Patents Assigned to New York University
  • Patent number: 11583525
    Abstract: A method is disclosed for treating a cancer in a subject that involves administering to the subject a therapeutically affective amount of a geranylgeranyltransferase I (GGTase I) inhibitor, such as GGTI-2418, wherein the cancer comprises a defective PTEN, a hyperactivated FBXL2, or a low level of IP3R3. In some embodiments, the method further involves administering to the subject a therapeutically affective amount of an Akt inhibitor.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: February 21, 2023
    Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., NEW YORK UNIVERSITY
    Inventors: Said M. Sebti, Michele Pagano, Shafi Kuchay
  • Patent number: 11584782
    Abstract: Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB, antibodies specific to LukA, antibodies specific to LukB, therapeutic compositions containing LukA and/or LukB, or anti-LukA and/or anti-LukB antibodies, uses of the compositions to treat acute inflammatory conditions or S. aureus infection, methods for identifying inhibitors of LukAB-mediated cytotoxicity of human phagocytes, and methods for using LukAB as a marker to predict severity of S. aureus infection.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: February 21, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Victor J. Torres, Ashley L. Dumont
  • Patent number: 11570987
    Abstract: Described herein are compounds, pesticidally acceptable salts thereof, and compositions thereof that are useful, for example, for pest management and for controlling pests. In certain embodiments provided are enantioenriched and/or enantiopure compounds and pesticidally acceptable salts thereof, and methods of making same. Methods of controlling pests with the compounds of the disclosure are also provided.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: February 7, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Xiaolong Zhu, Jingxiang Yang, Michael D. Ward, Bart Kahr
  • Patent number: 11564667
    Abstract: The invention relates to methods and compositions for restoring normal microbiota in pre-term newborns or newborns delivered by Cesarean section and methods for preventing or ameliorating diseases associated with delivery by Cesarean section or pre-term birth comprising administering to said newborns at the time of birth or shortly thereafter an effective amount of a vaginal microbiota inoculum obtained from the newborn's mother or a donor or an effective amount of a probiotic composition. The invention also relates to a device for collecting maternal vaginal microbiota from the vaginal canal of a patient. The device can have a housing forming a cavity, an absorbent material removable disposed within the cavity, and a deployment element disposed in the housing and movable along a length of the housing. The movement of the deployment element can displace the absorbent material out of the cavity and in to the vaginal canal.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 31, 2023
    Assignee: New York University
    Inventor: Maria Gloria Dominguez-Bello
  • Patent number: 11560359
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: January 24, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Richard Bonneau, Kevin Drew
  • Patent number: 11559682
    Abstract: A cochlear implant includes an electrode array having a plurality of electrode contacts arranged along at least a portion of a length of an electrode array, and a processing arrangement configured to map at least one electrode contact to first and/or second mappings. The first mapping provides a first electrical stimulation from the electrode contact to a first ground electrode positioned external to a patient's cochlea to stimulate hearing at a first location in the cochlea positioned adjacent to the electrode contact when the implant is inserted into the cochlea. The second mapping provides a second electrical stimulation from the electrode contact to the second ground electrode to stimulate hearing at a location in the cochlea positioned further towards the apex of the cochlea as compared to a distal end of the electrode array when the implant is inserted into the cochlea.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: January 24, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: David M. Landsberger, J. Thomas Roland
  • Patent number: 11552238
    Abstract: A method of fabricating a superconducting-semiconducting stack includes cleaning a surface of a substrate, the substrate comprising a group IV element; depositing an insulating buffer layer onto the substrate, the insulating buffer layer comprising the group IV element; depositing a p-doped layer onto the insulating buffer layer; depositing a diffusion barrier onto the p-doped layer; and processing the superconducting-semiconducting stack through dopant activation.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: January 10, 2023
    Assignee: New York University
    Inventors: Javad Shabani, Kasra Sardashti
  • Patent number: 11543338
    Abstract: Holographic Video Microscopy analysis of non-spherical particles is disclosed herein. Properties of the particles are determined by application of light scattering theory to holography data. Effective sphere theory is applied to provide information regarding the reflective index of a sphere that includes a target particle. Known particles may be co-dispersed with unknown particles in a medium and the holographic video microscopy is used to determine properties, such as porosity, of the unknown particles.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: January 3, 2023
    Assignees: New York University, Spheryx, Inc.
    Inventors: David G. Grier, Mary Ann Odete, Fook Chiong Cheong, Annemarie Winters, Jesse J. Elliott, Laura A. Philips
  • Patent number: 11538553
    Abstract: A system for identifying and evaluating a pocket of a protein includes performing a Voronoi tessellation and developing a Voronoi diagram of a surface of the protein. All alpha-spheres on the surface of the protein are identified. The alpha-spheres are filtered based on radius and remaining alpha-spheres are clustered into alpha-clusters. At least one alpha-cluster is selected for quantitative evaluation. Alpha-sphere contact atoms are determined for a plurality of interaction points of the pocket. A Delaunay triangulation of the four contact atoms of each interaction point is performed. A plurality of alpha-spaces for each interaction point are determined. An alpha-atom and an alpha-atom contact surface area (ACSA) of each interaction point is determined. The pocket is ranked, a pocket-fragment complementarity is determined, and the pocket is matched between various conformations of the proteins.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 27, 2022
    Assignee: New York University
    Inventors: Yingkai Zhang, David Rooklin
  • Patent number: 11535855
    Abstract: Methods for increasing or decreasing Nitrogen (N) uptake/assimilation and/or usage in plants comprising over-expressing or repressing one or more transcription factors that have been identified by evaluating temoporal transcription of the TFs in response to N signaling and validated based on TF perturbation studies in plant cells and plants. Combinations of TFs may be used, where each TF may be independently induced or repressed to achieve a desired increase or decrease in N uptake/assimilation.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: December 27, 2022
    Assignee: New York University
    Inventors: Gloria M. Coruzzi, Matthew Brooks, Kranthi Varala
  • Patent number: 11529069
    Abstract: An exemplary system, method and computer-accessible medium for generating a denoised magnetic resonance (MR) image(s) of a portion(s) of a patient(s) can be provided, which can include, for example, generating a plurality of MR images of the portion(s), where a number of the MR images can be based on a number of MR coils in a MR apparatus used to generate the MR images, generating MR imaging information by denoising a first one of the MR images based on another one of the MR images, and generating the denoised MR image(s) based on the MR imaging information. The number of the MR coils can be a subset of a total number of the MR coils in the MR apparatus. The number of the MR coils can be a total number of the MR coils in the MR apparatus. The MR information can be generated by denoising each of the MR images based on the other one of the MR images.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: December 20, 2022
    Assignee: New York University
    Inventors: Dmitry Novikov, Gregory Lemberskiy, Steven H. Baete, Jelle Veraart, Els Fieremans
  • Patent number: 11533593
    Abstract: An exemplary multi-robot system can include, for example, a first robot(s), which can include a communication arrangement and a sensor arrangement configured to detect a presence of an object(s) within a predetermined distance from the first robot(s), and determine a distance from the first robot(s) to the object(s), where the first robot(s) can broadcast a query to the object(s) using the communication arrangement, identify the object(s) as a second robot(s) or a non-robot based on a response received from the object(s). The sensor arrangement can be a Light Detection and Ranging (LiDAR) sensor arrangement. The LiDAR sensor arrangement can be a two-dimensional LiDAR sensor arrangement.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: December 20, 2022
    Assignee: New York University
    Inventors: Saiprasanth Krishnamoorthy, Vikram Kapila
  • Patent number: 11519920
    Abstract: The present invention relates to antibody-based probes (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to a phospho-serine-containing epitope of Tau, such as, for example, Tau-phospho-serine 396/404 peptide. Such imaging ligands are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The scFv molecules of the present invention have utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: December 6, 2022
    Assignee: New York University
    Inventor: Einar M. Sigurdsson
  • Patent number: 11517221
    Abstract: The present disclosure is directed to indicating systems and methods for incontinence products. The indicating system may include an indicator panel for an incontinence product that is adapted to provide a qualitative or quantitative indication of a characteristic of a liquid absorbed by the indicator panel.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: December 6, 2022
    Assignees: New York University, Pixie Scientific TTC
    Inventors: Andrew D. Hollingsworth, Scott Meek, William Gotimer
  • Patent number: 11523399
    Abstract: An exemplary system, method and computer-accessible medium for determining a degradation(s) of a wireless link(s) can be provided, which can include, for example, periodically determining a wireless channel quality of the wireless link(s) between a sender and a receiver, recording a history of the wireless channel quality, determining whether a plurality of diffractive pulses are present based on the history and determining the degradation(s) based on the presence of the plurality of diffractive pulses. The wireless channel can be in a beam-forming direction. The degradation(s) can be an impending degradation.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: December 6, 2022
    Assignee: New York University
    Inventors: Dennis Shasha, Aditya Dhananjay, Marco Mezzavilla, Sundeep Rangan
  • Publication number: 20220374070
    Abstract: A system for producing a shared virtual reality having a communication network. The system has a plurality of inside-out tracked HMDs that are worn by participants to view the shared virtual reality in communication with the network, right and left hand controllers that are held by the participant and right and left trackers that are worn on the ankles or feet of the participant. The system has a server computer in communication with the network which produces a full body pose of at least one of participant of the participants and transmits the full body pose via the network to all other participants HMD, so that each participant can see the full body pose in each participant's view into the shared virtual reality. A method for producing a shared virtual reality of participants.
    Type: Application
    Filed: August 4, 2022
    Publication date: November 24, 2022
    Applicants: New York University, Tactonic Technologies, LLC
    Inventors: Kenneth Perlin, Benjamin Ahlbrand, Charles Hendee
  • Patent number: 11508128
    Abstract: A system for viewing a shared virtual reality having a plurality of virtual reality headsets. Each headset producing a shared virtual reality that is viewed by persons wearing the headsets. The system comprises a communication network to which each headset is in communication to send and receive a virtual orientation and a virtual position associated with each person of the persons wearing the headsets. The system comprises a computer in communication with each headset through the network which transmits a virtual audience that is viewed by each headset. The virtual audience formed from the virtual orientation and the virtual position associated with each person wearing the headset over time as each person views the virtual story, so each person views in the headset the person is wearing the virtual story, the virtual orientation and virtual position of each other person of the persons wearing the headset. A method for viewing a shared virtual reality.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: November 22, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Sebastian Herscher, Kenneth Perlin, Kris Layng
  • Patent number: 11504455
    Abstract: A processing technique for creating nanowires and hierarchically porous micro/nano structures of ceramic materials is provided. The process includes evaporation of micron-sized water droplets containing dissolved organic salts on heated substrates followed by thermal decomposition of the deposited material. The micron-sized droplets may be generated by supercritical CO2 assisted nebulization, in which high-pressure streams of aqueous solution and supercritical CO2 are mixed, followed by controlled depressurization through a fine capillary. Rapid evaporation takes place on the heated substrates and structures are generated due to CO2 effervescence from the droplets and evaporation of water, along with the pinning of the three phase contact line. Depending on the mass deposited, a mesh of nano-wires or membrane-like structures may result. Sintering of the membrane-like scaffolds above the decomposition temperature of the organic salt creates nanopores within the structures, creating a dual hierarchy of pores.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: November 22, 2022
    Assignee: New York University
    Inventors: Sachin Khapli, Ramesh Jagannathan
  • Patent number: 11498255
    Abstract: A method of extruding filament comprises the steps of cutting a bulk source material into pieces having size S1, performing a first extrusion pass comprising the steps of melting the pieces in an extruding device at a temperature T1 and extruding a first filament at an extrusion speed V1, and performing at least one additional extrusion pass k comprising the steps of cutting the first filament into pieces having size Sk, melting the pieces in an extruding device at temperature Tk, and extruding a final filament at an extrusion speed Vk. A system for extruding filament is also described.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: November 15, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Nikhil Gupta, Brooks Saltonstall, Ashish Kumar Singh
  • Patent number: 11492401
    Abstract: The present invention relates to antibody-based molecules, including full-length antibodies, antigen-binding domains thereof, and antibody derivatives that are capable of binding to and activating human muscle-specific tyrosine protein kinase (MuSK). The present invention further discloses methods of treating neuromuscular conditions using the aforementioned MuSK antibodies.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: November 8, 2022
    Assignees: NEW YORK UNIVERSITY, ARGENX IIP BV
    Inventors: Steven J. Burden, Shohei Koide, Akiko Koide, Nadia Leloup, Julien Oury, Karen Silence, Roeland Vanhauwaert, Christophe Blanchetot