Patents Assigned to Nelson Research & Development Company
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Patent number: 4138484Abstract: A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a GABA-like compound such as Lioresal. Neuroleptic drugs are potentiated by coadministering to a schizophrenic a neuroleptic drug and a GABA-like drug such as Lioresal.Type: GrantFiled: July 25, 1977Date of Patent: February 6, 1979Assignee: Nelson Research & Development CompanyInventor: Kjell Fuxe
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Patent number: 4132781Abstract: There is disclosed a topical antibacterial composition and method for topical antibiotic treatment. The method involves contacting the skin of a human or animal with an effective amount of a composition containing an antibiotic of the erythromycin family and 2-pyrrolidone or an N-lower alkyl-2-pyrrolidone. The preferred use of the foregoing composition and method is in the treatment of acne.Type: GrantFiled: December 19, 1974Date of Patent: January 2, 1979Assignee: Nelson Research & Development CompanyInventor: Richard B. Stoughton
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Patent number: 4129652Abstract: A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a GABA-like compound such as Lioresal. Neuroleptic drugs are potentiated by coadministering to a schizophrenic a neuroleptic drug and a GABA-like drug such as Lioresal.Type: GrantFiled: July 25, 1977Date of Patent: December 12, 1978Assignee: Nelson Research & Development CompanyInventor: Kjell Fuxe
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Patent number: 4122170Abstract: There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-alkyl substituted-azacyclopentan-2-one, as defined herein, and contacting the skin or other membranes of the human or animal with the resulting composition, whereby penetration of the skin or membranes is enhanced.Type: GrantFiled: June 6, 1977Date of Patent: October 24, 1978Assignee: Nelson Research & Development CompanyInventor: Vithal Jagannath Rajadhyaksha
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Patent number: 4087609Abstract: Novel compounds having the structural formula ##STR1## where B is NR, O, S, ##STR2## or --CH.sub.2 ; (M).sub.n is a saturated or unsaturated aliphatic hydrocarbon chain; X is NR, O or S; A is SO.sub.2 R, CN, NO.sub.2 or H; Y is NR.sub.2, N.sub.3, halogen or SH; R is H and/or a lower alkyl group; D is N.sub.3 or halogen and n is 1-12.Type: GrantFiled: November 15, 1976Date of Patent: May 2, 1978Assignee: Nelson Research & Development CompanyInventors: Nathan L. Smith, Vithal J. Rajadhyaksha
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Patent number: 4084000Abstract: A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a GABA-like compound such as Lioresal. Neuroleptic drugs are potentiated by coadministering to a schizophrenic a neuroleptic drug and a GABA-like drug such as Lioresal.Type: GrantFiled: August 16, 1976Date of Patent: April 11, 1978Assignee: Nelson Research and Development CompanyInventor: Kjell Fuxe
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Patent number: 4039664Abstract: There is disclosed a composition and method for topically administering griseofulvin to a human or animal in a manner such that a high degree of epidermal, especially stratum corneum, retention of griseofulvin is attained, by contacting the skin of a human or animal with an effective amount of a therapeutic composition containing griseofulvin in a vehicle system comprising 2-pyrrolidone and N-methyl-2-pyrrolidone in a ratio ranging between about 1:4 and about 4:1, said composition containing at least about 10% by weight of said vehicle system.Type: GrantFiled: April 11, 1975Date of Patent: August 2, 1977Assignee: Nelson Research & Development CompanyInventors: Richard B. Stoughton, Richard L. Harris, Frank J. Dea
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Patent number: 4038417Abstract: A composition and method for treating psoriasis in humans comprising the administration to a human suffering from psoriasis of a beta-adrenergic receptor stimulating compound such as isoproterenol.Type: GrantFiled: June 19, 1975Date of Patent: July 26, 1977Assignee: Nelson Research & Development CompanyInventor: Eric Loren Nelson
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Patent number: 4038415Abstract: Novel prostaglandin dehydrogenase inhibiting agents having the structural formula ##STR1## X is hydroxyl, dialkylaminomethyl, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, cyano, nitro, trihaloalkyl, --NR.sub.1 R.sub.2 or --NHCOR.sub.1 where R.sub.1 and R.sub.2 are hydrogen, lower alkyl or NH.sub.2 and n is 0-5.Type: GrantFiled: September 1, 1976Date of Patent: July 26, 1977Assignee: Nelson Research & Development CompanyInventors: Vithal J. Rajadhyaksha, Richard A. Schroer, Phillip J. Brock, Earl R. Krueger
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Patent number: 4016204Abstract: An improved method of synthesis of trans-2-phenylcyclopropylamine wherein the improvement comprises isomerizing an intermediate ester, namely, cis,trans-ethyl-2-phenylcyclopropanecarboxylate, by reacting said ester with anhydrous sodium ethoxide, to form a reaction product containing not more than about 5 percent cis ester and further reacting said resultant product to form trans-2-phenylcyclopropylamine.Type: GrantFiled: October 31, 1975Date of Patent: April 5, 1977Assignee: Nelson Research & Development CompanyInventor: Vithal Jagannath Rajadhyaksha
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Patent number: 4016223Abstract: Novel prostaglandin dehydrogenase inhibiting agents having the structural formula ##STR1## M is H or a pharmaceutically acceptable salt, X is hydrogen, dialkylaminomethyl, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, cyano, nitro, trihaloalkyl, --NR.sub.1 R.sub.2 or --NHCOR.sub.1 where R.sub.1 and R.sub.2 are hydrogen, lower alkyl or NH.sub.2 and n is 0-5.Type: GrantFiled: August 7, 1975Date of Patent: April 5, 1977Assignee: Nelson Research & Development CompanyInventors: Vithal J. Rajadhyaksha, Richard A. Schroer, Phillip J. Brock, Earl R. Krueger
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Patent number: 4007089Abstract: A method for binding biologically active compounds to carriers comprising reacting an asymmetric bifunctional linking compound having at least one phenyl azide moiety and at least one s-triazine moiety with a carrier in the presence of light to form a carrier bound to the linking compound through the phenyl azide moiety, and reacting said carrier bound to the linking compound with a biologically active compound under reaction conditions sufficient to bind the biologically active compound to the linking compound through the s-triazine moiety.Type: GrantFiled: April 30, 1975Date of Patent: February 8, 1977Assignee: Nelson Research & Development CompanyInventor: Nathan L. Smith, III
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Patent number: 4006204Abstract: The invention relates to compounds represented by the following general structure: ##STR1## and their method of making. These compounds are therapeutically useful as anti-inflammatory agents and operate as inhibitors of prostaglandin synthetase and also as prostaglandin receptor blockers.Type: GrantFiled: April 30, 1975Date of Patent: February 1, 1977Assignee: Nelson Research & Development CompanyInventors: Vithal J. Rajadhyaksha, James V. Peck, William D. Fairbairn
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Patent number: 3991203Abstract: There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-substituted azacyclopentan-2-one, as defined herein, and contacting the skin or other membranes of the human or animal with the resulting composition, whereby penetration of the skin or membranes is enhanced.Type: GrantFiled: June 19, 1975Date of Patent: November 9, 1976Assignee: Nelson Research & Development CompanyInventor: Vithal Jagannath Rajadhyaksha
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Patent number: 3991198Abstract: Methods of temporarily alleviating symptoms of hypersomnia or mental fatigue or drowsiness or temporarily suppressing appetite by administering to a human or animal having one or more of the aforementioned symptoms an effective amount of piperoxan together with a suitable pharmaceutical carrier. Piperoxan is also useful for potentiating the effects of anti-depressant drugs.Type: GrantFiled: June 25, 1975Date of Patent: November 9, 1976Assignee: Nelson Research & Development CompanyInventor: Kjell Fuxe
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Patent number: 3989815Abstract: There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of N-bis-azacyclopentan-2-onyl alkanes, as defined herein, and contacting the skin or other membranes of the human or animal with the resulting composition, whereby penetration of the skin or membranes is enhanced.Type: GrantFiled: June 19, 1975Date of Patent: November 2, 1976Assignee: Nelson Research & Development CompanyInventor: Vithal Jagannath Rajadhyaksha
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Patent number: 3989816Abstract: There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-substituted-azacycloheptan-2-one, as defined herein, and contacting the skin or other membranes of the human or animal with the resulting composition, whereby penetration of the skin or membranes is enhanced.Type: GrantFiled: June 19, 1975Date of Patent: November 2, 1976Assignee: Nelson Research & Development CompanyInventor: Vithal Jagannath Rajadhyaksha
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Patent number: 3988442Abstract: A method for stimulating the production of thyroid stimulating hormone (TSH) and enhancing thyroid function in animals comprising administering to an animal having low thyroid function an effective amount of a cyclic nucleotide derivative having the structural formula ##SPC1##Wherein R is selected from the group consisting of amino, thiomethyl and azido and pharmaceutically acceptable salts thereof.Type: GrantFiled: July 16, 1975Date of Patent: October 26, 1976Assignee: Nelson Research & Development CompanyInventor: Georges D. Cehovic
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Patent number: 3984501Abstract: Compounds having the structural formula ##SPC1##Wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, ##EQU1## NHCOR.sub.1, NR.sub.1 R.sub.2 or ##EQU2## where R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl; R, R.sub.1 and R.sub.2 being the same or different, T is 0 or 1 and n is 0-5; and pharmaceutically acceptable salts thereof.Type: GrantFiled: February 3, 1975Date of Patent: October 5, 1976Assignee: Nelson Research & Development CompanyInventors: Vithal J. Rajadhyaksha, James V. Peck, Julia J. Chouw
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Patent number: 3978216Abstract: A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a GABA-like compound such as Lioresal. Neuroleptic drugs are potentiated by coadministering to a schizophrenic a neuroleptic drug and a GABA-like drug such as Lioresal.Type: GrantFiled: July 16, 1975Date of Patent: August 31, 1976Assignee: Nelson Research & Development CompanyInventor: Kjell Fuxe