Patents Assigned to Nippon Suisan Kaisha, Ltd.
  • Patent number: 11330817
    Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: May 17, 2022
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideaki Yamaguchi, Yuhei Kosuge, Rie Ikeda, Nobushige Doisaki, Seizo Sato
  • Publication number: 20220106617
    Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides, comprising hydrolyzing a feedstock oil containing glycerides comprising docosahexaenoic acid as a constituent fatty acid by action of a first lipase and a second lipase, thereby increasing the proportion of docosahexaenoic acid in glyceride fractions, wherein the first lipase is at least one lipase selected from the group consisting of a lipase derived from a microorganism of the genus Thermomyces, a lipase derived from a microorganism of the genus Pseudomonas, a lipase derived from a microorganism of the genus Burkholderia, and a lipase derived from a microorganism of the genus Alcaligenes, and wherein the second lipase is a partial glyceride lipase.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 7, 2022
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuuji HIROUCHI, Isao YAMAZAKI, Natsuko WATANABE, Kiyomi FURIHATA
  • Publication number: 20220049185
    Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.
    Type: Application
    Filed: October 26, 2021
    Publication date: February 17, 2022
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideaki YAMAGUCHI, Nobushige DOISAKI, Seizo SATO, Yuhei KOSUGE
  • Patent number: 11248190
    Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: February 15, 2022
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
  • Publication number: 20220042052
    Abstract: A method for producing a microbial oil includes steps of: genetically modifying a labyrinthulid by disrupting and/or silencing a gene, or by transforming another gene in addition to the disruption and/or gene silencing of the gene, and culturing the labyrinthulid, such that a fatty acid composition accumulated in the labyrinthulid comprises an increased EPA content; and collecting the microbial oil having the increased EPA content from the labyrinthulid. The labyrinthulid before the modification is selected from (A) a labyrinthulid belonging to the genus Parietichytrium or genus Schizochytrium and having very weak or no activity of producing PUFAs via a PUFA-PKS pathway; and (B) a labyrinthulid belonging to the genus Thraustochytrium in which a host PUFA-PKS gene is disrupted or silenced to a very weak level. The increased EPA content is preferably not less than 11.5% of a total fatty acid composition.
    Type: Application
    Filed: August 13, 2021
    Publication date: February 10, 2022
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KONAN GAKUEN, NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuji OKITA, Makoto Ito, Rie Hamaguchi, Hatsumi Goda, Seiya Mochinaga, Daisuke Honda
  • Publication number: 20220022431
    Abstract: The transplant fish production method includes selecting a donor fish species, selecting first and second fish species which are a combination that could be sterile, producing a hybrid fish species of the selected first fish species and second fish species, and transplanting reproductive cells of the donor fish species into the produced hybrid fish species.
    Type: Application
    Filed: March 1, 2021
    Publication date: January 27, 2022
    Applicants: National University Corporation Tokyo University of Marine Science and Technology, Nippon Suisan Kaisha, Ltd.
    Inventors: Goro YOSHIZAKI, Yutaka TAKEUCHI, Ryosuke YAZAWA, Wataru KAWAMURA
  • Publication number: 20210401014
    Abstract: A method for pickling a marine product under conditions satisfying the following a) to c): a) the total ionic strength during treatment is from 0.2 to 0.8 mol/kg; b) the total sodium chloride concentration is less than 1.5% by weight; and c) the pH of the pickled shrimp meat is from 6.5 to 8.6, where, the total ionic strength and total sodium chloride concentration mean the ionic strength and the sodium chloride concentration with respect to the sum of the weight of the marine products and the weight of the water of the pickling solution, assuming that the weight of the marine products is the weight of water.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Takashi MORI, Kota INOHARA, Akiko TAKAHASHI, Kiminori SUGIYAMA
  • Patent number: 11193085
    Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 7, 2021
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideaki Yamaguchi, Nobushige Doisaki, Seizo Sato, Yuhei Kosuge
  • Publication number: 20210324432
    Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides, comprising hydrolyzing a feedstock oil containing glycerides comprising docosahexaenoic acid as a constituent fatty acid by action of a Candida cylindracea derived lipase and a partial glyceride lipase, thereby increasing the proportion of docosahexaenoic acid in glyceride fractions, wherein the lipase hydrolysis reaction is performed at a temperature no higher than 30° C. for a period no longer than 15 hours.
    Type: Application
    Filed: September 4, 2019
    Publication date: October 21, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuuji HIROUCHI, Isao YAMAZAKI, Kiyomi FURIHATA, Nobushige DOISAKI
  • Publication number: 20210324433
    Abstract: The purpose of the present invention is to provide an oil/lipid that contains dihomo-?-linolenic acid at a higher purity. Provided is a microbial oil/lipid that is specified by a high content of dihomo-?-linolenic acid contained therein and/or a reduced content of undesirable constituting fatty acid(s).
    Type: Application
    Filed: June 28, 2021
    Publication date: October 21, 2021
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventors: Seizo SATO, Takayoshi SEKIGUCHI, Misaki TAKAHASHI
  • Publication number: 20210315187
    Abstract: A method of rearing an aquaculture shrimp includes keeping shrimps in a land-farming nursery, and feeding to the shrimps kept in the land-farming nursery a feed including astaxanthin in an amount of 50 ppm or greater.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 14, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hiroshi MINAMI, Kosuke MATSUOKA
  • Patent number: 11103476
    Abstract: [Problem] To provide a composition for external skin use that has anti-inflammatory and antiallergic activity, and is very safe. [Solution] A composition for external skin use for inflammatory diseases contains dihomo-gamma-linolenic acid (DGLA) as the active ingredient thereof. It is preferable for the DGLA to be present as a glyceride, a phospholipid, or an alkyl ester. The amount of DGLA contained in the composition for external use is 0.1-50 wt %.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: August 31, 2021
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Jiro Takeo, Hiroyuki Kawahara
  • Patent number: 11071288
    Abstract: An aquacultured shrimp contains carotenoid and does not have a broken 2nd antenna.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 27, 2021
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hiroshi Minami, Kosuke Matsuoka
  • Patent number: 11034643
    Abstract: A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 15, 2021
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Nobushige Doisaki, Kazuhiko Hata, Shinji Tokiwa, Kazunori Matsushima
  • Publication number: 20210139813
    Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
    Type: Application
    Filed: January 21, 2021
    Publication date: May 13, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Nobushige DOISAKI, Kiyomi FURIHATA, Hideaki YAMAGUCHI
  • Publication number: 20210102142
    Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 8, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuhei KOSUGE, Hideaki YAMAGUCHI, Nobushige DOISAKI
  • Patent number: 10952414
    Abstract: An aquaculture system including an aquaculture tank for holding aquaculture water for culturing an aquatic organism, a thermal insulation house that covers the aquaculture tank, an insulation positioned on at least part of a region surrounding the aquaculture tank, and a temperature adjuster that adjusts a temperature inside the thermal insulation house and/or a temperature of the aquaculture water in the aquaculture tank.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: March 23, 2021
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Hiroshi Minami, Mitsuho Maeda, Eisuke Yasue, Kosuke Matsuoka
  • Publication number: 20210077447
    Abstract: The present invention provides a composition for improving lymphatic circulation, which contains a component selected from at least one highly unsaturated fatty acid, salt thereof, and ester thereof as an active ingredient. The present invention also provides a composition for improving lymphatic circulation, which contains as active ingredients a triglyceride comprising the at least one highly unsaturated fatty acid as a constituent fatty acid and a triglyceride comprising the at least one middle chain fatty acid as a constituent fatty acid. The present invention also provides a composition for improving lymphatic circulation, which contains as an active ingredient a triglyceride comprising the at least one highly unsaturated fatty acid and the at least one middle chain fatty acid as constituent fatty acids.
    Type: Application
    Filed: February 8, 2019
    Publication date: March 18, 2021
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Kenichi YANAGIMOTO, Li HAN, Bungo SHIROUCHI
  • Publication number: 20210071101
    Abstract: Docosahexaenoic acid-containing oil containing docosahexaenoic acid in a concentration of 40 wt. % or more of the total weight of fatty acids in the oil, and having an endothermic peak temperature determined by differential scanning calorimetry (DSC) of 15° C. or lower; a biomass including the same; and a method for producing docosahexaenoic acid-containing oil including obtaining a biomass by culturing microorganisms of the genus Aurantiochytrium capable of producing this docosahexaenoic acid-containing oil, recovering the biomass after culture, and extracting the oil from the biomass after recovery.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 11, 2021
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventors: Takayoshi SEKIGUCHI, Yuji OKITA, Yumiko NISHIZAWA
  • Patent number: 10927323
    Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: February 23, 2021
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi