Patents Assigned to National University Corporation Tottori University
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Publication number: 20190358480Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid, N-methyl-2-pyrrolidone and a fluoride; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.Type: ApplicationFiled: July 6, 2018Publication date: November 28, 2019Applicants: KOKIGUMI CO., LTD, KOKIGUMI CO., LTD, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Toshimitsu MYOGA, Koichi TAKAHASHI, Kazuhiro IIZUKA, Yuhei MATSUBARA, Toshiyuki TANAKA, Hisaki OKAMOTO
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Publication number: 20190343884Abstract: The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for producing fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity and a method for producing Tyr-Pro, each of which is characterized by comprising fermenting milk with a mushroom.Type: ApplicationFiled: June 22, 2017Publication date: November 14, 2019Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITYInventors: Kenji OKAMOTO, Toru NABIKA
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Publication number: 20190336552Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.Type: ApplicationFiled: April 8, 2019Publication date: November 7, 2019Applicants: Astellas Pharma Inc., National University Corporation Tottori UniversityInventors: Takafumi Nakamura, Hajime KUROSAKI, Motomu NAKATAKE
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Patent number: 10458881Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.Type: GrantFiled: January 25, 2017Date of Patent: October 29, 2019Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITYInventors: Masahiro Hyodo, Hidehiko Ogata, Naoki Kawamura, Tsuguhiro Nonaka, Masayuki Ishii
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Patent number: 10413546Abstract: A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.Type: GrantFiled: February 23, 2016Date of Patent: September 17, 2019Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NIPPON MEDICAL SCHOOL FOUNDATION, NIPPON CHEMIPHAR CO., LTD.Inventors: Takeshi Nishino, Shinsuke Kato, Masako Kato, Hidenori Suzuki, Ken Okamoto
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Publication number: 20190254264Abstract: This application provides: a non-human animal that comprises a mouse artificial chromosome comprising a human antibody heavy chain gene or gene locus, a human antibody light chain ? gene or gene locus, and/or a human antibody light chain ? gene or gene locus, and in which endogenous antibody genes or gene loci corresponding to at least 2 human antibody genes or gene loci have been knocked out, wherein the animal can be stably retained through generations and can produce human antibodies; a method for producing the non-human animal; and a method for producing human antibodies using the non-human animal.Type: ApplicationFiled: October 31, 2017Publication date: August 22, 2019Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, TRANS CHROMOSOMICS, INC.Inventors: Yasuhiro KAZUKI, Satoshi ABE, Mitsuo OSHIMURA
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Patent number: 10369159Abstract: [Problem] To provide a therapeutic agent for estrogen-dependent gynecological diseases such as endometriosis, uterine fibroids, and uterus adenomyosis. [Solution] To use an estrogen receptor ?-inhibiting ? partial agonist represented by the formula (a), a pharmaceutically-acceptable salt thereof, or a hydrate of either of the afore-mentioned, as an active ingredient.Type: GrantFiled: September 21, 2018Date of Patent: August 6, 2019Assignees: Nobelpharma Co., Ltd., National University Corporation Tottori UniversityInventors: Kenichiro Nakao, Tasuku Harada, Fuminori Taniguchi
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Patent number: 10370647Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.Type: GrantFiled: July 22, 2016Date of Patent: August 6, 2019Assignee: National University Corporation Tottori UniversityInventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
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Publication number: 20190210805Abstract: A method includes acquiring starting position information of moving bodies; acquiring destination position information of movement destinations; acquiring path information indicating paths on which the moving bodies can move; calculating, for each moving body, a minimum movement amount required for the moving body to move on a path from the starting position to each movement destination, based on the starting position information, the destination position information, and the path information; allocating a movement destination not allocated to any moving body to a moving body that has a minimum movement amount being the smallest of the minimum movement amounts and that has no allocation of any movement destination; further allocating, when there is a movement destination not allocated to the moving body on a movement route, the not-allocated movement destination to the allocated moving body; and determining movement routes of the moving bodies based on the allocation.Type: ApplicationFiled: September 5, 2017Publication date: July 11, 2019Applicants: Ricoh Company, Ltd., NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Toshihiro OKAMOTO, Koichi KUDO, Ichiro MAEDA, Takayoshi YOKOTA, Tsubasa TAMURA
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Patent number: 10016639Abstract: Provided is a dropping-type fire extinguishing body that, in fire extinguishing using a gel-like fire extinguishing agent, can allow the fire extinguishing agent to be smoothly conveyed and dropped. A dropping-type fire extinguishing body 1 to be dropped onto the fire site to extinguish the fire, wherein a gelling agent 3 is contained in a bag body 2 formed of a water-permeable material and water is permeated into the body and is mixed with the gelling agent to prepare a gel-like fire extinguishing agent, thereby filling the gel-like fire extinguishing agent into the inside of the bag body.Type: GrantFiled: February 25, 2015Date of Patent: July 10, 2018Assignees: ILUKA COLLEGE CO., LTD., NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Noriko Asayama, Yuhei Matsubara
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Publication number: 20180117047Abstract: A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.Type: ApplicationFiled: February 23, 2016Publication date: May 3, 2018Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NIPPON MEDICAL SCHOOL FOUNDATION, NIPPON CHEMIPHAR CO., LTD.Inventors: Takeshi NISHINO, Shinsuke KATO, Masako KATO, Hidenori SUZUKI, Ken OKAMOTO
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Publication number: 20180075978Abstract: Provided is a photoelectric conversion device having high durability against light irradiation including a cathode, an anode, an active layer that is provided between the cathode and the anode and contains a perovskite compound, and an electron transport layer that is provided between the cathode and the active layer and contains a fullerene derivative represented by Formula (1) below: wherein, in Formula (1), Ring A represents a fullerene skeleton; R1, R2, R3, and R4 represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an arylalkyl group, a monovalent heterocyclic group, or a group represented by Formula (2) below; and n represents an integer of 1 or more; wherein, in Formula (2), m represents an integer of 1 to 6; q represents an integer of 1 to 4; X represents a hydrogen atom, an alkyl group, or an aryl group; when m is plurally present, a plurality of ms may be the same or different.Type: ApplicationFiled: March 24, 2016Publication date: March 15, 2018Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Yasunori UETANI, Toshiyuki ITOH
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Patent number: 9872833Abstract: An object of the present invention is to provide a drug delivery system capable of sustainedly releasing a drug noninvasively at any given point in time. The present invention relates to a liposome complex comprising a liposome membrane-constituting substance bonded to a light-absorbing compound having an absorption wavelength in the near-infrared region, selected from the group consisting of indocyanine green dyes, phthalocyanine dyes, squarylium dyes, croconium dyes, and diimmonium dyes.Type: GrantFiled: October 3, 2012Date of Patent: January 23, 2018Assignees: National University Corporation Tottori University, National University Corporation Chiba UniversityInventors: Yoshiharu Okamoto, Yutaka Tamura, Akiko Suganami, Hideki Hayashi, Tomoyuki Madono, Hisahiro Matsubara, Taro Toyota
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Publication number: 20170340687Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.Type: ApplicationFiled: July 31, 2017Publication date: November 30, 2017Applicants: Astellas Pharma Inc., National University Corporation Tottori UniversityInventors: Shinsuke Nakao, Tatsuya Kawase, Takafumi Nakamura
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Patent number: 9809803Abstract: This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.Type: GrantFiled: November 20, 2014Date of Patent: November 7, 2017Assignees: National University Corporation Tottori University, The Chemo-Sero-Therapeutic Research InstituteInventor: Takafumi Nakamura
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Patent number: 9790491Abstract: A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including a single-stranded or double-stranded polynucleotide containing the base sequence shown in SEQ ID NO:41 or a base sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 41, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided.Type: GrantFiled: June 28, 2011Date of Patent: October 17, 2017Assignee: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventor: Norimasa Miura
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Patent number: 9775331Abstract: Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm distal region at a mouse chromosome long-arm site proximal to the centromere; and a telomere sequence, wherein the vector is stably retained in a cell and/or tissue of a mammal. In addition, disclosed are cells or non-human animals comprising the vector, and use of the cells or non-human animals.Type: GrantFiled: December 18, 2014Date of Patent: October 3, 2017Assignees: National University Corporation Tottori University, Trans Chromosomics, Inc.Inventors: Mitsuo Oshimura, Yasuhiro Kazuki, Masato Takiguchi, Takashi Matsuoka
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Publication number: 20170131175Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.Type: ApplicationFiled: January 25, 2017Publication date: May 11, 2017Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITYInventors: Masahiro Hyodo, Hidehiko Ogata, Naoki Kawamura, Tsuguhiro Nonaka, Masayuki Ishii
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Patent number: 9539280Abstract: Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.Type: GrantFiled: July 10, 2014Date of Patent: January 10, 2017Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, MARINE PRODUCTS KIMURAYA CO., LTD.Inventors: Saburo Minami, Yoshiharu Okamoto, Yasunari Miki
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Patent number: D838839Type: GrantFiled: August 18, 2017Date of Patent: January 22, 2019Assignee: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventors: Kazunori Fujiwara, Katsuyuki Kawamoto, Hiroya Kitano, Masaru Ueki, Kazutake Uehara