Patents Assigned to NexMed Holdings, Inc.
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Publication number: 20140357713Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.Type: ApplicationFiled: May 7, 2014Publication date: December 4, 2014Applicant: NexMed Holdings, Inc.Inventors: Bassam B. Damaj, Richard Martin
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Patent number: 8900625Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.Type: GrantFiled: March 15, 2013Date of Patent: December 2, 2014Assignee: Nexmed Holdings, Inc.Inventors: Bassam B. Damaj, Richard M. Martin
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Patent number: 8841345Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.Type: GrantFiled: March 22, 2004Date of Patent: September 23, 2014Assignee: Nexmed Holdings, Inc.Inventors: Mingqi Lu, Qin Wang, James L. Yeager, Y. Joseph Mo
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Publication number: 20140213654Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: ApplicationFiled: February 5, 2014Publication date: July 31, 2014Applicant: NEXMED HOLDINGS, INC.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y Joseph Mo
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Publication number: 20140206766Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: ApplicationFiled: February 4, 2014Publication date: July 24, 2014Applicant: NEXMED HOLDINGS, INC.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
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Publication number: 20140200274Abstract: In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.Type: ApplicationFiled: April 6, 2012Publication date: July 17, 2014Applicant: Nexmed Holdings, IncInventors: Daniel W. Frank, Richard Martin, Bassam B. Damaj
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Publication number: 20140163464Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those Components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.Type: ApplicationFiled: December 3, 2013Publication date: June 12, 2014Applicant: Nexmed Holdings, Inc.Inventors: Yiping Wang, William S. Wei, Daniel W. Frank
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Publication number: 20140142188Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: ApplicationFiled: January 14, 2014Publication date: May 22, 2014Applicant: NEXMED HOLDINGS, INC.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
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Patent number: 8632813Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: GrantFiled: October 19, 2007Date of Patent: January 21, 2014Assignee: Nexmed (Holdings), Inc.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Joseph Mo
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Publication number: 20130323189Abstract: Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.Type: ApplicationFiled: August 9, 2013Publication date: December 5, 2013Applicants: NexMed Holdings, Inc., Apricus Biosciences, IncInventors: Stanley W. Kepka, Y Joseph Mo, Hang-Yong Wang, Mingqi Lu, William R. Pfister
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Patent number: 8596859Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.Type: GrantFiled: November 6, 2008Date of Patent: December 3, 2013Assignee: Nexmed Holdings, Inc.Inventors: Yiping Wang, William S. Wei, Daniel W. Frank
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Publication number: 20130267562Abstract: 2R-dodecyl 2-(N,N dimethylamino)-propionate (R-DDAIP) provides an unexpectedly improved activity in facilitating transport of a pharmaceutically active compound across biological membranes and tissues, compared to S-DDAIP of the same enantiomeric purity, or racemic DDAIP. Purified S-DDAIP is also provided.Type: ApplicationFiled: November 30, 2011Publication date: October 10, 2013Applicant: NEXMED HOLDINGS, INCInventors: Bassam B. Damaj, Richard Martin
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Publication number: 20130210766Abstract: Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.Type: ApplicationFiled: May 4, 2011Publication date: August 15, 2013Applicant: NEXMED HOLDINGS, INC.Inventors: Bassam B. Damaj, Richard Martin
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Publication number: 20130209393Abstract: Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino) propionate.Type: ApplicationFiled: May 4, 2011Publication date: August 15, 2013Applicant: NEXMED HOLDINGS, INC.Inventors: Bassam B. Damaj, Richard Martin
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Publication number: 20130178463Abstract: A buccal delivery system is disclosed suitable for delivery of a therapeutic agent to the oral cavity of a patient. The delivery system comprises a matrix for containing and releasing the therapeutic agent into the oral cavity and an alkyl N,N-disubstituted amino acetate in said matrix. A particularly preferred delivery system comprises a matrix containing an effective amount of therapeutic agent together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino) propionate salt.Type: ApplicationFiled: September 23, 2011Publication date: July 11, 2013Applicants: Rutgers, The State University of New Jersey, Nexmed Holdings, Inc.Inventors: Bassam B. Damaj, Richard Martin, Bozena Michniak-Kohn, Long-Sheng Hu
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Publication number: 20120322820Abstract: Methods of treating one or more growth deregulated cells are disclosed. An effective amount of a pharmaceutical composition including a proton pump inhibitor is administered thereby treating a growth deregulated cell outside of the gastric lumen of a subject.Type: ApplicationFiled: August 28, 2012Publication date: December 20, 2012Applicant: NEXMED HOLDINGS, INC.Inventor: Bassam DAMAJ
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Patent number: 8173688Abstract: The present invention provides, in part, compounds and compositions including a thiazole moiety, that may be useful, for example, for treating cancers, for example kidney cancer.Type: GrantFiled: June 13, 2008Date of Patent: May 8, 2012Assignee: Nexmed Holdings, Inc.Inventor: Bassam Damaj
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Patent number: 7560489Abstract: A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)-alkyl(C8-C22)carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.Type: GrantFiled: October 11, 2006Date of Patent: July 14, 2009Assignee: NexMed Holdings, Inc.Inventors: Daniel W. Frank, Yiping Wang
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Patent number: 7462362Abstract: A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.Type: GrantFiled: March 22, 2004Date of Patent: December 9, 2008Assignee: NexMed Holdings, Inc.Inventors: Stanley W. Kepka, Y. Joseph Mo, Hang-Yong Wang, Mingqi Lu, William R. Pfister
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Publication number: 20080069883Abstract: Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are methods of improving microcirculation in a replanted body part.Type: ApplicationFiled: October 19, 2007Publication date: March 20, 2008Applicant: NexMed Holdings, Inc.Inventors: Tian Wen, Liu Liu, Mingqi Lu, Jieshan Bai, Y. Mo