Abstract: A clot removal device for removing a clot from a body vessel, the clot removal device including: an elongated member sized to traverse vasculature and having a proximal end and a distal end, the elongated member comprising a longitudinal axis; and an engagement structure connected to the distal end of the elongated member, the engagement structure comprising a plurality of pinching cells connected to each other, the at least one pinching cell being configured to engage clot in an expanded deployed configuration and to pinch the clot upon actuation to the clot pinching configuration, a first pinching cell of the plurality of pinching cells being connected to a second pinching cell of the plurality of pinching cells such that the second pinching cell is rotatable respective the first pinching cell substantially about the longitudinal axis.

Abstract: Devices described herein include an actuated clot retrieval catheter system. The system includes a catheter having a frame disposed proximate the distal end of the catheter. The frame expands to form a seal with the inner wall of a vessel. In some examples, the frame also captures a clot for removal from the vessel. The frame is manufactured from a shape memory material that can be heat set into a predetermined shape. An electrical connection to an electronic circuit causes a current to run through the frame. The electrical resistance of the shape memory material causes the frame to heat and transition from a martensite to an austenite phase. When the frame is heat set into an expanded configuration, the current causes the frame heat and expand. When the frame is heat set into a closed configuration, the current causes the frame heat and collapse upon a clot.

Abstract: A joint assembly for an endovascular device, comprising a shaft comprising a main body and an enlarged end, a proximal strut comprising a slot, wherein the slot engages the enlarged end of the shaft and a locking collar comprising a proximal face and a distal face, and at least partially covering the enlarged end of the shaft and the slot of the proximal strut, such that the locking collar constrains the proximal strut such that the proximal strut cannot disengage from the enlarged end of the shaft when the joint assembly and the clot retrieval device is under load.

Abstract: A balloon guide catheter including a catheter shaft having a main lumen defined therein extending axially therethrough to receive a guidewire therein and an inflation lumen defined axially therein arranged semi-encircling the main lumen. The inflation lumen having an inlet port radially outward from the catheter shaft and an exhaust vent(s) disposed proximate the distal end of the catheter shaft. The exhaust vent(s) being disposed longitudinally through a distal terminating end of the inflation lumen or radially inward in fluid communication with the main lumen. A porous membrane is disposed at the exhaust vent(s) to permit only gas to pass therethrough. Secured about the outer surface proximate the distal end of the catheter shaft and coinciding with the inlet port is a balloon.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable to a diameter larger than the outer sheath through which it is delivered. The distal mouth of the tip can be beveled at an angle inclined from the longitudinal axis of the shaft. The braided tip can be braced with a reinforcing ring which can be welded or overmolded to the distal end of the braid and prevents the tip from collapsing under aspiration forces. The reinforcing ring can have relief features positioned to allow the oblique orientation of the ring to maintain a circular inner channel when the tip is compressed and delivered through a guide sheath and expanded at a target site. The distal tip can be expanded to a profile that is either symmetric or asymmetric with the catheter shaft.

Abstract: A self-expanding intravascular medical device including a multi-component assembly with a self-expanding outer cage component comprising a plurality of struts; and a single cell wave-shape component disposed within the self-expanding outer cage component forming a channel therein. The proximal end of the single cell wave-shape component is connected to the self-expanding outer cage component at a proximal joint.

Abstract: An aspiration catheter having a braid formed from a continuous braiding process and having a braided distal tip design with braid terminations joining strand ends is presented herein. The braid terminations can include sleeves, bands, crimps, or other types of connectors that secure pairs ends of oppositely-wound strands to each other at a distal circumference of the braid. The braid terminations can include radiopaque material to help visualize the distal end of the catheter during a procedure.

Abstract: A design capable of both mechanical thrombectomy and stenting for treating occlusions in the cerebral vasculature provides for a three-catheter setup. The first outer catheter has the largest diameter and can serve as a guide catheter while also being a sheath for the other catheters. The second deployment catheter can be configured for the aspiration of occlusions and can include a stepped or recessed section proximal of the distal tip that can act as a housing for a braided expandable stent. The outer diameter of this stepped section can be lined with an inflation device on top of which the braided stent sits. Internal to the second deployment catheter is a microcatheter which can deliver mechanical thrombectomy devices to the target site to retrieve an occlusion in the vessel, after which the stent can be expanded and implanted in the vessel.

Abstract: A system has an outer catheter and an inner aspirating clot retrieval catheter having an expansile distal tip for flow restriction, improved aspiration efficiency, and a large mouth into which a clot or other obstructions can be retrieved. The clot retrieval catheter can have a support tube proximal of the tip. The expansile tip can be a strut framework, and a flexible, low-modulus cover is disposed around at least a portion of the tip strut framework and the proximal support tube. The distal end of the tip can be encapsulated by a low-friction elastomeric lip for atraumatic contact with the walls of a blood vessel. The tip has a collapsed delivery configuration and expands radially into a deployed configuration. The tip strut framework, support tube, and cover can all have characteristics which enhance the deliverability of the clot retrieval catheter to the target.

Abstract: A system for removing an obstruction from a blood vessel. The system can include a catheter with a proximal section with a proximal section lumen diameter and a distal section with a distal section lumen diameter less than the proximal section lumen diameter. The system can include a clot retrieval device with a clot engaging element. The system can include a shaft advanceable through the lumen of the catheter to the obstruction in the vessel. The shaft can include a shaft proximal section, a shaft distal section attached to the clot engaging element with a diameter less than that of the shaft proximal section and configured to cross the obstruction. The shaft proximal section diameter can be larger than the diameter of the distal section lumen diameter of the catheter, thereby inhibiting the shaft proximal section from distally advancing through the catheter distal section.

Abstract: A clot retrieval catheter may have a tailored, highly flexible body section capable of navigating tortuous routes and an expandable tip for local flow restriction/arrest. The catheter may contain one or more spines extending the length of the elongate shaft which may be interwoven with the shaft braid. The distal portion of the spine may be formed into a spine hoop as part of the distal hoops of the tip section. Alternatively, the spine may form a loop around the shaft braid. Spines can be made from metal, polymer, or fiber strands. Polymer spines can be formed using a lamination or coextrusion manufacturing method. The support tube can also have a polymer jacket or membrane disposed around at least a portion of the structure.

Abstract: Designs are disclosed for devices capable of removing both firm and soft clots from body vessels that can have dual layers where an inner expandable body of cells runs within an outer expandable cage of cells. The designs can feature a constrained delivery configuration and an expanded deployed configuration. An outer cage can have wide opening struts to allow for clot integration into the device. Both the inner body and outer cage can be configured with shapes to pinch a clot in addition to embedding in it. The devices can also be capable of having a portion of the outer cage fold and invert proximally after engaging with a target clot to internalize it. These factors can increase the device's ability to capture clots of all compositions, allowing for safer and more efficient flow restoration.

Abstract: A clot removal device for removing a clot from a body vessel is presented. The device can facilitate clot retrieval by expanding in such a way as to engage the clot over a significant surface area. The clot can have at least one firm portion and at least one soft portion. At least one firm portion of the clot can be pinched by a proximal portion of the device while at least one soft portion of the clot can be retained by the distal portion of the device upon extraction. However, dislodgement and removal of the clot can cause softer portions the clot to shear or break, resulting in small floating fragments of clot in the vessel no longer attached to the main clot. This device can also capture and retain sheared or expanded distal portions of the clot upon removal of the clot from a vessel.

Abstract: Devices described herein include an actuated clot retrieval catheter system. The system includes a catheter having a metallic region positioned at the distal tip of the catheter. The metallic region includes at least two abutting metals in a bimetallic coil configuration. The bimetallic coil expands to form a seal with the inner wall of a vessel. In some examples, the bimetallic coil also captures a clot for removal from the vessel. The bimetallic coil is manufactured from metal-based materials having different thermal expansion coefficients. Conductive wires extend along a longitudinal axis of the catheter from an electrical current controller to at least a portion of the metallic region. Electrical current to the metallic region causes the bimetallic coil to transition from a tight configuration to an expanded configuration and remove the clot.

Abstract: A clot retrieval device for removing clot from a blood vessel, including a shaft; a plurality of expandable bodies distal of the shaft, each expandable body comprising a plurality of scaffolding segments forming closed cells, wherein at least one of the clot scaffolding segments terminates in a distal apex free from connection to an adjacent closed cell; and a plurality of clot inlet mouths between expandable bodies through which clot may pass and enter the device.

Abstract: A clot removal device for removing a clot from a body vessel is presented. The device can facilitate clot retrieval by expanding in such a way as to engage the clot over a significant surface area. The clot can have at least one firm portion and at least one soft portion. At least one firm portion of the clot can be pinched by a proximal portion of the device while at least one soft portion of the clot can be retained by the distal portion of the device upon extraction. However, dislodgement and removal of the clot can cause softer portions the clot to shear or break, resulting in small floating fragments of clot in the vessel no longer attached to the main clot. This device can also capture and retain sheared or expanded distal portions of the clot upon removal of the clot from a vessel.

Abstract: The designs herein can be for a flexible and kink-resistant catheter with a support tube which can be radially expanded to enable it to be slid over an inner liner on a mandrel during assembly. The designs are flexible enough to allow the catheter to access remote vessel occlusions but also benefit from good compressive and tensile stiffness. The designs can have a laser cut frame with interlocking structure of circumferentially discontinuous rib struts. The discontinuities can be aligned to form at least one continuous axial seam which is separable to allow for the radial expansion during manufacturing. A series of polymeric outer jackets can coat or encapsulate the struts of the frame, giving variable stiffness and preventing disengagement of the interlocking structure while the catheter is pushed through tortuous anatomy.

Abstract: A balloon guide catheter having a sleeved inflation lumen secured with a wire wrap for improved inflation lumen kink protection and a welded balloon construction provides a robust and flexible catheter with an exceptionally large inner lumen relative to its outer profile and enables rapid and reliable balloon inflation and deflation in a highly deliverable and kink resistant catheter. Balloon guide catheters having multiple sleeved inflation lumens and proximal luers for utilizing the multiple inflation lumens are also provided.

Abstract: The systems and devices disclosed herein are for a catheter tip that includes a support frame. The support frame can include a longitudinal axis, a collapsed delivery configuration, and an expanded deployed configuration. The support frame can include a collapsed inner diameter in the collapsed delivery configuration and a larger expanded inner diameter in the expanded deployed configuration when the support frame is placed in axial compression. In some examples, the support frame can include one or more profiled spine members extending along the longitudinal axis and a plurality of ribs extending from the one or more profiled spine members. In some examples, the support frame can include a connector rib and a plurality of offset ribs extending from the connector rib. One or more connector members can connect respective ribs of the offset ribs. In some examples, the support frame can include struts forming a lattice structure.

Abstract: A method and/or use of restoring blood flow in neurovasculature by removing thrombus in a plurality of human patients experiencing ischemic stroke using a revascularization device as either a first-line device or a second-line device.