Patents Assigned to Nippon Kayaku Kabushiki-Kaisha
  • Gas generator for an air bag
    Patent number: 5938236
    Abstract: A gas generator for air bags including a housing (3) defined by a side cylinder (1b) having a plurality of gas outflowing holes (10) and an upper cover (1a) and a lower cover (2a) for closing ends of the side cylinder (1b); an igniter (4), a gas generating agent (6) and a cooling filter member (8) disposed in this order in the housing (3) from a center thereof toward a radially outward side thereof; and a metallic foil (11) disposed on an inner wall surface of the side cylinder (1b) to cover the gas outflowing holes (10) from inside. The cooling filter member (8) extends from the upper cover (1a) to the lower cover (2a). The cooling filter member (8) is cylindrical in shape and has a thick walled portion (8a) formed on an outside diameter side on an end axially opposite to the gas outflowing holes (10), and the thick walled portion (8a) is press fitted into an inner surface of the housing (3).
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: August 17, 1999
    Assignees: Nippon Kayaku Kabushiki-Kaisha, Kabushiki Kaisha Kobe Seiko Sho
    Inventors: Koji Tanaka, Takashi Saso, Ken-ichi Nagahashi, Seigo Taguchi
  • Marking method
    Patent number: 5928842
    Abstract: The present invention provides a polyolefin resin-based marking composition capable of developing a vivid color in dark brown to black on irradiation with laser beams, moldings of the composition, and a laser marking method. The marking composition comprises a polyolefin resin-based marking composition containing from 0.005% by weight to less than 0.5% by weight of a silicon compound based on the polyolefin resin.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: July 27, 1999
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masaki Shinmoto, Shoiti Hayashihara
  • Process for producing optically active cyanohydrins
    Patent number: 5900503
    Abstract: An optically active cyanohydrin represented by the following general formula (1): ##STR1## wherein each of R1 and R2 is a hydrogen atom or an amino-protecting group, and the configurations relating to the carbon atoms at the *2-position and *3-position are as follows: in the case of the carbon atom at the *2-position being in R-configuration, the carbon atom at the *3-position is in S-configuration, and in the case of the carbon atom at the *2-position being in S-configuration, the carbon atom at the *3-position is in R-configuration, can be efficiently produced by crystallizing one of the optically active cyanohydrins while treating a mixture of cyanohydrin diastereomers in the presence of an amine and an organic solvent to change the configuration relating to the carbon atom at the 2-position and thereby cause isomerization.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: May 4, 1999
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yoshinobu Miyazawa, Taichi Koshigoe, Kouichi Ohkawa, Jouji Sekine, Shinichiro Saeki
  • Laser marking article and laser marking method
    Patent number: 5897938
    Abstract: The present invention relates to a laser marking article having two or more layers of thin films on the surface thereof, wherein one of the layers other than the outermost layer is a thin film made of a laser marking ground composition containing a laser beam-absorbing whitish inorganic compound powder and a binder as essential ingredients, and to a laser marking method comprising irradiating said laser marking article with a laser beam.According to the present invention, a vivid white-colored mark can be formed on the surface of an article even in case of low-energy laser irradiation or even in case of high-speed marking.
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: April 27, 1999
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masaki Shinmoto, Shoiti Hayashibara, Mitsuyo Nishitoh
  • Remedy for autoimmune diseases
    Patent number: 5886049
    Abstract: Disclosed is use of nonsteroidal anti-estrogen compounds such as toremifene citrate as active ingredient for treating autoimmune diseases.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: March 23, 1999
    Assignees: Nippon Kayaku Kabushiki Kaisha, Orion-yhtyma Oy
    Inventors: Junpei Itoh, Osamu Miyazaki, Hisao Ekimoto, Michinori Koyama, Tetsushi Saino, Lauri Kangas, Anni Warri, Christer Granberg
  • Human s-myc-like polypeptide and a gene coding for said polypeptide
    Patent number: 5861307
    Abstract: Human s-myc-like gene, mycL2 (SEQ ID NO: 3) was isolated and identified from human placenta genomic DNA by PCR and human s-Myc-like polypeptide MycL2 (SEQ ID NO: 2) as the expression product of the gene was identified. The genetic DNA embedded in liposome can be targeted to glioma cells to prevent the growth of tumor cells or cause apotosis.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: January 19, 1999
    Assignees: President of National Cancer Center, Nippon Kayaku Kabushiki Kaisha
    Inventors: Yoshiyuki Kuchino, Shigehide Kagaya
  • Process for producing dioxazine compounds, colored materials therewith and dioxazine compounds having a plate-like crystal form
    Patent number: 5859242
    Abstract: The present invention relates to a process for producing a dioxazine compound represented by the formula (1) which comprises carrying out a ring closure reaction of a compound represented by the formula (2) in the presence of a dioxazine derivative of the formula (3), colored materials containing this dioxazine compound, and dioxazine compounds having a plate-like crystal form: ##STR1##
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: January 12, 1999
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masaaki Ikeda, Junko Yoshioka, Masao Onishi
  • Squib for an air bag with an auto ignition composition
    Patent number: 5847310
    Abstract: A squib for a gas generator, comprising a magazine which is formed with a squib cup and a squib plug and is sealed; a pair of electrode lead pins penetrating through said squib plug to said magazine; a bearing wire connected to ends of said electrode lead pins; and an explosive contained in said magazine, said explosive composition containing a spontaneous firing explosive composition comprising carbohydrates, oxohalogenates and metal oxides.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: December 8, 1998
    Assignee: Nippon Kayaku Kabushiki-Kaisha
    Inventors: Ken-ichi Nagahashi, Yuji Ito, Ayumu Kimura, Masaharu Murakami, Eishi Sato, Michihisa Taguchi
  • Lanperisone formulation
    Patent number: 5843478
    Abstract: A lanperisone hydrochloride compression-molded formulation comprising the first granules containing lanperisone hydrochloride and the second granules containing substantially no lanperisone hydrochloride but at least one pharmaceutical additive(s) selected from the group consisting of sugars, crystalline celluloses and cellulose derivatives is an excellent formulation which has a high storage stability because the decomposition of lanperisone hydrochloride is suppressed.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: December 1, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Hiroshi Ohtaki, Rie Joshita
  • Epoxy resin, epoxy resin composition and hardened product thereof
    Patent number: 5840824
    Abstract: An object is to provide hardened products having excellent water resistance and mechanical strength, and an epoxy resin and an epoxy resin composition for use in the production thereof. An epoxy resin obtained by the glycidylation of a novolak type resin which is prepared by the condensation of biphenyls with phenols and naphthols, and a resin composition containing said epoxy resin and hardened products thereof.
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: November 24, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yasumasa Akatsuka, Kenichi Kuboki, Yoshio Shimamura, Ryoichi Hasegawa
  • Marking composition and laser marking method
    Patent number: 5824715
    Abstract: A marking composition comprising an energy ray curing resin, a leuco dye and a color developer both of which are low in solubility in toluene, which composition is capable of forming a vivid black color on irradiation with laser beams, and a laser marking method for forming a clear-cut black-colored mark by using the above composition.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: October 20, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Shoiti Hayashihara, Masaru Kudo, Masaki Shinmoto
  • Process for producing etoposide
    Patent number: 5821348
    Abstract: A protected 4'-demethyl-4-epipodophyllotoxin is reacted with a protected glucose derivative in a non-halogen type organic solvent in a 0.1-7-fold parts by volume based on 1 part by weight of the protected 4'-demethyl-4-epipodophyllotoxin to give an etoposide derivative of formula (3) which is protected at its functional groups: ##STR1## wherein each of R.sub.1 and R.sub.2 each is a protective group for hydroxy, if necessary, followed by removal of these protective groups. By use of the non-halogen type organic solvent in lieu of any harmful halogen type solvent, formation of undesirable by-products can be minimized so that the etoposides can be obtained in a high yield and high purity.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: October 13, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yukihiro Fusauchi, Hiroshi Yoshikawa
  • Gas generator with gas generant cushioning member and method of making thereof
    Patent number: 5806887
    Abstract: A gas generator for an air bag, including a combustion chamber and a hermetic container accommodated in the combustion chamber. Gas generant pellets are charged in the hermetic container. The hermetic container has a wall adapted to be destroyed during combustion of the gas generant pellets. A partition foil piece covers a surface formed by the gas generant pellets charged in the hermetic container so as to conform to a profile of the surface formed by the gas generant pellets. The partition foil piece is non-reactive with the gas generant pellets and has a strength lower than that of the hermetic container. A cushioning member presses the partition foil piece toward the gas generant pellets by a resilient force of the cushioning member so as to suppress movement of the gas generant pellets charged in the hermetic container.
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: September 15, 1998
    Assignees: Sensor Technology Co., Ltd., Nippon Kayaku Kabushiki-Kaisha
    Inventors: Koji Tanaka, Kenjiro Nishida, Hisafumi Kobayashi, Hiroyuki Ochi
  • Nerve cell differentiation promoter
    Patent number: 5804186
    Abstract: A nerve cell differentiation promoter which comprises a physiologically active substance NK175203 or a pharmacologically acceptable salt thereof as an active ingredient is provided. It is expected that the nerve cell differentiation promoter of the present invention is applicable to a medicine for dementia, a nerve cell protective medicine or a medicine for peripheral neuropathy caused by anticancer agents.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: September 8, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Daisuke Komagata, Tomio Morino
  • Composition adaptable or suitable for being marked and molding thereof
    Patent number: 5792807
    Abstract: The present invention relates to a marking composition capable of developing a vivid white color upon the application of laser beams, which composition comprises a polyolefin resin having no fluidity at a temperature of 50.degree. C. and at least one inorganic material selected from talc, calcium carbonate and aluminum hydroxide, wherein the inorganic material is blended in a ratio of 1-300 w/w % based upon the polyolefin resin. The invention also provides the resin moldings obtained by molding the marking compositions.
    Type: Grant
    Filed: September 18, 1996
    Date of Patent: August 11, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Shoiti Hayashihara, Masaru Kudho, Masaki Shinmoto, Chie Umeyama
  • Pharmaceutical use of forskolin derivatives
    Patent number: 5789439
    Abstract: The present invention relates to novel pharmaceutical use of forskolin derivatives represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2 and Ac are as defined later ##STR2## (wherein R.sup.3 and R.sup.4 are each hydrogen or lower alkyl group, or R.sup.3 and R.sup.4 may be combined to represent lower alkylene group which may have oxygen or nitrogen atom in the linking chain, and n is an integer of 1 to 5); R.sup.2 represents hydrocarbon group having 2 to 3 carbon atoms; and Ac represents acetyl group.The above-mentioned forskolin derivative or a physiologically acceptable salt thereof can be used as a platelet aggregation inhibiting or controlling agent, spasmolytic agent, therapeutic agent for skin ulcer, peripheral circulation improving agent for limbs and differentiation inducing and promoting agent.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: August 4, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Makoto Hosono, Akira Fujita, Giichi Izumi, Tochiro Tatee, Takashi Takahira, Yasuhiko Furuta, Michiko Sakai, Osamu Ishizuka, Takashi Terada, Junpei Itoh
  • Naphthalene ring-containing resins, resin compositions and cured products thereof
    Patent number: 5780571
    Abstract: This invention provides resins and resin compositions which afford cured products with high heat resistance, low water absorption and high adhesion which are useful as electric and electronic materials. Resins obtained by condensation reaction between 4,4'-di(.omega.-substituted methyl)biphenyl or the like and naphthols; epoxy resins obtained by glycidyleterifying said resins; epoxy resin compositions containing these resins; and cured products thereof are disclosed.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: July 14, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Hiroaki Ohno, Hiromi Morita, Shigeru Moteki, Yasumasa Akatsuka
  • Spontaneously-firing explosive composition
    Patent number: 5756928
    Abstract: A gas generator for an air bag is provided which contains a spontaneously-firing explosive composition in which at least one of a squib, igniting agent and a gas generant is contained in a casing formed of a light alloy material, the spontaneously-firing explosive composition containing carbohydrates, oxohalogenates and metal oxides or alternatively carbohydrates, oxohalogenates, metal oxides and one or more synthetic resins. The spontaneously-firing explosive composition has a spontaneous firing property in temperature range of either 165.degree.-220.degree. C. or 165.degree.-200.degree. C. The effective temperature range may be selected as needed.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: May 26, 1998
    Assignees: Sensor Technology Co., Ltd., Nippon Kayaku Kabushiki-Kaisha
    Inventors: Yuji Ito, Ayumu Kimura, Masaharu Murakami, Eishi Sato, Michihisa Taguchi
  • Process for preparing benzo?c!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents
    Patent number: 5747502
    Abstract: The present invention relates to benzo?c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: May 5, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Miyoji Hanaoka, Hisao Ekimoto, Fumiko Kobayashi, Yukio Irie, Katsutoshi Takahashi, Masanobu Suzuki, Takeshi Nakanishi, Osamu Kogawa, Keizou Ishikawa
  • Process for producing dioxazine compounds, colored materials therewith and dioxazine compounds having a plate-like crystal form
    Patent number: 5734050
    Abstract: The present invention relates to a process for producing a dioxazine compound represented by the formula (1) which comprises carrying out a ring closure reaction of a compound represented by the formula (2) in the presence of a dioxazine derivative of the formula (3): ##STR1##
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: March 31, 1998
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masaaki Ikeda, Junko Yoshioka, Masao Onishi