Abstract: A compound for inhibiting BMI-1/MCL-1 having a structure of Formula (I), wherein the various groups are as described. A pharmaceutical composition for treating cancer includes an effective amount of a compound of Formula (I).

Abstract: The present invention provides a three-dimensional printing article for making dental products and the preparation method thereof, which comprises: Ethoxylated bisphenol A dimethacrylate, Diurethane dimethacrylate, Triethylene glycol dimethacrylate, and Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide. It not only improves the present time-consuming and labor-intensive dental device making, but also can be used in mass production of dental devices.

Abstract: The present invention relates to a liposomal lupeol acetate (Lipo-LA) and its use in the treatment or prevention of rheumatoid arthritis (RA). The liposomal lupeol acetate of the present invention especially inhibits inflammatory responses and osteoclast generation (osteoclastogenesis) in the progression of rheumatoid arthritis (RA) at a half dose of the un-capsulated lupeol acetate, which may significantly reduce the incidence of RA and improve the therapeutic efficacy of lupeol acetate.

Abstract: Provided are an optical tomography digital-impression imaging system and a method for use thereof, said system including: an optical coherence tomography scanner, used for obtaining tomographic slice thicknesses of a plurality of tissue areas of each optical tomography digital image; an information analysis and processing component electrically connected to the optical coherence tomography scanner. The information analysis and processing component has a refractive index compensation and optical path correction functions; by way of analysis and processing, tomographic slice thickness correction values corresponding to the tissue areas are obtained, thus establishing a digital model of the tissue areas.

Abstract: The present invention provides an urinary crystal detection method, which is used with a crystal collecting unit and a crystal detecting unit. The method comprises steps of using magnetic particles to attach urinary crystals from a sample. Then, providing a magnetic field to separate the urinary crystals. Further to analyz their constituent by the Raman signals of the urinary crystal to access an urinary calculus result for urinary stone patient.

Abstract: Compositions and methods for reducing or overcoming acquired resistance to cetuximab are provided. Compositions and methods for treatment of cetuximab-resistant cancers are also provided. In addition, methods of inhibiting the growth of EGFR-expressing tumor cells that are resistant to cetuximab therapy are provided herein.

Abstract: An ultrasound probe structure dedicated for guiding the puncture needle. It has a passage in the center of the structure and the diameter of the passage is equal to the outer diameter of puncture needle. The bony and non-bony tissues can be distinguished according to the strength of the echoes so that the puncture needle can be guided to avoid hitting the bony tissue before or during insertion.

Abstract: A method and a pharmaceutical composition for treating an atherosclerotic lesion are provided, including administering a subject in need thereof a therapeutically effective amount of a composition comprising hypoxia-cultured MSCs obtained by culturing auto- or allo-MSCs under low oxygen conditions.

Abstract: A wearable training device for gait rehabilitation and a method using the same are provided. The training device includes a power supply unit, a light emitting unit, a support member and a trigger unit. The power supply unit and the light emitting unit are coupled with each other and disposed on the support member attached on a user's lower limb. The trigger unit is contacted a sole of foot of the lower limb on which the support member is attached, and coupled to the light emitting unit. When the sole of foot is landed, the trigger unit is triggered to activate the light emitting unit to project a visible light on the ground where a front stepping point of user's opposite lower limb is located, to form a stepping prompt point with visible prompt effect on the ground. Therefore, the user can be guided to step.

Abstract: An integrated medical bite block is engaged by a user's teeth and installed into the user's mouth. The bite block includes a through passageway, an upper grove, and a lower grove. The through passageway is penetrating through the bite block. One end of the through passageway comprises an inlet opening, the other end comprises an oral opening. The oral opening is connected with the user's mouth. An upper surface of the bite block provides the upper grove configured for receiving one or more upper teeth (maxillary teeth) of the user, and a lower surface of the bite block provides a lower grove configured for receiving one or more lower teeth (mandibular teeth) of the user. One distance between the lower grove and the oral opening is greater than the other distance between the upper grove and the oral opening, thereby the invention serves to extend forward the mandible and reposition a malposition between the mandible and the maxilla of the user.

Abstract: An electric walking aid and control method thereof are disclosed. A location of the electric walking aid, and a distance between the electric walking aid and the user, are dynamically controlled and adjusted to provide the user with static and dynamic support function, so as to support the user under static and dynamic situation of interaction between walk and stand, during the walking training process.

Abstract: A dual targeting drug carrier is provided. The dual targeting drug carrier comprises a first targeting molecule and a second targeting molecule, wherein the targeting molecule comprises peptide, protein or antibody. The targeting molecule can bind to specific receptors, proteins, or glycoproteins to recognize the specific tumor cells, tissues, or organs. The dual targeting drug carriers are further conjugated with imaging agents, radioactive molecules (radiopharmaceuticals, isotopes, or chemotherapeutic drugs) or nanoparticles to form a conjugate.

Abstract: A system of mapping a cardiac image of single heart chamber and a method thereof are disclosed. In the system and method thereof, one heart chamber (such as a left atrium, a left ventricular, a right atrium, right ventricular or aortic structure) can be selected in a 3D-based cardiac image (such as a CT or MRI image), and slices of the selected heart chamber are reconstructed and unwrapped by a 2D mapping visual display manner. The visual display and required angle alignment planes for subsequent analysis will be adjusted and achieved by operator manually, with specific global and regional architectural analysis performed by automatic algorithm.

Abstract: The present invention provides a method for preventing or treating a functional gastrointestinal disorder in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier. The present invention further provides a method for preventing or treating visceral hypersensitivity in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier. Moreover, the present invention provides a method for preventing or treating functional abdominal pain, irritable bowel syndrome or constipation in a subject in need thereof that includes a step of administering a composition, wherein the composition includes an effective amount of Lactobacillus plantarum subsp. plantarum PS128 and a carrier.

Abstract: Provided are an optical tomography digital-impression imaging system and a method for use thereof, said system including: an optical coherence tomography scanner, used for obtaining tomographic slice thicknesses of a plurality of tissue areas of each optical tomography digital image; an information analysis and processing component electrically connected to the optical coherence tomography scanner. The information analysis and processing component has a refractive index compensation and optical path correction functions; by way of analysis and processing, tomographic slice thickness correction values corresponding to the tissue areas are obtained, thus establishing a digital model of the tissue areas.

Abstract: A personalize exercise decision-making device and manipulating method for patients with chronic diseases are disclosed from this invention. The device can provide an appropriate exercise suggestion to the user by the classification of the database based on the personal information, such as chronic diseases and drug administration, and the immediate physiological data. The device of the invention can also check the immediate physiological data, such as systolic blood pressure, diastolic blood pressure, heart rate and oxygenation concentration, to confirm the state of user whether can exercise. Further more, the device can monitor, analyze and store the physiological data for providing an instant feedback to user during the exercise. If the immediate physiological data of the user is over an exercise threshold in exercise, the device will provide a warning signal.

Abstract: The present invention provides a microfluidic bio-reactor device, which comprises: a first cell culture layer; a microfluidic base, which is located on the top of the first cell culture layer; a microfluidic layer, which is located on the top of the microfluidic base and have an air-bubble removal device; a microfluidic roof, which is located on the top of the microfluidic layer; the present invention also provides a method for culturing cells by the microfluidic bio-reactor device of the present invention and the kit with a cell-loading device and present microfluidic bio-reactor device.

Abstract: The present invention provides a method of obtaining a classification boundary, to limit an axial depth in a puncturing operation. The following steps of method comprises: At first, obtaining a plurality of tomographic images from the axial depth of a tissue is performed. Then, obtaining a plurality of characteristic values from the tomographic images, the characteristic values are classified by a Support Vector Machine method. A classification boundary will be obtained through a distribution of the graph for defining a specific compartment of the tissue. In addition, an automatic recognition method and system using the above mentioned method are also disclosed in the present invention.

Abstract: The present invention relates to treatment of pulmonary fibrosis with umbilical mesenchymal stem cell.

Abstract: The present invention is related to a method for treating cancer metastasis and composition thereof. By using an IL-35 antagonist, cancer metastasis can be effectively treated so that an increased cancer fee and overall survival can be achieved.