Patents Assigned to Nippon Chemiphar Co., Ltd.
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Patent number: 4764617Abstract: A novel quinaldinamide derivative having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents a lower alkyl group or R.sup.1 and R.sup.2 are combined together with the adjacent nitrogen atom to form a 5-7 membered ring; and X represents the hydrogen atom, a lower alkyl group or a lower alkoxy group, and its acid-addition salt, which show prominent central muscle relaxant effect, namely rigidity relieving effect on anemic decerebrated rigidity.Type: GrantFiled: August 13, 1986Date of Patent: August 16, 1988Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Haruhiko Shinozaki, Masaru Satoh, Naoya Moritoh, Koichi Hashimoto, Toshiro Kamishiro
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Patent number: 4644063Abstract: 1,3-Oxazolidine-one derivatives of the following formula ##STR1## where R is straight or branched alkyl of C.sub.3 -C.sub.8, X is hydrogen, halogen, lower alkyl or lower alkoxy and n is 4, 5 or 6, or their acid addition salts are effective for medicinal and agricultural use.Type: GrantFiled: May 29, 1985Date of Patent: February 17, 1987Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mituo Masaki, Haruhiko Shinozaki, Masaru Satoh, Naoya Moritoh, Koichi Hashimoto, Toshiro Kamishiro
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Patent number: 4596803Abstract: A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.Type: GrantFiled: March 8, 1984Date of Patent: June 24, 1986Assignee: Nippon Chemiphar Co., Ltd.Inventors: Tomoh Masaki, Toshiro Kamishiro, Takashi Okazoe, Koichi Kumakura, Mitsuo Masaki
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Patent number: 4528194Abstract: A piperazine derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydroxyl group, an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; R.sup.3 is a hydrogen atom, or an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; and R.sup.4 is a hydrogen atom or a lower alkoxy group containing 1-5 carbon atoms, provided that R.sup.2 is a group other than the lower alkoxy group containing 1-5 carbon atoms when both R.sup.3 and R.sup.4 are hydrogen atoms; or a pharmaceutically acceptable salt is effectively useful as a cerebral circulation-improving agent.Type: GrantFiled: July 12, 1983Date of Patent: July 9, 1985Assignee: Nippon Chemiphar Co., Ltd.Inventor: Mitsuo Masaki
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Patent number: 4507297Abstract: A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.Type: GrantFiled: March 25, 1982Date of Patent: March 26, 1985Assignee: Nippon Chemiphar Co., Ltd.Inventors: Tomoh Masaki, Toshiro Kamishiro, Takashi Okazoe, Koichi Kumakura, Mitsuo Masaki
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Patent number: 4495118Abstract: Large and thin ceramic plates of, particularly at least 30.times.30 cm in size and not greater than 20 mm especially not greater than 8 mm in thickness and having oriented crystals are produced by a method comprising drawing a green body from an extruder in a curved shape, cutting and spreading the green body in a plate form, rolling the plates in the same direction as that of drawing, subjecting the rolled plates to the treatment with far infrared rays or high-frequency heating before the plates contain a moisture reduced to less than 15% while the plates are transferred in the same direction as that of drawing, drying the plates thus treated while the plates are further transferred in the same direction, and then firing the plates in a kiln. The ceramic plates are large and thin but nevertheless easy to handle.Type: GrantFiled: April 13, 1983Date of Patent: January 22, 1985Assignee: Nippon Chemiphar Co., Ltd.Inventor: Hideo Ikami
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Patent number: 4465851Abstract: A compound having the formula ##STR1## wherein R.sub.1 represents an indanyl, indolyl, quinolyl or chromonyl group, the group of the formula ##STR2## (in which R.sub.2 represents a halogen atom or a nitro group), or the group of the formula ##STR3## (in which R.sub.3 represents a halogen atom, or an alkyl, nitro, cyano, acetamino, aminosulfonyl, benzoyl, phenoxy or trifluoromethyl group, R.sub.4 represents a hydrogen or halogen atom, or an alkyl group, and R.sub.5 represents a hydrogen or halogen atom, or an alkyl group), or a pharmaceutically acceptable salt thereof. The compound is obtained by reacting 4-guanidinomethylcyclohexanecarboxylic acid or a reactive derivative thereof with a compound of the formula R.sub.1 --OH wherein R.sub.1 is the same as defined above, or a reactive derivative thereof.Type: GrantFiled: January 4, 1982Date of Patent: August 14, 1984Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mutsumi Muramatsu, Toshio Satoh, Hiroyasu Sekine, Atsushi Tendo
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Patent number: 4433152Abstract: A compound of the formula, ##STR1## wherein R represents a hydrogen atom, a naphthyl, indanyl, tetrahydronaphthyl or pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, and an alkyl, alkenyl, alkoxy, alkanoyl, cyano, formyl, trifluoromethyl, phenyl, phenylalkyl, alkanoyl-amino, aminosulfonyl, carboxyl, alkoxycarbonyl, benzyloxycarbonyl, benzoylvinyl, phenylvinylcarbonyl, carboxyvinyl, and diphenyl-methyloxycarobnylvinyl group, A represents an oxygen or sulfur atom, and n represents an integer of 0 to 3, with the proviso that when n is an integer of 0, R must not be a hydrogen atom, or a pharmaceutically acceptable salt thereof is effectively useful for inhibiting a complement reaction, inflammation caused by an allergic reaction, and platelet aggregation.Type: GrantFiled: May 19, 1982Date of Patent: February 21, 1984Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mutsumi Muramatsu, Toshio Satoh, Hiroyasu Sekine, Atsushi Tendo, Yoshio Kikawa, Kaname Kondo
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Patent number: 4377702Abstract: Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinfammatory activities.Type: GrantFiled: September 15, 1980Date of Patent: March 22, 1983Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4348410Abstract: A compound of the formula: ##STR1## wherein R.sub.1 represents a vanilyl, napthyl, pyridyl or .alpha.-tocopheryl group, or a group of the formula, ##STR2## wherein R.sub.2 represents a hydrogen atom, a lower alkoxy, formyl, lower alkanoyl or phenyl group, or a group of the formula --(CH.sub.2).sub.n COOR.sub.3, wherein R.sub.3 represents a hydrogen atom, a lower alkyl, phenyl, benzyl, anisyl or lower alkoxycarbonylmethyl group, and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof is effective for use as an anti-ulcer agent.Type: GrantFiled: September 15, 1980Date of Patent: September 7, 1982Assignees: Nippon Chemiphar Co., Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Mutsumi Muramatsu, Toshio Satoh, Yukio Yanagimoto, Tadami Shinuchi, Toshio Nakajima, Isao Nakajima
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Patent number: 4342774Abstract: An N-acylcarnosine aluminum salt of the formula, ##STR1## wherein R represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a lower alkoxy group-substituted phenyl group, and n is an integer of 1 to 3 is effective for use as a digestive ulcer-remedying or anti-ulcer agent.Type: GrantFiled: September 10, 1980Date of Patent: August 3, 1982Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Takashi Sonehara, Masaru Sato, Mitsuo Mazaki
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Patent number: 4339379Abstract: An N-acylcarnosine aluminum salt of the formula, ##STR1## wherein R represents a lower alkyl group having 1 to 6 carbon atoms is effective for use as an anti-ulcer agent.Type: GrantFiled: October 7, 1980Date of Patent: July 13, 1982Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Toru Yamanaka, Mitsuko Yoshioka, Kazuki Okai
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Patent number: 4339378Abstract: An N-acylcarnosine aluminum salt of the formula, ##STR1## Wherein R represents a lower alkyl group or a phenyl group, and n is an integer of 2 to 3 is effective for use as a digestive ulcer-remedying or anti-ulcer agent.Type: GrantFiled: October 7, 1980Date of Patent: July 13, 1982Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Toru Yamanaka, Taketoshi Kinoshita
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Patent number: 4282245Abstract: A compound of the formula (I), ##STR1## wherein R.sub.1 represents a halogen atom, or a hydroxy, nitro, amino, trihalogenomethyl or lower alkoxy group having 1 to 5 carbon atoms, and R.sub.2 represents a hydroxy or amino group is an antiinflammatory agent.Type: GrantFiled: May 23, 1979Date of Patent: August 4, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4263437Abstract: Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinflammatory activities.Type: GrantFiled: February 27, 1979Date of Patent: April 21, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4247706Abstract: A compound of the formula, ##STR1## wherein R represents a hydroxy or amino group is an antiinflammatory and analgesic agent.Type: GrantFiled: October 12, 1979Date of Patent: January 27, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4238491Abstract: Hypertension in human is treated by orally administering an effective amount of methylreserpate with little or no undesirable side effect such as central nervous system depression. Methylreserpate can be prepared from Reserpine, a Rauwolfia alkaloid.Type: GrantFiled: May 9, 1978Date of Patent: December 9, 1980Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Hiroshi Katagihara
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Patent number: 4166127Abstract: Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.Type: GrantFiled: January 16, 1978Date of Patent: August 28, 1979Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu
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Patent number: 4140631Abstract: A sealant for separation of a sample of blood into serum or plasma and clot portions, which has a specific gravity of about 1.03 to 1.08 and a viscosity of about 5,000 to 1,000,000 cps at a shearing speed of 1 second.sup.-1 when measured at 25.degree. C. and comprises as the essential component a polymer essentially consisting of the units of at least one of alkyl acrylates and alkyl methacrylates, and which forms a separator between the serum or plasma portion as the upper layer and the clot portion as the lower layer formed as the result of centrifugation of the blood sample so that the serum or plasma portion is readily separated from the clot portion by decantation.Type: GrantFiled: September 29, 1977Date of Patent: February 20, 1979Assignees: Nippon Paint Co., Ltd., Nippon Chemiphar Co., Ltd.Inventors: Hidefumi Okuda, Toshio Abo, Rikio Shinohara
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Patent number: 4101667Abstract: Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.Type: GrantFiled: May 25, 1976Date of Patent: July 18, 1978Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu