Patents Assigned to National University Corporation, Hamamatsu University School of Medicine
  • Publication number: 20220259518
    Abstract: The present invention provides an odorant composition having good palatability allowing peoples to feel comfortable using a small number of chemical compounds. An odorant composition according to an embodiment of the present invention consists of: when the total mass of ingredients contained in the odorant composition is 100.0% by mass, 40.0% by mass or more and 97.5% by mass or less of an ingredient (A) composed of aldehydes; 1.0% by mass or more and 20.0% by mass or less of an ingredient (B) composed of a ketone(s); and the balance being an ingredient (C) composed of a chemical compound(s) other than the ingredient (A) and the ingredient (B). The aldehydes of the ingredient (A) are: an essential ingredient (A1) composed of nonanal; and an optional ingredient (A2) selected from the group consisting of decanal, heptanal, octanal, benzaldehyde, undecanal, hexanal, and combinations thereof.
    Type: Application
    Filed: July 11, 2021
    Publication date: August 18, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Takahiko HARIYAMA, Mamiko OZAKI
  • Publication number: 20220184058
    Abstract: The present invention addresses the problem of providing a therapeutic agent for an abdominal aortic aneurysm, the therapeutic agent making drug therapy possible. The present invention provides a therapeutic agent for aortic aneurysm, the therapeutic agent having as active ingredients: (?)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these; and a statin.
    Type: Application
    Filed: March 13, 2020
    Publication date: June 16, 2022
    Applicants: National University Corporation Hamamatsu University School of Medicine, Kowa Company, Ltd.
    Inventors: Naoki UNNO, Hiroki TANAKA, Tatsuro YATA, Takafumi KAYAMA, Keisuke INOUE, Kiyoshi TOYA
  • Publication number: 20220120660
    Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first imaging apparatus, a second imaging apparatus, and a control device. The first imaging apparatus includes a first optical system and a first imaging element, and captures an image of the cell at a first position in a moving direction. The second imaging apparatus includes a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, and captures an image of the cell at a second position downstream of the first position. The control device obtains a passing position of the cell in a cross section of the flow path based on the image obtained by the first imaging element, generates the focus adjustment signal, and provides the signal to the second optical system.
    Type: Application
    Filed: February 14, 2020
    Publication date: April 21, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Hirotoshi KIKUCHI, Hidenao YAMADA, Amane HIROTSU, Daisuke YAMASHITA, Shigetoshi OKAZAKI
  • Patent number: 11285483
    Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: March 29, 2022
    Assignees: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Hirotoshi Kikuchi, Shigetoshi Okazaki, Hidenao Yamada, Yusuke Ozaki, Amane Hirotsu, Daisuke Yamashita
  • Publication number: 20220008489
    Abstract: The present invention provides a mitochondrial function-improving agent containing a lactic acid bacterium belonging to Lactobacillus farciminis or Pediococcus acidilactici, a culture of the lactic acid bacterium, or a culture supernatant of the lactic acid bacterium.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 13, 2022
    Applicants: MEIJI CO., LTD., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Takashi ITO, Mitsutoshi SETOU, Satoru OZAKI, Chinami MIZOGUCHI, Yukio ASAMI
  • Patent number: 11166948
    Abstract: The present invention addresses the problem of providing a therapeutic agent for abdominal aortic aneurysms, with which pharmacotherapy is possible. The present invention provides a therapeutic agent for an aortic aneurysm comprising, as an active component, (?)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: November 9, 2021
    Assignees: National University Corporation Hamamatsu University School of Medicine, Kowa Company, Ltd.
    Inventors: Naoki Unno, Hiroki Tanaka, Tatsuro Yata, Keisuke Inoue, Yuichi Makinose, Noboru Kaneta
  • Patent number: 10890530
    Abstract: An image acquisition apparatus includes a spatial light modulator, an optical scanner, a detection unit, a control unit. The spatial light modulator performs focused irradiation on irradiation regions on a surface or inside of an observation object with modulated excitation light. The detection unit has imaging regions in an imaging relation with the irradiation regions on a light receiving surface, each of the imaging regions corresponds to one or two or more pixels, and a pixel that corresponds to none of the imaging regions exists adjacent to each imaging region. The control unit corrects a detection signal of a pixel corresponding to each imaging region on the basis of a detection signal of the pixel that exists adjacent to the imaging region and corresponds to none of the imaging regions, and generates an image of the observation object on the basis of the corrected detection signal.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 12, 2021
    Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Naoya Matsumoto, Shigetoshi Okazaki
  • Publication number: 20200400562
    Abstract: An interference image acquisition apparatus includes a light source, a beam splitter, a second reflection mirror, an imager, and a first reflection mirror. A cell is placed on one side of a transparent material, and the first reflection mirror is placed on the other side of the transparent material. In a two-beam interferometer, an optical path difference between an optical path length of a first light beam reflected by the first reflection mirror and an optical path length of a second light beam reflected by the second reflection mirror is set to a coherence length of light output from the light source or less. The imager acquires an interference image in a state in which the cell is placed at a position conjugate to an imaging plane in a first optical system between the imaging plane and the first reflection mirror.
    Type: Application
    Filed: November 22, 2018
    Publication date: December 24, 2020
    Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Toyohiko YAMAUCHI, Kentaro GOTO, Hisayuki MATSUI, Satoshi HIRAKAWA, Hidenao YAMADA
  • Publication number: 20200300762
    Abstract: An image acquisition apparatus includes a spatial light modulator, an optical scanner, a detection unit, a control unit. The spatial light modulator performs focused irradiation on irradiation regions on a surface or inside of an observation object with modulated excitation light. The detection unit has imaging regions in an imaging relation with the irradiation regions on a light receiving surface, each of the imaging regions corresponds to one or two or more pixels, and a pixel that corresponds to none of the imaging regions exists adjacent to each imaging region. The control unit corrects a detection signal of a pixel corresponding to each imaging region on the basis of a detection signal of the pixel that exists adjacent to the imaging region and corresponds to none of the imaging regions, and generates an image of the observation object on the basis of the corrected detection signal.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 24, 2020
    Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Naoya MATSUMOTO, Shigetoshi OKAZAKI
  • Patent number: 10741282
    Abstract: A medical tool work support system, a medical tool work support method, and a medical tool work support program alleviate a workload on a user. The medical tool work support system includes a display, a memory that stores data indicating a work procedure on a medical tool in a work step to be performed for surgery using the medical tool, and a display controller that causes the display to display the work procedure based on the data stored in the memory.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: August 11, 2020
    Assignees: ROLAND DG CORPORATION, NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Masaki Hanajima, Takeshi Tsuji, Takaaki Kokubo, Naomi Ishino
  • Patent number: 10631764
    Abstract: A breast measurement apparatus includes a distance measurement unit measuring a distance from a skin to a light absorption portion for a measurement region of a breast which is a normal region including no tumor or an object region including a tumor, a light measurement unit measuring a hemoglobin amount in the measurement region by a light measurement method using measurement light of a predetermined wavelength, a correlation data storage unit storing normal correlation data of the distance to the light absorption portion and a normal hemoglobin amount generated based on measurement results for normal regions, and an evaluation value calculation unit calculating a property evaluation value of the tumor based on the normal hemoglobin amount, obtained from the normal correlation data and the distance to the light absorption portion in the object region, and an object hemoglobin amount in the object region.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: April 28, 2020
    Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Yukio Ueda, Etsuko Yamaki, Harumi Sakahara, Hiroyuki Ogura, Hatsuko Nasu, Nobuko Yoshizawa
  • Patent number: 10413176
    Abstract: An inattention measurement device, system, and method wherein an index value indicating an inattention level of a subject is calculated based on information relating to a history of a gazing point of a subject when presented with a task of searching for a prescribed target.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 17, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Norio Mori, Katsuaki Suzuki, Kenji Tsuchiya, Chie Shimmura
  • Patent number: 10352527
    Abstract: Provided is a luminous, apparatus such as a display, having a function of preventing attraction of insects. A display apparatus 1 has a light emission surface 1 whose peripheral edge region is at least partially formed as a low-attraction region which is less capable of attracting bugs, wherein the low-attraction region is composed of an optical property gradient region whose at least one optical property gradually changes in a direction from an inward side to an outward side of the light emission surface.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: July 16, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Yoshihiro Uozu, Takahiko Hariyama, Mantaro Hironaka
  • Publication number: 20190209012
    Abstract: A biological measurement device includes a probe including a contact surface that includes a plurality of light input portions that input light to a measurement target part and a plurality of light receiving portions that receive measurement light output from the measurement target part, the contact surface being pressed against the measurement target part, and a calculation unit that calculates internal information on the basis of a result of detecting the measurement light obtained for each combination of the light input portion and the light receiving portion, wherein the plurality of light input portions and the plurality of light receiving portions constitute lattices having an interval d in a first direction and a second direction orthogonal to each other on the contact surface.
    Type: Application
    Filed: September 4, 2017
    Publication date: July 11, 2019
    Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kenji YOSHIMOTO, Yukio UEDA, Etsuko OHMAE, Tetsuya MIMURA, Nobuko YOSHIZAWA, Hatsuko NASU, Hiroyuki OGURA, Harumi SAKAHARA
  • Publication number: 20190070608
    Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 7, 2019
    Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Hirotoshi KIKUCHI, Shigetoshi OKAZAKI, Hidenao YAMADA, Yusuke OZAKI, Amane HIROTSU, Daisuke YAMASHITA
  • Patent number: 10180387
    Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 15, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Yusuke Ozaki, Hidenao Iwai, Hiroyuki Konno, Hirotoshi Kikuchi, Toyohiko Yamauchi
  • Patent number: 10143379
    Abstract: A fluorescence detection device comprises: a plurality of light sources that apply an excitation light from an outside of a living body toward fluorescent dye previously injected into the living body; and a plurality of detectors that detect fluorescence emitted from the fluorescent dye by the excitation light, and output the detected fluorescence as an electric signal. The plurality of light sources and the plurality of detectors are arranged in at least one line. At least one detector is placed between two light sources, and at least one light source is placed between two detectors.
    Type: Grant
    Filed: February 18, 2013
    Date of Patent: December 4, 2018
    Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Naoki Unno, Yoshimasa Hattori, Mitsuharu Miwa
  • Publication number: 20170212033
    Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Yusuke OZAKI, Hidenao IWAI, Hiroyuki KONNO, Hirotoshi KIKUCHI, Toyohiko YAMAUCHI
  • Patent number: 9676820
    Abstract: A method is provided for inhibiting proliferation of a high LIX1L-expressing tumor cell, in which the expression or function of a LIX1L gene with respect to a tumor cell highly expressing the LIX1L gene is inhibited.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: June 13, 2017
    Assignee: National University Corporation Hamamatsu University School of Medicine
    Inventors: Satoki Nakamura, Haruhiko Sugimura
  • Patent number: 9597031
    Abstract: The present invention has an object to measure lymphatic pressure with more safety and ease at lower cost. To achieve this, a lymphatic pressure-measuring system 1 includes: a manchette 11 fitted on a vital observation portion; a measurement unit 13 that measures and outputs pressure of the manchette 11; an infrared camera 21 that detects fluorescence emitted from fluorescent dye previously injected into a lymph vessel in the vital observation portion; and an image processing device 22 that generates and displays an image showing a position of the fluorescent dye in the lymph vessel based on a detection result of the infrared camera 21. The infrared camera 21 repeats the detection while the pressure of the manchette 11 decreases from first pressure to block a lymph flow in the vital observation portion to second pressure at restart of the lymph flow. The measurement unit 13 repeats the measurement during the period.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: March 21, 2017
    Assignee: National University Corporation Hamamatsu University School of Medicine
    Inventor: Naoki Unno