Patents Assigned to National University of Singapore
  • Publication number: 20220298224
    Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 22, 2022
    Applicants: National University of Singapore, Singapore Health Services PTE LTD.
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Publication number: 20220299385
    Abstract: A composite structure for a pressure sensor, a pressure sensor, a method of pressure sensing using the pressure sensor, and a method of fabricating a composite structure for a pressure sensor. The method of fabricating a composite structure for a pressure sensor comprises the steps of forming an array of microstructures made from an elastomeric material; and forming a flexible conductive coating on the array of microstructures such that a surface morphology of microstructures is substantially maintained for the coated array of the microstructures; wherein the conductive coating exhibits a Young's modulus that is higher than that of the elastomeric material.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 22, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chee Keong TEE, Haicheng YAO, Pengju LI, Wen CHENG
  • Patent number: 11447606
    Abstract: Disclosed herein is a porous polymeric material having a repeating unit according to Formula (I) or (IV), wherein each of A and E has a ? conjugated system and each of X and G contain a flexible tetraphenylethylene (TPE) group. Also disclosed herein are fluorescent chemical sensors or biosensors or environmental monitoring assays or nanosheets or composite materials that include the polymer, and a method of detecting a volatile organic chemical or a metal ion in solution phase.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 20, 2022
    Assignee: National University of Singapore
    Inventors: Dan Zhao, Jinqiao Dong
  • Publication number: 20220293430
    Abstract: Exemplary methods of etching a silicon-containing material may include flowing a fluorine-containing precursor into a remote plasma region of a semiconductor processing chamber. The methods may include forming a plasma within the remote plasma region to generate plasma effluents of the fluorine-containing precursor. The methods may include flowing the plasma effluents into a processing region of the semiconductor processing chamber. A substrate may be positioned within the processing region. The substrate may include a trench formed through stacked layers including alternating layers of silicon nitride and silicon oxide. The methods may include isotropically etching the layers of silicon nitride while substantially maintaining the silicon oxide.
    Type: Application
    Filed: February 1, 2022
    Publication date: September 15, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Mikhail Korolik, Paul E. Gee, Bhaskar Jyoti Bhuyan, John Sudijono, Wei Ying Doreen Yong, Kah Wee Ang, Samarth Jain
  • Patent number: 11440958
    Abstract: The present invention provides compositions comprising an anti-CD7 chimeric activating receptor (CAR) and an anti-CD7 protein expression blocker, and methods of using such compositions in cancer therapy.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: September 13, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Yi Tian Png, Natasha Vinanica, Takahiro Kamiya, Dario Campana
  • Publication number: 20220275012
    Abstract: Dinuclear molybdenum coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a dinuclear molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: May 18, 2022
    Publication date: September 1, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
  • Publication number: 20220277763
    Abstract: Disclosed is a system for assessing quality of a singing voice singing a song. The system comprises memory and at least one processor. The memory stores instructions that, when executed by the at least one processor, cause the at least one processor to receive a plurality of inputs comprising a first input and one or more further inputs, each input comprising a recording of a singing voice singing the song, to determine, for the first input, one or more relative measures of quality of the singing voice by comparing the first input to each further input; and to assess quality of the singing voice of the first input based on the one or more relative measures. Also disclosed is a method implemented on such a system.
    Type: Application
    Filed: August 5, 2020
    Publication date: September 1, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chitralekha GUPTA, Haizhou LI, Ye WANG
  • Publication number: 20220275378
    Abstract: Dumbbell-shaped DNA minimal vectors represent genetic vectors solely composed of the gene expression cassette of interest and terminal closing loop structures. Dumbbell vectors for small hairpin RNA or microRNA expression are extremely small-sized which is advantageous with regard to cellular delivery and nuclear diffusion. Conventional strategies for the generation of small RNA-expressing dumbbell vectors require cloning of a respective plasmid vector which is subsequently used for dumbbell protection. Here, we present a novel cloning-free method for the generation of small RNA-expressing dumbbell vectors which also does not require any restriction endonucleases. The method comprises the PCR amplification of a universal DNA template using primers containing the sense or antisense strand of the sequence of interest, the denaturing and refolding of the amplified product to form stem-loop structures, and the structures are covalently closed using DNA ligases to obtain dumbbell structures.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 1, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Volker PATZEL, Samantha Leeanne CYRILL
  • Patent number: 11426408
    Abstract: The present invention relates to the use of serotonergic compounds for the treatment of virus-induced thrombocytopenia. More particularly, the invention relates to methods of treating thrombocytopenia by blocking serotonin activity. For example, inhibitors of receptor 5HT2A and/or receptor 5HT1A and/or inhibitors of mast cell degranulation and/or inhibitors of serotonin uptake may be used. Preferably, the thrombocytopenia is induced by dengue or Japanese Encephalitis virus, and the inhibitors are preferably ketanserin, WAY-100135, sarpogrelate, or fluoxetine.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 30, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Ashley Lauren St. John, Mohamad Fadhli Bin Masri, Abhay Rathore
  • Publication number: 20220267288
    Abstract: The invention concerns a novel cardiac therapeutic effective against atrial fibrillation (AF); a pharmaceutical composition comprising same; the use of same to treat cardiac disease; and a method of treating cardiac disease involving the use of same.
    Type: Application
    Filed: July 8, 2020
    Publication date: August 25, 2022
    Applicant: National University of Singapore
    Inventors: Chun Yong Eric Chan, Aneesh Vidyadhar Karkhanis, Gopalakrishnan Venkatesan
  • Publication number: 20220260571
    Abstract: A method for diagnosing Non-Small Cell Lung Cancer (NSCLC) from a sample extracted from a subject by testing the sample for the presence of biomarkers, the biomarkers being autoantibodies against XAGE1D, LRRFIP2 and GAGE2C. Also claimed are a method of manufacturing a kit, and compositions comprising a panel of said antigens or exosomal autoantibodies.
    Type: Application
    Filed: December 12, 2019
    Publication date: August 18, 2022
    Applicants: SENGENICS SDN BHD, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Jonathan Michael BLACKBURN, Arif ANWAR, Boon Cher GOH, Lingzhi WANG, Sok Hwee Esther CHEOW, Ross Andrew SOO, Win Lwin THUYA
  • Publication number: 20220256819
    Abstract: Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5? end of the EGFP gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used. Thus, new varieties of ornamental fish of different fluorescence patterns, e.g., skin fluorescence, muscle fluorescence, skeletal muscle-specific and/or ubiquitous fluorescence, are developed.
    Type: Application
    Filed: February 25, 2022
    Publication date: August 18, 2022
    Applicant: National University of Singapore
    Inventors: Zhiyuan GONG, Jiangyan HE, Bensheng JU, Toong Jin LAM, Yanfei XU, Tie YAN
  • Publication number: 20220251569
    Abstract: Methods of treating and preventing fibrosis and pathological inflammation through inhibition of WWP2 are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: June 12, 2020
    Publication date: August 11, 2022
    Applicant: National University of Singapore
    Inventors: Enrico Giuseppe Petretto, Aida Moreno Moral
  • Publication number: 20220236281
    Abstract: Methods and systems including a set of interacting nucleic acid structures for use in detecting and/or identifying a target comprising: a nucleic acid sequence capable of being conjugated to a moiety directed to the target; and a nucleic acid nanostructure comprising a segment sequence complementary to a portion of the nucleic acid sequence capable of being conjugated to a moiety directed to the target. The moiety directed to the target may be an antibody, and the nucleic acid nanostructure may be a tetrahedron.
    Type: Application
    Filed: May 19, 2020
    Publication date: July 28, 2022
    Applicants: NATIONAL UNIVERSITY OF SINGAPORE, NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE. LTD.
    Inventors: Huilin SHAO, Noah Riandiputra SUNDAH, Ching Wan CHAN, Tze Ping LOH
  • Publication number: 20220230874
    Abstract: Chalcogen silane precursors are described. Methods for depositing a silicon nitride (SixNy) film on a substrate are described. The substrate is exposed to the chalcogen silane and a reactant to deposit the silicon nitride (SixNy) film. The exposures can be sequential or simultaneous. The chalcogen silane may be substantially free of halogen. The chalcogen may be selected from the group consisting of sulfur (S), selenium (Se), and tellurium (Te).
    Type: Application
    Filed: January 18, 2021
    Publication date: July 21, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Chandan Kr Barik, Michael Haverty, Muthukumar Kaliappan, Cong Trinh, Bhaskar Jyoti Bhuyan, John Sudijono, Anil Kumar Tummanapelli, Richard Ming Wah Wong, Yingqian Chen
  • Publication number: 20220220140
    Abstract: Molybdenum(0) coordination complexes comprising an arene ligand and one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 14, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
  • Publication number: 20220220137
    Abstract: Molybdenum(VI) coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 14, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong, Mark Saly, Bhaskar Jyoti Bhuyan, Feng Q. Liu
  • Publication number: 20220220136
    Abstract: Dinuclear molybdenum coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a dinuclear molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 14, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
  • Publication number: 20220220138
    Abstract: Molybdenum(IV) and molybdenum(III) coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 14, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
  • Publication number: 20220220607
    Abstract: Molybdenum(0) coordination complexes comprising at least one cycloheptatriene ligand and optionally one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 14, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong