Patents Assigned to National University of Singapore
  • Patent number: 11517583
    Abstract: The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA; and a method for killing cells or treating a disease using said tsRNA.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: December 6, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Volker Patzel, Sushmita Poddar
  • Patent number: 11510881
    Abstract: Methods and compositions that provide an environment that promotes enhanced protein expression and/or folding are provided. More particularly, engineered thermostable ferritin assemblies capable of encapsulating polypeptides, nucleic acids or small molecules, which includes a modified ferritin subunit which lacks an unstructured carboxy-terminal sequence are provided. Methods and compositions for delivery of protein therapeutics are also provided.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: November 29, 2022
    Assignee: National University of Singapore
    Inventors: Chester Lee Drum, Nihar Masurkar, Siddharth Deshpande, Goutam Chakraborty, Girish Vallerinteavide Mavelli
  • Patent number: 11512213
    Abstract: Disclosed herein is a polymeric film, the film comprising a polymeric matrix material, a plurality of perovskite nanocrystals and/or aggregates of perovskite nanocrystals dispersed throughout the polymeric matrix material. There is also disclosed a perovskite polymer resin composition, a perovskite-polymer resin composition, a perovskite ink and a method of forming a luminescent film using any one of the compositions or ink. Preferably, the perovskite material is a lead halide perovskite containing a cation selected from Cs, an alkylammonium ion, or a formamidinium ion. The polymeric matrix is preferably formed from monomers comprising a vinyl or an acrylate group.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: November 29, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Zhi Kuang Tan, Ying-Chieh Wong, Jun De Andrew Ng, Beiye Li
  • Publication number: 20220370961
    Abstract: There is provided a multi-layered membrane comprising a top layer, a bottom layer, and a spacer layer; wherein said spacer layer is interposed between said top layer and said bottom layer; wherein said top layer, said bottom layer and said spacer layer are each independently composed of one or more selective layers, each selective layer comprising a 2D material; wherein said spacer layer comprises at least one channel for receiving a fluid; wherein said bottom layer comprises a hole with an area in the range of 1 ?m2 to 1 mm2; and wherein said hole is capable of being in fluid communication with said at least one channels of said spacer layer. There is also provided a method to synthesize the top layer of a multi-layered membrane as disclosed herein, methods for separating a plurality of ions or molecules in a fluid stream, a device comprising a multi-layered membrane as disclosed herein, and use of the method or the device as disclosed herein in osmotic power generation.
    Type: Application
    Filed: October 7, 2020
    Publication date: November 24, 2022
    Applicant: National University of Singapore
    Inventors: Slaven Garaj, Massimo Spina
  • Publication number: 20220373530
    Abstract: A method of detecting at least one contaminant in a flow of a liquid fuel includes measuring one or more parameters of a flow of the liquid fuel. Based on the measured one or more parameters, one or more properties of the liquid fuel are determined. A plurality of features are from selected ones of the one or more parameters and one or more properties. A trained classification model is applied on the extracted features to determine a type and a quantity of at least one contaminant in the liquid fuel.
    Type: Application
    Filed: June 26, 2020
    Publication date: November 24, 2022
    Applicant: National University of Singapore
    Inventors: Vivek Kolladikkal Premanadhan, Boon Chit So, Kin Cheong Lee
  • Patent number: 11504279
    Abstract: Disclosed is a device for incision and insertion of a ventilation tube during myringotomy, comprising a cutter member configured to make an incision; a holder member configured to dispose the ventilation tube in an orientation in which a longitudinal axis of the ventilation tube is substantially perpendicular to the cutter member; and a pusher member configured to apply a pushing force to a first end of the ventilation tube in a direction substantially perpendicular to the longitudinal axis, the first end of the ventilation tube being disposed closer to the cutter member than a second end of the ventilation tube; wherein the holder member comprises a pivot element configured to releasably engage the second end of the ventilation tube such that the ventilation tube is pivotable under the pushing force applied to the first end of the ventilation tube by the pusher member, for insertion of the first end of the ventilation tube into the incision.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: November 22, 2022
    Assignee: National University of Singapore
    Inventors: Cailin Ng, Wenyu Liang, Kok Kiong Tan, Chee Wee Gan, Lynne Hsueh Yee Lim
  • Publication number: 20220367870
    Abstract: Various embodiments may relate to an electrode. The electrode may include an electrode core including an electrode active material. The electrode may also include one or more monolayer amorphous films. Each of the one or more monolayer amorphous films may be a continuous layer surrounding the electrode core.
    Type: Application
    Filed: September 30, 2020
    Publication date: November 17, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Barbaros OEZYILMAZ, Cagdas CETIN, Chee Tat TOH, Irfan Haider ABIDI, Pieremanuele CANEPA, Xiao Feng LIM
  • Patent number: 11500037
    Abstract: A method and a system of detecting winding fault during online operation of an electrical machine, said method comprising, acquiring a set of signals from the machine over a period, said set of signals comprising two or more magnetic flux signals, each flux signal obtained from a respective flux sensor positioned on the external surface of the machine; extracting an internal winding fault indicator from the set of signals; comparing the internal winding fault indicator with a baseline indicator; and determining the internal winding fault when the internal winding fault indicator deviates from the baseline indicator by a threshold.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: November 15, 2022
    Assignees: Sembcorp Industries Ltd, National University of Singapore
    Inventors: Subash Chandar Athikessavan, Shiva Shankaranarayanan Muthuraj, Sanjib Kumar Panda, Elango Jeyasankar, Sai Srinivas Manohar
  • Patent number: 11497145
    Abstract: A server (10), a server rack (50) and a data centre (100, 150) are provided. The server (10) includes a housing (12) defining a gaseous flow passage. A plurality of active components (14) and a plurality of passive components (16) are provided in the housing (12). A plurality of liquid cooling devices (18) is attached to respective ones of the active components (14).
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 8, 2022
    Assignee: National University of Singapore
    Inventors: Poh Seng Lee, Yong Jie Chen, Matthew Lee Liong Law, Navin Raja Kuppusamy
  • Publication number: 20220339316
    Abstract: Described is a haemostatic device comprising a substrate and a surface formed on the substrate. The surface comprises at least one of micro- and nano-sized materials, the materials being partially embedded in a base, the surface substantially preventing wetting of the substrate. An embodiment of the device is carbon nano fibres embedded partially in a PDMS or PTFE base, on a substrate.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 27, 2022
    Applicants: National University of Singapore, ETH Zurich
    Inventors: Choon Hwai YAP, Zhe LI, Dimosthenis POULIKAKOS, Athanasios MILIONIS
  • Patent number: 11479719
    Abstract: A nanocrystal scintillator that contains a thin-film layer of perovskite-based quantum dots coated on a substrate layer. The quantum dots each have a formula of CsPbXaY3-a, CH3NH3PbX3, or NH2CH?NH2PbX3, in which each of X and Y, independently, is Cl, Br, or I, and a is 0-3. The substrate layer is an aluminum substrate, a fluoropolymer substrate, a fiber optic plate, a ceramic substrate, or a rubber substrate. Also disclosed are an ionizing radiation detector and an ionizing radiation imaging system containing such a nanocrystal scintillator.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: October 25, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Xiaogang Liu, Qiushui Chen
  • Patent number: 11474167
    Abstract: A method for detecting a magnetic field using a spin-orbit torque magnetic field sensor is described. The spin-orbit torque magnetic field sensor comprises a magnetic layer having a switchable magnetic state. The method comprises: (i) providing an alternating current to the sensor for creating an oscillatory spin-orbit torque in the magnetic layer to switch the switchable magnetic state between two magnetic states; and (ii) measuring an output voltage of the sensor, the output voltage being dependent on the magnetic field and is a time average of a time-varying anomalous Hall voltage generated in the magnetic layer in response to the oscillatory spin-orbit torque and the magnetic field.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: October 18, 2022
    Assignee: National University of Singapore
    Inventors: Yihong Wu, Hang Xie
  • Patent number: 11474601
    Abstract: In a described embodiment, a sensor-based communication apparatus (100) is disclosed. The communication apparatus (100) comprises a plurality of sensor nodes (112) associated with respective unique pulse signatures (200) and adapted to communicate with respective sensors (113) with each sensor (113) configured to generate a sensory signal (113a) in response to a respective stimulus (113b). Each sensor node (112) is triggered, upon receipt of the corresponding sensory signal (113a), to transmit the associated unique pulse signature (200) independently and asynchronously through a transmission medium (110) shared by the sensor nodes (112), and the unique pulse signatures (200) transmitted by the sensor nodes (112) being a representation (300) of a stimulus event associated with the stimuli detected by the corresponding sensors (113). A method and a communication medium are also disclosed.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: October 18, 2022
    Assignee: National University of Singapore
    Inventors: Chee Keong Tee, Wang Wei Lee, Kian Ann Ng, John Ho
  • Publication number: 20220325089
    Abstract: A dielectric material, to a device comprising the dielectric material and to use of the dielectric material in the fabrication of a device. One dielectric material may comprise a halogen-based elastomer mixed with a halogen based surfactant and exhibiting electro-mechanical self-healing properties and/or an increased dielectric constant compared to the halogen-based elastomer. Another dielectric material may comprise a halogen-based polymer mixed with a halogen based surfactant and exhibiting an increased dielectric constant compared to the halogen-based polymer.
    Type: Application
    Filed: May 31, 2019
    Publication date: October 13, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chee Keong TEE, Yu Jun TAN
  • Patent number: 11465100
    Abstract: There is provided a thin film composite (TFC) hollow fibre membrane comprising a porous hollow fibre support layer formed of a polymer and a selective layer, formed of a cross-linked polyamide, on an inner circumferential surface of the hollow fibre support layer, wherein the TFC hollow fibre membrane has a power density of 25-50 W/m2 at a pressure of 30 bar. There is also provided a method of forming the TFC hollow fibre membrane.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: October 11, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chunfeng Wan, Tianshi Yang, Wenxiao Gai, Tai-Shung Neal Chung
  • Publication number: 20220322505
    Abstract: There is provided a thermal material comprising an electrode, a film of reduced graphene oxide, a porous membrane that is sandwiched between the electrode and the film of reduced graphene oxide, and an ionic liquid that is disposed within pores of the porous membrane. There is also provided a method of preparing a thermal material. There is further provided a method of changing an article's apparent temperature. There is further provided a device comprising the thermal material as described herein.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 6, 2022
    Applicant: National University of Singapore
    Inventors: Daria Andreeva-Baeumler, Konstantin Novoselov
  • Publication number: 20220306662
    Abstract: Molybdenum(IV) and molybdenum(III) coordination complexes are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: June 16, 2022
    Publication date: September 29, 2022
    Applicants: Applied Materials, Inc., National University of Singapore
    Inventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
  • Publication number: 20220298224
    Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 22, 2022
    Applicants: National University of Singapore, Singapore Health Services PTE LTD.
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Publication number: 20220299385
    Abstract: A composite structure for a pressure sensor, a pressure sensor, a method of pressure sensing using the pressure sensor, and a method of fabricating a composite structure for a pressure sensor. The method of fabricating a composite structure for a pressure sensor comprises the steps of forming an array of microstructures made from an elastomeric material; and forming a flexible conductive coating on the array of microstructures such that a surface morphology of microstructures is substantially maintained for the coated array of the microstructures; wherein the conductive coating exhibits a Young's modulus that is higher than that of the elastomeric material.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 22, 2022
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chee Keong TEE, Haicheng YAO, Pengju LI, Wen CHENG
  • Patent number: 11447606
    Abstract: Disclosed herein is a porous polymeric material having a repeating unit according to Formula (I) or (IV), wherein each of A and E has a ? conjugated system and each of X and G contain a flexible tetraphenylethylene (TPE) group. Also disclosed herein are fluorescent chemical sensors or biosensors or environmental monitoring assays or nanosheets or composite materials that include the polymer, and a method of detecting a volatile organic chemical or a metal ion in solution phase.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 20, 2022
    Assignee: National University of Singapore
    Inventors: Dan Zhao, Jinqiao Dong