Patents Assigned to National University of Singapore
  • Publication number: 20200249156
    Abstract: A THz data acquisition and analysis system, use of the THz data analysis system, and a THz data acquisition and analysis method. THz data acquisition and analysis method comprises performing a THz spectroscopy measurement on a sample; acquiring sample data based on the THz spectroscopy measurement; and performing a comparison between the sample data and reference data for identifying the sample.
    Type: Application
    Filed: August 21, 2018
    Publication date: August 6, 2020
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Yang WU, Hyunsoo YANG
  • Publication number: 20200241290
    Abstract: Light deflection prism for altering a field of view of a camera of a device comprising a surface with a camera aperture region defining an actual light entrance angular cone projecting from the surface. A method comprises disposing a first surface of a light deflection prism on the surface so as to overlap the angular cone; internally reflecting a central ray, entering the prism under a normal incidence angle through a second surface, at a third surface of the prism towards the first surface under a normal angle of incidence such that the central ray enters the prism at an angle of less than 90° relative to a normal of the device surface and such that a ray at one boundary of an effective light entrance angular cone defined as a result of the light reflection at the third surface is substantially parallel to the device surface.
    Type: Application
    Filed: August 1, 2018
    Publication date: July 30, 2020
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventor: Mark Brian Howell BREESE
  • Publication number: 20200239968
    Abstract: The present invention provides a method for predicting the treatment response of a human gastroesophageal cancer patient, the method comprising: a) measuring the gene expression of at least 3 of the following genes: CDH1, CDK6, COX2, ELOVL5, GATA4, EGFR, TBCEL, FGF7, CDH17, FNBP1, PIP5K1B, TWIST, CD44, MET, CEACAM1, TOX3, GLIPR2, GSTP1, RON, TMEM136, MYB, BRCA2, FGF1, POU5F1, EPR, DPYD, ABL2 and SH3RF1 in a sample obtained from the gastroesophageal tumour of the patient to obtain a sample gene expression profile of at least said genes; and b) making a prediction of the treatment response and/or prognosis of the patient based on the sample gene expression profile. Also provided are related computer-implemented methods and methods of treatment of gastroesophageal cancer.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 30, 2020
    Applicants: The Institute of Cancer Research: Royal Cancer Hospital, The Royal Marsden NHS Foundation Trust, National University of Singapore
    Inventors: Elizabeth Smyth, Anguraj Sadanandam, Gift Nyamundanda, David Cunningham, Boon Ooi Patrick Tan
  • Patent number: 10722850
    Abstract: Disclosed is a hollow fiber that contains an outer layer made of a first polymer and an inner layer made of a second polymer, the inner layer including at its outer surface a macrovoid-free thin interface sublayer in contact with the inner surface of the outer layer. The first polymer is immiscible with the second polymer. Also disclosed is a process of preparing the above-described hollow fiber.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: July 28, 2020
    Assignee: National University of Singapore
    Inventors: Yee Kang Ong, Tai-Shung Chung
  • Patent number: 10723112
    Abstract: The present invention discloses a method for transferring a thin film from a first substrate to a second substrate comprising the steps of: providing a transfer structure and a thin film provided on a surface of a first substrate, the transfer structure comprising a support layer and a film contact layer, wherein the transfer structure contacts the thin film; removing the first substrate to obtain the transfer structure with the thin film in contact with the film contact layer; contacting the transfer structure obtained with a surface of a second substrate; and removing the film contact layer, thereby transferring the thin film onto the surface of the second substrate.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: July 28, 2020
    Assignee: National University of Singapore
    Inventors: Lay-Lay Chua, Peter Ho, Rui-Qi Png, Fong Yu Kam, Jie Song, Loke-Yuen Wong, Jing-Mei Zhuo, Kian Ping Loh, Geok Kieng Lim
  • Publication number: 20200232000
    Abstract: This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-phenylalanine, styrene or substituted styrene to a plurality of enzyme catalyzed chemical transformations in a one-pot reaction system, using recombinant microbial cells overexpressing the enzymes. To produce phenylacetaldehyde from styrene, the cells are modified to overexpress styrene monooxygenase (SMO) and styrene oxide isomerase (SOI). To produce phenylacetic acid from styrene, SMO, SOI and aldehyde dehydrogenase are overexpressed. Alternatively, to produce 2-phenylethanol, SMO, SOI and aldehyde reductase or alcohol dehydrogenase are overexpressed, while to produce phenylethylamine, SMO, SOI and transaminase are overexpressed.
    Type: Application
    Filed: May 23, 2018
    Publication date: July 23, 2020
    Applicant: National University of Singapore
    Inventors: Zhi Li, Shuke Wu, Yi Zhou, Benedict Ryan Lukito
  • Patent number: 10716555
    Abstract: An expander for widening and holding apart an opening of a tissue. The expander may include a body configured to deform from a compacted state into a pre-determined shape in an expanded state in response to a pre-determined physiological condition the body is exposed to. The body with the pre-determined shape in the expanded state may be configured to hold apart the opening of the tissue.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: July 21, 2020
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Michael Julien Alexandre Girard, Kian Yu Royston Tan, Shamira Asith Perera
  • Publication number: 20200222444
    Abstract: The disclosure provides a method of inhibiting proliferation of a cell, inhibiting m3C formation in a cell, inhibiting activity of Mettl8 in a cell, or activating ATM and p53 in a cell, the method comprising contacting the cell with a Mettl8 inhibitor. The disclosure also provides a composition comprising a cell with a reduced expression or activity of Mettl8. In another aspect, the disclosure provides methods of rendering a tumor cell sensitive to a cancer therapy.
    Type: Application
    Filed: July 6, 2018
    Publication date: July 16, 2020
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Xin-Yuan FU, Xinyu LIU, Lu Ang XU
  • Patent number: 10709560
    Abstract: A prosthetic mitral valve designed to resemble a patient's nat-ural mitral valve is provided. The prosthetic mitral valve includes an asym-metrical, flexible ring dimensioned to match a native mitral annulus of a pa-tient, two leaflets suspended from the flexible ring, and at least two sets of cords attached to the leaflets and merging into two bundles to be fabricated using pre-operative three-dimensional imaging technologies.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: July 14, 2020
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventor: Theodoros Kofidis
  • Patent number: 10706904
    Abstract: A method of providing a reference voltage for reading of a resistive memory array, and a read circuit for reading of a resistive memory array. The method comprises the steps of generating a first reference voltage when a bitline of the resistive memory array is in a first resistance state, and generating a second reference voltage when the bitline is in a second resistance state; wherein the first reference voltage is different from the first reference voltage and the first resistance state is different from the second resistance state.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: July 7, 2020
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, AGENCY FPR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Kien Trinh Quang, Massimo Alioto, Sergio Ruocco
  • Publication number: 20200211235
    Abstract: A method of modifying a retina fundus image for a deep learning model is disclosed. In a described embodiment, the method includes converting a retina fundus image to a binary image by converting pixels of the retina fundus image to low intensity modified pixels and high intensity modified pixels of the binary image, and determining a first boundary between the low intensity modified pixels and high intensity modified pixels of the binary image. The method further includes removing outlier boundary values from the first boundary, constructing a second boundary from remaining boundary values, identifying the pixels of the retina fundus image that are within the second boundary, and constructing a modified retina fundus image containing the identified pixels for a deep learning model.
    Type: Application
    Filed: July 24, 2018
    Publication date: July 2, 2020
    Applicants: National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Wynne Hsu, Mong Li Lee, Gilbert Lim, Tien Yin Wong, Shu Wei Daniel Ting
  • Publication number: 20200212508
    Abstract: A Li-ion thin film microbattery, a microbattery array, a method of fabricating a Li-ion thin film microbattery and a method of fabricating a microbattery array. The Li-ion thin film microbattery comprises a Li-free cathode comprising a transition metal oxide thin film; an anode comprising a lithiated Ge or Si thin film; and an electrolyte film disposed between the cathode and the anode; wherein a Li-source of the Li-ion thin film microbattery is provided by means of the lithiated Ge or Si thin film.
    Type: Application
    Filed: July 28, 2017
    Publication date: July 2, 2020
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Daniele PEREGO, Rajamouly OMAMPULIYUR SWAMINATHAN, Ye Lin Thu (No Family Name), Shao-Horn YANG, Wee Kiong CHOI, Carl Vernette THOMPSON, II
  • Patent number: 10690666
    Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 23, 2020
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Fu Xin-Yuan, Wanqiang Sheng, Yongliang Zhang, Fan Yang
  • Patent number: 10683586
    Abstract: A method of making graphene includes providing a seed gas in the presence of a metallic substrate, providing a pulsed, ultraviolet laser beam, and moving the substrate or the laser beam relative to the other, thereby advancing a graphene crystallization front and forming an ordered graphene structure. In some instances, the substrate can have a surface with two-fold atomic symmetry. A method of recrystallizing graphene includes providing a pulsed, ultraviolet laser beam to a polycrystalline graphene sheet.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: June 16, 2020
    Assignee: National University of Singapore
    Inventors: Barbaros Ozyilmaz, Andreas Volker Stier, Chee Tat Toh, Antonio Helio Castro Neto
  • Patent number: 10686127
    Abstract: A magnetic system containing a plurality of stacked layer arrays, each of which includes a first anti-ferromagnetic (AFM1) layer, a heavy metal (HM) layer formed of a material having strong spin-orbit coupling, and, optionally, a ferromagnetic (FM) layer or a second anti-ferromagnetic (AFM2) layer. Also disclosed is a method of preparing such a magnetic system.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: June 16, 2020
    Assignee: National University of Singapore
    Inventors: Yihong Wu, Yanjun Xu, Yumeng Yang
  • Patent number: 10683484
    Abstract: This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 16, 2020
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Yuanyu Hu, Huck Hui Ng, Yock Young Dan
  • Patent number: 10682602
    Abstract: There is provided a nanofibrous filter comprising a substrate and self-assembled nanofibers deposited on the substrate. The self-assembled nanofibers comprise ?-conjugated molecules self-assembled by non-covalent interactions, wherein the ?-conjugated molecules are phthalocyanine derivative molecules or diketopyrrolopyrrole derivative molecules. There is also provided a method of preparing the nanofibrous filter.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 16, 2020
    Assignee: National University of Singapore
    Inventors: Swee Ching Tan, Varun Kumar Singh, Sai Kishore Ravi
  • Patent number: 10672608
    Abstract: A method of fabricating a device on a carrier substrate, and a device on a carrier substrate. The method comprises providing a first substrate; forming one or more device layers on the first substrate; bonding a second substrate to the device layers on a side thereof opposite to the first substrate; and removing the first substrate.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 2, 2020
    Assignees: Massachusetts Institute of Technology, National University of Singapore, Nanyang Technological University
    Inventors: Kwang Hong Lee, Li Zhang, Soo Jin Chua, Eng Kian Kenneth Lee, Eugene A. Fitzgerald, Chuan Seng Tan
  • Patent number: 10668468
    Abstract: A sample holding device for use in transverse illumination of a sample or sub-components of a sample comprising: a support substrate comprising a sample well adapted to contain and be compatible with said sample wherein said well is provided on at least one wall with an angled reflective surface adjacent said sample well which when in use directs a transverse light beam from a light source through a sample contained within said sample well to provide substantially transverse illumination of a sample contained therein and imaging the sample using a single objective.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: June 2, 2020
    Assignees: National University of Singapore, Centre National de la Recherche Scientifique
    Inventors: Virgile Nicolas Robert Viasnoff, Vincent Studer, Gianluca Grenci, Remi Galland, Jean-Baptiste Sibarita
  • Patent number: 10663833
    Abstract: In accordance with a version of the invention, graphene with a ferroelectric material is used as the transparent electrode material in an electrochromic device. The use of curved and dynamically flexing substrates enables flexible and stretchable applications for electrochromic films. Furthermore, the nonreactive and impermeable nature of graphene increases the durability of the device through increased resistance to external impurities. In addition, the incorporation of ferroelectric materials allows the device to exhibit nonvolatile usage; that is, devices can remain transparent with no external power source. Furthermore, devices may exhibit a charging effect, permitting recovery of energy stored in alignment of ferroelectric dipoles within the ferroelectric material.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 26, 2020
    Assignee: National University of Singapore
    Inventors: Barbaros Özyilmaz, Eeshan Sandeep Kulkarni, Iñigo Martin Fernandez, Chee Tat Toh, Antonio Helio Castro Neto