Abstract: An aptamer having a G-quartet structure and being at least one selected from the group consisting of the following polynucleotides, the aptamer having a binding ability to an amyloid protein oligomer: (1) a polynucleotide comprising a base sequence represented by any one of SEQ ID NO:1 to SEQ ID NO:18; (2) a polynucleotide comprising a base sequence that includes at least four sets of at least two consecutive guanosine nucleotides and in which one or several bases has been deleted, substituted, or added in a base sequence represented by any one of SEQ ID NO:18; and (3) a polynucleotide that is a multimer including the polynucleotide of (1) or (2) as a structural unit.
Type:
Application
Filed:
February 20, 2012
Publication date:
March 13, 2014
Applicant:
NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
Inventors:
Kazunori Ikebukuro, Kaori Tsukakoshi, Koji Sode
Abstract: It is intended to exert a higher control effect on plant-pathogenic fungi. The mycovirus of the present invention has 5 types of double-stranded RNAs, wherein 4 types of double-stranded RNAs out of the 5 types of double-stranded RNAs have 81%, 75%, 72%, and 73% or higher homologies to the nucleotide sequences represented by SEQ ID NOs: 1 to 4, respectively. As an example, a novel mycovirus MoCV3 is used.
Type:
Application
Filed:
February 24, 2012
Publication date:
February 6, 2014
Applicant:
NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
Abstract: A process is provided for producing an electrolytic capacitor element that can uniformly form a highly electrically conductive polymer having a nano thickness level on a nano porous anode element substrate and suitable for use in high-capacitance electrolytic capacitors used in emergency power supplies and backup power supplies in electronic equipment. An oxide film and an electrically conductive polymer film are formed by pulsed constant current electrolysis of a monomer for an electrically conductive polymer and a nanoporous valve action metal in an electrolysis solution comprising an ionic liquid.
Type:
Grant
Filed:
June 2, 2006
Date of Patent:
February 4, 2014
Assignee:
National University Corporation, Tokyo University of Agriculture and Technology
Abstract: The bacterium that can perform complete dechlorination of trichloroethene, and the bacteria consortium containing the bacterium are provided, and the method to dechlorinate soils or ground water contaminated with trichloroethene using the bacterium is also provide.
Type:
Grant
Filed:
September 23, 2011
Date of Patent:
January 21, 2014
Assignees:
PaGE Science Co., Ltd., National University Corporation Tokyo University of Agriculture and Technology
Abstract: The present invention provides an aptamer that binds to prostate-specific antigen (PSA), the aptamer including: a preceding region having a random polynucleotide sequence consisting of from 1 to 10 nucleotides; a first region, at a 3? end of the preceding region, consisting of nnnnCT wherein each n is independently selected from A, T, G and C; a second region consisting of nnCTTT wherein each n is independently selected from A, T, G and C, and at least one part of the second region is complementary to the first region; and a third region positioned between the first region and the second region and consisting of a random polynucleotide sequence having from 3 to 30 nucleotides.
Type:
Application
Filed:
July 2, 2010
Publication date:
January 9, 2014
Applicant:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: A switching resistance RAM that is highly integrated as well as reduced in a read-out time is realized. There is formed an NPN type bipolar transistor BT composed of a collector layer made of an N-well 11, a base layer made of a P+ type Si layer 12A formed in a surface of the N-well 11, and an emitter layer made of an N+ type Si layer 15 formed in a surface of the P+ type Si layer 12A. Also, there are formed a word line WL0 electrically connected to the N+ type Si layer 15 and bit lines BL1-BL4 intersecting with the word line WL0. Also, there are formed a plurality of switching layers 14 formed on a surface of the P+ type Si layer 12A, each being electrically connected to corresponding each of the bit lines and switching between an ON state and an OFF state and an electric potential fixing line 19A to fix the P+ type Si layer 12A at a predetermined electric potential.
Type:
Grant
Filed:
September 8, 2008
Date of Patent:
July 2, 2013
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: According to the invention, there is provided a method for producing a gallium trichloride gas, the method including: a first step of reacting a metallic gallium and a chlorine gas to produce a gallium monochloride gas; and a second step of reacting the produced gallium monochloride gas and a chlorine gas to produce a gallium trichloride gas.
Type:
Application
Filed:
May 11, 2011
Publication date:
May 23, 2013
Applicant:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and protein in a sample (S) is detected in an optical manner. Specifically, the sample (S) is irradiated with excitation rays (Le) and with measuring rays (L2) for measuring a photothermal effect produced in the sample (S) through the irradiation with the excitation rays (Le). A measurement signal for the photothermal effect in the sample (S) by the excitation rays (Le) is produced on the basis of any phase change of the measuring rays (L2). A temporal variation in the measurement signal is used for making a judgment on the presence or absence of any occurrence of interaction between nucleic acid and protein.
Type:
Grant
Filed:
June 14, 2007
Date of Patent:
February 5, 2013
Assignees:
National University Corporation Tokyo University of Agriculture and Technology, Kobe Steel, Ltd.
Abstract: The instant invention is directed to a microfluidic device which separates and captures with high efficiency a large amount of cells in a sample at one-cell level without damaging the cells by utilizing a microfabrication technology.
Type:
Grant
Filed:
July 31, 2008
Date of Patent:
January 22, 2013
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: A spinning solution composition which provides regenerated silk fiber that exhibits a strength and elongation close to those of natural silk fiber, is rapidly degradable in vivo, and can be caused to have ability to gradually release a drug to prevent inflammation; a process for producing such regenerated silk fiber by use of the composition; and regenerated silk fiber obtained through the process.
Type:
Grant
Filed:
March 1, 2007
Date of Patent:
January 8, 2013
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: Disclosed is a photoinduced carrier lifetime measuring method capable of obtaining photoinduced carrier effective lifetime of a semiconductor substrate with high accuracy regardless of the surface state of the sample. The method includes the steps of: irradiating a microwave onto a semiconductor substrate while periodically pulse-irradiating an induction light onto the semiconductor substrate; detecting the microwave transmitted through the semiconductor substrate or reflected by the semiconductor substrate; and obtaining the effective lifetime of photoinduced carriers generated in the semiconductor substrate by the pulse irradiation of the induction light, based on an irradiation duration Ti and a non-irradiation duration T2 when performing the induction light pulse irradiation and an integrated value of each microwave intensity obtained by the detection.
Type:
Application
Filed:
September 6, 2010
Publication date:
December 6, 2012
Applicant:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: A manufacturing method of a thin film semiconductor substrate includes implanting ions at a specified depth into a semiconductor substrate, forming a bubble layer in the semiconductor substrate by vaporizing the ions through heating, bonding an insulating substrate onto the semiconductor substrate, and cleaving the semiconductor substrate along the bubble layer to form a semiconductor thin film on a side of the insulating substrate. At the forming, the semiconductor substrate is heated at a temperature in a temperature range of approximately 1000° C. to 1200° C. for a duration in a range of approximately 10 ?s to 100 ms. The heating of the semiconductor substrate is performed by using, for example, a light beam.
Type:
Grant
Filed:
September 2, 2011
Date of Patent:
September 4, 2012
Assignees:
National University Corporation Tokyo University of Agriculture and Technology, Nissin Ion Equipment Co., Ltd.
Abstract: The present invention provides an organic material that is characterized by including a rigid matrix and a dye having a phosphorescence lifetime of 0.1 seconds or more in a rigid medium at 77 K and that exhibits such a strong and long-lived phosphorescence as to be recognizable with the naked eyes even at ordinary temperature: namely, an ordinary-temperature-phosphorescent organic material.
Type:
Grant
Filed:
November 28, 2008
Date of Patent:
August 14, 2012
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: An optically active compound represented by the following formula (5): wherein, in the formula (5), R1 and R2 may be the same or different are an alkyl group optionally having a substituent group selected from the group consisting of an alkoxy group and a halogen atom, a cycloalkyl group optionally having a substituent group selected from the group consisting of an alkoxy group and a halogen atom, an aryl group optionally having a substituent group selected from the group consisting of an alkyl group, an alkoxy group and a halogen atom, an alkoxy group optionally having a substituent group selected from the group consisting of a halogen atom and an aryl group or an aryloxy group optionally having a substituent group selected from the group consisting of an alkyl group, an alkoxy group and a halogen atom; a1 and a2 independently are 0 or 1; and * is axial asymmetry.
Type:
Grant
Filed:
March 7, 2011
Date of Patent:
July 17, 2012
Assignees:
National University Corporation Tokyo University of Agriculture and Technology, Takasago International Corporation
Inventors:
Ken Tanaka, Tohru Yokozawa, Tomohiko Hakamata
Abstract: There is provided a process for industrial production of simple 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone from low molecular mixtures derived from plant components such as vanillin, vanillic acid and protocatechuic acid, via a multistage enzyme reaction. A recombinant plasmid containing a vanillate demethylase gene (vanAB genes), benzaldehyde dehydrogenase gene (ligV gene) and protocatechuate 3,4-dioxygenase gene (pcaHG genes); transformants incorporating the plasmid; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of vanillin, vanillic acid, protocatechuic acid or a mixture of two or more thereof.
Type:
Grant
Filed:
August 10, 2007
Date of Patent:
July 3, 2012
Assignees:
Kabushiki Kaisha Toyota Jidoshokki, National University Corporation, Tokyo University of Agriculture and Technology, Nagoya University of Technology, Forestry and Forest Products Research Institute
Abstract: An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a ? bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.
Type:
Application
Filed:
January 21, 2010
Publication date:
May 31, 2012
Applicant:
NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
Abstract: The present invention provides a novel mycovirus that suppresses phytopathogenic fungi and a novel method for controlling plant diseases. A novel mycovirus that is present endogenously in a predetermined rice blast fungus, has four types of double-stranded RNAs of 2.8 to 3.6 kb, and suppresses a phytopathogenic fungus has been found. This virus suppresses phytopathogenic fungi such as rice blast fungus.
Type:
Grant
Filed:
January 5, 2009
Date of Patent:
May 29, 2012
Assignee:
National University Corporation Tokyo University of Agriculture and Technology
Abstract: A manufacturing method of a thin film semiconductor substrate includes implanting ions at a specified depth into a semiconductor substrate, forming a bubble layer in the semiconductor substrate by vaporizing the ions through heating, bonding an insulating substrate onto the semiconductor substrate, and cleaving the semiconductor substrate along the bubble layer to form a semiconductor thin film on a side of the insulating substrate. At the forming, the semiconductor substrate is heated at a temperature in a temperature range of approximately 1000° C. to 1200° C. for a duration in a range of approximately 10 ?s to 100 ms. The heating of the semiconductor substrate is performed by using, for example, a light beam.
Type:
Application
Filed:
September 2, 2011
Publication date:
March 29, 2012
Applicants:
NISSIN ION EQUIPMENT CO., LTD., National University Corporation Tokyo University of Agriculture and Technology