Patents Assigned to NexMed Holdings, Inc.
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Patent number: 11246932Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: GrantFiled: March 30, 2018Date of Patent: February 15, 2022Assignee: NEXMED HOLDINGS, INC.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
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Patent number: 10632086Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: GrantFiled: December 15, 2017Date of Patent: April 28, 2020Assignee: NEXMED HOLDINGS, INC.Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Publication number: 20190076529Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: ApplicationFiled: March 30, 2018Publication date: March 14, 2019Applicant: NEXMED HOLDINGS, INC.Inventors: Tian WEN, Liu LIU, Mingqi LU, Jieshan BAI, Y. Joseph MO
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Publication number: 20180333377Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: ApplicationFiled: December 15, 2017Publication date: November 22, 2018Applicant: NEXMED HOLDINGS, INC.Inventors: Daniel W. FRANK, Richard MARTIN, Bassam B. DAMAJ
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Patent number: 9855231Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: GrantFiled: July 29, 2016Date of Patent: January 2, 2018Assignee: NEXMED HOLDINGS, INC.Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Patent number: 9517218Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: GrantFiled: January 7, 2015Date of Patent: December 13, 2016Assignee: NEXMED HOLDINGS, INC.Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Publication number: 20160331761Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: ApplicationFiled: July 29, 2016Publication date: November 17, 2016Applicant: Nexmed Holdings, Inc.Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Publication number: 20160067266Abstract: A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester a (C1-C4)-alkyl (C8-C22) carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).Type: ApplicationFiled: November 13, 2015Publication date: March 10, 2016Applicant: NEXMED HOLDINGS, INC.Inventors: William Shifeng WEI, Yiping WANG, Jianzhen PAN, Sung Hi JO
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Patent number: 9220701Abstract: A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di (C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester a (C1-C4)-alkyl(C8-C22)carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1-C8) alkylamino substituted, (C4-C18)alkyl(C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).Type: GrantFiled: October 2, 2009Date of Patent: December 29, 2015Assignee: NEXMED HOLDINGS, INC.Inventors: William Shifeng Wei, Yiping Wang, Jianzhen Pan, Sung Hi Jo
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Publication number: 20150320764Abstract: This invention relates to treating female sexual arousal disorder and/or improving female sexual response, and related symptoms, preferably with topical prostaglandin compositions.Type: ApplicationFiled: May 8, 2015Publication date: November 12, 2015Applicant: NEXMED HOLDINGS, INC.Inventors: Susan Meier-Davis, Daniel W. Frank, Richard Martin
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Publication number: 20150272875Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: ApplicationFiled: March 30, 2015Publication date: October 1, 2015Applicant: Nexmed Holdings, Inc.Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
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Publication number: 20150265709Abstract: Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino)propionate.Type: ApplicationFiled: June 4, 2015Publication date: September 24, 2015Applicant: NEXMED HOLDINGS, INC.Inventors: Bassam B. Damaj, Richard Martin
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Patent number: 9066854Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: GrantFiled: August 20, 2014Date of Patent: June 30, 2015Assignee: NEXMED HOLDINGS, INC.Inventors: Mingqi Lu, Qin Wang, James L. Yeager, Y. Joseph Mo
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Patent number: 9060929Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a vasoactive prostaglandin, a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: GrantFiled: August 20, 2014Date of Patent: June 23, 2015Assignee: NEXMED HOLDINGS, INC.Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
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Patent number: 9056044Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a vasoactive prostaglandin, a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: GrantFiled: August 20, 2014Date of Patent: June 16, 2015Assignee: NEXMED HOLDINGS, INC.Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
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Patent number: 8962595Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.Type: GrantFiled: May 4, 2011Date of Patent: February 24, 2015Assignee: Nexmed Holdings, Inc.Inventors: Bassam B. Damaj, Richard Martin
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Patent number: 8940794Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: GrantFiled: April 6, 2012Date of Patent: January 27, 2015Assignee: Nexmed Holdings, Inc.Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Publication number: 20150011587Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: ApplicationFiled: August 20, 2014Publication date: January 8, 2015Applicant: NEXMED HOLDINGS, INC.Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
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Publication number: 20150011638Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: ApplicationFiled: August 20, 2014Publication date: January 8, 2015Applicant: NexMed Holdings, Inc.Inventors: Y. Joseph Mo, Qin Wang, James L. Yeager, Mingqi Lu
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Publication number: 20150011585Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: ApplicationFiled: August 20, 2014Publication date: January 8, 2015Applicant: NEXMED HOLDINGS, INC.Inventors: Mingqi Lu, Qin Wang, James L. Yeager, J. Joseph Mo