Patents Assigned to National University Corporation Hokkaido University
  • LIGHT HYDROCARBON PARTIAL OXIDATION CATALYST AND CARBON MONOXIDE PRODUCTION METHOD USING SAME
    Publication number: 20210163300
    Abstract: The present disclosure relates to a partial oxidation catalyst that causes a light hydrocarbon partial oxidation reaction to proceed readily with high activity and high selectivity and a high-yield carbon monoxide production method using the same. The present disclosure further relates to a light hydrocarbon partial oxidation catalyst containing a zeolite supporting cobalt and rhodium.
    Type: Application
    Filed: March 25, 2019
    Publication date: June 3, 2021
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, TOSOH CORPORATION
    Inventors: Atsushi FUKUOKA, Hirokazu KOBAYASHI, Sae SOMEYA
  • Intracellular substance transport system and use thereof
    Patent number: 11007276
    Abstract: The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 18, 2021
    Assignee: National University Corporation Hokkaido University
    Inventor: Shin-Ichiro Nishimura
  • PEPTIDE MACROCYCLIZATION ENZYME
    Publication number: 20210139917
    Abstract: A peptide cyclase that has the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof, or a peptide cyclase that has an amino acid sequence encoded by a base sequence encoding the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof; DNA encoding the peptide cyclase; a method for producing the peptide cyclase; and a method for producing a cyclic peptide using the peptide cyclase.
    Type: Application
    Filed: April 25, 2019
    Publication date: May 13, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Toshiyuki WAKIMOTO, Takefumi KURANAGA, Kenichi MATSUDA
  • PHOSPHINE OXIDE COMPOUND, RARE EARTH COMPLEX, AND LIGHT-EMITTING MATERIAL
    Publication number: 20210130378
    Abstract: A phosphine oxide compound represented by the following formula (I) and a rare earth complex containing the same are disclosed: wherein n represents an integer of 3 or more, Ar1 represents an n-valent aromatic group, L represents a divalent linker group, and Ar2 and Ar3 each independently represent a monovalent aromatic groups.
    Type: Application
    Filed: February 21, 2018
    Publication date: May 6, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yasuchika HASEGAWA, Pedro paulo FERREIRA DA ROSA, Takayuki NAKANISHI, Yuichi KITAGAWA, Koji FUSHIMI
  • NUCLEANT ENHANCING NUCLEATION OF A PROTEIN CRYSTAL AND PROTEIN CRYSTALLIZATION METHOD WITH THE SAME
    Publication number: 20210130400
    Abstract: A balanced-lattice-ledge nucleant having ledge inducing local densification of proteins and a balanced-lattice inducing self-organized crystal packing. Using this balanced-lattice-ledge nucleant enhances nucleation of protein crystals.
    Type: Application
    Filed: October 26, 2020
    Publication date: May 6, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Min YAO, Long LI
  • AGENT FOR PREVENTING OR AMELIORATING ALZHEIMER'S DISEASE
    Publication number: 20210121490
    Abstract: The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid ? proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid ? proteins and thus enables the prevention or amelioration of Alzheimers disease.
    Type: Application
    Filed: October 3, 2018
    Publication date: April 29, 2021
    Applicants: DAICEL CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Kaori TAKAHASHI, Katsuyuki MUKAI, Yasuyuki IGARASHI, Kohei YUYAMA
  • TREATMENT AGENT AND PHARMACEUTICAL COMPOSITION FOR GLIOMA
    Publication number: 20210113540
    Abstract: An object of the present invention is to provide an effective treatment agent and a pharmaceutical composition for prevention or treatment of glioma. The present invention provides a glioma treatment agent which comprises a compound represented by formula (1) or a salt thereof.
    Type: Application
    Filed: June 6, 2019
    Publication date: April 22, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yukiko ISHII, Toru KONDO
  • Information transmission system transmitting visible optical signal received by video camera
    Patent number: 10985840
    Abstract: An information transmitter apparatus for use in an information transmission system is provided, where the information transmission system includes the information transmitter apparatus and an information receiver apparatus. The information transmitter apparatus transmits a surface-shaped visible light signal using a light source, where the visible light signal is modulated according to a modulated signal modulated using a plurality of respective-order carriers different from each other, and the respective-order carriers has a fundamental frequency and multiple frequencies of a frame output signal of a video camera of rolling shutter system provided in an information receiver apparatus. The information receiver apparatus receives the visible light signal using the video camera.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: April 20, 2021
    Assignees: INTER-UNIVERSTY RESEARCH INSTITUTE CORPORATION RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hiromichi Hashizume, Masanori Sugimoto, Takayuki Akiyama, Hayato Kumaki, Shota Shimada
  • Electricity measuring type surface plasmon resonance sensor and electricity measuring type surface plasmon resonance sensor chip used in the same
    Patent number: 10983052
    Abstract: An electricity measuring type surface plasmon resonance sensor including: a plasmon polariton intensifying sensor chip in which a prism and a sensor chip including a transparent electrode, an n-type transparent semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the transparent electrode, the n-type transparent semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the transparent electrode and the plasmon resonance film electrode.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: April 20, 2021
    Assignees: IMRA JAPAN KABUSHIKIKAISHA, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hironori Suzuki, Giles Allison, Masanori Sasaki, Koki Hayashi, Hiroaki Misawa, Kosei Ueno
  • BIARYL SULFONAMIDE DERIVATIVE HAVING FILOVIRUS CELL ENTRY INHIBITION ACTIVITY
    Publication number: 20210107871
    Abstract: The objective of the present invention is to provide a novel compound inhibiting the entry of a filovirus into a cell, a medical composition, an anti-filovirus agent, or a filovirus entry inhibitor containing the compound, as well as a method for inhibiting a filovirus cell entry process in vitro, a method for treating a filovirus infectious disease, and the like. The objective has been achieved by providing: the compound represented by formula (I) or a hydrate thereof; or a pharmaceutically acceptable salt of the compound or a hydrate thereof.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 15, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Ayato Takada, Masahiro Sakaitani, Wakako Furuyama
  • LEARNING APPARATUS, LEARNING METHOD, AND PROGRAM FOR LEARNING APPARATUS, AS WELL AS INFORMATION OUTPUT APPARATUS, INFORMATION OUPUT METHOD, AND INFORMATION OUTPUT PROGRAM
    Publication number: 20210056414
    Abstract: Provided is a learning apparatus capable of generating learning pattern information for causing meaningful output information corresponding to input information to be accurately output, while reducing the amount of learning data needed to generate the learning pattern corresponding to the input information. When generating learning pattern data PD for obtaining meaningful output corresponding to image data GD, the learning pattern data PD corresponding to the results of deep-layer learning processing using the image data GD, the learning apparatus: acquires, from an external source, external data BD corresponding to the image data GD; on the basis of a correlation between image feature data GC indicating a feature of the image data GD and external feature data BC indicating a feature of the external data BD, converts the image feature data GC; and generates converted image feature data MC.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 25, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Miki HASEYAMA, Takahiro OGAWA
  • Nanocrystal production method, and steel production method
    Patent number: 10927442
    Abstract: A nanocrystal production method includes a light irradiation step of applying light to a surface of a metal material immersed in water to form nanocrystals on the surface. In this nanocrystal production method, the metal material contains iron, the nanocrystal contains at least one of iron oxide and iron hydroxide, and in the spectrum of the light, a wavelength at which the intensity is maximum is not less than 360 nm and less than 620 nm.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 23, 2021
    Assignees: Showa Denko Materials Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shuichiro Adachi, Masaki Kitagawa, Seiichi Watanabe, Lihua Zhang, Noriyuki Okinaka, Dai Takai
  • 2,3-BISPHOSPHINOPYRAZINE DERIVATIVE, METHOD FOR PRODUCING SAME, TRANSITION METAL COMPLEX, ASYMMETRIC CATALYST, AND METHOD FOR PRODUCING ORGANIC BORON COMPOUND
    Publication number: 20210047351
    Abstract: Provided is a 2,3-bisphosphinopyrazine derivative represented by the following general formula (1), wherein R1, R2, R3, and R4 represent an optionally substituted straight-chain or branched alkyl group having 1 to 10 carbon atoms, an optionally substituted cycloalkyl group, an optionally substituted adamantyl group, or an optionally substituted phenyl group, R5 represents an optionally substituted alkyl group having 1 to 10 carbon atoms or an optionally substituted phenyl group, each R5 may be the same group or a different group, R6 represents a monovalent substituent, n denotes an integer of 0 to
    Type: Application
    Filed: March 1, 2019
    Publication date: February 18, 2021
    Applicants: Nippon Chemical Industrial Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hajime Ito, Hiroaki Iwamoto, Tsuneo Imamoto, Ken Tamura, Natsuhiro Sano
  • INFRARED RADIATION DEVICE
    Publication number: 20210045195
    Abstract: An infrared radiation device includes a body including a heat generating part and first and second metamaterial structures that are capable of radiating infrared rays having a peak wavelength of a non-Planck distribution upon receipt of thermal energy from the heat generating part. The first metamaterial structure is disposed on a first surface side of the heat generating part, and the second metamaterial structure is disposed on a second surface side opposite to the first surface side of the heat generating part.
    Type: Application
    Filed: October 19, 2020
    Publication date: February 11, 2021
    Applicants: NGK Insulators, Ltd., National University Corporation Hokkaido University, Niigata University
    Inventors: Michiro AOKI, Yoshio KONDO, Tsuyoshi TOTANI, Atsushi SAKURAI
  • DRUG FOR CHRONIC INFLAMMATORY DISEASE AND METHOD FOR EVALUATING SUSCEPTIBILITY TO CHRONIC INFLAMMATORY DISEASE
    Publication number: 20210032633
    Abstract: [Problem] The purpose of the present invention is to provide new treatment targets and treatment methods for chronic inflammatory disease based on a molecular biological mechanism relating to the onset of keloid. [Solution] The present invention relates to a drug for the prevention and/or treatment of chronic inflammatory disease that contains as an active ingredient a substance that suppresses the expression and/or inhibits the activity of a specific NEDD4 splicing variant protein.
    Type: Application
    Filed: February 4, 2018
    Publication date: February 4, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Masaaki Murakami, Daisuke Kamimura, Munekumi Fujita
  • CREATION OF PEPTIDE-BASED ANTI-TUMOR AGENT
    Publication number: 20210017232
    Abstract: An object of the present invention is to provide an echinomycin derivative that has anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echinomycin derivative represented by formula (I), and a production method therefor based on a chemical procedure.
    Type: Application
    Filed: January 31, 2019
    Publication date: January 21, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Satoshi ICHIKAWA, Keita KOJIMA, Mikihiro FUJIYA, Hiroaki KONISHI
  • Latent-heat storage body microcapsules and process for producing latent-heat storage body microcapsules
    Patent number: 10894907
    Abstract: In the present invention, after a primary coating film is formed by boehmite treatment of the surface of a core particle in a solution comprising Al ions, a secondary coating film is formed by cooling the solution to the supersaturation temperature of the Al ions to cause deposition of a hydroxide of aluminum on the surface of the primary coating film, and an Al oxide film is formed on the surface of the core particle by heat treating the secondary coating film in an oxidizing atmosphere. Consequently, the shell is thickened by the amount of secondary coating film formed, so that the cyclic strength of the capsule can be secured and the composition change of the PCM in the production process is remarkably suppressed.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: January 19, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Takahiro Nomura, Tomohiro Akiyama, Nan Sheng, Daiki Hanzaki
  • Anti-PD-L1 antibody for detecting PD-L1
    Patent number: 10865246
    Abstract: The present invention provides an anti-PD-L1 antibody capable of staining tumor cells such as melanoma cells. An anti-PD-L1 antibody comprising (a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and (b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDF (SEQ ID NO: 5). A composition for detecting PD-L1, comprising the above antibody as an active ingredient. A method for preparing the above antibody is also provided.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: December 15, 2020
    Assignees: Fuso Pharmaceutical Industries, Ltd., National University Corporation Hokkaido University
    Inventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Satoshi Takagi, Yumiko Kagawa, Yasuhiko Suzuki, Chie Nakajima
  • Spectral camera control device and method for controlling spectral camera
    Patent number: 10864998
    Abstract: [Problem] To provide a spectral camera control device, a spectral camera control program, a spectral camera control system, an aircraft equipped with said system, and a spectral image capturing method, with which it is possible for each of a spatial resolution and an exposure time for spectral image capture to be set arbitrarily, and with which spatial distortion and displacement of the spectral image can be suppressed. [Solution] This spectral camera control device is installed together with a spectral camera 3 provided with a liquid crystal tunable filter 33 in an aircraft 1 capable of stationary flight, and causes the spectral camera 3 to capture an image in a snapshot mode each time the transmission wavelength of the liquid crystal tunable filter 33 is switched while the aircraft 1 is in stationary flight.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: December 15, 2020
    Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yukihiro Takahashi, Junichi Kurihara, Tetsuro Ishida
  • OPTICALLY ACTIVE 2,3-BISPHOSPHINOPYRAZINE DERIVATIVE, METHOD FOR PRODUCING SAME, TRANSITION METAL COMPLEX, AND METHOD FOR PRODUCING ORGANIC BORON COMPOUND
    Publication number: 20200377536
    Abstract: An optically active 2,3-bisphosphinopyrazine derivative represented by the following general formula (1): wherein R1 represents a group selected from a branched alkyl group having 3 or more carbon atoms, an adamantyl group, an optionally substituted cycloalkyl group, and an optionally substituted aryl group; R2 represents a group selected from a branched alkyl group having 3 or more carbon atoms, an adamantyl group, and an optionally substituted cycloalkyl group, provided that when R1 is a tert-butyl group, R1 and R2 are not the same; R3 represents a monovalent substituent; n represents an integer of 0 to 4; and * represents an asymmetric center on a phosphorus atom.
    Type: Application
    Filed: September 28, 2018
    Publication date: December 3, 2020
    Applicants: Nippon Chemical Industrial Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Hajime Ito, Hiroaki Iwamoto, Tsuneo Imamoto, Ken Tamura