Patents Assigned to National University Corporation Hokkaido University
  • Publication number: 20220364065
    Abstract: An object is to provide a composition and a method for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells. It has been found that while dihydroorotate dehydrogenase inhibitors exhibit cytotoxic activity against pluripotent stem cells, they do not exhibit significant cytotoxic activity against differentiated cells such as somatic stem cells.
    Type: Application
    Filed: December 19, 2019
    Publication date: November 17, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventor: Toru KONDO
  • Patent number: 11499093
    Abstract: A rare earth complex including a rare earth ion and a ligand coordinated with the rare earth ion and having a condensed polycyclic aromatic group.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: November 15, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuichi Kitagawa, Fumiya Suzue, Takayuki Nakanishi, Koji Fushimi, Yasuchika Hasegawa
  • Patent number: 11492352
    Abstract: The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.
    Type: Grant
    Filed: June 29, 2019
    Date of Patent: November 8, 2022
    Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, SHIONOGI & CO., LTD.
    Inventors: Akihiro Ishii, Akihiko Sato, Makoto Kawai, Yoshiyuki Taoda
  • Patent number: 11492373
    Abstract: A balanced-lattice-ledge nucleant having ledge inducing local densification of proteins and a balanced-lattice inducing self-organized crystal packing. Using this balanced-lattice-ledge nucleant enhances nucleation of protein crystals.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: November 8, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Min Yao, Long Li
  • Patent number: 11492433
    Abstract: The hydrogel includes a first network structure and a second network structure. The second network structure is entwined with the first network structure. The first network structure contains a polymer crosslinked with a first crosslinking agent. The second network structure contains a polymer crosslinked with a second crosslinking agent. 50 mol % or more of the first crosslinking agent does not contain a decomposable bond. 50 mol % or more of the second crosslinking agent does not contain a decomposable bond.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: November 8, 2022
    Assignees: NGK SPARK PLUG CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Masaya Iwata, Shinjiro Kasahara, Jian Ping Gong, Takayuki Kurokawa, Takayuki Nonoyama
  • Publication number: 20220336763
    Abstract: A laminate which allows to obtain an organic thin-film solar cell having excellent output characteristics and transparency is provided. The laminate as above has a titanium oxide layer that is disposed on the member serving as a light-transmissive electrode layer and serves as an electron transport layer. The titanium oxide layer has a thickness of not less than 1.0 nm and not more than 200.0 nm. The titanium oxide layer contains indium oxide and metallic indium, InOx/Ti is not less than 0.50 and not more than 20.00 in atomic ratio, and InM/Ti is less than 0.100 in atomic ratio, where an elemental titanium content is represented by Ti, an indium oxide content is represented by InOx, and a metallic indium content is represented by InM.
    Type: Application
    Filed: September 28, 2020
    Publication date: October 20, 2022
    Applicants: JFE Steel Corporation, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Mikito Suto, Hiroyuki Masuoka, Akira Matsuzaki, Hiroki Habazaki, Hikaru Kobayashi
  • Publication number: 20220332842
    Abstract: In order to provide an antibody having high therapeutic and prophylactic effects against cancer and the like, three types of mouse monoclonal antibodies were prepared which exhibit high affinities for a human-derived Eva1 protein. Moreover, constant regions of these antibodies were substituted with human-derived constant regions to also prepare chimeric antibodies. Further, these mouse antibodies and chimeric antibodies were found to have high ADCC and/or CDC activities. Furthermore, it was also revealed that administering these antibodies to mice having been subjected to melanoma cell administration suppresses the metastasis and the like of the cells to the lungs.
    Type: Application
    Filed: April 25, 2022
    Publication date: October 20, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Toshitada TAKEMORI, Mikako Shirouzu, Miho Tanaka, Tamami Ueshima, Toru Kondo
  • Patent number: 11466114
    Abstract: A composition for forming a phase-separated structure contains a block copolymer having a block (b1) consisting of a repeating structure of a styrene unit and a block (b2) consisting of a repeating structure of a methyl methacrylate unit, in which the block (b2) is disposed at least at one terminal portion of the block copolymer, the block copolymer has a structure (e1) represented by General Formula (e1) at least at one main chain terminal, and the structure (e1) is bonded to the main chain terminal of the block (b2) disposed at a terminal portion of the block copolymer. Ree0 represents a hydrocarbon group containing a hetero atom, and Re1 represents a hydrogen atom or a halogen atom.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: October 11, 2022
    Assignees: TOKYO OHKA KOGYO CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Ken Miyagi, Takahiro Dazai, Toshifumi Satoh, Takuya Isono
  • Publication number: 20220315613
    Abstract: Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I): wherein R1, R2, R3, R4, R5, and R6 each independently represent an alkyl group which may have a substituent.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 6, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuichi KITAGAWA, Kaori SHIMA, Satoshi WADA, Yasuchika HASEGAWA, Koji FUSHIMI
  • Patent number: 11453678
    Abstract: Disclosed is a cross-coupling reaction method which forms a chemical bond selected from C—N, C—B, C—C, C—O and C—S bonds, the method comprising: preparing an aromatic compound (1) having a leaving group; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic amino compound (2-1), a diboronic acid ester or the like (2-2), an aromatic boronic acid or the like (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the compound (1) with the compound (2) in the presence of a palladium catalyst, a base and a compound (4) having a carbon-carbon double bond or a carbon-carbon triple bond, in the absence of a solvent.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: September 27, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hajime Ito, Koji Kubota
  • Patent number: 11439848
    Abstract: A template matching is performed on two fluoroscopic images by using a template image prepared in advance and a position corresponding to a high matching score is listed as a candidate for the position of a marker 29. From two lists of the candidates of the position of the marker 29, the lengths of common vertical lines for all combinations are calculated. Then, the position of the marker 29 is detected based on the matching score and the common vertical line. Then, based on the detected position of the marker 29, an amount of a proton beam to be irradiated to a target is controlled. Therefore, a tracking target can be accurately detected even when the conditions for X-ray fluoroscopy is severe, e.g., a thick object.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 13, 2022
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yusuke Fujii, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Takahiro Yamada
  • Publication number: 20220284577
    Abstract: A processor of a fundus image processing device acquires a fundus image 50 photographed by a fundus image photographing device. The processor acquires blood vessel images 60A and 60B that indicate at least one of an arteriole and a venule in the fundus image 50 by inputting the fundus image 50 into a mathematical model trained by a machine learning algorithm. The processor acquires a blood vessel area that is an area of at least one of the arteriole and the venule in the whole of the blood vessel images 60A and 60B.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 8, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NIDEK CO., LTD.
    Inventors: Michiyuki SAITO, Kousuke NODA, Kanae FUKUTSU, Susumu ISHIDA, Ryosuke SHIBA, Yoshiki KUMAGAI
  • Patent number: 11426425
    Abstract: The present invention has an objective of providing a novel composition for treating a fibrocartilaginous tissue injury. The present invention provides a composition for treating a fibrocartilaginous tissue injury, which is to be applied to an injured fibrocartilaginous tissue part of a target and which comprises a monovalent metal salt of alginic acid, more preferably a low endotoxin monovalent metal salt of alginic acid.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: August 30, 2022
    Assignees: Mochida Pharmaceutical Co., Ltd., National University Corporation Hokkaido University
    Inventors: Eiji Kondo, Norimasa Iwasaki, Tomohiro Onodera, Wooyoung Kim, Yasuyuki Kawaguchi
  • Patent number: 11426603
    Abstract: A treatment planning apparatus 501 or a clinical decision support apparatus 701 calculates a dose distribution, calculates the damage to a normal tissue for a plurality of number of times of radiation irradiation based on the calculated dose distribution, and displays at least one or more calculated damages to the normal tissues on display apparatuses 603 and 703 or outputs the same to an outside of the apparatuses 501 and 701. Accordingly, since effects can be calculated for a plurality of number of times of irradiation, the optimum number of time of irradiation can be presented, and an operator and a doctor can be presented with a suitable decision material of a radiation irradiation planning.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 30, 2022
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Keiji Kobashi, Masahiro Mizuta, Hiroyuki Date, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki, Shusuke Hirayama, Yusuke Fujii, Toru Umekawa, Rintarou Fujimoto
  • Patent number: 11389486
    Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: July 19, 2022
    Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATION
    Inventors: Kenichi Yamahara, Akihiko Taguchi, Toshihiro Soma, Shunsuke Ohnishi, Akira Kobayashi
  • Patent number: 11383207
    Abstract: The present invention pertains to a polycrystalline membrane containing metal nitride particles represented by the general formula MNx (where M is a metal element in which the Fermi energy is in a position higher than ?4.4 eV vs L.V. and x is the range over which a rock salt-type structure can be assumed), in which the crystallite size determined by transmission electron microscopy is 10 nm or less, at least some of the crystallites have rock salt-type structure, and the crystallites exhibit (111) orientation but substantially do not exhibit (100) orientation. The present invention also pertains to a method for manufacturing a polycrystalline membrane, comprising forming, by sputtering, a polycrystalline membrane on a substrate having a temperature of less than 200° C.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: July 12, 2022
    Assignee: National University Corporation Hokkaido University
    Inventors: Yoshitaka Aoki, Chiharu Kura, Hiroki Habazaki
  • Patent number: 11384121
    Abstract: An object of the present invention is to provide an echinomycin derivative that has anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echinomycin derivative represented by formula (I), and a production method therefor based on a chemical procedure.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 12, 2022
    Assignee: National University Corporation Hokkaido University
    Inventors: Satoshi Ichikawa, Keita Kojima, Mikihiro Fujiya, Hiroaki Konishi
  • Patent number: 11377743
    Abstract: Provided are: a multilayer structure in which a titanium oxide layer exhibits excellent photocatalytic activity; and a method for producing this multilayer structure. The above-described multilayer structure comprises: a conductive part which contains a metal element A other than Ti, while having electrical conductivity; and a titanium oxide layer which is arranged on the conductive part and contains 1.0% by atom or more of the metal element A.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: July 5, 2022
    Assignees: JFE Steel Corporation, National University Corporation Hokkaido University
    Inventors: Mikito Suto, Takeshi Suzuki, Yusuke Nakagawa, Katsumi Kojima, Hiroki Habazaki, Yuki Satoh
  • Publication number: 20220193118
    Abstract: Provided is a composition for suppressing pain which contains a monovalent metal salt of alginic acid, the composition being applied to a nucleus pulposus cavity part to suppress pain at a surgical site and/or a surrounding site thereof which occurs after surgery. Accordingly, a composition is provided, which suppresses pain and/or inflammation at a surgical site and/or a surrounding site thereof which occurs after surgery performed on an intervertebral disc as typified by intervertebral discectomy.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 23, 2022
    Applicants: National University Corporation Hokkaido University, Mochida Pharmaceutical Co., Ltd
    Inventors: Hideki SUDO, Katsuro URA, Katsuhisa YAMADA
  • Patent number: 11362817
    Abstract: A quantum cryptographic key output apparatus includes a semiconductor laser device that repeatedly generates pulsed laser light, an encoder that encodes the pulsed laser light based on a quantum cryptographic key, an optical branching unit that branches the pulsed laser light, and an attenuator that attenuates a light intensity of first pulsed laser light so that the number of photons of the first pulsed laser light has any one of a plurality of candidate values that are values equal to or smaller than 1. Further, the output apparatus includes a light intensity determination unit that determines whether or not a light intensity of a second pulsed laser light is in a predetermined range, and an information output unit that outputs specifying information for specifying the first pulsed laser light corresponding to second pulsed laser light of which the light intensity is not in the predetermined range to an input apparatus.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: June 14, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Akihisa Tomita, Kensuke Nakata