Patents Assigned to Nippon Chemiphar Co., Ltd.
  • Patent number: 4081334
    Abstract: An antigen membrane for syphilis diagnosis comprises cardiolipin immobilized in a polymer maxtrix. The membranes are used in syphilis diagnosis and in an apparatus for syphilis diagnosis.
    Type: Grant
    Filed: March 18, 1977
    Date of Patent: March 28, 1978
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventors: Shuichi Suzuki, Masuo Aizawa, Isao Ishigur, Rikio Shinohara, Yoichi Nagamura
  • Patent number: 4068070
    Abstract: .alpha.-Cyanoamine compounds represented by the following formula or an acid addition salt thereof ##STR1## WHEREIN R.sub.1 is a halogen atom or lower alkoxy group, R.sub.2 and R.sub.3 are a hydrogen atom or lower alkoxy group, R.sub.4 is a hydrogen atom or lower alkyl group, R.sub. 5 is a hydrogen atom, --COOR.sub.6 (R.sub.6 is lower alkyl group), ##STR2## (R.sub.7 is lower alkoxy group, m is a numeral 0-3), --R.sub.8 --COOR.sub.9 (R.sub.8 is lower alkylene group, R.sub.9 is lower alkyl group), ##STR3## (R.sub.10 and R.sub.11 are a hydrogen atom or lower alkyl group, or R.sub.10 and R.sub.11 jointly form alkylene group), or ##STR4## (R.sub.1 to R.sub.4 are the same as defined above) and n is a numeral 2 or 3; but it is excluded when R.sub.5 is hydrogen atom or --COOR.sub.6 (R.sub.
    Type: Grant
    Filed: January 12, 1976
    Date of Patent: January 10, 1978
    Assignees: Fuji Chemical Industry Co., Ltd., Nippon Chemiphar Co., Ltd.
    Inventors: Katsumi Sakai, Yukio Onogawa, Yoshitaka Inamoto, Hiroshi Nakajima, Yasuo Fujimoto, Kuniichiro Ohno, Masashi Yoshida, Shigehito Araki
  • Patent number: 4062862
    Abstract: 5-Benzyl-2-oxazolidone derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen, halogen, lower alkyl, trihalogenomethyl, phenyl, benzyl, hydroxy, lower alkoxy, phenoxy, benzyloxy, acyloxy, allyloxy, alkylcarbonyl, arylcarbonyl or alkylenedioxy group, and R.sub.2 represents a hydrogen atom, a lower alkyl, lower alkylcarbonyl, lower-dialkylamino-lower-alkyl, aryl, aralkyl or arylcarbonyl group.
    Type: Grant
    Filed: July 1, 1976
    Date of Patent: December 13, 1977
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventors: Yasuo Fujimoto, Terumi Tamada
  • Patent number: 4001223
    Abstract: Adamantane derivatives of this invention are represented by the formula ##STR1## wherein R.sub.1 is ##STR2## or --CH.sub.2 -- and R.sub.2 is ##STR3## or --CH.sub.2 CH=CH--. Said derivatives are cerebral vasodilators or intermediates for the same.
    Type: Grant
    Filed: December 16, 1975
    Date of Patent: January 4, 1977
    Assignees: Idemitsu Kosan Co., Ltd., Nippon Chemiphar Co., Ltd.
    Inventors: Michio Sugimoto, Fumitada Yamamoto, Kosaku Honna, Konomu Kurisaki, Hirozo Sugahara, Kiyoshi Watanabe, Yasuo Fujimoto, Syoji Ryu
  • Patent number: 3962247
    Abstract: .alpha.-Cyanoamine compounds represented by the following formula or an acid addition salt thereof ##SPC1##Wherein R.sub.1 is a halogen atom or lower alkoxy group, R.sub.2 and R.sub.3 are a hydrogen atom or lower alkoxy group, R.sub.4 is a hydrogen atom or lower alkyl group, R.sub.5 is a hydrogen atom, -COOR.sub.6 (R.sub.6 is lower alkyl group), ##SPC2##(R.sub.7 is lower alkoxy group, m is a numeral 0-3), --R.sub.8 --COOR.sub.9 (R.sub.8 is lower alkylene group, R.sub.9 is lower alkyl group), ##EQU1## (R.sub.10 and R.sub.11 are a hydrogen atom or lower alkyl group, or R.sub.10 and R.sub.11 jointly form alkylene group), or ##SPC3##(R.sub.1 to R.sub.4 are the same as defined above) and n is a numeral 2 or 3; but it is excluded when R.sub.5 is hydrogen atom or --COOR.sub.6 (R.sub.
    Type: Grant
    Filed: August 6, 1974
    Date of Patent: June 8, 1976
    Assignees: Fuji Chemical Industry Co., Ltd., Nippon Chemiphar Co., Ltd.
    Inventors: Katsumi Sakai, Yukio Onogawa, Yoshitaka Inamoto, Hiroshi Nakajima, Yasuo Fujimoto, Kuniichiro Ohno, Masashi Yoshida, Shigehito Araki
  • Patent number: 3948899
    Abstract: .alpha.-Cyanobenzylpiperazines represented by the formula ##SPC1##Or an acid addition salt thereof, wherein R.sub.1 is a halogen or 1-3C lower alkoxy, R.sub.2 and R.sub.3 are each hydrogen or 1-3C lower alkoxy, R.sub.4 is 1-3C lower alkyl, and R.sub.5 is hydrogen or 1-3C lower alkyl, which are produced by reacting an aromatic carbonyl compound with hydrogen cyanide or a salt thereof and N-alkoxycarbonyl piperazine or an acid addition salt thereof.
    Type: Grant
    Filed: August 7, 1974
    Date of Patent: April 6, 1976
    Assignees: Fuji Chemical Industry Co., Ltd., Nippon Chemiphar Co., Ltd.
    Inventors: Katsumi Sakai, Riitiro Iwaki, Katsuki Taoka, Hiroshi Nakajima, Yasuo Yamada
  • Patent number: 3933826
    Abstract: Protoberberine derivatives having the general formula: ##SPC1##Wherein R.sub.1 is a lower alkoxy group, i.e. C.sub.1 to C.sub.5 alkoxy; R.sub.2 is a lower alkyl group, i.e. C.sub.1 to C.sub.5 alkyl, pyridyl group, phenyl group substituted by two or three lower alkoxy groups, i.e. C.sub.1 to C.sub.5 alkoxy or a phenylvinyl group substituted by two or three lower alkoxy groups, i.e. C.sub.1 to C.sub.5 alkoxy; having excellent analgesic, vasodilating and hypotensive effects and are prepared from know protoberberines by reaction with carobxylic acids.
    Type: Grant
    Filed: November 20, 1973
    Date of Patent: January 20, 1976
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventor: Tetsuji Kametani