Patents Assigned to National University Corporation Kagawa University
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Publication number: 20240115343Abstract: Provided is a grip tool that allows detecting a slip of an object. The grip tool includes a pair of grip portions that sandwiches to grip an object; an opening/closing mechanism that opens and closes the pair of grip portions; and at least one sensor unit disposed in one or both of the pair of grip portions. The sensor unit includes a plurality of force sensors disposed in a predetermined distribution. The plurality of force sensors each have a function of measuring forces in triaxial directions received from the object. The sensor unit can measure a load distribution received from the object. The slip of the object is detectable based on the load distribution.Type: ApplicationFiled: October 2, 2020Publication date: April 11, 2024Applicant: National University Corporation Kagawa UniversityInventors: Hidekuni TAKAO, Masao FUJIWARA
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Publication number: 20240085366Abstract: A vascular sap measurement sensor includes an indicator electrode probe, a reference electrode probe, and a supporting portion. The indicator electrode probe is an ion-sensitive field effect transistor. The reference electrode probe includes a solid reference electrode, the solid reference electrode including a base layer, a silver chloride layer, and a chloride layer, the base layer being formed of an electrically conductive body, the silver chloride layer being formed on a surface of the base layer, the chloride layer being formed on a surface of the silver chloride layer. The supporting portion supports the indicator electrode probe and the reference electrode probe arranged in parallel.Type: ApplicationFiled: October 8, 2020Publication date: March 14, 2024Applicant: National University Corporation Kagawa UniversityInventors: Fusao SHIMOKAWA, Kazuma ISHIDA
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Publication number: 20240002828Abstract: A highly safe and highly heat-resistant L-rhamnose isomerase usable in the food industry and the production thereof are disclosed. The L-rhamnose isomerase is derived from a microorganism belonging to the genus Enterobacter, has a subunit molecular mass of 47 kDa as measured by SDS-PAGE, and has the following substrate specificities (A) isomerase activity that recognizes and reacts with a CHO group at C1 and an OH group at C2 of an aldose to convert the CHO group at C1 into an OH group and the OH group at C2 into a CO group, or recognizes and reacts with an OH group at C1 and a CO group at C2 of a ketose to convert the OH group at C1 into a CHO group and the CO group at C2 into an OH group; and (B) reactivity with L-rhamnose, L-lyxose, L-mannose, D-allose, D-ribose, and L-talose.Type: ApplicationFiled: November 30, 2021Publication date: January 4, 2024Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Kazuya AKIMITSU, Ken IZUMORI, Akihide YOSHIHARA, Shiro KATO, Susumu MOCHIZUKI, Hiromi YOSHIDA, Shigehiro KAMITORI
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Publication number: 20230366762Abstract: Provided is a tactile sensor that allows restraining a decrease in spatial resolution and sensitivity of a sensor element and has waterproof and dust-proof properties. A tactile sensor includes a sensor element and a casing that houses the sensor element. The sensor element includes: a base portion; a contact having a contact end; a support body that supports the contact in a displaceable manner with respect to the base portion; and a displacement detector that detects a displacement of the contact with respect to the base portion. The casing includes a film having flexibility that covers at least the contact end among the sensor element, and the contact end is secured to an inner surface of the film.Type: ApplicationFiled: October 7, 2021Publication date: November 16, 2023Applicant: National University Corporation Kagawa UniversityInventor: Hidekuni TAKAO
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Patent number: 11815411Abstract: A tactile sensor includes a base portion, a displacement portion, a displacement portion support body that supports the displacement portion in a displaceable manner in a first direction with respect to the base portion, a hair in a straight line arranged along a second direction, a hair fixing portion to which a base end of the hair is fixed, a hair fixing portion support body that turnably supports the hair fixing portion with respect to the displacement portion, a displacement detector that detects a displacement of the displacement portion with respect to the base portion, and a turn detector that detects a turn of the hair fixing portion with respect to the displacement portion. The sensations specific to the hairy skin, such as perception of a liquid surface and static electricity, can be detected from a shearing force and a moment acting on the hair.Type: GrantFiled: October 21, 2019Date of Patent: November 14, 2023Assignee: National University Corporation Kagawa UniversityInventor: Hidekuni Takao
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Publication number: 20230304952Abstract: Provided are a plant water content sensor and a plant water content measuring method configured to measure a water content of a plant in a non-destructive manner. A plant water content sensor includes a water content probe, which includes a readout electrode pair made of a pair of electrodes disposed at a predetermined interval thereof, a water sensitive film, which is bridged across the pair of electrodes, and a supporting portion, which supports the water content probe. A water content of the plant is measurable by sticking the water content probe into the plant and reading out impedance or an electrostatic capacity from the readout electrode pair.Type: ApplicationFiled: August 2, 2021Publication date: September 28, 2023Applicant: National University Corporation Kagawa UniversityInventors: Fusao SHIMOKAWA, Fumiya INO
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Patent number: 11653685Abstract: A D-psicose-containing sweetener with the modification of the taste of D-psicose includes D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.Type: GrantFiled: October 16, 2020Date of Patent: May 23, 2023Assignees: MATSUTANI CHEMICAL INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Hideki Fujihara, Kazuhiro Okuma, Tetsuo Iida, Ken Izumori, Masaaki Tokuda, Kazuhiro Fukada
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Publication number: 20220390468Abstract: A heart failure marker that is simple, and preferably usable by non-invasive test. A method for measuring heart failure risk, comprising: (A) measuring an angiotensinogen amount value of urine collected from a subject.Type: ApplicationFiled: November 6, 2020Publication date: December 8, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, SHIONOGI & CO., LTD.Inventors: Tetsuo MINAMINO, Shota YOKOYAMA, Ryo KAWAKAMI
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Patent number: 11516562Abstract: A core selective switch in an optical node device included in a spatial channel optical network includes a spatial demultiplexing unit, an optical switch, and an optical interconnect unit, wherein the spatial demultiplexing unit is an MCF collimator array in which a plurality of MCF collimators each comprising both an MCF having S cores and a collimator lens are two-dimensionally arranged in a plane, the optical switch is a variable reflection angle mirror array in which S variable reflection angle mirrors are two-dimensionally arranged in a plane in a manner similar to a core arrangement in the MCF, the optical interconnect unit is a steering lens, and a beam light output from each core of an input MCF is focused on a variable reflection angle mirror corresponding to the core to be reflected to couple to a corresponding core of a desired output MCF.Type: GrantFiled: January 16, 2020Date of Patent: November 29, 2022Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventor: Masahiko Jinno
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Publication number: 20220316945Abstract: A spectrometry device wherein light rays emitted from an object face measurement point combine into one parallel light beam by an objective lens, this is divided into a first and second light beam by a phase shifter, and the first and second light beam emit toward a light-receiving face of a photodetector while providing an optical path length difference. A light-shielding plate is arranged on a face optically conjugate the object face respective to the objective lens, and only light passed through translucent portions of the light-shielding plate is directed to the objective lens. A lateral length of each light-shielding plate translucent portion and the interval between two adjacent translucent portions are based on the objective lens focal length, the distance from the phase shifter to the photodetector light-receiving face, a photodetector pixel pitch, a pixel length, and a predetermined wavelength range of the light emitted from the measurement point.Type: ApplicationFiled: August 28, 2020Publication date: October 6, 2022Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventor: Ichiro ISHIMARU
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Patent number: 11402270Abstract: A combining light emitted from a measurement point of an object to be measured into one parallel light beam by combining optical system; dividing, by phase shifter, parallel light beam emitted from combining optical system into first and second light beam, emitting first and second light beam toward light-receiving face while providing an optical path length difference between the first and second light beam, and causing the first and second light beam to planarly enter the light-receiving face so that at least a part of an incident region of first light beam on the light-receiving face and at least a part of an incident region of second light beam overlap with each other; and obtaining an interferogram at measurement point based on intensity distribution of light in a region where an incident region of the first and second light beam on light-receiving face overlap, and acquiring spectrum by Fourier-transforming interferogram.Type: GrantFiled: June 13, 2019Date of Patent: August 2, 2022Assignee: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventor: Ichiro Ishimaru
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Publication number: 20220184105Abstract: Provided is a pharmaceutical composition that is for prevention or treatment of urinary tract organ cancer, causes no adverse side effects, can be continuously used for a long time, and is administered to the urinary tract organ by injection into the urinary tract organ cavity. A solution for injection into the urinary tract organ cavity contains D-allose. The inside of the urinary tract organ cavity is the inside of the upper urinary tract and the inside of the bladder. The solution is for injection therapy into the urinary tract organ cavity. The solution uses enhancement of sugar uptake into cancer cells of the urinary tract organ (for example, RT112, 253J, J82) by D-allose. The solution contains D-allose together with a pharmaceutically acceptable diluent or carrier. The solution is a pharmaceutical composition for prevention or treatment of urinary tract organ cancer.Type: ApplicationFiled: January 16, 2020Publication date: June 16, 2022Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Rikiya Taoka, Yoshiyuki Kakehi, Mikio Sugimoto, Xia Zhang, Yuki Matsuoka, Ken Izumori, Akihide Yoshihara
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Publication number: 20220175931Abstract: Provided is an improved glucose-containing peritoneal dialysate, an ophthalmic composition, or an infusion that can suppress a blood glucose level increase even when used in a long-term treatment and can also suppress an infectious disease, by only addition. A D-glucose-containing osmotic pressure regulator includes D-allose and/or D-allulose as an additive for suppressing a blood glucose level increase by continuous absorption of glucose into the body and for suppressing an infectious disease. The osmotic pressure regulator is used as a mixture with a peritoneal dialysate, an ophthalmic composition, or an infusion. A peritoneal dialysis method for suppressing a blood glucose level increase by continuous absorption of glucose into the body through peritoneal dialysis and for suppressing an infectious disease uses a dialysate containing D-allose and/or D-allulose in an effective amount.Type: ApplicationFiled: March 10, 2020Publication date: June 9, 2022Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Tetsuo Minamino, Taro Ozaki, Akihide Yoshihara, Ken Izumori
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Publication number: 20220152068Abstract: To provide a composition for the treatment of renal cell carcinoma and a composition or a method for enhancing the uptake of a drug into renal cell carcinoma cells. Provided are a D-allose-containing composition for the treatment of renal cell carcinoma, and a D-allose-containing composition or method for enhancing the uptake of a drug into renal cell carcinoma cells. The composition is a pharmaceutical composition to be administered in an effective amount to patients requiring the treatment of renal cell carcinoma in humans or animals other than humans.Type: ApplicationFiled: January 23, 2020Publication date: May 19, 2022Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Rikiya Taoka, Yoshiyuki Kakehi, Mikio Sugimoto, Xia Zhang, Yuki Matsuoka, Ken Izumori, Akihide Yoshihara
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Patent number: 11324763Abstract: Problem: A malaria transmission blocker or a malaria parasite growth inhibitor is provided as a result of finding a druq which inhibits malaria parasite growth in the body of a vector mosquito. Solution: A malaria parasite growth inhibitor or transmission blocker containing a rare sugar such as D-allose or D-psicose as an active ingredient.Type: GrantFiled: March 20, 2015Date of Patent: May 10, 2022Assignees: National University Corporation Kagawa University, MATSUTANI CHEMICAL INDUSTRY CO., LTD.Inventors: Masaaki Tokuda, Meiji Arai, Kazuhiro Okuma
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Patent number: 11278564Abstract: A readily-available brain function-improving agent or food composition having an A? intracerebral deposition suppressing effect or a learning function-improving effect is provided based on finding, as a result of orally administering Pantoea LPS to Alzheimer's disease model mice and studying the effects, that oral administration of Pantoea LPS significantly decreased intracerebral A? peptide accumulation and improved learning function.Type: GrantFiled: December 4, 2017Date of Patent: March 22, 2022Assignees: Control of Innate Immunity Technology Research Association, National University Corporation Kagawa University, BioMedical Research Group Inc., Macrophi Inc.Inventors: Gen-Ichiro Soma, Hiroyuki Inagawa, Chie Kohchi, Yutaro Kobayashi
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Patent number: 11279922Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.Type: GrantFiled: February 22, 2019Date of Patent: March 22, 2022Assignees: The Board of Trustees of the University of Arkansas, The Kitasato Institute, Montefiore Medical Center, National University Corporation Kagawa UniversityInventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
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Patent number: 11231272Abstract: Optical measuring apparatus includes: a light source irradiating an object to be measured; a splitter splitting transmitted light or reflected light from the object to be measured; a phase changer changing a phase of a first light which is one of the lights split; a phase fixer maintaining a phase of a second light which is the other light split; a multiplexer multiplexing lights output from the phase changer and the phase fixer; a detector detecting the light (interference image) output from the multiplexer; and a controller that extracts a reference point from the interference image, when a displacement of the reference point is detected, corrects a luminance value for each pixel of the interference images in accordance with a displacement of the object to be measured indicated by a displacement of the reference point, constructs an interferogram based on the luminance value for each pixel of the interference images after the correction.Type: GrantFiled: October 30, 2018Date of Patent: January 25, 2022Assignees: NEC CORPORATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Takeshi Akagawa, Masahiro Kubo, Katsumi Abe, Ersin Altintas, Yuji Ohno, Tetsuri Ariyama, Ichiro Ishimaru
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Publication number: 20210395718Abstract: To provide a ketose 3-epimerase that can be used in the food industry and is highly safe, highly active, and heat resistant, a microorganism that produces this enzyme, and a method of producing a ketose. The present invention provides a ketose 3-epimerase that can be obtained from a microorganism belonging to the genus Arthrobacter, has a molecular mass of about 36 kDa as measured by SDS-PAGE, and has the following substrate specificities (A) and (B): (A) having an activity of epimerizing position 3 of a D- or L-ketose and preparing a D- or L-ketose corresponding thereto, and (B) having the highest epimerization activity on position 3 of D-allulose, among D- or L-ketohexoses.Type: ApplicationFiled: November 21, 2019Publication date: December 23, 2021Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Kazuya Akimitsu, Ken Izumori, Akihide Yoshihara, Shiro Kato, Susumu Mochizuki, Hiromi Yoshida, Shigehiro Kamitori
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Publication number: 20210389192Abstract: A tactile sensor includes a base portion, a displacement portion, a displacement portion support body that supports the displacement portion in a displaceable manner in a first direction with respect to the base portion, a hair in a straight line arranged along a second direction, a hair fixing portion to which a base end of the hair is fixed, a hair fixing portion support body that turnably supports the hair fixing portion with respect to the displacement portion, a displacement detector that detects a displacement of the displacement portion with respect to the base portion, and a turn detector that detects a turn of the hair fixing portion with respect to the displacement portion. The sensations specific to the hairy skin, such as perception of a liquid surface and static electricity, can be detected from a shearing force and a moment acting on the hair.Type: ApplicationFiled: October 21, 2019Publication date: December 16, 2021Applicant: National University Corporation Kagawa UniversityInventor: Hidekuni TAKAO