Patents Assigned to National University Corporation Hokkaido University
  • Patent number: 11179096
    Abstract: A scoliosis diagnosis assistance device includes: a first shape information acquisition module configured to acquire back shape information representing the three-dimensional shape of a back of a subject; a second shape information acquisition module configured to acquire minor-symmetry information representing a three-dimensional shape having a minor-symmetry relationship with the three-dimensional shape of the back of the subject with respect to a sagittal plane of the three-dimensional shape; a deviation distribution acquisition module configured to acquire a distribution of deviation between the three-dimensional shape represented by the back shape information and the three-dimensional shape represented by the mirror-symmetry information; and an output controller configured to cause a display to display the distribution of deviation, for example.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: November 23, 2021
    Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NOA CO., LTD.
    Inventors: Satoshi Kanai, Hideki Sudo, Yuichiro Abe, Hiroshi Nagaeda
  • Publication number: 20210333287
    Abstract: Disclosed is a method for acquiring information of a target polypeptide, comprising: acquiring a diffusion time of a fluorescently labeled target polypeptide and a diffusion time of each of a plurality of fluorescently labeled reference polypeptides by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy, and acquiring information on size of the fluorescently labeled target polypeptide from the diffusion time of the fluorescently labeled target polypeptide with reference to the diffusion times of the plurality of fluorescently labeled reference polypeptides, wherein information on size of each of the plurality of fluorescently labeled reference polypeptides is known, and the sizes of the plurality of reference polypeptides are different from each other.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 28, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, SYSMEX CORPORATION
    Inventors: Masataka KINJO, Akshay GANGULY, Lausonia RAMASWAMY
  • Patent number: 11155582
    Abstract: An antiviral peptide provided according to the present invention includes (1) an amino acid sequence (TM sequence) constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2, or 3 amino acid residues in the TM sequence; and (2) an amino acid sequence (CPP sequence) functioning as a cell penetrating peptide (CPP), wherein a total number of amino acid residues is 100 or less.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: October 26, 2021
    Assignees: TOAGOSEI CO., LTD, National University Corporation Hokkaido University
    Inventors: Tetsuhiko Yoshida, Ayato Takada, Nahoko Baileykobayashi
  • Patent number: 11131583
    Abstract: An object state detection and transmission system includes a spectrometer configured to measure a reflectance spectrum based on reflected light reflected by a target object, a spectroscopic terminal apparatus integrally provided with an electronic device, the spectroscopic terminal apparatus being configured to receive a measured reflection spectrum; and a server apparatus connected to the spectroscopic terminal apparatus via a communication line. The electronic device includes a photographic camera configured to photograph the target object to capture a photographed image; a Global Positioning System (GPS) communication unit configured to measure a position of the target object; a sensor configured to measure an azimuth and an angle of the target object; a Central Processing Unit (CPU) configured to clock a current time of the photographing and the measurement; and a wireless communication unit configured to transmit resultant data to the server apparatus.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: September 28, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yukihiro Takahashi, Nobuyasu Naruse
  • Publication number: 20210292168
    Abstract: An alkali metal amide is dissolved in a cyclic alkylene urea represented by the formula (1) (wherein each of R1 and R2 represents a C1 to C3 alkyl group, and R3 represents a C1 to C4 alkylene group).
    Type: Application
    Filed: August 20, 2019
    Publication date: September 23, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NISSAN CHEMICAL CORPORATION
    Inventors: Kiyoharu TADANAGA, Akira MIURA, Tadayuki ISAJI, Shinichi MAEDA
  • Publication number: 20210292321
    Abstract: The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.
    Type: Application
    Filed: June 29, 2019
    Publication date: September 23, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, Shionogi & Co., Ltd.
    Inventors: Akihiro ISHII, Akihiko SATO, Makoto KAWAI, Yoshiyuki TAODA
  • Publication number: 20210294009
    Abstract: This light absorbing device includes: a light reflecting layer; a dielectric layer disposed on the light reflecting layer; and a plurality of metal nanostructures disposed on the dielectric layer. A portion of each of the plurality of metal nanostructures is buried in the dielectric layer and another portion thereof is exposed to the outside.
    Type: Application
    Filed: December 25, 2018
    Publication date: September 23, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Hiroaki MISAWA, Xu SHI, Kosei UENO, Tomoya OSHIKIRI, Quan SUN, Keiji SASAKI
  • Patent number: 11116793
    Abstract: A modified metal nanoparticle comprising a metal nanoparticle and a cyclic polyether modifying the metal nanoparticle.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: September 14, 2021
    Assignee: National University Corporation Hokkaido University
    Inventors: Takuya Yamamoto, Jose Enrico Quinsaat
  • Publication number: 20210269460
    Abstract: Disclosed is a rare-earth complex including a rare-earth ion, and a ligand coordinate-bonded to the rare-earth ion and having a condensed polycyclic aromatic group. The condensed polycyclic aromatic group is a residue formed by removing a hydrogen atom bonded to a condensed aromatic ring from a condensed polycyclic aromatic compound represented by the following Formula (I). In Formula (I), R1 and R2 represent hydrogen atoms or groups which are bonded to each other to form one aromatic ring or a condensed aromatic ring including two or more aromatic rings.
    Type: Application
    Filed: July 4, 2019
    Publication date: September 2, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuichi KITAGAWA, Marina KUMAGAI, Yasuchika HASEGAWA, Takayuki NAKANISHI, Koji FUSHIMI
  • Publication number: 20210260248
    Abstract: The present invention provides a medical film material which comprises a flat-plate-like or film-like demineralized dentin matrix (DDM) that is derived from a removed bovine tooth and completely demineralized, and which has an area falling within the range front 2 to 50 cm2. The present invention also provides a method for surgerizing a non-human animal using the medical film material. The present invention also provides a method for producing the medical film material, which comprises thinning and demineralizing a removed bovine tooth to produce a demineralized dentin matrix (DDM) film that is completely demineralized, wherein either one of the thinning procedure and the demineralization procedure may be carried out first.
    Type: Application
    Filed: July 22, 2019
    Publication date: August 26, 2021
    Applicant: National University Corporation Hokkaido University
    Inventor: Naoto Okubo
  • Publication number: 20210254079
    Abstract: The present invention provides mammalian cell expression vectors that impart to mammalian host cells an ability to produce high levels of foreign gene-derived proteins. A ubiquitously acting chromatin opening element (UCOE) is introduced into an expression vector that has a plasmid DNA integrated into a transcriptional hot spot on the chromosome of a dihydrofolate reductase gene-deficient host cell so that it allows for selection of strains that grow in hypoxanthine-thymidine (hereinafter denoted as HT)-free medium, whereby transformants will produce a protein of interest in increased amounts.
    Type: Application
    Filed: May 12, 2019
    Publication date: August 19, 2021
    Applicants: National University Corporation Hokkaido University, Fuso Pharmaceutical Industries, Ltd.
    Inventors: Yasuhiko SUZUKI, Miki NAKAGAWA, Yayoi KAMEDA, Satoru KONNAI, Tomohiro OKAGAWA, Naoya MAEKAWA, Shinya GOTO, Yamato SAJIKI, Kazuhiko OHASHI, Shiro MURATA, Yuzuru KITAHARA, Keiichi YAMAMOTO
  • Publication number: 20210253753
    Abstract: Disclosed is a gel material having a high water content and excellent mechanical properties. The gel material includes repeating units derived from the following monomers (A) and (B): (A) an anionic monomer containing a polymerizable carbon-carbon multiple bond and an aromatic ring, and (B) a cationic monomer containing a polymerizable carbon-carbon multiple bond and an aromatic ring. The gel material has a water content of 20% by mass to 95% by mass, a tensile elastic modulus of 9 MPa to 1000 MPa, and a tensile elongation at break of 50% to 5000%.
    Type: Application
    Filed: August 27, 2019
    Publication date: August 19, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, TORAY INDUSTRIES, INC.
    Inventors: Jian Ping GONG, Takayuki KUROKAWA, Honglei GUO, Takahiro MATSUDA, Chengtao YO
  • Patent number: 11091432
    Abstract: An object of the present invention is to provide a method for producing a fluorinated organic compound with a high yield without using carbon tetrachloride in view of the fact that the production of a fluorinated organic compound with a sufficient yield was impossible for a hitherto-known method that uses a fluorinating agent that contains IF5-pyridine-HF alone. Another object of the present invention is to provide a fluorinating reagent that is capable of achieving this object. The present invention provides a composition comprising (1) IF5 and (2) an aprotic solvent (with the proviso that carbon tetrachloride is excluded), wherein the aprotic solvent is contained in an amount within a range of 50 mass ppm to 20 mass %.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: August 17, 2021
    Assignees: DAIKIN INDUSTRIES, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Masahiro Higashi, Yosuke Kishikawa, Shoji Hara
  • Patent number: 11084835
    Abstract: Provided is a 2,3-bisphosphinopyrazine derivative represented by the following general formula (1), wherein R1, R2, R3, and R4 represent an optionally substituted straight-chain or branched alkyl group having 1 to 10 carbon atoms, an optionally substituted cycloalkyl group, an optionally substituted adamantyl group, or an optionally substituted phenyl group, R5 represents an optionally substituted alkyl group having 1 to 10 carbon atoms or an optionally substituted phenyl group, each R5 may be the same group or a different group, R6 represents a monovalent substituent, n denotes an integer of 0 to 2.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 10, 2021
    Assignees: NIPPON CHEMICAL INDUSTRIAL CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hajime Ito, Hiroaki Iwamoto, Tsuneo Imamoto, Ken Tamura, Natsuhiro Sano
  • Publication number: 20210221918
    Abstract: An object of the present invention is to provide cellulose acetate that has excellent compatibility with a resin, can reinforce a resin, and has excellent thermal stability. An embodiment of the present invention is cellulose acetate having a cellulose triacetate I crystal structure, wherein a temperature at which a weight loss relative to weight at 100° C. reaches 5% is 200° C. or higher when the cellulose acetate is heated at a heating rate of 10° C./min under a nitrogen atmosphere.
    Type: Application
    Filed: June 12, 2019
    Publication date: July 22, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NIPPON PAPER INDUSTRIES CO., LTD., DAICEL CORPORATION
    Inventors: Yasumitsu URAKI, Haruo KONNO, Shu SHIMAMOTO
  • Patent number: 11057201
    Abstract: A random number sequence generation apparatus includes: a semiconductor laser device repeatedly generating a pulsed laser beam having a disordered phase; an interferometer including a first transmission line and a second transmission line, a first port connected to an input terminal side and to which the pulsed laser beam is input, a second port connected to an output terminal side and outputs the pulsed laser beam, and a third port connected to the input terminal side; a Faraday mirror connected to the second port and reflecting the pulsed laser beam; a photodiode connected to the third port and outputs an electrical signal in accordance with interference light of the pulsed laser beam that is reflected by the Faraday mirror and passes through one of the transmission lines; and an AD converter configured to generate a random number sequence on the basis of the electrical signal and a threshold.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: July 6, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Akihisa Tomita, Kensuke Nakata
  • Patent number: 11053265
    Abstract: An optically active 2,3-bisphosphinopyrazine derivative represented by the following general formula (1): wherein R1 represents a group selected from a branched alkyl group having 3 or more carbon atoms, an adamantyl group, an optionally substituted cycloalkyl group, and an optionally substituted aryl group; R2 represents a group selected from a branched alkyl group having 3 or more carbon atoms, an adamantyl group, and an optionally substituted cycloalkyl group, provided that when R1 is a tert-butyl group, R1 and R2 are not the same; R3 represents a monovalent substituent; n represents an integer of 0 to 4; and * represents an asymmetric center on a phosphorus atom.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: July 6, 2021
    Assignees: NIPPON CHEMICAL INDUSTRIAL CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hajime Ito, Hiroaki Iwamoto, Tsuneo Imamoto, Ken Tamura
  • Publication number: 20210199676
    Abstract: Provided are a method of assisting the detection of nonalcoholic steatohepatitis (NASH) and a method that is able to assist in determining the degree of progression of any condition associated with NASH, which are far less invasive than liver biopsy and include simple operations and are independent of the skills of technicians. The present invention provides a method of assisting the detection of nonalcoholic steatohepatitis, including measuring the abundance of LDL-TG and/or ApoE-rich HDL-C contained in a test blood sample isolated from a living body.
    Type: Application
    Filed: August 22, 2019
    Publication date: July 1, 2021
    Applicants: Denka Company Limited, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Kazuhiro NOUSO, Yasuki ITO, Motoko OHTA, Hitoshi CHIBA, Toshihiro SAKURAI, Hiroyuki OKADA
  • Publication number: 20210177778
    Abstract: The purpose of the present invention is to provide an agent for promoting exosome production with which exosome production can be easily promoted.
    Type: Application
    Filed: May 16, 2018
    Publication date: June 17, 2021
    Applicants: DAICEL CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Katsuyuki MUKAI, Kohei YUYAMA, Yasuyuki IGARASHI
  • Publication number: 20210163300
    Abstract: The present disclosure relates to a partial oxidation catalyst that causes a light hydrocarbon partial oxidation reaction to proceed readily with high activity and high selectivity and a high-yield carbon monoxide production method using the same. The present disclosure further relates to a light hydrocarbon partial oxidation catalyst containing a zeolite supporting cobalt and rhodium.
    Type: Application
    Filed: March 25, 2019
    Publication date: June 3, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, TOSOH CORPORATION
    Inventors: Atsushi FUKUOKA, Hirokazu KOBAYASHI, Sae SOMEYA