Patents Assigned to National University Corporation Hokkaido University
  • Patent number: 11904185
    Abstract: A proton beam therapy system 1 includes an irradiation nozzle 25 for irradiating a target 31A with a particle beam, a proton beam irradiation control system 41 that controls the irradiation nozzle 25, a dose monitor 27B that measures an irradiation amount of the particle beam emitted to the target 31A, a position monitor 27A that measures a position of the particle beam emitted to the target 31A, and a dose distribution evaluation system during irradiation 55 that calculates a dose distribution of the particle beam emitted to the target 31A during irradiation. This system supports a medical staff to quickly and appropriately make an intervention determination for treatment such as discontinuation of particle therapy, a change in conditions thereof, or the like in the process of particle irradiation.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: February 20, 2024
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shusuke Hirayama, Rintarou Fujimoto, Masumi Umezawa, Yuusuke Fujii, Keiji Kobashi, Taeko Matsuura, Shinichi Shimizu
  • Publication number: 20240050477
    Abstract: The present invention provides a lipid nanoparticle and the like containing a pH-sensitive cationic lipid represented by formula (1) (in formula (1), R1 and R2 are each independently a straight-chain C10-14 alkyl group, a straight-chain C10-20 alkenyl group having one or two unsaturated bonds, or —CH(R5)(R6)(where R5 and R6 are each independently a straight-chain C5-10 alkyl group); p represents an integer of 3-8; and R3 and R4 are each independently a methyl group or an ethyl group].
    Type: Application
    Filed: February 17, 2022
    Publication date: February 15, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Takashi Nakamura, Hideyoshi Harashima, Yusuke Sato, Koharu Yamada, Taisei Nakade
  • Publication number: 20240043476
    Abstract: The present invention provides a peptide that consists of an amino acid sequence with 20 or fewer residues containing at least one amino acid sequence selected from the group consisting of the amino acid sequence represented in SEQ ID NO: 1, the amino acid sequence represented in SEQ ID NO: 2 and the amino acid sequence represented in SEQ ID NO: 38, the peptide having an activity to inhibit proliferation of a tumor cell or having an activity to inhibit binding between an epidermal growth factor receptor and a signal-transducing adaptor family member-2 (STAP-2); a peptide with a cell-penetrating peptide added to a terminus of the above peptide with or without a linker sequence interposed between the cell-penetrating peptide and the terminus; and pharmaceutical compositions containing any of these peptides.
    Type: Application
    Filed: August 18, 2021
    Publication date: February 8, 2024
    Applicant: National University Corporation Hokkaido University
    Inventors: Tadashi Matsuda, Kenji Oritani, Yuichi Kitai
  • Patent number: 11883683
    Abstract: A particle therapy system includes an accelerator 1 which generates a particle beam for extraction, an irradiation apparatus 21 which irradiates the particle beam to an irradiation target 26, a gantry 18 which rotates together with the irradiation apparatus 21, and an MRI apparatus 50 which rotates together with the gantry 18. The MRI apparatus 50 includes a magnetic circuit composed of an iron core 60 and a plurality of coils 61 serving as a magnetic flux source. The iron core 60 includes two oppositely disposed magnetic poles 63A and 63B, and a return yoke 64 for connecting the magnetic poles 63A and 63B. The magnetic poles 63A, 63B have cavities 65A, 65B. The particle beam passing through the cavity 65A is irradiated to the irradiation target 26.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 30, 2024
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yusuke Fujii, Ryuya Ando, Manabu Aoki, Kikuo Umegaki, Shinichi Shimizu, Taeko Matsuura, Hiroki Shirato
  • Publication number: 20240026286
    Abstract: The present invention relates to a method of producing cancer stem cells that comprises culturing a living cell population containing cancer cells in the presence of a gel substance to obtain a living cell population containing cancer stem cells, wherein the gel substance is a material that induces expression of osteopontin in at least a portion of cells contained in the living cell population. Moreover, the present invention relates to an agent for inducing conversion of cancer cells to cancer stem cells that comprises a gel substance that induces expression of osteopontin in at least a portion of the cells contained in a living cell population. The gel substance is a synthetic polymer gel composed of, for example, double network gel, PNaSS gel, PCDME gel, PA gel, PAMPS gel, PDMA gel or PAAc gel. The present invention provides means and a method that enable the preparation of cancer stem cells in a relatively short period of time and at a relatively low culturing cost without requiring expensive equipment.
    Type: Application
    Filed: October 4, 2023
    Publication date: January 25, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shinya TANAKA, Kazunori YASUDA, Jian Ping GONG, Masumi TSUDA, Takayuki KUROKAWA
  • Publication number: 20240011152
    Abstract: A dielectric composition comprises a crystal of an oxynitride. A peak attributed to absence of a center of symmetry of the crystal of the oxynitride is detected by Raman spectroscopy of the dielectric composition within a Raman shift range of 500 cm?1 or less.
    Type: Application
    Filed: July 7, 2023
    Publication date: January 11, 2024
    Applicants: TDK CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Kumiko YAMAZAKI, Shuto KANO, Yuji MASUBUCHI, Shinichi KIKKAWA
  • Patent number: 11846006
    Abstract: A heat-resistant alloy contains at least one element selected from a group consisting of Al, Ti, Ni, Cr, and Mo, O, and Y, and a ratio of a content of Y in terms of mass to a content of O in terms of mass is 0.5 or greater and 100 or less.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: December 19, 2023
    Assignees: TOKYO METROPOLITAN PUBLIC UNIVERSITY CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Koji Kakehi, Shigenari Hayashi, Yen-Ling Kuo
  • Publication number: 20230366819
    Abstract: Disclosed is a method for obtaining information on von Willebrand factor (VWF), comprising the following steps: denaturing, with urea, VWF contained in a biological sample; fluorescently labeling the denatured VWF using a capturing agent that comprises a fluorescent substance and binds to the denatured VWF; and obtaining information on the size of the fluorescently-labeled VWF by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy.
    Type: Application
    Filed: May 10, 2023
    Publication date: November 16, 2023
    Applicants: National University Corporation Hokkaido University, SYSMEX CORPORATION
    Inventors: Masataka KINJO, Akshay GANGULY, Lausonia RAMASWAMY
  • Patent number: 11814639
    Abstract: An object of the present invention is to provide a cucumber mosaic virus (CMV)-resistant solanaceous plant. The present invention provides a CMV-resistant solanaceous plant having a mutated eIF4E gene encoding an eIF4E protein nonfunctional for CMV. In addition, the present invention provides a method for producing a CMV-resistant plant, the method comprising mutating an eIF4E gene of a solanaceous plant into a mutated eIF4E gene encoding an eIF4E protein nonfunctional for CMV.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: November 14, 2023
    Assignees: Kikkoman Corporation, National University Corporation Hokkaido University
    Inventors: Hiroki Atarashi, Kenji Nakahara, Tetsuya Yamada, Chikara Masuta
  • Patent number: 11814368
    Abstract: The present invention provides a compound exhibiting coronavirus 3 CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: November 14, 2023
    Assignees: SHIONOGI & CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuki Tachibana, Shota Uehara, Yuto Unoh, Kenji Nakahara, Yoshiyuki Taoda, Yukiko Yamatsu, Shigeru Ando, Michihito Sasaki
  • Patent number: 11808901
    Abstract: A nuclear reaction detection device 100 includes a semiconductor memory 100 arranged in an environment in which radiation is incident, a position information storage unit 210 that stores spatial position information of a semiconductor element in the semiconductor memory 100, a bit position specifying unit 220 that detects that an SEU (Single Event Upset) has occurred in the semiconductor element included in the semiconductor memory 100, and specifies the semiconductor element in which the SEU has occurred, and a position calculating unit 230 that calculates a spatial position in which the SEU has occurred, based on the specified semiconductor element and the spatial position information.
    Type: Grant
    Filed: July 3, 2020
    Date of Patent: November 7, 2023
    Assignees: Nippon Telegraph and Telephone Corporation, National University Corporation Hokkaido University, National University Corporation Tokai National Higher Education and Research System
    Inventors: Hidenori Iwashita, Gentaro Funatsu, Michihiro Furusaka, Takashi Kamiyama, Hirotaka Sato, Yoshiaki Kiyanagi
  • Publication number: 20230348835
    Abstract: The present invention provides a method of culturing an alga that enables practical realization of low-cost and space-saving production of biofuels and bioenergy by culturing the alga using a reaction tank equipped with a digestive solution tank comprising digestive solution containing high concentration of nutrient salts, a membrane with a pore size of 0.45 µm or less and a culture tank comprising culture solution and the alga, which comprises consuming the nutrient salts by the alga in the culture tank to maintain the difference in concentration the nutrient salts between the digestive solution tank and the culture tank and supplying the nutrient salts contained in the digestive solution through the membrane into the culture solution by the diffusion depending on the concentration difference as well as an alga culture system therefor.
    Type: Application
    Filed: September 10, 2021
    Publication date: November 2, 2023
    Applicant: National University Corporation Hokkaido University
    Inventors: Masahiro Sato, Takumi Nakashima, Kazuei Ishii, Satoru Ochiai
  • Patent number: 11802166
    Abstract: An object of the present disclosure is to provide a cellulose acetate film having excellent bending properties and high transparency. The subject cellulose acetate film contains cellulose acetate having a cellulose triacetate I crystal structure, the cellulose acetate film having a light transmittance of 70% or higher at 660 nm.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 31, 2023
    Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, DAICEL CORPORATION
    Inventors: Yasumitsu Uraki, Haruo Konno, Shu Shimamoto
  • Publication number: 20230330646
    Abstract: A method for making a functional structural body includes a skeletal body of a porous structure composed of a zeolite-type compound, and at least one type of metallic nanoparticles present in the skeletal body, the skeletal body having channels connecting with each other, the metallic nanoparticles being present at least in the channels of the skeletal body.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 19, 2023
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.
    Inventors: Takao MASUDA, Yuta NAKASAKA, Takuya YOSHIKAWA, Sadahiro KATO, Masayuki FUKUSHIMA, Kojiro INAMORI, Hiroko TAKAHASHI, Yuichiro BANBA, Kaori SEKINE
  • Publication number: 20230333125
    Abstract: A problem of the present invention is to provide a diagnostic biomarker of nonalcoholic steatohepatitis (NASH) useful for differentiation of simple steatosis (SS) from NASH and use thereof. Specifically, the present invention relates to a diagnostic biomarker of nonalcoholic steatohepatitis used to differentiate nonalcoholic steatohepatitis from simple steatosis comprising the oxidized apolipoprotein A-I (ApoA-I) modified by dioxidation of the 72nd tryptophan in the ApoA-I consisting of the amino acid sequence as shown in SEQ ID NO: 1.
    Type: Application
    Filed: June 15, 2021
    Publication date: October 19, 2023
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, EIKEN KAGAKU KABUSHIKI KAISHA
    Inventors: Toshihiro SAKURAI, Shu-Ping HUI, Hitoshi CHIBA
  • Patent number: 11781146
    Abstract: The present invention provides mammalian cell expression vectors that impart to mammalian host cells an ability to produce high levels of foreign gene-derived proteins. A ubiquitously acting chromatin opening element (UCOE) is introduced into an expression vector that has a plasmid DNA integrated into a transcriptional hot spot on the chromosome of a dihydrofolate reductase gene-deficient host cell so that it allows for selection of strains that grow in hypoxanthine-thymidine (hereinafter denoted as HT)-free medium, whereby transformants will produce a protein of interest in increased amounts.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 10, 2023
    Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Yasuhiko Suzuki, Miki Nakagawa, Yayoi Kameda, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Shinya Goto, Yamato Sajiki, Kazuhiko Ohashi, Shiro Murata, Yuzuru Kitahara, Keiichi Yamamoto
  • Patent number: 11780948
    Abstract: A resin composition for forming a phase-separated structure includes a block copolymer having a block (b1) formed of a repeating structure of styrene units, the block (b1) being partially substituted with a constituent unit represented by the following General Formula (c1) and a block (b2) having a repeating structure of methyl methacrylate units.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: October 10, 2023
    Assignees: Tokyo Ohka Kogyo Co., Ltd., National University Corporation Hokkaido University
    Inventors: Ken Miyagi, Takahiro Dazai, Toshifumi Satoh, Takuya Isono, Shunma Tanaka
  • Patent number: 11768152
    Abstract: An information processing system includes a storage, an interface device, and a computing circuit. The storage stores a database, in which spectrum data concerning light from a light source and a measurement condition data at a time of measurement of the light are associated with a plant status data concerning growth of a plant and/or a harvest data concerning a harvest of the plant. The interface device receives an input of a user measurement condition which is to be applied at a time of measurement of the plant by a user and which includes data concerning angles at the time of measurement and data concerning a plant status and/or a harvest to be predicted. The computing circuit determines at least two wavelengths contained in the light from the light source to be measured under the user measurement condition by referring to the database based on the user measurement condition.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: September 26, 2023
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yukihiro Takahashi, Tatsuharu Ono, Nobuyasu Naruse, Yurino Ishida
  • Patent number: 11768109
    Abstract: The spectroscopic measuring instrument includes: a spectrometer to make measurement of a reflection spectrum of an object relative to a light source and output measurement information representing a result of the measurement; a shadow projector including obstacle(s) to allow light from the light source to cast shadow(s) on an object surface; an imaging device to output image information representing an image of an imaging area including the object surface; a storage interface removably connectable to a computer readable medium; and a processing device. The processing device is connected to the spectrometer, the imaging device and the storage interface, and performs a measurement process of storing the measurement information from the spectrometer and the image information from the imaging device in the computer readable medium connected to the storage interface.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: September 26, 2023
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yukihiro Takahashi, Youhei Moteki, Nobuyasu Naruse
  • Patent number: 11767345
    Abstract: The synthetic peptide disclosed here includes (1) an amino acid sequence represented by any of SEQ ID NOS:1 to 10, or a modified amino sequence formed by deletion, substitution or addition of 1, 2 or 3 amino acid residues in any of these amino acid sequences, together with (2) an amino acid sequence (CPP sequence) that functions as a cell penetrating peptide (CPP), and consists of a total of not more than 100 amino acid residues.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: September 26, 2023
    Assignees: TOAGOSEI CO., LTD, National University Corporation Hokkaido University
    Inventors: Tetsuhiko Yoshida, Ayato Takada, Nahoko Baileykobayashi