Patents Assigned to NeoMend, Inc.
  • Patent number: 11571493
    Abstract: Methods for preparing a PEG composition by co-precipitation of two or more components to produce a substantially homogenous powder. According to some embodiments, the two or more components are at least and partially soluble in a solvent, and at least one component is a functionalized PEG. Contacting the at least two component with the solvent at least partially dissolves the components which are then co-precipitated. The resulting product is substantially homogenous, unlike product made by other methods. The PEG composition may be co-precipitated with additional compounds, such as a colorant like indocyanine green.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 7, 2023
    Assignee: Neomend, Inc.
    Inventors: Tina Lanette McArthur, Tracy Hutchison, Jon McKannan, Charles Vaughn Cassingham
  • Patent number: 10987093
    Abstract: Devices and methods are disclosed for delivering sealing compound to a wound in animals, including humans. Such wound sealing is important after deep skin penetrating lacerations or subsequent to internal wounds. The apparatus utilize an aerosol dispensing system that both mixes and applies a multi-part sealant compound. The aerosol system includes a plurality of sealant component chambers, a source of pressurized gas, an aerosol mixing head, a pressure regulator, a pneumatic switch, and a component pumping mechanism. The aerosol system, either a reusable or a disposable device, is further provided with a system that keeps dry components from liquid components and then automatically mixes the liquid and dry components prior to application. The system provides for easy control over the application, inexpensive manufacture, and simplified preparation, thus minimizing the time needed for application and enhancing the potential outcomes of the patient.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: April 27, 2021
    Assignee: NeoMend, Inc.
    Inventors: Charles Vaughn Cassingham, William Jerome Mezger
  • Patent number: 10300223
    Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 28, 2019
    Assignee: Neomend, Inc.
    Inventor: Peter G. Davis
  • Patent number: 10144017
    Abstract: A nozzle tip assembly comprises a nozzle housing and a break-up insert. The nozzle assembly is adapted for receiving multiple pre-cursor fluids from multiple lumen. The pre-cursor fluids are kept substantially separate and forced around the break-up insert into a channel formed between the insert and the nozzle housing. Fluid is forced into fluted channels on a distal end of the break-up insert into a swirl chamber where mixing occurs prior to being expelled through an exit orifice in the nozzle housing.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 4, 2018
    Assignee: Neomend, Inc.
    Inventors: Peter G. Davis, Tina L. McArthur, Andrew J. Basilio, Kristina L. Clampitt
  • Patent number: 9662098
    Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: May 30, 2017
    Assignee: Neomend, Inc.
    Inventors: Peter Barker, Jr., William Jerome Mezger
  • Publication number: 20150374936
    Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 31, 2015
    Applicant: NEOMEND, INC.
    Inventor: Peter G. DAVIS
  • Publication number: 20150045455
    Abstract: Methods for preparing a PEG composition by co-precipitation of two or more components to produce a substantially homogenous powder. According to some embodiments, the two or more components are at least and partially soluble in a solvent, and at least one component is a functionalized PEG. Contacting the at least two component with the solvent at least partially dissolves the components which are then co-precipitated. The resulting product is substantially homogenous, unlike product made by other methods. The PEG composition may be co-precipitated with additional compounds, such as a colorant like indocyanine green.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 12, 2015
    Applicant: NEOMEND, INC.
    Inventors: Tina Lanette Mcarthur, Tracy Hutchison, Jon Mckannan, Charles Vaughn Cassingham
  • Publication number: 20140263749
    Abstract: A nozzle tip assembly comprises a nozzle housing and a break-up insert. The nozzle assembly is adapted for receiving multiple pre-cursor fluids from multiple lumen. The pre-cursor fluids are kept substantially separate and forced around the break-up insert into a channel formed between the insert and the nozzle housing. Fluid is forced into fluted channels on a distal end of the break-up insert into a swirl chamber where mixing occurs prior to being expelled through an exit orifice in the nozzle housing.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: NEOMEND, INC.
    Inventors: Peter G. DAVIS, Tina L. MCARTHUR, Andrew J. BASILIO, Kristina L. CLAMPITT
  • Patent number: 8802146
    Abstract: A blended electrophilic material with a first component having a functionality of at least three and a second component having a functionality of two is mixed with a nucleophilic material. The blended electrophilic material cross-links with the nucleophilic material to form a non-liquid, three dimensional structure which can applied, e.g., as an adhesion barrier.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: August 12, 2014
    Assignee: Neomend, Inc.
    Inventors: Charles Vaughn Cassingham, William Jerome Mezger
  • Publication number: 20140148791
    Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicant: Neomend, Inc.
    Inventors: Peter BARKER, Jr., William Jerome MEZGER
  • Patent number: 8642085
    Abstract: A blended electrophilic material with a first component having a functionality of at least three and a second component having a functionality of two is mixed with a nucleophilic material. The blended electrophilic material cross-links with the nucleophilic material to form a non-liquid, three dimensional structure which can applied, e.g., as an adhesion barrier.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: February 4, 2014
    Assignee: Neomend, Inc.
    Inventors: Charles Vaughn Cassingham, William Jerome Mezger
  • Patent number: 8641662
    Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: February 4, 2014
    Assignee: Neomend, Inc.
    Inventors: Peter Barker, Jr., William Jerome Mezger
  • Patent number: 8409605
    Abstract: A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: April 2, 2013
    Assignee: Neomend, Inc.
    Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
  • Patent number: 8409249
    Abstract: Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: April 2, 2013
    Assignee: Neomend, Inc.
    Inventors: Olexander Hnojewyj, Bruce Addis, Daniel Browne, David Cheung
  • Patent number: 8383144
    Abstract: A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: February 26, 2013
    Assignee: Neomend, Inc.
    Inventor: Olexander Hnojewyj
  • Patent number: 8221452
    Abstract: Systems and methods introduce a closure material to seal a vessel puncture site. The system and methods provide a catheter adapted for passage through a tissue puncture and sized to occupy substantially all the tissue puncture. The catheter includes a lumen in fluid communication with a fluid delivery port adjacent the catheter distal end. One or more dispensers are in fluid communication with the catheter lumen for dispensing first and second fluid compositions in the catheter lumen. An actuator causes the first and second fluid compositions to be dispensed from the dispensers and mixed by flowing the first and second fluid compositions through a static mixer. The first and second fluid compositions are dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form a nonfluent closure composition adjacent the vessel puncture site.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: July 17, 2012
    Assignee: Neomend, Inc.
    Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick, Eugene Skalnyi
  • Patent number: 8034367
    Abstract: A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: October 11, 2011
    Assignee: Neomend, Inc.
    Inventor: Olexander Hnojewyj
  • Publication number: 20110245803
    Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.
    Type: Application
    Filed: April 5, 2011
    Publication date: October 6, 2011
    Applicant: NEOMEND, INC.
    Inventors: Peter BARKER, JR., William Jerome MEZGER
  • Publication number: 20110245866
    Abstract: Devices and methods are disclosed for delivering sealing compound to a wound in animals, including humans. Such wound sealing is important after deep skin penetrating lacerations or subsequent to internal wounds. The apparatus utilize an aerosol dispensing system that both mixes and applies a multi-part sealant compound. The aerosol system includes a plurality of sealant component chambers, a source of pressurized gas, an aerosol mixing head, a pressure regulator, a pneumatic switch, and a component pumping mechanism. The aerosol system, either a reusable or a disposable device, is further provided with a system that keeps dry components from liquid components and then automatically mixes the liquid and dry components prior to application. The system provides for easy control over the application, inexpensive manufacture, and simplified preparation, thus minimizing the time needed for application and enhancing the potential outcomes of the patient.
    Type: Application
    Filed: April 5, 2011
    Publication date: October 6, 2011
    Applicant: NEOMEND, INC.
    Inventors: Charles Vaughn CASSINGHAM, William Jerome MEZGER
  • Publication number: 20110224721
    Abstract: A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.
    Type: Application
    Filed: May 23, 2011
    Publication date: September 15, 2011
    Applicant: NEOMEND, INC.
    Inventors: Stuart D. EDWARDS, Ronald LAX, Theodore L. PARKER, Thomas C. Wehman, Theodore Kucklick