Patents Assigned to Nippon Kayaku Kabushiki-Kaisha
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Patent number: 6409810Abstract: A black recording having high solubility, being stable even after being stored for long, and capable of forming a printed image with a high optical density and excellent water and light resistances. The recording fluid contains a trisazo compound of general formula (1): wherein D is an 8-hydroxy-1-naphtyl group substituted with one or two sulfo groups; A is a 1,4-phenylene group or 1,4-naphtylene group which may be substituted with amino, hydroxy, alkyl, alkoxy, acylamino or ureido; and B is a phenyl group which may be substituted with hydroxy, amino or sulfo, or a salt thereof and is used for the recording.Type: GrantFiled: November 22, 1999Date of Patent: June 25, 2002Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hiroaki Ono, Takashi Miyazawa, Toru Tabei, Yasuo Shirasaki, Isao Yamaguchi, Kazunobu Nagasaki
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Patent number: 6387958Abstract: Disclosed is use of nonsteroidal anti-estrogen compounds such as toremifene citrate as active ingredient for treating autoimmune diseases.Type: GrantFiled: July 16, 2001Date of Patent: May 14, 2002Assignees: Nippon Kayaku Kabushiki Kaisha, Orion-yhtyma OyInventors: Junpei Itöh, Osamu Miyazaki, Hisao Ekimoto, Michinori Koyama, Tetsushi Saino, Lauri Kangas, Anni Warri, Christer Granberg
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Patent number: 6384063Abstract: A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.Type: GrantFiled: March 31, 2000Date of Patent: May 7, 2002Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Masashi Nagai, Tomio Morino, Tsugio Tomiyoshi, Takaaki Nishikiori, Atsushi Kuwahara, Takamichi Sato, Takashi Harada
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Patent number: 6376685Abstract: Highly pure optically active threo-3-amino-1,2-epoxy compounds appropriate for materials for manufacturing drugs and a process for producing the same on an industrial scale. An optically active threo-3-amino-1,2-diol derivative is subjected in an organic solvent in the presence of a base to alkylsufonylation or arylsulfonylation to thereby give the corresponding optically active threo-3-amino-2-hydroxy-1-sulfonyloxy compound. Next, the resultant product is subjected to epoxidation in the presence of a base to give the corresponding optically active threo-3-amino-1,2-epoxy compound. The thus obtained epoxy compound is purified by using an organic solvent and water, thus giving a highly pure epoxy compound.Type: GrantFiled: July 12, 2000Date of Patent: April 23, 2002Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yukihiro Sagawa, Jouji Sekine, Hisao Sato
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Publication number: 20010028164Abstract: A gas generator for air bags for use in an air bag system for safely protecting a driver and riders in a vehicle from shock from collisions. The gas generator has the following features to enable a component count to be reduced, thereby manufacturing the gas generator at low cost, while preventing slag in a gas flowing outside.Type: ApplicationFiled: June 15, 2001Publication date: October 11, 2001Applicant: Nippon Kayaku Kabushiki-KaishaInventors: Takashi Saso, Koji Tanaka, Akihiko Kuroiwa, Norihisa Miyamoto
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Patent number: 6300337Abstract: The present Invention relates to a novel acetamide derivative represented by the following Formula 1, which has an inhibition activity for chymotrypsin type proteases and is useful as an inhibitor for the above enzyme, especially as an inhibitor for chymase, and the use thereof as a medicine, for example, an antiasthma drug or a drug for curing vascular injuries complicated with angiogenesis and atheroma. wherein R0 represents a substituted or unsubstituted phenyl group, R1 represents an aryl group, a heteroaryl or an aliphatic lower alkyl group with or without substituents, R2 represents a substituted or unsubstituted alkyl, an aryl alkyl, a heteroaryl alkyl, and a heteroaryloxy alkyl or the like, J represents a carbonyl group, or a methylene group or the like, L represents a methoxy, hydroxyl or acetyloxy group or the like, X and Y independently represents a nitrogen atom or a carbon atom, Z represents a methylene group or a polyethylene group optionally having a substituent.Type: GrantFiled: August 8, 2000Date of Patent: October 9, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Koichi Ishida, Yoshikazu Suzuki
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Patent number: 6295930Abstract: A circuit breaker includes, a cylindrical portion having a gunpowder and a exploding unit for exploding the gunpowder by application of electric power to the gunpowder, the cylindrical portion being provided with an opening at at least one end; a base material securing the cylindrical portion, at least the surface of which is made of insulating material; a conductor fixed to the base material and having a break portion located at a position opposite to the opening of the cylindrical portion, the break portion being broken by explosive force of the gunpowder; a first metallic cover portion covering the cylindrical portion and the break portion; and a second metallic cover portion covering the base material from an opposite side to the cylindrical portion, wherein the first and second cover portions are fixed to the base material by directly connecting the first and second cover portions each other.Type: GrantFiled: December 29, 1998Date of Patent: October 2, 2001Assignees: Harness System Technologies Research, Ltd., Sumitomo Wiring Systems, Ltd., Sumitomo Electric Industries, Ltd., Nippon Kayaku Kabushiki KaishaInventors: Masahiro Kume, Motonori Kido, Yoshiyuki Miyazaki, Hideaki Toyama, Akio Matsumaru, Jun Yasukuni, Kenjiro Nishida, Junya Amano, Ayumu Kimura, Hiroshi Hori, Mitsuru Tanigawa
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Patent number: 6294547Abstract: A novel naphthyridine compound represented by the general formula (1): wherein R1, R2 and R3 are independently a hydrogen atom, a lower alkyl group or the like, or R1 and R2, or R2 and R3, when taken together, form a cyclic group; each of X and Y is a methylene or ethylene group; Z is a phenyl group, a substituted phenyl group or the like; A is a hydrogen atom, a lower alkyl group or the like; and G is an acyl group, shows antagonism for tachykinin receptors and is useful as a prophylactic or therapeutic agent for diseases for which the tachykinin receptors are considered to be responsible. A specific example of such a compound is 2-[(−)-4-(N-benzoyl-N-methyl)amino-3-(3,4-dichlorophenyl)butyl]-10-acetylamino-1,2,3,4-tetrahydro-benzo[b][1,6]naphthyridine.Type: GrantFiled: December 21, 1999Date of Patent: September 25, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hiroko Oka, Masashi Iida, Yoshitaka Sato, Maki Honda
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Patent number: 6294239Abstract: An ultraviolet-curable adhesive composition comprising a photopolymerization initiator whose molar absorption coefficient at a wavelength of 360-450 nm is at least 400 and an ultraviolet-curable compound. The adhesive composition of this invention can bond substrates which show transmittances of 0.01-20% to all of energy beams of a wavelength of 280-380 nm, to one another.Type: GrantFiled: May 12, 2000Date of Patent: September 25, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kiyohisa Tokuda, Kazuhiko Ishii
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Patent number: 6284185Abstract: An ultraviolet-curable adhesive composition comprising a photopolymerization initiator whose molar absorption coefficient at a wavelength of 360-450 nm is at least 400 and an ultraviolet-curable compound. The adhesive composition of this invention can bond substrates which show transmittances of 0.01-20% to all of energy beams of a wavelength of 280-380 nm, to one another such as base boards for an optical disk.Type: GrantFiled: March 9, 2000Date of Patent: September 4, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kiyohisa Tokuda, Kazuhiko Ishii
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Patent number: 6283505Abstract: A gas generator for air bags for use in an air bag system for safely protecting a driver and riders in a vehicle from shock from collisions. The system includes a housing (3) formed by a side cylinder (1b) with a plurality of gas exhaust openings (8) the housing being closed at its ends by an upper cap (1a) and a lower cap (2a); an igniting device (16), provided in the housing (3) at a center portion thereof; gas generating agents (6), provided in the housing (3) at a location radially outside of the igniting device (16), to be burnt to generate gas; a cooling/filtering member (7) provided in the housing (3) at a location radially outside of the gas generating agents (6) to enclose the gas generating agents and extending from the side of the upper cap (1a) to the side of the lower cap (2a); and an annular projection (50) for preventing the gas generated by the burning of the gas generating agents (6) from flowing toward an end portion of the cooling/filtering member (7).Type: GrantFiled: May 12, 1999Date of Patent: September 4, 2001Assignees: Nippon Kayaku Kabushiki-Kaisha, Kabushiki Kaisha Kobe Seiko ShoInventors: Takashi Saso, Koji Tanaka, Akihiko Kuroiwa, Norihisa Miyamoto
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Patent number: 6271238Abstract: The present invention relates to novel acetamide compounds having a substituted heterocyclic group and consecutive dicarbonyl structures, for example, 1-pyrimidinylacetamide compounds, and these compounds have inhibitory activity on chymotrypsin type proteases and are useful as inhibitors for said enzymes, particularly as chymase inhibitors. The novel acetamide compounds of the present invention are shown in formula (I) below: wherein R0 is substituted or unsubstituted phenyl; R1 is aryl or heteroaryl which may be substituted or unsubstituted; R2 is substituted or unsubstituted alkyl, arylalkyl, or heteroarylalkyl; R3 is hydrogen; acyl group; sulfonyl group; isocyanate group; thiourea; a lower alkyl or a substituted lower alkyl; aryl (1-7C) alkyl, heteroaryl (1-7C) alkyl, aryl and heteroaryl; X represents a carbon atom and Y represents a nitrogen atom; and Z is a polymethylene group wherein a hydrogen atom in the polymethylene may be replaced.Type: GrantFiled: March 1, 1999Date of Patent: August 7, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Yoshikazu Suzuki, Koichi Ishida
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Patent number: 6254958Abstract: The present invention aims to develop a photosensitive resin composition which exhibits a rapid ink absorption rate, which has an excellent water resistance, and which is appropriate for providing an ink receiving layer forming a sharp ink dot shape and having an excellent color formability of ink. A photosensitive resin composition forming an excellent ink receiving layer is obtained by incorporating at least one selected from an ethylenically unsaturated group-containing compound having quaternary nitrogen and a grain flour (filler) such as a wheat flour or the like in a photosensitive resin composition containing a quaternary nitrogen-free ethylenically unsaturated group-containing compound, a photopolymerization initiator etc.Type: GrantFiled: July 22, 1998Date of Patent: July 3, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Kenji Yoshida, Kiyohisa Tokuda, Kazuhiko Ishii
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Patent number: 6251355Abstract: The present invention relates to a novel fine cisplatin powder utilized as an anticancer agent. The fine cisplatin powder obtained in the present invention does not cause secondary agglomeration, is excellent in fluidity and easily handleable in the pharmaceutical preparation step. Furthermore, the fine cisplatin powder is reduced in the content of N,N-dimethylformamide as the residual solvent, and can be dissolved rapidly in physiological saline, thus being suitable for cancer therapy particularly by intra-arterial injection. This fine powder can be produced by contriving specified means for crystallizing cisplatin from a solution thereof in N,N-dimethylformamide.Type: GrantFiled: June 10, 1999Date of Patent: June 26, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Toshitaka Murata, Keizou Ishikawa, Osamu Kogawa, Kenji Iwata
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Patent number: 6221868Abstract: Remedies/preventives (therapeutic or preventive agents) against frequent urination (pollakiuria)/urinary incontinence which contain as an active ingredient compound having a tropone structure or pharmacologically acceptable salt thereof and a novel compound having the tropone structure. The compounds having a tropone structure and having the above pharmacological effects are those represented by, for example, general (1): wherein R1 and R2 represent each a hydrogen atom, lower alkyl group, etc., R3 represents —OR or —NR2; R4, R5 and R12 represents each a hydrogen atom or a lower alkyl group, X represents a nitrogen atom or CH, Z represents —CHAr2, an unsubstituted or substituted phenyl, etc. m is 1 or 2. These compounds are novel ones excluding those wherein Z is —CHAr2.Type: GrantFiled: December 20, 1999Date of Patent: April 24, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Ichiro Koga, Kazuhisa Narita, Atsushi Okada
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Patent number: 6214435Abstract: A novel aminium compound exhibiting excellent solubility for solvents and high safety in terms of handling and environment is provided. An aminium compound represented by the following formula (1): wherein R1 represents substituted or unsubstituted alkyl and A2− represents a divalent organic anion.Type: GrantFiled: December 20, 1999Date of Patent: April 10, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Masao Onishi, Tadayuki Kiyoyanagi
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Patent number: 6210912Abstract: A method for detecting the onset of chronic rejection at an early stage after organ transplantation, characterized by assaying nitrogen trioxide (NO3), matrix metalloproteinase (MMP)-2 or the precursor thereof in body fluids drawn out of body.Type: GrantFiled: February 12, 1999Date of Patent: April 3, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Isamu Koyama, Tadaki Yasumura, Kyuichi Nemoto, Takako Mae, Kan Saiga, Hisako Takagi, Atsuko Isoda, Toshio Tanabe
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Patent number: 6187783Abstract: A novel phenanthridinium derivative represented by general formula (A): wherein R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally be substituted with a substituent selected from the group consisting of a lower alkyl group, a halogen and a hydroxy group; each of Y and Z independently represents a hydrogen, a hydroxy or a lower alkoxy group; or Y and Z are combined together to form methylenedioxy or a phenyl ring; and, X− is an acid residue or a hydrogen acid residue, exhibits an antitumor activity and has resistance to chemical reduction as well as biological metabolic reactions and is thus advantageous for use as a medicine.Type: GrantFiled: May 20, 1999Date of Patent: February 13, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Akira Masuda, Masato Suwa, Masanobu Suzuki
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Patent number: 6184253Abstract: Disclosed is use of nonsteroidal anti-estrogen compounds such as toremifene citrate as active ingredient for treating autoimmune diseases.Type: GrantFiled: November 16, 1998Date of Patent: February 6, 2001Assignees: Nippon Kayaku Kabushiki Kaisha, Orion-yhtyma OyInventors: Junpei Itoh, Osamu Miyazaki, Hisao Ekimoto, Michinori Koyama, Tetsushi Saino, Lauri Kangas, Anni Warri, Christer Granberg
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Patent number: 6180796Abstract: The present invention provides a method for inhibiting tubulin polymerization and for treating rheumatism by administering to individuals in need thereof an effective amount of sulfonamide derivatives represented by the general formula (1): wherein R1 and R2 may be the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, a hydroxy group; each R3, R4, R5 and R6 represents a hydrogen atom; A represents any group of (1) 5-membered heterocyclic group which is optionally substituted by a lower alkyl group or phenyl group, whose ring members include at least 1 nitrogen atom and may include any atom(s) selected from the group consisting of nitrogen atom, oxygen atom, and sulfur atom, (2) an alicyclic group which is optionally substituted by a lower alkyl group or phenyl group, and (3) an alicyclic group whose ring members include at least 1 nitrogen atom and may include any atom(s) selected from the group consType: GrantFiled: November 15, 1999Date of Patent: January 30, 2001Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hirohisa Morohashi, Hiroshi Sato