Abstract: In nuclear magnetic resonance spectroscopy spatial localization of the output signal is achieved by using gradient magnetic fields and radio-frequency inversion pulses to define slices through a sample from which a signal is obtained. The use of intersecting slices allows the field of view to be reduced to the region of intersection to study a localized volume of interest in the sample. Conventionally, three orthogonal gradient magnetic fields can be defined by energizing successively three gradient magnetic field coils. With the present invention combinations of the gradient magnetic field coils are energized simultaneously to allow the field of view to be more closely conformed to a described volume of interest. This simultaneous energization allows the field of view to be rotated relative to the axes of the coils and/or allows non-orthogonal intersecting slices to be defined to alter the shape of the field of view at the intersection of the slices.

Abstract: Recombinant DNA encoding a polypeptide precursor of the HN or F glycoprotein of Newcastle Disease Virus has been prepared and sequenced.

Abstract: A process for the production of a boronic acid of formula III, ##STR1## in which an organometallic of formula IV, ##STR2## in which formula IV, M represents a metallic moiety such as --MgX, X being a halogen or an alkali metal is treated with a trialkoxy borane of formula B(OR).sub.3, R representing an alkyl group and the product is hydrolysed.

Abstract: The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them.The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 includes hydrogen, amino and alkyl or alkoxy each of up to 4 carbon atoms;R.sup.2 includes hydrogen, alkyl, hydroxyalkyl and halogenoalkyl each of up to 4 carbon atoms;R.sup.3 is hydrogen or alkyl or up to 3 carbon atoms;Ar is phenylene or heterocyclene;L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR.sup.4 --, --NR.sup.4.CO--, --CH.dbd.CH-- or --CO.O--, wherein R.sup.4 is alkyl of up to 4 carbon atoms; and Y is a branched alkyl group bearing substituents Y.sup.2 and Y.sup.3 the definition of each independently including hydroxy, cyano, aryl and heteroaryl, and the definition of Y.sup.

Abstract: The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them.The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R.sup.1 is substituted alkyl or alkoxy each of up to 3 carbon atoms;R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms;Ar is phenylene or heterocyclene;L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR.sup.3 --, --NR.sup.3.CO--, --CH.dbd.CH--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 S--, --SCH.sub.2 --, --CO.CH.sub.2 --, --CH.sub.2 CO-- or --CO.O--, wherein R.sup.3 is alkyl of up to 6 carbon atoms; andY is aryl or heteroaryl or a hydrogenated derivative thereof; orY is a group of the formula --A--Y.sup.

Abstract: A polypeptide which inhibits the replication of Herpes Simplex Virus and like viruses, which has the amino acid sequence of consecutive amino acids of HSV protein Vmw 65 and comprises the sequence 367 to 373: ##STR1## (identified as SEQ ID NO: 1) or a conservatively modified variant thereof, its therapeutic use and antibodies thereto.

Abstract: A pharmaceutical composition which comprises a mixture of an alpha-2 adrenoceptor antagonist, preferably idazoxan, or a pharmaceutically acceptable salt thereof, and either a catecholamine precursor or an inhibitor of aromatic L-amino acid decarboxylase, preferably carbidopa. The compositions can be used for treatment of endogenous depression or low blood pressure.

Abstract: A compound of formula I: ##STR1## wherein R is hydrogen; oran alkyl, alkenyl or alkynyl group of up to 6 carbon atoms; nis O; 1 or 2; Z represents --CH.dbd.CH-- or --S--; each X independently represents halogeno, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or trifluoromethyl; and Y represents a group of formula: ##STR2## or a pharmaceutically acceptable salt or ester thereof.

Abstract: A compound of formula I optionally in the form of an acid addition salt ##STR1## in which formula: A represents a substituent which is: hydroxyl, O-alkyl, O-cycloalkyl, O-alkenyl, O-aryl, O-aralkyl, O-carbamate, O-carbonate, O-acyl or halogena is 0-5;the substituents A are identical or different when a is more than 1;B represents a C.sub.1 -C.sub.6 aliphatic hydrocarbon group optionally carrying one or more of the substituents: hydroxyl, amino, halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, aryloxy or carboalkoxy and optionally comprising one or more sites of unsaturation and/or one or more carbonyl groups or ketal derivatives thereof;b is 0 or 1;c, d, f and h, which may be identical or different, are 2, 3, 4, 5 or 6; andi is 0 or 1D, E and F, which may be identical or different, represent hydrogen or C.sub.1 -C.sub.

Abstract: A problem on removing dental restorative material can be to know its exact extent, otherwise sound tooth material may be unnecessarily removed. The inventive restorative material is made identifiable by adding crushed ruby powder, which fluoresces under standard dental blue light.

Abstract: A phosphonate ester (vinyl phosphonic acid reacted with equimolar diol) will cure on command (e.g. exposure to light) in the presence of an initiator. By adding inert filler, poly(vinyl phosphonic acid), ion-leachable glass powder and water, a command-curable dental cement with glass ionomer characteristics is obtained.

Abstract: The new hybridoma cell lines RF-HBs-1, RF-HBs-2 and RF-HBs-4 each secrete a nonoclonal antibody to hepatitis B surface antigen. The production of the antibodies may be carried out in vitro by culturing one of the cell lines or in vivo by establishing one of the cell lines as an ascites tumour in a mouse and isolating antibodies from the ascites fluid or from the serum. The antibodies have therapeutic, preventative and diagnostic uses in respect of hepatitis B virus infections and can be used to purify hepatitis B surface antigen. The relative specificities of the three monoclonal antibodies make them particularly useful in radiometric assay techniques employing specific combinations of the antibodies in solid phase.

Abstract: An apparatus for harvesting crop parts from a standing crop and leaving stripped stems in the field has a crop stripping rotor under a hood. Grain strikes the underside of the hood, and four or more piezoelectric impact detectors detect the pattern of grain strike density on the hood. Front end grain losses are found, based on the pattern of grain strikes on the underside of the hood. The hood position is adjusted by a ram in response to data measured by the detectors.

Abstract: A camera for use in holography comprises a source of coherent radiation (55), a beam splitter (55,56) for splitting radiation from said source into a reference and a recording beam, a film holder (62) for holding a recording medium (61), means for directing the reference beam on to the recording medium, means for directing the recording beam on to an object and means for combining the recording beam after reflection from the object with the reference beam to form a hologram within the recording medium.

Abstract: Compounds of formula (I), wherein X.sup.1 and X.sup.5 are each separately selected from hydrogen and C.sub.1-4 alkyl, halogeno and halogeno-substituted C.sub.1-4 alkyl groups: X.sup.2, X.sup.3 and X.sup.4 are each separately selected from hydrogen and C.sub.1-4 alkyl, hydroxy, C.sub.1-4 alkoxy and phenoxy groups; R.sup.1 and R.sup.2 are each separately selected from hydrogen and C.sub.1-4 alkyl groups; R.sup.3 and R.sup.4 are each hydrogen or together constitute the second bond of a carbon-carbon double bond joining --CR.sup.1 R.sup.3 and --CR.sup.2 R.sup.4 ; and Y is hydroxymethyl, formyl, cyano, carbamoyl, carbamoyl N-substituted by one or two of the same or different C.sub.1-4 alkyl groups, carboxy or a carboxylic ester or carboxylate salt, are of value as avian repellents.

Abstract: To combat the accumulation of plaque on dentures, a non self-supporting coating of a non-toxic, negatively charged polysaccharide is applied. The polysaccharide coating is gradually sacrificed or ablated during wear. Ablation appears to remove microorganisms along with coating material. The polysaccharide is further defined by an ability to reduce the adhesion of Streptococcus salivarius cells in a simple in vitro bacterial adhesion test by at least 25% over a control.

Abstract: Admixture of insulin and a hydroxypyridone being: (1) a 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen and hydroxy groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen or hydroxy group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, cycloalkoxy, aliphatic ester, halogen or hydroxy group, or a salt thereof.

Abstract: A method of building a free standing or building wall using prefabricated wall panels (10, 12, 14) wherein the assembly is accomplished at a factory from traditional or conventional building bricks or blocks. Each panel has an integral support means (26) to resist separation of the bricks or blocks when lifted for transport. A joint element (118) is provided between adjacent edges of adjacent panels and serves a labyrinth seal (102) with interleaved seal elements extending lengthwise of the joint. Springs (124) act between opposite sides (120, 122) of the joint so that it is resiliently compressed to accommodate differing spacings between the panels. A thermal insulation compartment (126, 128) is provided between the joint elements.

Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of val

Abstract: A rotating impeller for stirring liquids contained in tanks. Strip-like blades of simple form radiate from a central hub, in swept-back configuration relative to the direction of rotation. The blades are angled relative to the hub so as to exert a forward and downward force upon the liquid as the impeller rotates, and the blade curvature is such that the area projected upon the liquid by the solid structure of the rotating blade is less than the corresponding area that would be projected by an otherwise similar blade in which imaginary straight lines connected all adjacent vertices, and any void areas lying within the boundaries of those imaginary lines had been filled in. The preferred arrangement of the blades is such that when the impeller is arranged with its axis vertical, curvature of each blade along its length is such that it extends away from the hub in a diminishing downward curve, reaches a lowest point, and then rises again before the blade tip is reached.