Patents Assigned to National University Corporation Kagawa University
  • Patent number: 10391286
    Abstract: [Subjects] To provide a biliary tract drainage tube in which both an external drainage tube and an internal drainage tube can be installed in a single endoscopic procedure. [Method to Solve] A biliary tract drainage tube used to drain a biliary tract is provided with long external drainage tube 2 and internal drainage tube 3 that is provided on the tip of the external drainage tube so as to be separable from the external drainage tube. Both external drainage tube 2 and internal drainage tube 3 are placed in biliary tract Cd. Since internal drainage tube 3 can be left behind in the biliary tract by removing external drainage tube 2, another endoscopic procedure is not required when switching from external drainage tube 2 to internal drainage tube 3, and the burden placed on the patient can be lessened.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: August 27, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventor: Hideki Kamada
  • Patent number: 10386236
    Abstract: Reflected light detecting device and method with surface reflected light components collectively be extracted/removed when detecting reflected light arising in casting light onto target-object range having non-planar surface.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: August 20, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Hiroki Hayashi, Ichiro Ishimaru
  • Publication number: 20190175435
    Abstract: A muscular strength assisting apparatus includes a drive means held by a first attachment tool attached to a torso, and a transmission means for transmitting a force output by the drive means to a second attachment tool attached to an upper arm. The transmission means includes an output shaft member coupled to the second attachment tool, and a switching means capable of switching between transmission and interruption of a force from the drive means to the output shaft member. The switching means is disposed on a rear, upper or laterally outer side of the output shaft member.
    Type: Application
    Filed: June 23, 2017
    Publication date: June 13, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Daisuke SASAKI, Isao KIKUTANI, Kazuya YOKOYAMA
  • Patent number: 10202434
    Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: February 12, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
  • Patent number: 10190927
    Abstract: To provide a tactile sensor that allows a contact to be displaced largely and can detect fine ruggedness, flexibility, and other features of a surface of a measuring object. A sensor part S includes a frame 10 that includes a side part of a substrate B, a contact 20 that is disposed in parallel to the substrate B so that a tip of the contact 20 projects from a side face of the substrate B, a suspension 30 that supports the contact 20 to the frame 10, and displacement detectors 41 and 42 each of which detects displacement of the contact 20. The side face of the substrate B functions as a sensing surface. The contact 20 coming in contact with a measuring object O is displaced on a level parallel to the substrate B. Since the sensor part S can be configured widely in a planar manner along the substrate B, the structure has higher flexibility of design.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: January 29, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventor: Hidekuni Takao
  • Publication number: 20180116215
    Abstract: A composition comprising at least one monosaccharide selected from D-tagatose, D-allose, D-psicose, D-talose, D-sorbose, D-galactose, Lfructose, D-mannose and D-mannitol as an active ingredient and multiple surfactants selected from an anionic surfactant selected from aryl sulfonates, formalin condensates of aryl sulfonates, alpha-olefin sulfonates, alkyl sulfonates, alkyl diphenyl ether disulfonates, polyoxyethylene alkyl phenyl ether sulfonates, polyoxyethylene alkyl ether sulfosuccinic acid half esters, alkyl sulfates, sulfosuccinates, polyoxyalkylene aryl ether sulfates, polyoxyalkylene alkyl ether sulfates, polyoxyethylene-polyoxypropylene block polymer sulfates, polyoxyalkylene alkyl ether acetates, polyoxyalkylene aryl ether phosphates, polyoxyalkylene alkyl ether phosphates, polyoxyethylene-polyoxypropylene block polymer phosphates, alkyl phosphate esters, methyl taurates, polycarboxylates and fatty acid salts, wherein the anionic surfactants are at a blending ratio of 0.
    Type: Application
    Filed: December 27, 2017
    Publication date: May 3, 2018
    Applicants: MITSUI CHEMICALS AGRO, INC., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Toshiaki OHARA, Kiyoko TANAKA, Shuji ISHIZAKI, Shigehiro KATO, Kazuya AKIMITSU, Ken IZUMORI
  • Patent number: 9908921
    Abstract: The present invention provides galectin-9 variant having substantially the same bioactivity as in wild-type galectin-9 and being superior in protease stability, solubility, and yield. The galectin-9 variant according to the present invention is a protein including the following NCRD and the following CCRD composed of an N-terminal region and a C-terminal region. The C terminus of the NCRD and the N terminus of the CCRD are directly or indirectly bound to each other. The NCRD is (N1) a peptide composed of an amino acid sequence represented by SEQ ID NO: 1. The N-terminal region of the CCRD is (C-N1) a peptide composed of an amino acid sequence obtained by deletion of 1 to 17 amino acids in an amino acid sequence represented by SEQ ID NO: 3. The C-terminal region is (C-C1) a peptide composed of an amino acid sequence represented by SEQ ID NO: 5.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: March 6, 2018
    Assignee: National University Corporation Kagawa University
    Inventors: Nozomu Nishi, Aiko Itoh
  • Patent number: 9861099
    Abstract: Provided is a composition that enhances the effects of monosaccharides. The composition is a composition comprising a monosaccharide as an active ingredient thereof and comprising at least one or more assistants selected from a nonionic surfactant (excluding acetylene glycol-based surfactants, fluorine-based surfactants and silicone-based surfactants), an anionic surfactant (excluding lignin sulfonate), a cationic surfactant, an amphoteric surfactant, a water-soluble polymer, an amino acid, an amino sugar, a disaccharide alcohol and a salt, and is effective as an agricultural control composition against plant disease, particularly plant disease caused by fungi and plant disease caused by bacteria.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: January 9, 2018
    Assignees: MITSUI CHEMICALS AGRO, INC., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Toshiaki Ohara, Kiyoko Tanaka, Shuji Ishizaki, Shigehiro Kato, Kazuya Akimitsu, Ken Izumori
  • Patent number: 9857391
    Abstract: A plant water dynamics sensor usable for measuring the dynamics of water flowing in a fine point of a plant such as a distal end of a new branch or a pedicel comprises a heater-equipped temperature probe including a temperature sensor and a heater; a temperature probe including a temperature sensor; an electrical resistance probe including an electrical resistance measurement electrode; and a support that supports the probes while the probes are aligned parallel to each other. The position of a xylem XY can be detected based on an electrical resistance measured at the electrical resistance probe, so that each of the temperature sensors can be arranged correctly in a position at a phloem PH or at the xylem XY. This facilitates attachment of a plant water dynamics sensor and water dynamics in a plant can be measured with high accuracy.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: January 2, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Fusao Shimokawa, Hidekuni Takao, Takaaki Suzuki, Tsuyoshi Kobayashi, Ikuo Kataoka
  • Publication number: 20170336263
    Abstract: Reflected light detecting device and method with surface reflected light components collectively be extracted/removed when detecting reflected light arising in casting light onto target-object range having non-planar surface.
    Type: Application
    Filed: May 17, 2017
    Publication date: November 23, 2017
    Applicants: AOI ELECTRONICS CO., Ltd., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Hiroki HAYASHI, Ichiro ISHIMARU
  • Patent number: 9778166
    Abstract: In a microparticle measurement device, a sample is passed through each channel in a multi-flow channel, and a predetermined linear area is illuminated with light. Measurement light originating from a microparticle in the sample, such as scattered or fluorescent light, is shaped into a parallel beam by an objective lens and passes through a first and second transmission portions. The beams transmitted through these two portions are converged as first and second measurement beams onto the same straight line by a cylindrical lens. The intensity of the interference light formed by these beams is detected with a detector. Meanwhile, the light emitted from the light source and passing through the multi-flow channel without hitting the microparticle falls through the objective lens onto a non-reflection portion and does not travel toward the cylindrical lens. Accordingly, only the interference light formed by the measurement beams is allowed to fall onto the detector.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: October 3, 2017
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventor: Ichiro Ishimaru
  • Patent number: 9668958
    Abstract: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: June 6, 2017
    Assignees: MATSUTANI CHEMICAL INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Tetsuo Iida, Takashi Ichihara, Ken Izumori, Masaaki Tokuda, Takaaki Ogawa
  • Publication number: 20170100418
    Abstract: Problem: A malaria transmission blocker or a malaria parasite growth inhibitor is provided as a result of finding a druq which inhibits malaria parasite growth in the body of a vector mosquito. Solution: A malaria parasite growth inhibitor or transmission blocker containinq a rare sugar such as D-allose or D-psicose as an active ingredient.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 13, 2017
    Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Masaaki Tokuda, Meiji Arai, Kazuhiro Okuma
  • Publication number: 20170101457
    Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 13, 2017
    Applicants: OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
  • Patent number: 9579096
    Abstract: Provided is a suturing apparatus for endoscope capable of suturing an opening of a wound, with an endoscope inserted into cavity of a digestive tract, to the same extent as the surgical operation. The suturing apparatus includes a front arm 11, a rear arm 12, arm moving means 13 for causing the front arm 11 and the rear arm 12 to move closer to or away from each other, and rocking means for relatively rocking the front arm 11 and the rear arm 12. The rear arm 12 includes a needle-like member 14 provided on a surface on a side of the front arm 11 so that an axial direction thereof becomes parallel with a direction in which the front arm 11 and the rear arm 12 are moved closer to or away from each other. The front arm 11 is provided with a housing space 16 capable of housing a tip of the needle-like member 14 when the front arm 11 and the rear arm 12 are moved closer to each other. Each of the housing spaces houses an engagement member 21 capable of being engaged with the needle-like member 14.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: February 28, 2017
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Hirohito Mori, Tatsurou Sugitani, Yoshihito Momose
  • Patent number: 9579273
    Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: February 28, 2017
    Assignees: The Kitasato Institute, National University Corporation Kagawa University
    Inventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
  • Publication number: 20170045437
    Abstract: In a microparticle measurement device, a sample is passed through each channel in a multi-flow channel, and a predetermined linear area is illuminated with light. Measurement light originating from a microparticle in the sample, such as scattered or fluorescent light, is shaped into a parallel beam by an objective lens and passes through a first and second transmission portions. The beams transmitted through these two portions are converged as first and second measurement beams onto the same straight line by a cylindrical lens. The intensity of the interference light formed by these beams is detected with a detector. Meanwhile, the light emitted from the light source and passing through the multi-flow channel without hitting the microparticle falls through the objective lens onto a non-reflection portion and does not travel toward the cylindrical lens. Accordingly, only the interference light formed by the measurement beams is allowed to fall onto the detector.
    Type: Application
    Filed: February 20, 2015
    Publication date: February 16, 2017
    Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventor: Ichiro ISHIMARU
  • Patent number: 9528099
    Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: December 27, 2016
    Assignees: National University Corporation Kagawa University
    Inventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
  • Patent number: 9513165
    Abstract: A spectroscopic measurement device includes a dark filter that is arranged on an optical path between an imaging optical system and a light detection unit and includes a plurality of regions having different transmittances, the filter being configured such that a fixed reflected measurement light and a movable reflected measurement light that are guided to a same point by the imaging optical system and form interference light are transmitted through a same region; and an arithmetic processing unit that obtains an interferogram of the measurement light at a transmittance corresponding to each of two or more regions from a detection signal of each pixel of a light detection unit when a movable reflection unit is moved, and obtains a spectrum of the measurement light based on the interferogram.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: December 6, 2016
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventor: Ichiro Ishimaru
  • Patent number: 9510583
    Abstract: The purpose of the present invention is to provide a pest-accumulating device and pest-accumulating method that can attract pests, such as chicken mites and the like, and keep the said pests therein, and that can be easily handled by anyone, and to provide a pest-inspecting device that allows the captured pests to be evaluated. A pest-accumulating device for accumulating mites such as chicken mites and northern fowl mites, includes an accumulating part 10 made of a material that allows a charged layer to be formed on a surface thereof. When a charged layer is formed in the accumulating part 10, mites, such as chicken mites and northern fowl mites, can be gathered in the accumulating part. When the pest-accumulating device 1 of the present invention is set up in a fixed place in a poultry house CH, mites such as chicken mites that parasitize chickens CK, and even mites such as chicken mites that enter into narrow spaces in the poultry house and chicken cages KG, can be accumulated in the accumulating part 10.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: December 6, 2016
    Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Koh-en Yamauchi, Yoshiki Matsumoto, Tetsuya Kondo, Kohsyo Yamauchi