Abstract: A tracer comprising a polymer coated ion exchange core either labelled with nuclide, stable or radioactive or unlabelled and finding particular utility in circulatory determinations in animals or in the chemical process industries to detect or measure fluid flow.

Abstract: Diagnostic compositions comprising serum albumin which has been treated to remove fats and fatty acids with possible changes in molecular conformation, a reducing agent, preferably a stannous reducing agent, and a radionuclide, preferably technetium-99m, are highly useful in study and diagnosis of morphology and functions of animal tissues and organs, particularly in studying cardiovascular dynamics, placental imaging, cisternography, in determining blood and plasma volumes, in metabolism and turnover studies, in radioscintigraphic diagnosis of the lung and reticuloendothelial systems, e.g. pulmonary emboli, bronchogenic carcinoma, pneumonitis, emphysema, tuberculosis, pathology of liver and/or spleen manifest by changes in size or shape or pathology of adjacent structures or displacement of these organs, and other disorders.For pulmonary and reticuloendothelial applications, the albumin is converted to particulate forms by denaturation under conditions which form aggregates of appropriate size.

Abstract: An improved solid-phase radioimmunological assay method for assay of an antigen in a biological fluid, e.g., blood plasma, by use of a solid phase polymeric substrate on which is adsorbed in solid phase an antibody composite layer, comprising a solid phase precoat of an anti-antibody (Ab.sup.2) (i.e., an antibody to an animal blood serum and sometimes referred to as a second antibody) bound to said substrate and a solid phase antibody Ab specific to said antigen (sometimes referred to as a primary antibody) immunologically bound to said anti-antibody precoat.

Abstract: A technetium-99m-stannous-phosphate complex in which the phosphate moiety includes pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile, nonpyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannous-phosphate complex in which the phosphate moiety is pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.

Abstract: Radionuclide diagnostic agents, comprising technetium-99m, a reducing agent, preferably a stannous reducing agent, and certain polyhydroxycarboxylic acids and derivatives thereof, i.e. glucoheptonic acid, lactobionic acid, galacturonic acid and glucuronic acid and salts thereof, are highly useful, both in the study and diagnosis of kidney morphology and function, and in the diagnosis of ischemic, infarcted or diseased tissue.

Abstract: A technetium-99m-stannous-phosphate complex in which the phosphate moiety includes pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile, nonpyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannous-phosphate complex in which the phosphate moiety is pyrophosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.

Abstract: Liquid scintillation counting compositions which include certain polyethoxylated poly(oxypropylene) emulsifiers allow stable dispersion of aqueous or other samples merely by shaking. Preferred are mixtures of such emulsifiers, which give homogeneous, monophasic-appearing dispersions over wide ranges of temperature and aqueous sample content. Certain of these emulsifiers, without being mixed, are of particular advantage when used in analysis of samples obtained through radioimmunoassay techniques, which are extremely difficult to disperse. Certain of these emulsifiers, also without being mixed, uniformly give homogeneous, monophasic appearing aqueous counting samples over much wider ranges of aqueous sample content and temperature than prior sample emulsifiers.