Patents Assigned to National Tsing Hua University
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Patent number: 11719643Abstract: A method for detecting dust mite antigens includes the steps of collecting a dust sample, applying an extraction and cleanup procedure for dust mite antigens from the dust sample in order to obtain a sample solution ready for measurement, and placing the sample solution on a SERS chip without immunological modification and under a Raman spectrometer for SERS detection in order to identify whether any dust mite antigens exist in the sample solution.Type: GrantFiled: May 24, 2019Date of Patent: August 8, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Chun-Yu Chuang, Pin-Hsuan Yeh, Chao-Ming Tsen, Ching-Wei Yu, Wei-Chung Chao, Yung-Hsiang Wang, Cheng-Chien Li
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Publication number: 20230243776Abstract: Provided is a coronavirus detection method which is suitable for a coronavirus disease 2019 (COVID-19) detection. The method includes the following steps. A field-effect transistor-based biosensor (BioFET) platform is provided, wherein the BioFET platform includes a BioFET and a sensor card. The sensor card is detachably connected to the BioFET, wherein the sensor card includes a plurality of sensors and each of the plurality of sensors includes a response electrode. A nucleic acid probe specific to a nucleic acid sequence of COVID-19 virus is immobilized on a surface of the response electrode. A test solution is placed on the response electrode of the sensor card. A pulse voltage is applied to the response electrode, and a detection current generated from the sensor card is measured.Type: ApplicationFiled: January 28, 2022Publication date: August 3, 2023Applicant: National Tsing Hua UniversityInventors: Yu-Lin Wang, Akhil Kavanal Paulose
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Patent number: 11712696Abstract: A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module.Type: GrantFiled: August 5, 2021Date of Patent: August 1, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Te-Yu Chao, Yu-Ching Tung, Mao-Chih Hsieh, Yu-Ting Tai, Bing-Ying Ho, Wei-Chia Chang, Sung-Yang Wei, Chang-Hung Hsieh, Chung-Cheng Chou, Jen-Tsan Chi, Long Hsu, Hwan-You Chang, Huang-Ming Philip Chen, Cheng-Hsien Liu
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Publication number: 20230236797Abstract: A bit-serial computing device includes a computing circuit and a scaler. The computing circuit includes multiple MAC slices, and receives a multiplier vector and a multiplicand vector that contains multiple multiplicand inputs. Each multiplicand input contains multiple multiplicand segments that have different significances. The significances respectively correspond to the MAC slices. Correspondence between the significances and the MAC slices is variable. Each MAC slice calculates an inner product of the multiplier vector and a vector that is constituted by the multiplicand segments of the multiplicand inputs having the significance corresponding to the MAC slice. With respect to each MAC slice, the scaler multiplies the inner product that is calculated by the MAC slice by a weighting ratio that represents the significance corresponding to the MAC slice, so as to obtain a scaled inner product that corresponds to the MAC slice.Type: ApplicationFiled: January 18, 2023Publication date: July 27, 2023Applicant: National Tsing Hua UniversityInventors: Yu-Chih TSAI, Wen-Chien TING, Ren-Shuo LIU
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Publication number: 20230231104Abstract: Provided are a precursor solution, and a modified layer and a lithium-based battery prepared by using the same. The modified layer is formed on the negative electrode, the positive electrode and/or the separator of the lithium-based battery by using the precursor solution through photo-polymerization reaction or thermal curing. The lithium-based battery comprising the modified layer effectively promotes the charge and discharge capability, cycling life, and safety. The modified layer can be applied to a roll-to-roll process. The formation of lithium dendrites in the lithium-based battery comprising the modified layer is significantly suppressed or reduced during the charge-discharge cycles. The shuttle effect is effectively suppressed or reduced in lithium sulfur batteries and lithium iodine batteries. All the above effects are beneficial to increasing the product value of lithium ion batteries, lithium metal batteries, anode-free lithium batteries, lithium sulfur batteries, and lithium iodine batteries.Type: ApplicationFiled: March 21, 2022Publication date: July 20, 2023Applicant: National Tsing Hua UniversityInventors: Chi-Chang HU, Chih-Han YEN, Li-Qian WANG, Chen-Wei TAI, Hao-Yu KU
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Publication number: 20230229789Abstract: A data poisoning method and a data poisoning apparatus are provided. In the method, a training dataset and a validation dataset are retrieved. A perturbation is randomly initiated and added to data in the training dataset to generate poisoned training data. Values of multiple kernel functions of the poisoned training data and the validation dataset are computed by using kernel functions in a Gaussian process, and used to compute a mean of the Gaussian process on the validation dataset. A loss between the mean and the data in the validation dataset is computed by using a loss function of the Gaussian process, and used to generate an objective function that maximizes the loss. The objective function is solved to compute the perturbation that can maximize the loss.Type: ApplicationFiled: March 28, 2022Publication date: July 20, 2023Applicant: National Tsing Hua UniversityInventors: Shan-Hung Wu, Chia-Hung Yuan
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Patent number: 11703992Abstract: A method of identifying a flange specification based on an augmented reality interface includes steps of: providing a first interface, through which an operator picks real-time images of a flange at different viewing angles, and creating a virtual flange surface according to the real-time images; providing a second interface, through which the operator picks three circumferential points corresponding to the flange, and creating a virtual flange model having a virtual outer diameter; providing a third interface, through which the operator adjusts a virtual pitch circle diameter of the virtual flange model; providing a fourth interface, through which the operator adjusts a virtual thickness of the virtual flange model; providing a fifth interface, through which the operator inputs a count of bolts; and searching a database according to the virtual outer diameter, the virtual pitch circle diameter and the virtual thickness of the virtual flange model to obtain searched results.Type: GrantFiled: March 31, 2021Date of Patent: July 18, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Chih-Hsing Chu, Mu-Hsuan Lee, Yen-Ru Chen, Shau-Min Chen
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Patent number: 11697634Abstract: A method for producing a homocyclic or heterocyclic compound includes reacting a compound of formula (I) with a compound of formula (II) in presence of a base: R1—B-G??(I) In formula (I), B is an unsaturated moiety selected from substituted or unsubstituted vinylene, ethynylene, aryleneethynylene, substituted or unsubstituted arylenevinylene, and a combination thereof, the vinylene or arylenevinylene has n (=0, 1 or 2) substituent(s) R2, G is an electron-withdrawing group, R1 is hydrogen or a substituent, and two of R1, R2 and G may joint together to form a ring. In formula (II), R3 and R4 are independently hydrogen or a substituent, R5 is an electron-withdrawing group, and two of R3, R4 and R5 may joint together to form a ring. The conjugate acid of the base has a pKa in the range of 1 to 15.Type: GrantFiled: May 17, 2021Date of Patent: July 11, 2023Assignee: National Tsing Hua UniversityInventors: Chien-Chung Han, Suman Alishetty
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Publication number: 20230204563Abstract: A sensing device is provided. The sensing device includes a transistor, a disposable electrode, and a remote electrode. The transistor includes an extended gate, source and drain. The remote electrode is configured to receive a reference voltage. The disposable electrode is coupled between the transistor and the remote electrode. The disposable electrode includes a proximal end and a distal end. The proximal end of the disposable electrode is coupled to the extended gate of the transistor. The distal end of the disposable electrode is coupled to the remote electrode. The disposable electrode is adapted to load a cell and receive a membrane potential of the cell. The disposable electrode provides a gate voltage to the extended gate based on the change of the membrane potential and the reference voltage. The transistor provides different transistor currents at the drain based on the change of the gate voltage.Type: ApplicationFiled: January 26, 2022Publication date: June 29, 2023Applicant: National Tsing Hua UniversityInventors: Yu-Lin Wang, Shu-Yi Tsai
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Patent number: 11685861Abstract: A quantum dot structure includes a core and an inner shell. The core is a single crystal of a compound M1C1, and has a core surface having a first region and a second region. The first region has a crystal plane that is inactive with oxygen, and the second region has a crystal plane that is easily reactive with oxygen. The inner shell is a single crystal of a compound M2C2, and is formed on the first region of the core surface. A method for making the quantum dot structure is also disclosed.Type: GrantFiled: July 21, 2021Date of Patent: June 27, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Chang-Wei Yeh, Hsueh-Shih Chen
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Publication number: 20230199162Abstract: In a 3D imaging method using scanning-type coherent diffraction, a 2D photodetector detects diffraction of a coherent beam emitted from a light source that moves in a scanning manner toward a sample object to obtain multiple 2D diffraction data distributions; and a processor converts the 2D diffraction data distributions into multiple 3D intensity distributions in a reciprocal space, performs one or more iterations based on a sample function, a light source function and the 3D intensity distributions to obtain a phase-retrieval sample function, and generates a 3D reconstruction image of the sample object based on the phase-retrieval sample function.Type: ApplicationFiled: June 21, 2022Publication date: June 22, 2023Applicant: National Tsing Hua UniversityInventor: Chien-Chun CHEN
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Publication number: 20230192481Abstract: A carbon nanomaterial for gas storage and a method for manufacturing the same are provided. The specific surface area of the carbon nanomaterial for gas storage is greater than 2000 m2/g. The mesopore volume of the carbon nanomaterial for gas storage is greater than the micropore volume of the carbon nanomaterial for gas storage, and the carbon nanomaterial for gas storage has a peak intensity ratio (ID/IG) between G band and D band, as determined from the Raman spectrum, between 1.1 and 2. In the carbon nanomaterial for gas storage, the pore volume of pores with a pore width of 6 nm or less is bigger than that of pores with a pore width greater than 6 nm.Type: ApplicationFiled: March 22, 2022Publication date: June 22, 2023Applicant: National Tsing Hua UniversityInventors: Fan-Gang Tseng, Kuang-Hao Lo
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Publication number: 20230188865Abstract: An image sensor integrated with a convolutional neural network computation circuit is provided. The image sensor includes: a pixel array including pixels divided into pixel groups, wherein each pixel converts a light signal into a PWM signal; a convolution computation circuit controlling a turn-on time of a corresponding weighted current according to the first PWM signal of each pixel, and accumulating the weighted currents into an integrated current; a comparison circuit converting the integrated current into a second PWM signal and comparing it with that of an adjacent pixel group to output a larger one; and a classification circuit quantizing the second PWM signal to a quantization value according to a weight of a node in a fully-connected layer corresponding to each pixel group, accumulating the quantization values of all pixel groups into a feature value, and comparing the feature value with a feature threshold to obtain a classification result.Type: ApplicationFiled: March 9, 2022Publication date: June 15, 2023Applicant: National Tsing Hua UniversityInventors: Chih-Cheng Hsieh, Tzu-Hsiang Hsu
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Publication number: 20230176149Abstract: A magnetoresistive sensor and a manufacturing method thereof are provided. The method includes: forming an initial reference layer in an annular shape, wherein the initial reference layer includes an anti-ferromagnetic layer and a ferromagnetic layer; performing a heat treatment on the initial reference layer, wherein the ferromagnetic layer is magnetized to have a magnetization direction oriented along a vortex path during a heating step of the heat treatment, and an exchange bias oriented along the vortex path is induced at an interface of the anti-ferromagnetic layer and the ferromagnetic layer during a cooling step of the heat treatment; patterning the initial reference layer to form separated reference layers, wherein the reference layers are respectively formed in a annular sector shape, and the reference layers are arranged along the vortex path; forming spacer layers and free layers to form magnetoresistive devices; routing the magnetoresistive devices to form the magnetoresistive sensor.Type: ApplicationFiled: January 21, 2022Publication date: June 8, 2023Applicant: National Tsing Hua UniversityInventors: Chih-Huang Lai, Chia-Chang Lee, Yu-Shen Yen
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Patent number: 11670781Abstract: A fuel cell bipolar flow field plate and a fuel cell stack are provided. The fuel cell bipolar flow field plate includes a first gas channel and a second gas channel. Each of the gas channels has several sub-channels, each of the sub-channels has bending parts, and adjacent sub-channels have opposite flow directions. The sub-channels of the two gas channels form a four-leaf clover type pattern in a reaction area of the fuel cell bipolar flow field plate. A bending angle of each of the bending parts in the four-leaf clover type pattern is within 90 degrees.Type: GrantFiled: March 25, 2022Date of Patent: June 6, 2023Assignee: National Tsing Hua UniversityInventors: Ting-Cheng Wu, Fan-Gang Tseng, Fu-Lien Lin
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Patent number: 11667744Abstract: A block copolymer having the general formula as formula (1): mediator-P2-P1-X, formula (1), and the chemical structural formula is formula (2), in which the mediator in formula (1) and formula (2) is a regulator, which is a conjugated seven-membered ring structure, P1 is a first polymer which may be a conjugated or non-conjugated olefin monomer, R1 is the functional group of P1, n is the number of the monomer of P1, which is a positive integer and the range is 10˜1,500. P2 is a second polymer, m is the number of the monomer of P2, which is a positive integer and the range is 10˜1,500, and X is the end-functional group of the block copolymer.Type: GrantFiled: March 14, 2022Date of Patent: June 6, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventor: Chi-How Peng
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Publication number: 20230168549Abstract: A compressed sensing imaging method and a compressed sensing imaging system are provided. In the method, multiple grayscale masks having multiple elements with grayscale values represented by floating-point values or continuous values are generated as sensing matrices based on a compressed sensing theory. A spatial light modulator is controlled to modulate an electromagnetic wave projected on an object under test according to the grayscale value of each element in each grayscale mask, and a physical property of the electromagnetic wave passing through the object under test is detected to obtain multiple measured values. An image reconstruction algorithm is executed to reconstruct an image of the object under test by using the grayscale masks and the measured values obtained from the electromagnetic wave modulated by each grayscale mask.Type: ApplicationFiled: May 24, 2022Publication date: June 1, 2023Applicant: National Tsing Hua UniversityInventors: Shang-Hua Yang, Yuan-Hao Huang, Hao-Yu Yang, Yi-Chun Hung
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Publication number: 20230144108Abstract: A vapor chamber device adapted to be thermally coupled to a heat source includes a first casing and a second casing. The first casing includes a first plate, a first capillary structure at an inner surface of the first plate, and a first lateral wall protruding from the inner surface and surrounding the first capillary structure. The heat source is adapted to contact an outer surface of the first plate. The second casing is stacked on the first casing and includes a second plate, a plurality of supporting posts protruding from the second plate, and a second lateral wall protruding from the second plate and surrounding the supporting posts. The supporting posts face towards the first capillary structure, and the first lateral wall is connected to the second lateral wall.Type: ApplicationFiled: January 12, 2023Publication date: May 11, 2023Applicant: National Tsing Hua UniversityInventor: Shwin-Chung Wong
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Patent number: 11644250Abstract: A vapor chamber device adapted to be thermally coupled to a heat source includes a first casing and a second casing. The first casing includes a first plate, a first capillary structure at an inner surface of the first plate, and a first lateral wall protruding from the inner surface and surrounding the first capillary structure. The heat source is adapted to contact an outer surface of the first plate. The second casing is stacked on the first casing and includes a second plate, a plurality of supporting posts protruding from the second plate, and a second lateral wall protruding from the second plate and surrounding the supporting posts. The supporting posts face towards the first capillary structure, and the first lateral wall is connected to the second lateral wall.Type: GrantFiled: February 4, 2020Date of Patent: May 9, 2023Assignee: National Tsing Hua UniversityInventor: Shwin-Chung Wong
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Publication number: 20230137073Abstract: A high strength and wear resistant multi-element copper alloy is disclosed. The multi-element copper alloy comprises: 80-90 atomic percent Cu, 0.1-4 atomic percent Al, 6-10 atomic percent Ni, 0.1-3 atomic percent Si, 0.1-2 atomic percent V and/or Nb, and 0.1-2 atomic percent M. Experimental data reveal that, after being applied with an aging treatment under 450 degrees Celsius for 50 hours, hardness and strength of the multi-element copper alloy are both significantly enhanced because of age hardening, and softening due to overaging is not observed on the multi-element copper alloy. Moreover, measurement data have indicated that, this novel multi-element copper alloy exhibits better wear resistance superior to that of the conventional copper alloys.Type: ApplicationFiled: December 28, 2022Publication date: May 4, 2023Applicant: National Tsing Hua UniversityInventor: Jien-Wei Yeh