Patents Assigned to National Yang-Ming University
  • Patent number: 10888568
    Abstract: The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and/or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: January 12, 2021
    Assignee: National Yang Ming University
    Inventors: Chi-Ying Huang, Jane Hsiao, Pan-Chyr Yang, Meng-Hua Lee
  • Patent number: 10883142
    Abstract: A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including rs1057910 (CYP2C9*3) and rs3758581 on CYP2C19), and HLA alleles (including HLA-B*1502, HLA-B*1301, and HLA-B*5101) can predict adverse reactions caused by phenytoin or fosphenytoin. Accordingly, the present invention provides a kit to assess the risk of a patient for developing adverse reactions in response to phenytoin-related drugs, which comprises the determination of the presence of a specific allele selected from the group consisting of rs1057910 (CYP2C9*3), rs3758581 on CYP2C19, HLA-B*1502, HLA-B*1301, and HLA-B*5101, wherein the presence of at least one allele is indicative of a risk for the adverse drug reactions.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: January 5, 2021
    Assignees: Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung, National Yang-Ming University
    Inventors: Wen-Hung Chung, Shuen-Iu Hung
  • Publication number: 20200402659
    Abstract: A disease suffering probability prediction method and an electronic apparatus are provided. The method includes: determining a path length; obtaining a plurality of first paths conforming to the path length from a plurality of history data of a specific disease; obtaining a plurality of second paths positively related to the specific disease from the plurality of first paths; filtering the plurality of second paths to obtain a plurality of third paths, and establishing a prediction model according to the plurality of third paths; and inputting a path to be predicted to the prediction model and outputting a probability of suffering the specific disease.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 24, 2020
    Applicants: Acer Incorporated, National Yang-Ming University
    Inventors: Pei-Jung Chen, Tsung-Hsien Tsai, Liang-Kung Chen, Li-Ning Peng
  • Patent number: 10835622
    Abstract: The invention is a simplified model on kidney rejection in animals and its setting approach. The method involves isolating dendritic cells from male mice and isolating T cells from female mice and then using the naive T cells in vitro to culture concurrently with male dendritic cells. Those activated T cells from female origin were injected into renal cortex in male mice for the purpose of attacking renal cortex. The animal model simulates the renal transplant rejection method to enable effective induction of renal transplant immune reaction.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: November 17, 2020
    Assignees: NATIONAL YANG-MING UNIVERSITY, TAIPEI VETERANS GENERAL HOSPITAL, TAICHUNG VETERANS GENERAL HOSPITAL
    Inventors: Der-Cheng Tarng, Nien-Jung Chen, Shuo-chun Weng
  • Patent number: 10808063
    Abstract: The present disclosure provides a photopolymer composition and the applications thereof. The photopolymer composition comprises: 5 weight percent to 15 weight percent of gelatin methacrylate (GelMA), 0.1 weight percent to 5 weight percent of silanized biologically active additive, 0.1 weight percent to 5 weight percent of photoinitiator, and 75 weight percent to 95 weight percent of a solvent. Compared to a conventional hydrogel, the hydrogel prepared from the photopolymer composition of the present disclosure has improved compressive strength, mechanical strength and stability. Accordingly, the hydrogel is applicable to biomedical research and tissue repair.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: October 20, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Yuan-Min Lin, Jiun-Ming Su
  • Patent number: 10793527
    Abstract: The present invention discloses a compound of the formula (I), which acts as an agonist of adenosine monophosphate-activated protein kinase, which induce phosphorylation and activation of AMPK?, thereby further regulating downstream signaling pathways, inhibiting growth and proliferation of liver cancer cells and breast cancer cells, and also inducing apoptosis of adipocytes. Therefore, the compound provided by the present invention can be utilised for treatment and preparation of pharmaceutical composition for cancer, and lipid metabolism-related diseases or syndromes mediated by AMPK.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 6, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Chung-Wai Shiau, Jung-Chen Su, Yan-Ju Lin, Jui-Wen Huang
  • Patent number: 10780129
    Abstract: The present invention relates to a use of hypoxia-cultured mesenchymal stem cells (MSCs) for manufacture of a cell graft for treating a musculoskeletal disorder, particularly osteoarthritis.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 22, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventor: Shih-Chieh Hung
  • Patent number: 10773098
    Abstract: The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: September 15, 2020
    Assignee: National Yang-Ming University
    Inventors: Tse-Ying Liu, Ming-Hong Chen
  • Patent number: 10751152
    Abstract: In this invention, a high-accuracy jaw motion tracking system and method using the same are disclosed. The jaw motion tracking system of the invention mainly comprises an eyewear facebow static positioning device, a lower jaw dynamic tracking device and a stereo-vision charge-coupled device (CCD) and can provide information regarding the locations and relative movement of lower and upper jaws. The eyewear facebow static positioning device has several passive and active reflective markers. The lower jaw dynamic tracking device equips with a plural of lightweight light emitting devices. Using OpenCV-based self-developed algorithm and post-iterative compensator, the disclosed system can record the dynamical jaw movement with a high accuracy. The disclosed jaw motion tracking system and related method have minimal occlusal disturbance and provide smooth motion-tracking performance. The disclosed system can be used in clinical dentistry.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 25, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Liang-Yuan Cheng, Chih-Yu Hsu, Shyh-Yuan Lee, Yuan-Min Lin
  • Publication number: 20200172609
    Abstract: The preset invention relates to preventing, arresting, reversing or treating atherosclerosis, comprising a step of: administering to a subject in need thereof a therapeutically effective amount of a macrophage inflammatory protein-1 beta (MIP-1?) inhibitor.
    Type: Application
    Filed: August 10, 2018
    Publication date: June 4, 2020
    Applicants: NATIONAL YANG-MING UNIVERSITY, TAIPEI VETERANS GENERAL HOSPITAL, VIVASOLIS BIOTECHNOLOGY CO., LTD.
    Inventor: Jaw-Wen CHEN
  • Patent number: 10668093
    Abstract: The present invention relates to a method for treating a cancer with the combination of a topoisomerase II inhibitor (TOP2 inhibitor) and a histone deacetylation inhibitor (HDACi), provides synergistic cancer cell-killing effects, and prolonged overall survival, especially when the expression of checkpoint kinase 1 (CHK-1) is low.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: June 2, 2020
    Assignee: National Yang-Ming University
    Inventor: Jin-Hwang Liu
  • Patent number: 10668111
    Abstract: The present invention relates to treatment of pulmonary fibrosis with umbilical mesenchymal stem cell.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: June 2, 2020
    Assignees: NATIONAL YANG MING UNIVERSITY
    Inventor: Yu-Show Fu
  • Patent number: 10667780
    Abstract: The invention provides a contrast carrier device with geometric calibration phantom on computed tomography, comprising: a front ring body having a front outer peripheral surface; the front outer peripheral surface is provided with a front correction bead; a loading table, wherein one end of the loading table is connected with the front ring body; a rear ring body is oppositely arranged at the other end of the front ring body connected to the loading table, wherein the rear ring body has an outer peripheral surface, the rear peripheral surface is provided with a rear correction bead; a virtual axis passes through the center of the front ring body and the center of the rear ring body, respectively, and the front correction bead and the rear correction bead.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: June 2, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Meng-Tse Wu, Shih-Chun Jin, Jyh-Cheng Chen
  • Patent number: 10646195
    Abstract: The present invention provides a test phantom for X-ray imaging, which comprises a prosthetic fin and an edge patch; wherein the prosthetic fin has a plurality of different arithmetical series sizes of circular grooves and plurality of different arithmetical series thickness of the line pairs; wherein the edge patch connects on one side of the prosthetic fin. The present invention further provides a test phantom combination for X-ray imaging and a method for measuring parameters and focal spot.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: May 12, 2020
    Assignee: National Yang-Ming University
    Inventors: Suei-Ting Jhao, Jyh-Cheng Chen, Wei-Hung Shih, Yu-Jie Lan
  • Publication number: 20200143007
    Abstract: A method of making a complementary bone model includes performing standard topology optimization on a complementary bone model for a defected bone under different mechanics conditions; performing both a finite element analysis and a weighted topology optimization by performing topology optimization in terms of ratio coefficients under the different mechanics conditions; integrating the results of standard topology optimization to obtain a weighted topology optimization structure for making a complementary bone model which is three-dimensional; and using additive manufacturing technology to manufacture the complementary bone model, thereby finishing a complementary bone.
    Type: Application
    Filed: November 1, 2019
    Publication date: May 7, 2020
    Applicant: National Yang-Ming University
    Inventors: Chun-Li Lin, Cheng-Hsien Wu, Yu-Tzu Wang, Chia-Hsuan Li
  • Patent number: 10610736
    Abstract: An electric walking assistance device is provided. The electric walking assistance device comprises: a support member comprising at least one movable component; a user area where a user can stand, wherein the user area is a ground area adjacent to the support member. The electric walking assistance device further comprises at least one gait monitoring module and at least one gait assisting module, wherein the at least one gait monitoring module and the at least one gait assisting module are on the support member, the user's body, an arbitrary point within the detection range covering a range of user activities or any combinations thereof.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: April 7, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Chung-Huang Yu, Ying-Chun Jheng
  • Patent number: 10590184
    Abstract: This invention reveals the potential applications of modified porcine plasma fibronectin that could be applied as a safe material for clinical wound healing and tissue repair. In order to seek safe sources of plasma fibronectin for practical consideration in wound dressing, this invention isolated and modified fibronectin from porcine plasma and demonstrated that modified porcine plasma fibronectin has similar ability as homo plasma fibronectin being as a suitable substrate for stimulation of cell adhesion and directed cell migration. The present invention also reveals a material and a pharmaceutical composition enhance wound healing.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: March 17, 2020
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventor: Jean-Cheng Kuo
  • Publication number: 20200062738
    Abstract: A compound for inhibiting BMI-1/MCL-1 having a structure of Formula (I), wherein the various groups are as described. A pharmaceutical composition for treating cancer includes an effective amount of a compound of Formula (I).
    Type: Application
    Filed: April 30, 2018
    Publication date: February 27, 2020
    Applicants: Development Center for Biotechnology, National Yang-Ming University
    Inventors: Cheng-Wen Wu, Erh-Hsuan Jiann Lin, Chi-Ying Huang, Jia-Ming Chang, Shih-Hsien Chuang, Hui-Jan Hsu, Wei-Wei Chen
  • Patent number: 10519319
    Abstract: The present invention provides a three-dimensional printing article for making dental products and the preparation method thereof, which comprises: Ethoxylated bisphenol A dimethacrylate, Diurethane dimethacrylate, Triethylene glycol dimethacrylate, and Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide. It not only improves the present time-consuming and labor-intensive dental device making, but also can be used in mass production of dental devices.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: December 31, 2019
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Yuan-Min Lin, Hsuan Chen, Shyh-Yuan Lee, Pin-Ju Huang
  • Patent number: 10441540
    Abstract: The present invention relates to a liposomal lupeol acetate (Lipo-LA) and its use in the treatment or prevention of rheumatoid arthritis (RA). The liposomal lupeol acetate of the present invention especially inhibits inflammatory responses and osteoclast generation (osteoclastogenesis) in the progression of rheumatoid arthritis (RA) at a half dose of the un-capsulated lupeol acetate, which may significantly reduce the incidence of RA and improve the therapeutic efficacy of lupeol acetate.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 15, 2019
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Jeng-Jong Hwang, Wei-Hsun Wang