Patents Assigned to NexMed Holdings, Inc.
  • Patent number: 11246932
    Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 15, 2022
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
  • Patent number: 10632086
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: April 28, 2020
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20190076529
    Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 14, 2019
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Tian WEN, Liu LIU, Mingqi LU, Jieshan BAI, Y. Joseph MO
  • Publication number: 20180333377
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: December 15, 2017
    Publication date: November 22, 2018
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. FRANK, Richard MARTIN, Bassam B. DAMAJ
  • Patent number: 9855231
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 2, 2018
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Patent number: 9517218
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: December 13, 2016
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160331761
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Applicant: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20160067266
    Abstract: A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester a (C1-C4)-alkyl (C8-C22) carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: William Shifeng WEI, Yiping WANG, Jianzhen PAN, Sung Hi JO
  • Patent number: 9220701
    Abstract: A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di (C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester a (C1-C4)-alkyl(C8-C22)carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1-C8) alkylamino substituted, (C4-C18)alkyl(C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: December 29, 2015
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: William Shifeng Wei, Yiping Wang, Jianzhen Pan, Sung Hi Jo
  • Publication number: 20150320764
    Abstract: This invention relates to treating female sexual arousal disorder and/or improving female sexual response, and related symptoms, preferably with topical prostaglandin compositions.
    Type: Application
    Filed: May 8, 2015
    Publication date: November 12, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Susan Meier-Davis, Daniel W. Frank, Richard Martin
  • Publication number: 20150272875
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Applicant: Nexmed Holdings, Inc.
    Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
  • Publication number: 20150265709
    Abstract: Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino)propionate.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Bassam B. Damaj, Richard Martin
  • Patent number: 9066854
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: June 30, 2015
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Mingqi Lu, Qin Wang, James L. Yeager, Y. Joseph Mo
  • Patent number: 9060929
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a vasoactive prostaglandin, a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: June 23, 2015
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
  • Patent number: 9056044
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a vasoactive prostaglandin, a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: June 16, 2015
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager
  • Patent number: 8962595
    Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: February 24, 2015
    Assignee: Nexmed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard Martin
  • Patent number: 8940794
    Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 27, 2015
    Assignee: Nexmed Holdings, Inc.
    Inventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
  • Publication number: 20150011638
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Application
    Filed: August 20, 2014
    Publication date: January 8, 2015
    Applicant: NexMed Holdings, Inc.
    Inventors: Y. Joseph Mo, Qin Wang, James L. Yeager, Mingqi Lu
  • Publication number: 20150011585
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Application
    Filed: August 20, 2014
    Publication date: January 8, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Mingqi Lu, Qin Wang, James L. Yeager, J. Joseph Mo
  • Publication number: 20150011587
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Application
    Filed: August 20, 2014
    Publication date: January 8, 2015
    Applicant: NEXMED HOLDINGS, INC.
    Inventors: Y. Joseph Mo, Mingqi Lu, Qin Wang, James L. Yeager