Patents Assigned to New York University
  • Holographic characterization of protein aggregates
    Patent number: 11385157
    Abstract: Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: July 12, 2022
    Assignee: New York University
    Inventors: David G. Grier, Michael D. Ward, Xiao Zhong, Chen Wang, Laura A. Philips, David B. Ruffner, Fook Chiong Cheong
  • Medical image data
    Patent number: 11386553
    Abstract: Medical image data is received at a data processing system, which is an artificial intelligence-based system. An identification process is performed at the data processing system to identify a subset of the medical image data representing a region of interest including one or more target tendons. A determination process is performed at the data processing system to determine one or more characteristics relating to one or more abnormalities of the one or more target tendons. Abnormality data is output, the abnormality data relating to the one or more abnormalities and being based on the one or more characteristics.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: July 12, 2022
    Assignees: Siemens Healthcare GmbH, New York University
    Inventors: Jin-hyeong Park, Sasa Grbic, Matthias Fenchel, Esther Raithel, Dana Lin
  • SYSTEMS AND METHODS FOR INTERPOLATIVE THREE-DIMENSIONAL IMAGING WITHIN THE VIEWING ZONE OF A DISPLAY
    Publication number: 20220217301
    Abstract: Methods and systems for three-dimensional video capture are provided. A plurality of cameras (112) attached to a frame (108), each camera (112) configured to generate a three-dimensional array of pixels of a viewing zone of a display (110), may provide the arrays to an interpolator (122) executed by a processor (116) of a device (100). The interpolator (122) may combine the plurality of three-dimensional arrays of pixels from the plurality of cameras (112) into an output three-dimensional array of pixels for rendering locally at a display (110) or transmission to a remote device (102) for rendering at a display (110) of the remote device (102).
    Type: Application
    Filed: April 15, 2019
    Publication date: July 7, 2022
    Applicant: SHANGHAI NEW YORK UNIVERSITY
    Inventors: Cameron BALLARD, Bruce LUO, David SANTIANO, Michael NAIMARK, Grace HUANG, Mateo JUVERA MOLINA, Ada ZHAO
  • Periodontal disease therapy
    Patent number: 11376216
    Abstract: Disclosed are formulations for oral films and other compositions containing therapeutic agents. The therapeutic agents interfere with succinate/succinate receptor signaling. The films and compositions of the present disclosure can be used to treat periodontal disease.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: July 5, 2022
    Assignee: New York University
    Inventors: Xin Li, Deepak Saxena
  • CRYSTALLINE FORMS OF IMIDACLOPRID AND METHODS OF USE THEREOF
    Publication number: 20220204480
    Abstract: The present invention relates to crystalline polymorphs of imidacloprid for effective pest management strategies at lower dosages. The present invention further relates to processes of preparing the crystalline polymorphs, and to methods of controlling pests using the novel crystalline polymorphs.
    Type: Application
    Filed: December 10, 2021
    Publication date: June 30, 2022
    Applicant: New York University
    Inventors: Xiaolong ZHU, Jingxiang YANG, Chunhua T. HU, Michael D. WARD, Bart KAHR
  • Speculum sleeve
    Patent number: 11369260
    Abstract: The present invention relates to expandable sleeves, expandable sleeve systems, and their methods of use. In certain aspects, the expandable sleeves are compatible with commonly used speculums to enhance visualization and access of an orifice. The expandable sleeves sheathe over the blades of a speculum and form a taut barrier when the blades are opened to hold back the walls of a tissue orifice and cavity. The expandable sleeves include inflatable pouches that further push back the walls of the orifice. In certain aspects, the expandable sleeves are useful in performing pelvic exams, such as in patients having lax vaginal walls or excess surrounding tissue.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: June 28, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventor: Jacqueline F. Ford
  • INTERNEURON-SPECIFIC THERAPEUTICS FOR NORMALIZING NEURONAL CELL EXCITABILITY AND TREATING DRAVET SYNDROME
    Publication number: 20220195457
    Abstract: Provided are therapeutic virus vectors, particularly, recombinant adeno-associated virus (rAAV) vectors, designed to contain an enhancer sequence that specifically restricts expression of an effector gene (e.g., an SCN1A-encoding polynucleotide, Gq-DREADD-encoding polynucleotide, or PSAM-encoding polynucleotide) contained in the vector to PV-expressing GABAergic interneuron or to neuron cell populations in the brain. The rAAV vectors, compositions and methods thereof are useful for treating subjects afflicted with neuropathologies, seizures, pharmacologically-intractable forms of epilepsy including Dravet syndrome (DS), a form of infantile epilepsy associated with severe seizures, cognitive impairment and premature death, as the cause of DS involves loss of function of a sodium channel encoded by the SCN1A gene.
    Type: Application
    Filed: January 27, 2020
    Publication date: June 23, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, NEW YORK UNIVERSITY
    Inventors: Jordane DIMIDSCHSTEIN, Gordon FISHELL, Orrin DEVINSKY
  • Directionally targeted jet noise reduction system and method
    Patent number: 11365704
    Abstract: An exemplary engine noise reduction system, can be provided, which can include a noise reduction fluid source, and a microjet(s) placed at an axial location downstream from a nozzle exit of an engine and configured to asymmetrically inject a noise reduction fluid from the noise reduction fluid source into a jet flow of the engine. The engine can be a jet engine. The microjet(s) can include four microjets, which can be about 90 degrees apart in a plane at the axial location. The four microjets can be asymmetric microjets. The microjet(s) can be configured to inject the noise reduction fluid in a direction that is normal with respect to the jet flow.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: June 21, 2022
    Assignee: NEW YORK UNIVERSITY IN ABU DHABI CORPORTION
    Inventors: Sunil Kumar, Pankaj H. Rajput
  • System, method and computer-accessible medium for characterizing prostate microstructure using water diffusion and nuclear magnetic resonance relaxation
    Patent number: 11366190
    Abstract: An exemplary system, method and computer-accessible medium for characterizing a microstructure of a prostate of a patient can be provided, which can include, for example, generating a magnetic resonance (MR) radiofrequency (RF) pulse(s) by varying (i) a diffusion time, (ii) a diffusion gradient direction, (iii) a diffusion gradient pulse width, or (iv) a diffusion gradient pulse shape, applying the MR RF pulse(s) to the prostate of the patient, receiving a resultant MR signal from the prostate of the patient that can be based on the MR RF pulse(s), determining information regarding a plurality of compartments for the prostate from the resultant MR signal by varying an echo time or a mixing time, and characterizing the microstructure for each of the compartments by applying a microstructural model(s) to each of the compartments.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: June 21, 2022
    Assignee: New York University
    Inventors: Dmitry Novikov, Els Fieremans, Gregory Lemberskiy
  • Classification and mutation prediction from histopathology images using deep learning
    Patent number: 11367180
    Abstract: Systems and methods for classification and mutation prediction from histopathology images using deep learning. In particular, the examples described herein utilize lung cancer as an example, in particular adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) as two subtypes of lung cancer to identify and distinguish between.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: June 21, 2022
    Assignee: New York University
    Inventors: Nicolas Coudray, Paolo Santiago Ocampo, Andre L. Moreira, Narges Razavian, Aristotelis Tsirigos
  • METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING AUTOIMMUNE DISEASES
    Publication number: 20220184196
    Abstract: The application relates to methods for the diagnosis, treatment, and prevention of autoimmune and/or inflammatory disease such as systemic lupus erythematosus (SLE), lupus nephritis, IgA nephropathy, other types of glomerulonephritis.
    Type: Application
    Filed: December 20, 2021
    Publication date: June 16, 2022
    Applicant: New York University
    Inventor: Gregg SILVERMAN
  • Electrohydrogenation of nitriles
    Patent number: 11359295
    Abstract: Provided are methods of making aliphatic or aromatic compounds (e.g., small molecules or polymers) having one or more amine groups and/or imine groups. A method of the present disclosure is an electrohydrogenation method, where a potential is applied to an aliphatic or aromatic compound (e.g., small molecule or polymer) having one or more nitrile groups, where after the potential is applied one or more of the nitrile groups are reduced to an amine or imine. The electrohydrogenation may be carried out using non-pulsed or pulsed potential waveforms.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: June 14, 2022
    Assignee: New York University
    Inventors: Miguel A. Modestino, Daniela Eugenia Blanco, Zainub Aaliyah Imran Dookhith
  • Holographic characterization of protein aggregates
    Patent number: 11346761
    Abstract: Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: May 31, 2022
    Assignee: New York University
    Inventors: David G. Grier, Michael D. Ward, Xiao Zhong, Chen Wang, Laura A. Philips, David B. Ruffner, Fook Chiong Cheong
  • Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
    Patent number: 11332506
    Abstract: The present invention is directed to polymerized products and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: May 17, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Thomas M. Wisniewski, Fernando Goni
  • Electrohydrodimerization of aliphatic olefins with electrochemical potential pulses
    Patent number: 11313045
    Abstract: Methods of making aliphatic compounds having two or more electron withdrawing groups and compositions comprising aliphatic organic compounds having one or more electron withdrawing groups. The methods are based on electrohydrodimerization of aliphatic olefinic compounds having one or more electron withdrawing groups using pulsed potential waveforms. A method may produce adiponitrile by electrolysis of acrylonitrile using pulsed waveforms. A composition may be an electrochemically produced organic phase composition. A composition may comprise one or more undesirable products, such as, for example, propionitrile, AN-derived oligomers, and the like. A composition may not have been subjected to any purification and/or separation after electrochemical production of one or more aliphatic compounds comprising two or more electron withdrawing groups.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: April 26, 2022
    Assignee: New York University
    Inventors: Miguel A. Modestino, Daniela Eugenia Blanco Jimenez
  • Molecular host frameworks and methods of making and using same
    Patent number: 11312681
    Abstract: Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 26, 2022
    Assignee: New York University
    Inventors: Michael David Ward, Yuantao Li, Chunhua Tony Hu
  • Methods and kits for assessing central nervous system integrity
    Patent number: 11304601
    Abstract: The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction or associated cranial nucleus or supranuclear input, useful for detecting, diagnosing or screening for increased intracranial pressure, or useful for detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure by tracking eye movement of the subject. The methods may be performed by a) analyzing eye movement of the subject; b) comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement; and c) identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: April 19, 2022
    Assignees: New York University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Uzma Samadani, Shani Offen, Marisa Carrasco-Queijeiro, David Heeger
  • Sensor having a set of plates, and method
    Patent number: 11301083
    Abstract: A sensor having a set of plates that are in contact from their bottom at the corners with a set of protrusions that are in contact from above with a plurality of intersections, each having a sensing element, of a grid of wires disposed on a base, and a top surface layer that is disposed atop the set of plates, so that force imparted from above onto the top surface layer is transmitted to the plates and thence to the protrusions, and thence to the intersections of the grid of wires which are thereby compressed between the base and protrusions; and that the protrusions above thereby focus the imparted force directly onto the intersections. A sensor includes a computer in communication with the grid which causes prompting signals to be sent to the grid and reconstructs a continuous position of force on the surface from interpolation based on data signals received from the grid. A method for sensing.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: April 12, 2022
    Assignees: New York University, Tactonic Technologies, LLC
    Inventors: Kenneth Perlin, Charles Hendee, Alex Grau, Gerald Seidman
  • Electrical inhibition (EI) uterine pacemaker for controlling uterine contractions
    Patent number: 11291831
    Abstract: In an aspect of the present disclosure, a system and method for controlling uterine contractions is disclosed including receiving data from at least one sensor by a wireless apparatus inserted into the patient's vagina adjacent the cervix. The data includes an indication that a contraction of the uterus is imminent. The method further includes in response to receiving the data, causing a generator circuit of the wireless apparatus to supply electrical energy to an energy applicator of the wireless apparatus that is configured to apply the supplied electrical energy to the uterus of the patient via the cervix of the patient to control contractions of the patient's uterus.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 5, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Jeffrey Karsdon, Frederick Naftolin, Vikram Kapila, Ashwin Raj Kumar
  • Avobenzone-dendrimer conjugates
    Patent number: 11291620
    Abstract: The present invention relates to avobenzone-dendrimer conjugates comprising: a polyamide dendrimer conjugated with 1 to 18 units of avobenzone. Also disclosed are sunscreen formulations comprising an avobenzone-dendrimer conjugate and a dermatologically acceptable vehicle.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: April 5, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Marcus Weck, Elizabeth Anne Kaufman