Patents Assigned to Nelson Research & Development Company
  • Patent number: 4954448
    Abstract: Silicic acid modulates (i.e. enhances or inhibits) adenylate cycloase activity. This effect appears to be a general one, inasmuch as the modulation has occurred in all tissues studied. The results suggest that silicic acid can be used in human and veterinary medicine to modulate hormone or neurotransmitter response. The results also indicate that silicic acid can be used to prevent, treat, or delay the onset of calcium-related bone disease, or to improve bone strength in an vertebrate having a bone strength less than desired.
    Type: Grant
    Filed: December 27, 1988
    Date of Patent: September 4, 1990
    Assignee: Nelson Research & Development Company
    Inventors: Karl E. Wiegand, Robert K. Rude
  • Patent number: 4886545
    Abstract: This invention provides compositions comprising a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen. The invention also provides compositions comprising a physiologically-active agent and the hereinabove recited 1-substituted azacycloalkane compound in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: December 12, 1989
    Assignee: Nelson Research & Development Company
    Inventors: James V. Peck, Gevork Minaskanian
  • Patent number: 4465692
    Abstract: A method of selectively stimulating D-2 dopamine receptors in humans comprising administering to a human requiring D-2 dopamine receptor stimulation, a therapeutically effective amount of 2-(N-phenylethyl-N-propylamino)-5-hydroxytetralin or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 3, 1982
    Date of Patent: August 14, 1984
    Assignee: Nelson Research & Development Company
    Inventor: Alan S. Horn
  • Patent number: 4461638
    Abstract: The disclosure describes compositions and methods for improved delivery of plant nutrients comprising contacting a plant with a composition comprising an effective amount of a plant nutrient and an effective delivery enhancing amount of compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, m is 3-7, n is 0-17 and R is --CH.sub.3, ##STR2## where R" is H or halogen, with the proviso that if m is 3 and R is CH.sub.3, then n is 5-17.
    Type: Grant
    Filed: April 11, 1983
    Date of Patent: July 24, 1984
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4446140
    Abstract: A method for treating mouth pain by administering to a human having such pain an effective mouth pain reducing amount of dextromethorphan, preferably as the hydrobromide.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: May 1, 1984
    Assignee: Nelson Research & Development Company
    Inventor: Eric L. Nelson
  • Patent number: 4444762
    Abstract: Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: April 24, 1984
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4424210
    Abstract: Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: January 3, 1984
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4423040
    Abstract: Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: December 27, 1983
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4422970
    Abstract: In a method of synthesis of 1-substituted azacycloalkan-2-ones with primary alkyl halides and aralkyl halides as alkylating agents, the improvement comprising carrying out the N-alkylation in the presence of a phase transfer catalyst having the structural formula ##STR1## where X is suitable anion; and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each alkyl or aralkyl groups having 1-18 carbon atoms, or R.sub.2, R.sub.3 and R.sub.4 can form a part of a heterocyclic ring, with the proviso that the combined total of carbon atoms is between 16 and 40.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: December 27, 1983
    Assignee: Nelson Research & Development Company
    Inventors: Vithal J. Rajadhyaksha, James V. Peck, Gevork Minaskanian
  • Patent number: 4415563
    Abstract: Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: November 15, 1983
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4405616
    Abstract: In a method for administering systemically active agents including therapeutic agents through the skin or other body membranes of humans and animals typically in the form of a transdermal device or formulation, the improvement comprising the use therewith of an effective amount of a membrane penetration enhancer having the structural formula. ##STR1## wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: September 20, 1983
    Assignee: Nelson Research & Development Company
    Inventor: Vithal J. Rajadhyaksha
  • Patent number: 4311481
    Abstract: There is disclosed a method of improvement of dyeing fibers by utilizing in the dyeing process, an effective, dye-enhancing amount of a textile auxiliary having the structural formula ##STR1## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, n is O or a positive integer from 1-11 and R is an alkyl group (straight or branch chain) having 1-18 carbon atoms or aryl group, e.g., phenyl. The compounds disclosed herein enhance dye penetration of fibers and allow the dyeing process to take place at lower temperatures in less time.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: January 19, 1982
    Assignee: Nelson Research & Development Company
    Inventor: Eric L. Nelson
  • Patent number: 4310525
    Abstract: There is disclosed a method of treatment of inflammation in humans and animals comprising contacting the inflamed area with an effective, anti-inflammatory amount of 1-dodecylazacycloheptan-2-one.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: January 12, 1982
    Assignee: Nelson Research & Development Company
    Inventor: Eric L. Nelson
  • Patent number: 4228176
    Abstract: The disclosure describes a method for selectively inhibiting thromboxane biosynthesis with Burimamide, a compound previously known to be a histamine H.sub.2 -receptor blocker. The discovery is useful in the treatment of a number of cardiovascular and inflammatory diseases in which thromboxane biosynthesis is involved.
    Type: Grant
    Filed: April 9, 1979
    Date of Patent: October 14, 1980
    Assignee: Nelson Research & Development Company
    Inventors: Kenneth E. Eakins, Geoffrey Allan
  • Patent number: 4190673
    Abstract: A therapeutic composition comprising a topically administrable ophthalmic pharmaceutical carrier and colchicine. The foregoing composition temporarily alleviates the symptoms of glaucoma when topically administered to the eye.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: February 26, 1980
    Assignee: Nelson Research & Development Company
    Inventors: Kenneth E. Eakins, Parimal Bhattacherjee
  • Patent number: 4188394
    Abstract: A therapeutic composition comprising a topically administrable ophthalmic pharmaceutical carrier and vinblastine. The fore-going composition temporarily alleviates the symptoms of glaucoma when topically administered to the eye.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: February 12, 1980
    Assignee: Nelson Research & Development Company
    Inventors: Kenneth E. Eakins, Parimal Bhattacherjee
  • Patent number: 4172139
    Abstract: The disclosure describes a method for selectively inhibiting thromboxane biosynthesis with Burimamide, a compound previously known to be a histamine H.sub.2 -receptor blocker. The discovery is useful in the treatment of a number of cardiovascular and inflammatory diseases in which thromboxane biosynthesis is involved.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: October 23, 1979
    Assignee: Nelson Research & Development Company
    Inventors: Kenneth E. Eakins, Geoffrey Allan
  • Patent number: 4148878
    Abstract: A process for inhibiting platelet aggregation or thrombus formation by the addition of a member selected from the group consisting of a compound of the formula: ##STR1## WHEREIN X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, ##STR2## NHCOR.sub.1, NR.sub.1 R.sub.2 or ##STR3## where R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl; R, R.sub.1 and R.sub.2 being the same or different and n is 0-5; and pharmaceutically acceptable salts thereof, to in vivo and in vitro platelet systems.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: April 10, 1979
    Assignee: Nelson Research & Development Company
    Inventor: Eric L. Nelson
  • Patent number: 4148879
    Abstract: A process for inhibiting platelet aggregation or thrombus formation by the addition of a member selected from the group consisting of a compound of the formula: ##STR1## WHEREIN X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, ##STR2## NHCOR.sub.1, NR.sub.1 R.sub.2 or ##STR3## where R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl; R, R.sub.1 and R.sub.2 being the same or different, T is selected from the group consisting of O, NH, S and CH.sub.2 with the proviso that only one T is O, Z is 0 or 1 and n is 0-5; and pharmaceutically acceptable salts thereof, to in vivo and in vitro platelet systems.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: April 10, 1979
    Assignee: Nelson Research & Development Company
    Inventor: Eric L. Nelson
  • Patent number: 4147769
    Abstract: There is disclosed a shelf-stable microbicidal composition containing no water and including an ene-diol compound, a specific catalytic metal compound, and a propellant suitable for dispensing the ingredients from an aerosol container, with at least one of the ene-diol compound and the catalytic metal compound not in solution. Oxidation of the ene-diol compound catalyzed by the metal compound produces a microbicidal effect.
    Type: Grant
    Filed: January 9, 1978
    Date of Patent: April 3, 1979
    Assignee: Nelson Research & Development Company
    Inventors: Frank J. Dea, William D. Fairbairn, Michael W. Novack