Patents Assigned to National University Corporation
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Patent number: 11939592Abstract: An object of the present invention is to provide a recombinant phage having high safety and excellent practicality and usefulness. Provided are a recombinant bacteriophage which is deprived of its proliferative capacity and can infect only once due to the fact that a bacteriophage genome in which a part of a virion constituent gene is deleted is stored in a head, and a method for preparing the same. In addition, provided are a recombinant bacteriophage which is deprived of its proliferative capacity and can infect only once due to the fact that a plasmid having a packaging site and encoding a target gene is stored in a head, and a method for preparing the same.Type: GrantFiled: December 5, 2019Date of Patent: March 26, 2024Assignee: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventors: Shoichi Mitsunaka, Hiroki Ando
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Patent number: 11939267Abstract: A method and apparatus for producing AlN whiskers includes reduced incorporation of metal particles, an AlN whisker body, AlN whiskers, a resin molded body, and a method for producing the resin molded body. The method for producing AlN whiskers includes heating an Al-containing material in a material accommodation unit to thereby generate Al gas; and introducing the Al gas into a reaction chamber through a communication portion while introducing nitrogen gas into the reaction chamber through a gas inlet port, to thereby grow AlN whiskers on the surface of an Al2O3 substrate placed in the reaction chamber.Type: GrantFiled: May 2, 2022Date of Patent: March 26, 2024Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Toru Ujihara, Yukihisa Takeuchi, Daishi Shiojiri, Masaki Matsumoto, Hiroshi Saito, Ikuo Hayashi
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Patent number: 11938254Abstract: The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.Type: GrantFiled: March 26, 2019Date of Patent: March 26, 2024Assignee: NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITYInventor: Teiji Oda
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Publication number: 20240093240Abstract: The invention provides a site-specific modification method of a DNA molecule that enables gene function manipulation. In particular, the invention provides a method for manipulating gene function by a site-specific action on a target DNA molecule, said method comprising a step for preparing a complex containing an Argonaute protein, a guide RNA and an additional sequence and a step for contacting the target DNA molecule with the complex, wherein the guide RNA is designed to guide the complex to a region containing the desired site in the target DNA molecule.Type: ApplicationFiled: December 28, 2021Publication date: March 21, 2024Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITYInventors: Keiji NISHIDA, Hitoshi MITSUNOBU
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Publication number: 20240092421Abstract: A steering device and a method for controlling the steering device according to the present invention are capable of suppressing, in a steer-by-wire steering device including a steering operation input member and a turning actuator that applies a turning force to a road wheel based on a driving signal, a change in which a yaw rate gain of a vehicle rises with respect to the operation speed of the steering operation input member by changing a turning angle command value to an angle less than the angle before the change when a turning frequency of the road wheel is a predetermined frequency. As a result, it becomes possible to suppress a case in which the yaw rate gain of the vehicle becomes too sensitive with respect to a steering operation by a driver.Type: ApplicationFiled: December 28, 2021Publication date: March 21, 2024Applicants: HITACHI ASTEMO, LTD., National University Corporation Tokyo University of Agriculture and TechnologyInventors: Hiroki SONODA, Yoshiji HASEGAWA, Tomoaki FUJlBAYASHI, Hiroshi MOURI
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Publication number: 20240091342Abstract: Provided is an orally administrable vaccine against a coronavirus infectious disease. A transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium enables the provision of the orally administrable vaccine against a coronavirus infectious disease. The transformed Bifidobacterium designed to display a part or a whole of a constituent protein of a coronavirus on a surface of the Bifidobacterium can induce humoral immunity and cellular immunity through oral administration to suppress an increase in severity of pneumonia or the like even after viral infection.Type: ApplicationFiled: January 25, 2022Publication date: March 21, 2024Applicants: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, Kyoto UniversityInventors: Toshiro SHIRAKAWA, Shunpei UENO, Koichi KITAGAWA, Akihiko KONDO, Masanori KAMEOKA, Takane KATAYAMA
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Patent number: 11937495Abstract: An organic light-emitting device containing both a compound represented by the following general formula (1) and a compound represented by the following general formula (2) has a high light emission efficiency. The rings a to c each are a benzene ring that can be optionally condensed, R1 and R2 each represent a substituted or unsubstituted aryl group, etc., four of R31 to R35 each are a substituted or unsubstituted carbazol-9-yl group, but all of these four are not the same, and the remaining one is a hydrogen atom, a cyano group, etc.Type: GrantFiled: August 7, 2019Date of Patent: March 19, 2024Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KWANSEI GAKUIN EDUCATIONAL FOUNDATION, KYULUX, INC.Inventors: Hajime Nakanotani, Takuji Hatakeyama, Yasuhiro Kondo, Yasuyuki Sasada, Motoki Yanai, Chin-Yiu Chan, Masaki Tanaka, Hiroki Noda, Chihaya Adachi, Yoshitake Suzuki, Naoto Notsuka
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Patent number: 11932595Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.Type: GrantFiled: September 17, 2021Date of Patent: March 19, 2024Assignee: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY, TEIKYO UNIVERSITY and THE UNIVERSITY OF TOKYOInventors: Motonari Uesugi, Yasushi Takemoto, Kazuo Nagasawa, Atsushi Kittaka, Fumihiro Kawagoe, Hayato Nakagawa
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Patent number: 11932729Abstract: A polybenzimidazole production method for producing the polybenzimidazole including a repeating unit represented by the following formula (1): wherein Rf is —SO2—, —O—, —CO—, an alkylene group optionally containing a substituent, or a group represented by the following formula (a): two Xs are each individually a hydrogen atom or a monovalent organic group; and R1 is a divalent organic group, the production method including a step (1-1) of polymerizing a tetramine compound and a dicarboxylic acid derivative compound to provide a polybenzimidazole precursor polyamide, and a step (1-2) of dehydrocyclizing the polybenzimidazole precursor polyamide.Type: GrantFiled: December 8, 2022Date of Patent: March 19, 2024Assignees: DAIKIN INDUSTRIES, LTD., NATIONAL UNIVERSITY CORPORATION, IWATE UNIVERSITYInventors: Yoshiyuki Oishi, Tsuyoshi Noguchi, Tadashi Kanbara
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Patent number: 11933725Abstract: A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.Type: GrantFiled: November 9, 2020Date of Patent: March 19, 2024Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Okayama UniversityInventors: Akihiro Honda, Hideki Fukano
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Publication number: 20240085366Abstract: A vascular sap measurement sensor includes an indicator electrode probe, a reference electrode probe, and a supporting portion. The indicator electrode probe is an ion-sensitive field effect transistor. The reference electrode probe includes a solid reference electrode, the solid reference electrode including a base layer, a silver chloride layer, and a chloride layer, the base layer being formed of an electrically conductive body, the silver chloride layer being formed on a surface of the base layer, the chloride layer being formed on a surface of the silver chloride layer. The supporting portion supports the indicator electrode probe and the reference electrode probe arranged in parallel.Type: ApplicationFiled: October 8, 2020Publication date: March 14, 2024Applicant: National University Corporation Kagawa UniversityInventors: Fusao SHIMOKAWA, Kazuma ISHIDA
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Publication number: 20240081980Abstract: A vocalization assistance device includes: a mounting body that is mounted in an oral cavity of a person and that has a facing portion facing a palate of the person; a diaphragm that is provided at the facing portion and that is capable of outputting a sound recorded by a device having a recording function, as an original sound; and a passage that is provided at the facing portion and that is configured to transmit the original sound output from the diaphragm to a rear side of the oral cavity.Type: ApplicationFiled: January 25, 2022Publication date: March 14, 2024Applicant: National University Corporation Tokyo Medical and Dental UniversityInventors: Haruka TOHARA, Taishi YAMADA, Kazuharu NAKAGAWA, Kohei YAMAGUCHI, Daiki MIZUGUCHI
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Publication number: 20240082300Abstract: Provided is a chimeric target factor receptor capable of activating an antigen-presenting cell such as a dendritic cell in a target-factor-specific manner. The chimeric target factor receptor contains a target factor-binding domain, a transmembrane domain, and an intracellular domain containing a TLR intracellular domain.Type: ApplicationFiled: November 30, 2021Publication date: March 14, 2024Applicant: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventors: Hideki KASUYA, Yoshinori NAOE, Shigeru MATSUMURA, Ibrahim Ragab Nassr EISSA, Mohamed Abdelmoneim Ahmed ALI MOHAMED
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Patent number: 11926246Abstract: In a local cart traveling system, a frame track includes first and second metal rails each with an L-shaped cross section and facing each other. A local cart is within the frame track, and includes a first electricity receiving tire and a second electricity receiving tire to travel on horizontal travel surfaces of the rails. A voltage supplier supplies an AC voltage to the travel surfaces, so that the first metal rail and a first electricity receiving tire define a first capacitor and the second metal rail and the second electricity receiving tire define a second capacitor. The local cart includes a power receiver to receive AC power, and a travel motor that receives power after the AC power is rectified. The frame track includes a connecting plate as an electrical insulator covering portions of the surfaces of vertical walls of the first metal rail and the second metal rail.Type: GrantFiled: June 1, 2018Date of Patent: March 12, 2024Assignees: MURATA MACHINERY, LTD., NATIONAL UNIVERSITY CORPORATION TOYOHASHI UNIVERSITY OF TECHNOLOGYInventors: Minoru Mizutani, Kazuhiro Ishikawa, Masafumi Hayakawa, Takashi Ohira, Naoki Sakai, Hiroki Kuniyoshi, Makoto Teramoto
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Patent number: 11925972Abstract: A precision forging method includes arranging a metal material in a die cavity so that a distal end surface of a wall portion of the metal material is opposed toward a stopper and a bottom portion of the metal material is opposed toward a punch. Further, the precision forging method includes moving the punch, which includes a cutting blade on an edge of a working end surface, in the die cavity to cut part of the wall portion thickness-wise with the cutting blade and cause shear deformation in the cut portion.Type: GrantFiled: April 22, 2020Date of Patent: March 12, 2024Assignee: National University Corporation Tokai National Higher Education and Research SystemInventor: Zhigang Wang
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Publication number: 20240076548Abstract: Provided is a method for enabling recovery of metal element leaching capacity of a deep eutectic solvent used for leaching a metal element from an ore containing the metal element. A method for recycling a hydrophobic deep eutectic solvent disclosed here includes: preparing a hydrophobic deep eutectic solvent used for leaching a metal element from an ore containing the metal element; and bringing the hydrophobic deep eutectic solvent and hydrochloric acid into contact with each other. In the hydrophobic deep eutectic solvent, a hydrogen bond donor is a carboxy group-containing compound, and a hydrogen bond acceptor is chloride salt. The amount of use of the hydrochloric acid is such that hydrogen chloride is 1 mole or more with respect to 1 mole of the hydrogen bond acceptor.Type: ApplicationFiled: August 22, 2023Publication date: March 7, 2024Applicants: Prime Planet Energy & Solutions, Inc., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, TOYOTA TSUSHO CORPORATION, TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Yuji YAMAMOTO, Masahiro GOTO, Takafumi HANADA, Takeru MORIYAMA, Momoko PROCTER
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Patent number: 11925046Abstract: Provided is a light-emitting device including an organic light-emitting element and a control unit that controls the organic light-emitting element. The organic light-emitting element includes a first electrode, a second electrode, and an organic light-emitting layer which is disposed between the first electrode and the second electrode and in which separation of charges occurs due to incidence of excited light. The control unit changes a potential difference between the first electrode and the second electrode so that recoupling of the charges occurs, in a second period after passage of a delay period from a first period in which the excited light is incident to the organic light-emitting layer.Type: GrantFiled: July 29, 2020Date of Patent: March 5, 2024Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, HAMAMATSU PHOTONICS K.K.Inventors: Chihaya Adachi, Hajime Nakanotani, Takahiko Yamanaka, Shigeo Hara, Toru Hirohata
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Patent number: 11921081Abstract: A smell sensor includes an ion sensor in which a sensing section provided with a sensitive film configured to change a potential in accordance with a state of a measurement target is formed on a semiconductor substrate; a substance adsorption film disposed on the sensitive film and configured to change the state with adsorption of a smell substance; and a reference electrode configured to apply a reference voltage to the substance adsorption film. The reference electrode is disposed to be separated from the sensitive film and not to overlap the sensing section when viewed in a thickness direction of the semiconductor substrate.Type: GrantFiled: May 27, 2019Date of Patent: March 5, 2024Assignees: HAMAMATSU PHOTONICS K.K., National University Corporation TOYOHASHI UNIVERSITY OF TECHNOLOGYInventors: Toshiki Wakamori, Shinichi Nakahigashi, Kazuaki Sawada
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Patent number: 11918589Abstract: A medicament for preventive and/or therapeutic treatment of multiple sclerosis, especially a pain accompanying multiple sclerosis such as neuropathic pain, which contains a compound having a P2X4 receptor antagonist activity such as a compound represented by the general formula (IH), or a salt thereof or a hydrate or solvate thereof as an active ingredient.Type: GrantFiled: April 27, 2017Date of Patent: March 5, 2024Assignees: NIPPON CHEMIPHAR CO., LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Toshiyasu Imai, Toru Kawasaki, Toru Ogawa, Kazuhide Inoue
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Patent number: 11921045Abstract: A holographic three-dimensional multi-spot light stimulation device is provided with: a three-dimensional imaging holographic optical system A which employs fluorescent exciting light to acquire three-dimensional fluorescence distribution information resulting from fluorescent signal light from a plurality of stimulation target objects; and a three-dimensional light stimulation holographic optical system B which employs a light stimulation hologram generated on the basis of the acquired three-dimensional fluorescence distribution information to form a plurality of light spots in space, to impart stimulation simultaneously to the plurality of stimulation target objects.Type: GrantFiled: July 9, 2019Date of Patent: March 5, 2024Assignee: National University Corporation Kobe UniversityInventors: Osamu Matoba, Xiangyu Quan, Hiroaki Wake