer including a donor, and an N-doped region formed in at least a part of the Ga2O3-based crystal layer.

Abstract: A three-dimensional display, wherein an area in which eyes of observers are to be positioned when the observers observe a three-dimensional image is predefined as a viewing area, the viewing area is defined to be circular and surround a light ray controller at a position farther upward than a top board of a table, a light ray group is emitted to an outer peripheral surface of the light ray controller from a light ray generator arranged below the top board, and the light ray controller is formed such that the plurality of light rays emitted to a plurality of portions that are different from one another and arranged in a ridge line direction are transmitted through the plurality of portions while respectively being diffused in a virtual plane, and is formed such that center lines of a plurality of transmitted diffused light rays pass through the viewing area.

Abstract: A sample introduction unit 2 regularly collects a sample from a sample passage 1. A measurement unit 3 performs an LC/MS analysis for the collected sample. A spectrum matching judgment section 42 performs image recognition referring to mass spectra in a normal condition accumulated in a normal spectrum database 44, to determine whether a measured mass spectrum is in a normal condition. If the mass spectrum is non-normal, an abnormal peak locator 45 locates a peak which should not be detected in the normal condition, and an MSn analysis with the located peak selected as the target is performed in the measurement unit 3 under an MSn analysis execution commander 46. An identification processor 47 performs substance identification by a library search based on an acquired MSn spectrum. Upon successful identification, an alert commander 49 issues an alert. Thus, the system can automatically monitor hazardous substances with high accuracy.

Abstract: A driving consciousness estimation device includes a driving readiness estimation unit configured to estimate a driving readiness relating to a driving consciousness of the driver from a driver's reaction to the travelling environment, a driving task demand estimation unit configured to estimate a driving task demand which is an index required for the driver with respect to the driving readiness from the travelling environment, and an attention awakening unit configured to execute awakening of attention for the driver relating to the driving of the vehicle based on the result of comparison between the driving readiness and the driving task demand.

Abstract: The present invention relates to an electrode structure, a method of manufacturing the same, and a secondary battery including the same, and the electrode structure may include a negative electrode part; a positive current collector which is formed of a fabric material and surrounds an outer surface of the negative electrode part; and a positive electrode coupled to an edge of the positive current collector.

Abstract: A method for controlling a curvature of a display device as a control method of the curvature of the display device including a flexible display panel, a curvature change member, a controller, and a photo sensor includes: measuring an amount of a light incident to the flexible display panel by using a photo sensor; confirming a position of a part where the amount of the measured light is more than a predetermined reference value in the flexible display panel when the amount of the measured light is more than the reference value; and changing the curvature around the part where the amount of the measured light is more than the reference value in the flexible display panel by using the curvature change member.

Abstract: A semiconductor device 100 of the present invention includes a front end and back ends A and B, each including a plurality of layers. Further, in the plurality of layers of the back end B, (i) circuits 22, 23, and 24 having a security function are provided in at least one layer having a wiring pitch of 100 nm or more, (ii) a circuit having a security function is provided in at least one wiring layer in M5 or higher level (M5, M6, M7, . . . ), (iii) a circuit having a security function is provided in at least one layer, for which immersion ArF exposure does not need to be used, or (iv) a circuit having a security function is provided in at least one layer that is exposed by using an exposure wavelength of 200 nm or more.

Abstract: The work processing apparatus of the present invention comprises: a processing section for processing or treating a work; and a liquid chemical supplying section for supplying a liquid chemical to the processing section. The liquid chemical supplying section includes: a plurality of liquid chemical bags for storing the liquid chemical; a bag holding part in which the liquid chemical bags are attached and held; and a liquid feeding part, to which the liquid chemical bags are detachably connected, for feeding the liquid chemical from the liquid chemical bags to the processing section. Each of the liquid chemical bags is produced by overlapping flexible resin sheets with each other and welding their edge parts to form into a bag. Each of the liquid chemical bags has a port part communicating with an outside. A joint with a valve is attached to each of the port parts.

Abstract: Provided are a novel method for manufacturing a stack of carbon nanotube and graphene that can improve a capacitor characteristic, an electrode material including the stack of carbon nanotube and graphene, and an electric double-layer capacitor using the same. A method for manufacturing a stack of graphene and carbon nanotube includes a step of dispersing the graphene in an aqueous MOH solution (M represents an element selected from a group consisting of Li, Na, and K) to adsorb MOH on the graphene, a step of heating the graphene with MOH adsorbed thereon that is obtained in the adsorption step in vacuum or in an inert atmosphere in a temperature range of 400° C. or more and 900° C. or less to form pores in the graphene, and a step of dispersing the carbon nanotube and the graphene with the pores that are obtained in the step of forming the pores in a dispersion medium to stack the carbon nanotube and the graphene with the pores.