Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: A clot capture catheter that includes an elongate tubular shaft and a distal tip section that extends distally from the elongate tubular shaft. The elongate tubular shaft includes a proximal end, a distal end, a lumen, and a tubular support which includes an inner layer comprising a polymer material disposed within the tubular support and an outer layer comprising an elastomeric material disposed over the tubular support. The distal tip section includes a first layer and a third layer comprising an elastomeric material, and a second layer comprising a polymer material.

Abstract: A balloon guide catheter including a catheter shaft having a reflowable material outer layer. Secured without an adhesive to the catheter shaft is a balloon having a bond interface area with a plurality of punctures defined therein secured about the outer layer of the catheter shaft via seepage of the reflowable material of the outer layer into the plurality of punctures forming a radially outward reflow bond between the catheter shaft and the balloon. Along the bond interface area about the perimeter of the opening in the balloon, a single reflow jacket is secured to the balloon via seepage of the reflowable material of the single reflow jacket into the plural punctures of the balloon forming a radially inward reflow bond. The single reflow jacket is made of a reflowable material and has an opening defined therein aligned with the balloon.

Abstract: A method for removing a clot from a vessel involves the use of a device that can have dual layers where an inner expandable member runs within an outer expandable member. The inner expandable member can be divided into one or more sections, with a proximal section having a clot pinching structure configured to pinch the clot between the pinching structure and an outer catheter. A distal flow channel section of the inner member can be configured to create a flow channel through the clot to restore blood to the downstream vasculature. The struts of the outer expandable member can form closed cells that are not fully circumferential in a proximal portion to allow a clot to pass inside and engage the pinching structure, and fully circumferential in a distal portion to scaffold the vessel for dislodging the clot. A protective element at the distal end of the device can prevent the escape of clot fragments.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: A design capable of both mechanical thrombectomy and stenting for treating occlusions in the cerebral vasculature provides for a three-catheter setup. The first outer catheter has the largest diameter and can serve as a guide catheter while also being a sheath for the other catheters. The second deployment catheter can be configured for the aspiration of occlusions and can include a stepped or recessed section proximal of the distal tip that can act as a housing for a braided expandable stent. The outer diameter of this stepped section can be lined with an inflation device on top of which the braided stent sits. Internal to the second deployment catheter is a microcatheter which can deliver mechanical thrombectomy devices to the target site to retrieve an occlusion in the vessel, after which the stent can be expanded and implanted in the vessel.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft configured to retract a first catheter over the elongate shaft. The shaft extension member comprising one or more raised profiles configured to interfere with one or more indentations along the elongate shaft such that the shaft extension member is configured to extend between a first length and an intermediate length. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: The disclosed technology includes a clot retrieval device being configured to retrieve a clot from a blood vessel and having a constrained delivery configuration and a clot engaging configuration. The device can include a first expandable framework having a first plurality of struts that form a first body and a second expandable framework having a second plurality of struts that form a second body upon the clot retrieval device transitioning from the constrained delivery configuration to the clot engaging configuration. In the clot engaging configuration, the first body can be configured to move from a first position to a second position in relation to the second body. Upon moving from the first position to the second position, the clot retrieval device can pinch the clot between the first body and the second body.

Abstract: An apparatus for controlling movement of a wire configured to deploy an implant is presented herein. The apparatus can include a wire including a bump and a valve including a friction element configured to apply a friction force to the wire. The friction force can vary based on one or more of: a speed at which the wire is pulled through the friction element, a direction in which the wire is pulled through the friction element, and a contact between the bump and the friction element. The wire can be configured to deploy an implant upon a proximal retraction of the wire.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A device for removing clot from a blood vessel includes a shaft. An expandable framework of struts is fixedly coupled to a distal region of the shaft. The struts can be radially expandable from a first to a second radially expanded state in a deployed configuration. An actuation cable can be connected to a plurality of connections of the engaging framework of struts to apply an expansion force, by the struts, as the struts are actuated by the actuation cable from the first radially expanded state to the second radially expanded state. In the first radially expanded state, a distal end of the struts is spaced a first axial distance away from the shaft, and wherein in the second radially expanded state, a distal end of the struts is spaced a second axial distance, different than the first axial distance, away from the shaft.

Abstract: Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate for clots comprising a higher ratio of red blood cells to fibrin.

Abstract: The disclosed technology can include a catheter braid that can comprise a first region, which can comprise a plurality of wire segments arranged in a first weave pattern, and a second region, which can have a plurality of wire segments arranged in a second weave pattern. The first weave pattern can transition to the second weave pattern at a first transitional point, which can be disposed at an intersection of the first region and the second region. The first transitional point can be where at least one wire of the plurality of wires of the first region can be removed from the second region. The catheter braid can comprise a uniform cross section area across a majority of the first region and a majority of the second region.

Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system including an aspiration catheter, a vacuum pump, and connected in fluid communication therebetween a positive pressure pulse generator mechanism including at least one displaceable member displaceable within a housing, wherein the at least one displaceable member controls passage therethrough the housing of the vacuum pressure and produces the positive pressure pulse by compressing collectable fluid therein. The system further including at least one actuator arranged externally of the housing displacing the at least one displaceable member within the housing.

Abstract: An aspiration vacuum source comprises a vessel having a positive pressure fluid chamber and a vacuum chamber. The vacuum source having a primary tubing, and the positive pressure fluid chamber connected in fluid communication with the primary tubing via an auxiliary tubing. A fluid piston is slidably received within the positive pressure fluid chamber. A vacuum piston is slidably received within the vacuum chamber and produces a vacuum within the vacuum chamber upon movement of the vacuum piston. The fluid piston and the vacuum piston are each fixedly attached to be movable together within the positive pressure fluid chamber and the vacuum chamber, respectively. A secondary tubing is connected in fluid communication to the vacuum chamber. A manual pump is connected in fluid communication with the primary tubing. A vacuum is producible in the vacuum chamber in response to repeated manipulation of the manual pump.

Abstract: Cyclic aspiration system producing a cyclic aspiration pressure waveform of intermittent cyclic intervals of vacuum pressure below atmospheric pressure and positive pressure higher than vacuum pressure. The system including flexible inlet tubing connected in fluid communication between a vacuum pump and an aspiration catheter. A positive pressure pulse generator mechanism intermittently cyclically applies an external force compressing a section of the flexible inlet tubing reducing internal volume and displacing fluid collectable therein thereby generating a positive pressure pulse. Upon withdrawal of the external force applied, the flexible inlet tubing is configured to be forcibly restorable to a non-compressed state increasing the internal volume while reducing pressure therein until eventual regeneration of the vacuum pressure thereby minimizing recovery time and maximizing cycling frequency.

Abstract: Cyclic aspiration system including an aspiration catheter and a cyclic aspiration source connected in fluid communication thereto, wherein the cyclic aspiration pressure source produces a cyclic aspiration pressure waveform of intermittently cycling intervals of a vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system further including a non-powered internal structural impediment disposed within the lumen of the aspiration catheter and configured to engage with a clot capturable therein during resulting movement between the clot and the non-powered internal structural impediment while subject to the cyclic aspiration pressure waveform to assist in capture of the clot. The non-powered internal structural impediment may be permanently attached to the aspiration catheter or a separate component or device independently slidable within the lumen of the aspiration catheter.

Abstract: A pulsatile aspiration system is herein disclosed that includes a catheter and pump system. The catheter includes an outer wall, a proximal section, a distal section, and an internal wall dividing the proximal section into a central main lumen and an auxiliary lumen. The pump system is in fluid communication with the catheter and independently controls the negative fluid pressure and the positive fluid pressure in the central main lumen and the auxiliary lumen so as to produce at the distal end of the catheter a pulsatile aspiration waveform variable between a maximum aspiration pressure and a maximum positive pressure. The maximum aspiration pressure is producible at the distal end of the catheter when the resulting pressure is exclusively negative fluid pressure, and the maximum positive pressure is producible at the distal end of the catheter when the positive fluid pressure counterbalances that of the negative fluid pressure.