Patents Assigned to Nihon University
  • Patent number: 12198899
    Abstract: A magnetized plasmoid injection device including a cylindrical external electrode, a cylindrical internal electrode coaxially disposed inside the external electrode, a plasma generating gas supply unit that supplies plasma generating gas in a pulse shape between the external electrode and the internal electrode, a magnetic field generation unit that applies a magnetic field that generates magnetized plasmoid between the external electrode and the internal electrode, a power supply control unit that applies a discharge voltage between the external electrode and the internal electrode, and an impurity generation unit that contains an impurity in the magnetized plasmoid, the impurity generation unit having a cover electrode that opens to the external electrode, a thin-rod electrode that is located inside the cover electrode and is formed of an impurity, and an impurity generation power supply that applies a voltage to the cover electrode and the thin-rod electrode.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 14, 2025
    Assignee: Nihon University
    Inventors: Tomohiko Asai, Daichi Kobayashi, Taichi Seki
  • Publication number: 20220235331
    Abstract: A method of producing induced pluripotent stem cells including a step for introducing an initialization factor into somatic cells of a mammal, and culturing in a neural stem cell culture medium to obtain induced neural stem cell-like cells, and a step for cultivating said induced neural stem cell-like cells in a growth medium to obtain induced pluripotent stem cells, wherein the initialization factor contains an OCT family, a SOX family, a KLF family, a MYC family, a LIN28 family and a P53 function inhibitor.
    Type: Application
    Filed: April 17, 2020
    Publication date: July 28, 2022
    Applicants: Keio University, Nihon University
    Inventors: Hideyuki Okano, Seiji Shiozawa, Sho Yoshimatsu, Kazuya Edamura, Aozora Iguchi
  • Publication number: 20220213525
    Abstract: A nucleic acid detection kit including: (i) a first single-stranded circular DNA; (ii) a first oligonucleotide primer; (iii) a second single-stranded circular DNA; and (iv) a second oligonucleotide primer; wherein the first oligonucleotide primer is hound to a carrier through the 5?-end thereof, and the second oligonucleotide primer is bound, through the 5?-end thereof, to the carrier to which the first oligonucleotide primer is hound.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 7, 2022
    Applicant: Nihon University
    Inventors: Masayasu KUWAHARA, Hiroto FUJITA
  • Publication number: 20220013332
    Abstract: A magnetized plasmoid injection device including a cylindrical external electrode, a cylindrical internal electrode coaxially disposed inside the external electrode, a plasma generating gas supply unit that supplies plasma generating gas in a pulse shape between the external electrode and the internal electrode, a magnetic field generation unit that applies a magnetic field that generates magnetized plasmoid between the external electrode and the internal electrode, a power supply control unit that applies a discharge voltage between the external electrode and the internal electrode, and an impurity generation unit that contains an impurity in the magnetized plasmoid, the impurity generation unit having a cover electrode that opens to the external electrode, a thin-rod electrode that is located inside the cover electrode and is formed of an impurity, and an impurity generation power supply that applies a voltage to the cover electrode and the thin-rod electrode.
    Type: Application
    Filed: October 30, 2019
    Publication date: January 13, 2022
    Applicant: Nihon University
    Inventors: Tomohiko Asai, Daichi Kobayashi, Taichi Seki
  • Patent number: 11104120
    Abstract: A three-dimensional printing system (1) includes: a head (2) to which a first continuous material (FL) including a resin and a second continuous material (FB) including fibers are fed; a platform (3) on which a printing material based on the first and second continuous materials from the head is stacked; a cutting device (10) which is capable of cutting at least fibers; and a controller (5) which controls an operation device including at least one of the head, the platform, and the cutting device.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: August 31, 2021
    Assignees: Nihon University, Tokyo University of Science Foundation
    Inventors: Masahito Ueda, Yoshiyasu Hirano, Ryosuke Matsuzaki
  • Patent number: 10076291
    Abstract: The present invention has an object of providing an X-ray CT imaging device which can direct X-ray to an area of interest appropriately even when, for example, the height of the area of interest with respect to the X-ray detector, which is revolving, varies with respect to the revolution direction, and thus can reduce the amount of unnecessary exposure to the X-ray and can perform X-ray imaging of the area of interest with certainty. In an X-ray CT imaging device for performing X-ray CT imaging of a CT imaging area of a subject, during the X-ray CT imaging when a revolving arm is revolving, the expansion in a length direction of an X-ray cone beam, which is to be restricted by length direction blocking plates, is adapted to the shape of the CT imaging area in accordance with the revolution position of the revolving arm.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: September 18, 2018
    Assignees: Nihon University, J. Morita Manufacturing Corporation
    Inventors: Yoshinori Arai, Makoto Honjo, Masakazu Suzuki, Susumu Kirimura, Hideki Yoshikawa
  • Patent number: 9995664
    Abstract: Seat members 31 are held in a state of being movable with respect to first slide members 21 or second slide members 22 correspondingly. By rotating screws 39 in directions to increase the distances d between surfaces A of the first slide members 21 or the second slide members 22 and surfaces B of the seat members 31, chucks 25 are moved in directions to increase the distance between the chucks to apply pretension to a test piece correspondingly. When backlash in a force transmission system from a support part to the respective chucks 25 is eliminated, a biaxial tensile test is started.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: June 12, 2018
    Assignees: Shimadzu Corporation, Nihon University
    Inventors: Noriaki Komine, Susumu Takahashi
  • Patent number: 9877678
    Abstract: A respiration signal of a seated person is detected with high accuracy by using a vehicle seat that includes a seat cushion; and a sensor detecting a pressure signal from a load applied from a seated person. The sensor is provided to be along an edge of a contact portion between the seat cushion and buttocks of the seated person. The sensor transmits the detected pressure signal to an arithmetic operation device of the seated person. In a respiration measuring device, the arithmetic operation device computes the detected pressure signal detected by the sensor to obtain a respiration signal of the seated person.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: January 30, 2018
    Assignees: TS Tech Co., Ltd., Josho Gakuen Educational Foundation, Nihon University
    Inventors: Shinji Sugiyama, Toyokazu Nakano, Mieko Ohsuga, Ichiro Kageyama, Yukiyo Kuriyagawa, Shu Iida
  • Patent number: 9474770
    Abstract: The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: October 25, 2016
    Assignees: SBI Pharmaceuticals Co., Ltd., Nihon University
    Inventors: Kosaku Kinoshita, Katsuhisa Tanjoh, Akihiro Noda, Atsushi Sakurai, Tohru Tanaka, Kiwamu Takahashi, Motowo Nakajima, Fuminori Abe
  • Patent number: 9278992
    Abstract: The present invention provides a VDR ligand which does not induce hypercalcemia that is an adverse reaction of a vitamin D3 preparation; and a composition which comprises lithocholic acid propionate, a salt thereof, a solvate thereof, or a prodrug thereof.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: March 8, 2016
    Assignee: Nihon University
    Inventors: Makoto Makishima, Michiyasu Ishizawa, Manabu Matsunawa, Sachiko Yamada
  • Patent number: 8989343
    Abstract: An image processing device acquiring pseudo projection data by calculation when a virtual metallic body having a predetermined X-ray absorption coefficient is set in a photographic region of X-ray CT photography in a pseudo manner based on projection data, and the image processing device reconstructing the pseudo projection data to acquire pseudo CT image data. The image processing device acquires luminance (virtual metallic body luminance) of a virtual metallic body in the pseudo CT image data, and specifies a position of a metal equivalent region having luminance corresponding to the virtual metallic body luminance in normal CT image data. The image processing device acquires correction projection data by performing correction processing to the luminance of the metal equivalent region in the normal projection data, and the image processing device reconstructs the correction projection data to acquire correction CT image data.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 24, 2015
    Assignees: Nihon University, J. Morita Manufacturing Corporation
    Inventors: Yoshinori Arai, Masakazu Suzuki
  • Patent number: 8931661
    Abstract: A pressure vessel structure includes a vessel main body, and a grid layer provided on a periphery of the vessel main body and including a plurality of grid lines formed by intersecting strip-form raw materials so as to overlap alternately. Thus, a burst pressure of the pressure vessel is increased.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: January 13, 2015
    Assignees: Nissan Motor Co., Ltd., Nihon University
    Inventors: Natsuki Kuroiwa, Kentaro Kono, Takatada Usami, Goichi Ben, Kazuhiro Sakata
  • Patent number: 8895564
    Abstract: Provided is a novel compound which simultaneously inhibits both NMDA receptors and ASIC1a, which are associated with neurodegenerative disease and so on, and thus is useful for the prevention and treatment of various nervous system diseases. A biguanide derivative represented by the following general formula (1), a salt thereof, or a hydrate of the derivative or the salt: wherein, X1 represents a halogen atom, R1 represents an alkyl group, an optionally substituted aryl group, or an optionally substituted aralkyl group.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: November 25, 2014
    Assignee: Nihon University
    Inventors: Muneharu Miyake, Tadashi Kusama, Takashi Masuko
  • Patent number: 8817944
    Abstract: In an X-ray imaging apparatus that performs X-ray CT imaging, an X-ray generator (13) that generates an X-ray cone beam (BX1) and an X-ray detector (21) that detects the X-ray cone beam (BX1) radiated to an object (specifically, image object (OB)) are revolved for 180 degrees to be opposed to each other with the object being located therebetween. Further, the X-ray generator (13) is moved such that a revolution reference point (CP) that is set on an optical path (CB) of the X-ray cone beam (BX1) goes round of a predetermined oval shape while the X-ray detector (13) and the X-ray generator (21) are revolved for 180 degrees. Setting is made such that a CT image area (CA) to be imaged by the irradiation of the X-ray cone beam (BX1) has an approximately triangular shape through the above-mentioned operation.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: August 26, 2014
    Assignees: Nihon University, J. Morita Manufacturing Corporation
    Inventors: Yoshinori Arai, Masakazu Suzuki, Takahiro Yoshimura, Makoto Honjo
  • Patent number: 8798955
    Abstract: An acoustic energy measurement device that measures acoustic energy, the acoustic energy measurement device has a sound receiving unit that performs sound/electricity conversion and includes a plurality of unidirectional microphones being so disposed that a sum total of unit vectors facing a maximum sensitivity direction thereof becomes zero. The acoustic energy measurement device further includes a sound pressure calculation unit that calculates sound pressure using an output from the sound receiving unit. Still further, the acoustic energy measurement device has a particle velocity calculation unit that calculates particle velocity using an output from the sound receiving unit. Still further, the acoustic energy measurement device has an acoustic energy calculation unit that calculates acoustic energy using outputs from the sound pressure calculation unit and the particle velocity calculation unit.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: August 5, 2014
    Assignee: Nihon University
    Inventor: Toshiki Hanyu
  • Patent number: 8779195
    Abstract: A compound having the general formula (I) or a pharmacologically acceptable salt thereof: X—NH—Y—NH—R1??(I) [wherein X represents R2—SO2— in which R2 represents an optionally substituted lower alkyl group or phenyl group; Y represents a group selected from the group consisting of —R3—NH—R4—, —R5—NH—R6—NH—R7—, —R8—NH—R9—NH—R10—NH—R11—and —R12—NH—R13—NH—R14—NH—R15— in which R3 to R15 each independently represent a C3 to C5 alkylene group; and R1 represents hydrogen or an optionally substituted lower alkyl group, with the proviso that the case where X represents a tosyl group, Y represents —(CH2)3—NH—(CH2)4—NH—(CH2)3—and R1 represents hydrogen is excepted].
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: July 15, 2014
    Assignee: Nihon University
    Inventors: Muneharu Miyake, Tadashi Kusama, Takashi Masuko
  • Patent number: 8560253
    Abstract: A material hardness distribution display system (10) includes a probe unit (20) in which a plurality of probe elements (22) are two-dimensionally arranged. Each of the probe elements (22) has an oscillator (26) for introducing oscillation into a biological tissue and an oscillation detection sensor (28) which detects a reflected wave. The probe elements (22) are successively selected by a switch circuit (50) and connected to a hardness calculation unit (70) and a measurement depth calculation unit (82). The hardness calculation unit (70) executes a frequency component analysis for an incident wave signal to the oscillator (26) and a reflected wave signal from the oscillation detection sensor (28) to calculate the hardness of the biological tissue on the basis of the analysis results.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 15, 2013
    Assignee: Nihon University
    Inventors: Sadao Omata, Yoshinobu Murayama
  • Patent number: 8372587
    Abstract: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: February 12, 2013
    Assignee: Nihon University
    Inventors: Hiroki Nagase, Yui Shinojima, Tadashi Terui
  • Patent number: 8289871
    Abstract: A propagation delay time measuring system 100 includes a propagation delay time measuring apparatus 110 and a reply apparatus 120. The propagation delay time measuring apparatus 110 continuously transmits plural measuring packets a. A clock time of transmission is stored in the measuring packet a. The reply apparatus 120 sends back the measuring packets a, transmitted from the propagation delay time measuring apparatus 110, to the propagation delay time measuring apparatus 110. In the propagation delay time measuring system 100, the propagation delay time measuring apparatus 110 receives the measuring packets a sent back from the reply apparatus 120, and the propagation delay time measuring apparatus 110 measures a propagation delay time between the propagation delay time measuring apparatus 110 and the reply apparatus 120 using at least one of the received measuring packets a.
    Type: Grant
    Filed: December 25, 2007
    Date of Patent: October 16, 2012
    Assignee: Nihon University
    Inventor: Masami Kihara
  • Patent number: 8229986
    Abstract: The purpose of this invention is that the optimum approximation formula can be derived even if an analysis filter has non-linear characteristic in a discrete signal approximation system. The norm of source signal 1 is bounded. Analysis filters 2 of FIR filters yield the output signal that is expressed with polynomial of transformed source signal 1 through a unit filter. An interpolation function is calculated according to the filter characteristic based upon the multi-dimensional function transformed from the polynomial. The output signal of the analysis filter 2 is sampled after each constant interval to obtain a discrete signal. The approximation function of the power function of the source signal 1 is calculated with linear combination of the interpolation functions using the discrete signals as coefficients. The radical of this approximation function is calculated to derive the root approximation function of the source signal 1.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: July 24, 2012
    Assignee: Nihon University
    Inventor: Takuro Kida