Patents Assigned to NeuroNexus Technologies, Inc.
-
Patent number: 11690548Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.Type: GrantFiled: July 30, 2018Date of Patent: July 4, 2023Assignee: NeuroNexus Technologies, Inc.Inventors: Jamille Farraye Hetke, Daryl R. Kipke, Rio J. Vetter
-
Patent number: 11602630Abstract: A medical electrode array system comprising a thin-film substrate, a plurality of electrode contacts disposed on the thin-film substrate, and a plurality of traces. The plurality of electrode contacts is configured to provide electrical contact points. The plurality of traces is electrically connected to the plurality of electrode contacts. A electrode contact of the plurality of electrode contacts has a dedicated trace of the plurality of traces that provides electrical connectivity to the electrode contact. The thin-film substrate is configured to flex to maintain continuous contact with contours of patient anatomy. The plurality of traces includes flexible spring-like portions to add flexibility to the thin-film substrate.Type: GrantFiled: June 7, 2018Date of Patent: March 14, 2023Assignee: NeuroNexus Technologies, Inc.Inventors: Rio J. Vetter, Peter Gerow, David S. Pellinen, Carlos Rackham, Daryl R. Kipke, Jamille F. Hetke
-
Patent number: 11547849Abstract: Systems and methods for ruggedized neural probes are provided. Such probes may be adapted for penetrating tissue. An exemplary ruggedized penetrating electrode array system includes an elongate shank having one or more electrodes disposed on at least one exterior surface thereof and a backend structure. A proximal end of the elongate shank is secured to the backend structure. The exemplary array system further includes an elongate carrier secured to the backend structure and extending away from the backend structure toward the distal end of the elongate shank, the elongate carrier being more rigid than the elongate shank. Methods for fabricating such an array system are also provided.Type: GrantFiled: June 6, 2018Date of Patent: January 10, 2023Assignee: NeuroNexus Technologies, Inc.Inventors: Jamille Farraye Hetke, Rio J. Vetter, Carlos Rackham, Daryl R. Kipke
-
Patent number: 11524162Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.Type: GrantFiled: July 24, 2020Date of Patent: December 13, 2022Assignees: Medtronic Bakken Research Center B.V., NeuroNexus Technologies Inc.Inventors: Emil Toader, Hubert Cécile François Martens, Michel Marcel Jose Decré, Franciscus Paulus Maria Budzelaar, Pieter Gerrit Blanken, David James Anderson
-
Patent number: 11234627Abstract: An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.Type: GrantFiled: February 15, 2019Date of Patent: February 1, 2022Assignee: NeuroNexus Technologies, Inc.Inventors: John P. Seymour, Jongeun Jeon, Nicholas Hewitt, Abeer Khurram
-
Patent number: 11096614Abstract: A method for providing a neural interface system. At least one primary metallization layer is deposited on a substrate. The primary metallization layer has a thickness. A monolayer of nanospheres is deposited in a substantially uniform distribution. The nanospheres contact an upper surface of the primary metallization layer. The upper surface of the primary metallization layer not contacted by the nanospheres is treated to form a plurality of undulating structures having a substantially uniform arrangement. The treating comprises etching recesses part-way through the thickness of exposed portions of the primary metallization layer from the upper surface thereof.Type: GrantFiled: August 20, 2018Date of Patent: August 24, 2021Assignee: Neuronexus Technologies, Inc.Inventor: John P. Seymour
-
Patent number: 10946187Abstract: A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.Type: GrantFiled: December 18, 2017Date of Patent: March 16, 2021Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: Rio J. Vetter, Jamille Farraye Hetke, David S. Pellinen, Bencharong Suwarato, K C Kong
-
Patent number: 10842991Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.Type: GrantFiled: January 7, 2019Date of Patent: November 24, 2020Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: David S. Pellinen, Bencharong Suwarato, Rio J. Vetter, Jamille Farraye Hetke, Daryl R. Kipke
-
Publication number: 20200353261Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Applicants: Medtronic Bakken Research Center B.V., NeuroNexus Technologies, Inc.Inventors: Emil Toader, Hubert Cécile François Martens, Michel Marcel Jose Decré, Franciscus Paulus Maria Budzelaar, Pieter Gerrit Blanken, David James Anderson
-
Patent number: 10758727Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes.Type: GrantFiled: June 22, 2017Date of Patent: September 1, 2020Assignees: Medtronic Bakken Research Center B.V., NeuroNexus Technologies, Inc.Inventors: Emil Toader, Hubert Cécile François Martens, Michel Marcel Jose Decré, Franciscus Paulus Maria Budzelaar, Pieter Gerrit Blanken, David James Anderson
-
Patent number: 10688298Abstract: An implantable electrode system of is disclosed that includes a conductive electrode layer, an interconnect coupled to the electrode layer, an insulator that insulates the interconnect, and an anchor that more securely fixes the electrode layer in place. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording or stimulating function. A method for forming such an implantable electrode system includes forming an interconnect over a base layer, forming an anchoring structure over the base layer, depositing an insulating material layer over the interconnect structure and over the anchoring structure, exposing a portion of the interconnect structure, forming an electrode layer over the insulating layer, the electrode layer contacting the exposed portion of the interconnect structure.Type: GrantFiled: May 22, 2017Date of Patent: June 23, 2020Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: David S. Pellinen, Mayurachat Ning Gulari, Jamille Farraye Hetke, David J. Anderson, Daryl R. Kipke, Rio J. Vetter
-
Patent number: 10493297Abstract: An implantable optical electrode having a thin film electrode array including a plurality of electrodes, a light source associated with the thin film electrode array, and a passive bioactive agent delivery module associated with the thin film electrode array. Also disclosed are methods of manufacturing the array and a neural interface system with passive fluid delivery.Type: GrantFiled: July 25, 2012Date of Patent: December 3, 2019Assignee: NeuroNexus Technologies, Inc.Inventors: John P. Seymour, KC Kong, Rio J. Vetter
-
Patent number: 10252047Abstract: The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.Type: GrantFiled: April 14, 2015Date of Patent: April 9, 2019Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: John P. Seymour, Jamille Farraye Hetke, Rio J. Vetter, Daryl R. Kipke, David S. Pellinen, Kc Kong
-
Patent number: 10231636Abstract: An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.Type: GrantFiled: October 9, 2017Date of Patent: March 19, 2019Assignee: NeuroNexus Technologies, Inc.Inventors: John P. Seymour, Jongeun Jeon, Nicholas Hewitt, Abeer Khurram
-
Patent number: 10173051Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.Type: GrantFiled: October 21, 2014Date of Patent: January 8, 2019Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: David S. Pellinen, Bencharong Suwarato, Rio J. Vetter, Jamille Farraye Hetke, Daryl R. Kipke
-
Patent number: 10118030Abstract: A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.Type: GrantFiled: October 21, 2014Date of Patent: November 6, 2018Assignee: NeuroNexus Technologies, Inc.Inventors: David S. Pellinen, Bencharong Suwarato, Rio J. Vetter, Jamille Farraye Hetke, Daryl R. Kipke
-
Patent number: 10052476Abstract: Improved low-cost, highly reliable methods for increasing the electrochemical surface area of neural electrodes are described. A mono-layer of polymeric nanospheres is first deposited on a metallization supported on a dielectric substrate. The nanospheres self-assemble into generally repeating lattice forms with interstitial space between them. Then, the geometric surface area of the metallization material is increased by either selectively etching part-way into its depth at the interstitial space between adjacent nanospheres. Another technique is to deposit addition metallization material into the interstitial space. The result is undulation surface features provided on the exposed surface of the metallization. This helps improve the electrochemical surface area when the treated metallizations are fabricated into electrodes.Type: GrantFiled: November 16, 2015Date of Patent: August 21, 2018Assignee: NeuroNexus Technologies, Inc.Inventor: John P. Seymour
-
Patent number: 10034615Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.Type: GrantFiled: February 17, 2015Date of Patent: July 31, 2018Assignee: NeuroNexus Technologies, Inc.Inventors: Jamille Farraye Hetke, Daryl R. Kipke, Rio J. Vetter
-
Patent number: 9844660Abstract: A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.Type: GrantFiled: November 10, 2014Date of Patent: December 19, 2017Assignee: NEURONEXUS TECHNOLOGIES, INC.Inventors: Rio J. Vetter, Jamille Farraye Hetke, David S. Pellinen, Bencharong Suwarato, Kc Kong
-
Publication number: 20170326382Abstract: Waveguide neural interface devices and methods for fabricating such devices are provided herein. An exemplary interface device includes a neural device comprising an exterior neural device sidewall extending to a distal end portion of the neural device, an array of electrode sites supported by a first face of the neural device sidewall. The array includes a recording electrode site. The exemplary interface device further includes a waveguide extending along the neural device, the waveguide having a distal end to emit light to illuminate targeted tissue adjacent to the recording electrode site, and a light redirecting element disposed at the distal end of the waveguide. The light redirecting element redirects light traveling through the waveguide in a manner that avoids direct illumination of the recording electrode site on the first face of the neural device sidewall.Type: ApplicationFiled: May 8, 2017Publication date: November 16, 2017Applicant: NeuroNexus Technologies, Inc.Inventors: John P. Seymour, Mayurachat Ning Gulari, Daryl R. Kipke, KC Kong