Patents Assigned to Nereus Pharmaceuticals, Inc.
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Patent number: 8314251Abstract: The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).Type: GrantFiled: July 15, 2011Date of Patent: November 20, 2012Assignee: Nereus Pharmaceuticals, Inc.Inventors: Taotao Ling, Samuel Danishefsky
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Publication number: 20120282168Abstract: The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inhibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YY1, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN).Type: ApplicationFiled: April 26, 2012Publication date: November 8, 2012Applicants: Nereus Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Benjamin BONAVIDA, Michael PALLADINO
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Publication number: 20120277251Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Michael Palladino, George Kenneth Lloyd, Yoshio Hayashi
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Publication number: 20120270919Abstract: Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation.Type: ApplicationFiled: May 14, 2012Publication date: October 25, 2012Applicant: Nereus Pharmaceuticals, Inc.Inventors: Venkat Rami Reddy Macherla, Barbara Christine Potts, Rama Rao Manam, Katherine A. McArthur, Ta-Hsiang Chao, Saskia Theodora Cornelia Neuteboom
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METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF FOR TREATING INFECTIOUS DISEASES
Publication number: 20120264678Abstract: Disclosed are methods of treating infectious diseases comprising administering to an animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.Type: ApplicationFiled: June 6, 2012Publication date: October 18, 2012Applicant: NEREUS PHARMACEUTICALS, INC.Inventor: Michael Palladino -
Publication number: 20120238634Abstract: Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.Type: ApplicationFiled: March 9, 2012Publication date: September 20, 2012Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Michael A. Palladino, Emmanuel A. Theodorakis, Venkat Rami Reddy Macherla, Ta-Hsiang Chao, Young-Ger Suh
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Patent number: 8247552Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.Type: GrantFiled: April 4, 2011Date of Patent: August 21, 2012Assignee: Nereus Pharmaceuticals, Inc.Inventors: Michael Palladino, George Kenneth Lloyd, Yoshio Hayashi
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Patent number: 8227503Abstract: Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation.Type: GrantFiled: March 21, 2011Date of Patent: July 24, 2012Assignee: Nereus Pharmaceuticals, Inc.Inventors: Venkat Rami Reddy Macherla, Barbara Christine Potts, Rama Rao Manam, Katherine A. McArthur, Ta-Hsiang Chao, Saskia Theodora Cornelia Neuteboom
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Patent number: 8168803Abstract: Disclosed are methods of treating cancer, inflammatory conditions, and/or infectious disease in an animal comprising: administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.Type: GrantFiled: June 10, 2008Date of Patent: May 1, 2012Assignee: Nereus Pharmaceuticals, Inc.Inventors: Michael Palladino, Saskia Theodora Cornelia Neuteboom
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Patent number: 8133915Abstract: Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.Type: GrantFiled: January 14, 2011Date of Patent: March 13, 2012Assignees: Nereus Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Michael A. Palladino, Emmanuel A. Theodorakis, Venkat Rami Reddy Macherla, Ta-Hsiang Chao, Young-Ger Suh
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Patent number: 8067616Abstract: The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).Type: GrantFiled: October 27, 2010Date of Patent: November 29, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Taotao Ling, Venkata Rami Reddy Macherla, Barbara Christine Potts, Rama Rao Manam, Katherine A. McArthur
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Publication number: 20110269969Abstract: The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).Type: ApplicationFiled: July 15, 2011Publication date: November 3, 2011Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Taotao Ling, Samuel Danishefsky
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Publication number: 20110245260Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.Type: ApplicationFiled: April 4, 2011Publication date: October 6, 2011Applicant: Nereus Pharmaceuticals, Inc.Inventors: Michael Palladino, George Kenneth Lloyd, Yoshio Hayashi
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Patent number: 8003802Abstract: The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).Type: GrantFiled: March 6, 2009Date of Patent: August 23, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Taotao Ling, Samuel Danishefsky
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Publication number: 20110172285Abstract: Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation.Type: ApplicationFiled: March 21, 2011Publication date: July 14, 2011Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Venkat Rami Reddy Macherla, Barbara Christine Potts, Rama Rao Manam, Katherine A. McArthur, Ta-Hsiang Chao, Saskia Theodora Cornelia Neuteboom
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Publication number: 20110160309Abstract: Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.Type: ApplicationFiled: January 14, 2011Publication date: June 30, 2011Applicant: Nereus Pharmaceuticals, Inc.Inventors: Michael A. Palladino, Emmanuel A. Theodorakis, Venkat Rami Reddy Macherla, Ta-Hsiang Chao, Young-Ger Suh
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Patent number: 7956058Abstract: Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1?, R1?, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.Type: GrantFiled: June 7, 2006Date of Patent: June 7, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Yoshio Hayashi, Michael A. Palladino, Jr., Jennifer Grodberg
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Publication number: 20110105762Abstract: The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).Type: ApplicationFiled: October 27, 2010Publication date: May 5, 2011Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Taotao Ling, Venkata Rami Reddy Macherla, Barbara Christine Potts, Rama Rao Manam, Katherine A. McArthur
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Patent number: 7935704Abstract: Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1?, R1?, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.Type: GrantFiled: February 4, 2005Date of Patent: May 3, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Michael A. Palladino, George Kenneth Lloyd, Yoshio Hayashi, Benjamin Nicholson
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Patent number: 7919497Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.Type: GrantFiled: September 20, 2006Date of Patent: April 5, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Michael Palladino, George Kenneth Lloyd, Yoshio Hayashi