Patents Assigned to NeoMend, Inc.
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Publication number: 20100173843Abstract: A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.Type: ApplicationFiled: December 17, 2009Publication date: July 8, 2010Applicant: NEOMEND, INC.Inventor: OLEXANDER HNOJEWYJ
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Publication number: 20100099852Abstract: A blended electrophilic material with a first component having a functionality of at least three and a second component having a functionality of two is mixed with a nucleophilic material. The blended electrophilic material cross-links with the nucleophilic material to form a non-liquid, three dimensional structure which can applied, e.g., as an adhesion barrier.Type: ApplicationFiled: December 17, 2009Publication date: April 22, 2010Applicant: NEOMEND, INC.Inventors: Charles Vaughn Cassingham, William Jerome Mezger
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Patent number: 7351249Abstract: Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.Type: GrantFiled: August 5, 2002Date of Patent: April 1, 2008Assignee: NeoMend, Inc.Inventors: Olexander Hnojewyj, Bruce Addis, Daniel Browne, David Cheung
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Patent number: 7318933Abstract: Systems, methods, and compositions achieve rapid closure of vascular puncture sites. The systems and methods form a vascular closure composition by mixing together a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material having a functionality of at least three. The second component includes a nucleophilic material that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material has a pH within the reaction pH range. The systems and methods apply the composition to seal a vascular puncture site.Type: GrantFiled: October 22, 2004Date of Patent: January 15, 2008Assignee: NeoMend, Inc.Inventor: Olexander Hnojewyj
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Patent number: 7279001Abstract: Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.Type: GrantFiled: May 8, 2002Date of Patent: October 9, 2007Assignee: NeoMend, Inc.Inventors: Bruce Addis, Charles Milo, Olexander Hnojewyj
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Patent number: 7247314Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: December 2, 2004Date of Patent: July 24, 2007Assignee: Neomend, IncInventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Patent number: 7081125Abstract: A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.Type: GrantFiled: March 8, 2004Date of Patent: July 25, 2006Assignee: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick
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Patent number: 6994686Abstract: A delivery device applies a biocompatible and biodegradable barrier material to a tissue region, e.g., to seal a vascular puncture site. The material comprises two liquid components, which are pre-packaged in individual dispensers. Upon mixing, the liquid components cross-link to create a barrier matrix. A holder attaches to the delivery device. The holder mutually supports the first and second dispensers while the protein solution and polymer solution are conveyed from the dispensers into a fluid delivery channel. The protein and polymer solutions mix as a result of flow through the channel.Type: GrantFiled: February 28, 2001Date of Patent: February 7, 2006Assignee: NeoMend, Inc.Inventors: Gregory M Cruise, Olexander Hnojewyj
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Patent number: 6949114Abstract: Systems and methods convey a closure material into a catheter to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components which, upon mixing, undergo a reaction to form a solid closure material composition. The systems and methods assure ease of delivery and effective mixing of the components to create an in situ barrier at the puncture site.Type: GrantFiled: February 9, 2001Date of Patent: September 27, 2005Assignee: NeoMend, Inc.Inventors: Charles F. Milo, Olexander Hnojewyj, Timothy J McCoy, Bruce S Addis
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Patent number: 6899889Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: March 7, 2000Date of Patent: May 31, 2005Assignee: NeoMend, Inc.Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Patent number: 6830756Abstract: Systems, methods, and compositions achieve rapid closure of vascular puncture sites. The systems and methods form a vascular closure composition by mixing together a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material having a functionality of at least three. The second component includes a nucleophilic material that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material has a pH within the reaction pH range. The systems and methods apply the composition to seal a vascular puncture site.Type: GrantFiled: February 9, 2001Date of Patent: December 14, 2004Assignee: NeoMend, Inc.Inventor: Olexander Hnojewyj
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Publication number: 20040176801Abstract: A closure device is provided for sealing a puncture in a body vessel. The closure device includes an energy delivery device for delivering energy to tissue adjacent the vessel puncture which enhances an adhesiveness of the tissue to a closure composition precursor.Type: ApplicationFiled: March 18, 2004Publication date: September 9, 2004Applicant: NeoMend, Inc.Inventors: Stuart D. Edwards, Thomas Wehman, Theodore L. Parker, Eugene V. Skalnyi, Theodore Kucklick, John Evans
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Publication number: 20040172058Abstract: A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.Type: ApplicationFiled: March 8, 2004Publication date: September 2, 2004Applicant: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick
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Patent number: 6743248Abstract: A closure device is provided for sealing a puncture in a body vessel. The closure device includes an energy delivery device for delivering energy to tissue adjacent the vessel puncture which enhances an adhesiveness of the tissue to a closure composition precursor.Type: GrantFiled: April 13, 2000Date of Patent: June 1, 2004Assignee: NeoMend, Inc.Inventors: Stuart D. Edwards, Thomas Wehman, Theodore L. Parker, Eugene V. Skalnyi, Theodore Kucklick, John Evans
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Patent number: 6733515Abstract: A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.Type: GrantFiled: March 10, 1998Date of Patent: May 11, 2004Assignee: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick
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Publication number: 20030191496Abstract: Systems and methods introduce a closure material to seal a vessel puncture site. The system and methods provide a catheter adapted for passage through a tissue puncture and sized to occupy substantially all the tissue puncture. The catheter includes a lumen in fluid communication with a fluid delivery port adjacent the catheter distal end. One or more dispensers are in fluid communication with the catheter lumen for dispensing first and second fluid compositions in the catheter lumen. An actuator causes the first and second fluid compositions to be dispensed from the dispensers and mixed by flowing the first and second fluid compositions through a static mixer. The first and second fluid compositions are dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form a nonfluent closure composition adjacent the vessel puncture site.Type: ApplicationFiled: April 3, 2003Publication date: October 9, 2003Applicant: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick, Eugene Skalnyi
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Publication number: 20030109866Abstract: A device and method are provided for sealing a puncture in a body vessel. The device has an elongated body having a proximal end and a distal end sized to be positioned within a lumen of the body vessel; at least one closure composition precursor lumen within the elongated body having a entrance port adjacent the proximal end of the elongated body through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen and an exit port adjacent the distal end of the elongated body through which the one or more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture; and a microwave antenna for delivering microwave energy adjacent the distal end of the elongated body to the fluent closure compound precursor. The microwave antenna according to this embodiment is preferably incorporated onto the elongated body adjacent the body distal end.Type: ApplicationFiled: January 7, 2002Publication date: June 12, 2003Applicant: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick, Eugene Skalnyi
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Publication number: 20030100921Abstract: Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.Type: ApplicationFiled: May 8, 2002Publication date: May 29, 2003Applicant: NeoMend, Inc.Inventors: Bruce Addis, Charles F. Milo, Olexander Hnojewyj
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Patent number: 6562059Abstract: A device and method are provided for sealing a puncture in a body vessel. The device has an elongated body having a proximal end and a distal end sized to be positioned within a lumen of the body vessel; at least one closure composition precursor lumen within the elongated body having a entrance port adjacent the proximal end of the elongated body through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen and an exit port adjacent the distal end of the elongated body through which the one or more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture; and a microwave antenna for delivering microwave energy adjacent the distal end of the elongated body to the fluent closure compound precursor. The microwave antenna according to this embodiment is preferably incorporated onto the elongated body adjacent the body distal end.Type: GrantFiled: April 23, 2002Date of Patent: May 13, 2003Assignee: NeoMend, Inc.Inventors: Stuart D. Edwards, Ronald Lax, Theodore L. Parker, Thomas C. Wehman, Theodore Kucklick, Eugene Skalnyi
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Publication number: 20030040760Abstract: Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.Type: ApplicationFiled: August 5, 2002Publication date: February 27, 2003Applicant: NeoMend, Inc.Inventors: Olexander Hnojewyj, Bruce Addis, Daniel Browne, David Cheung