Patents Assigned to Nippon Suisan Kaisha, Ltd.
  • Patent number: 10576053
    Abstract: Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Torr or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: March 3, 2020
    Assignees: NIPPON SUISAN KAISHA, LTD., MOCHIDA PHARMACEUTICAL CO., LTD.
    Inventors: Nobushige Doisaki, Shingo Arato, Takuro Fukae
  • Patent number: 10525028
    Abstract: [Problem] To provide a composition for external skin use that has anti-inflammatory and antiallergic activity, and is very safe. [Solution] A composition for external skin use for inflammatory diseases contains dihomo-gamma-linolenic acid (DGLA) as the active ingredient thereof. It is preferable for the DGLA to be present as a glyceride, a phospholipid, or an alkyl ester. The amount of DGLA contained in the composition for external use is 0.1-50 wt %.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 7, 2020
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Jiro Takeo, Hiroyuki Kawahara
  • Publication number: 20190364857
    Abstract: An aquaculture system including an aquaculture tank for holding aquaculture water for culturing an aquatic organism, a thermal insulation house that covers the aquaculture tank, an insulation positioned on at least part of a region surrounding the aquaculture tank, and a temperature adjuster that adjusts a temperature inside the thermal insulation house and/or a temperature of the aquaculture water in the aquaculture tank.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 5, 2019
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventors: Hiroshi Minami, Mitsuho Maeda, Eisuke Yasue, Kosuke Matsuoka
  • Publication number: 20190364856
    Abstract: An aquaculture system including an aquaculture tank for holding aquaculture water for conducting biofloc aquaculture therein, and an immobilizing material in the aquaculture tank. The immobilizing material includes a carrier that carries nitrifying bacteria.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 5, 2019
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventor: Hiroshi MINAMI
  • Patent number: 10399923
    Abstract: A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: September 3, 2019
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Nobushige Doisaki, Kazuhiko Hata, Shinji Tokiwa, Kazunori Matsushima
  • Patent number: 10399922
    Abstract: A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 3, 2019
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Nobushige Doisaki, Kazuhiko Hata, Shinji Tokiwa, Kazunori Matsushima
  • Patent number: 10376485
    Abstract: A method for ameliorating metabolic syndrome may include administering, to a patient in need thereof, an effective amount of a monounsaturated fatty acid having 22 carbons or a salt or an ester thereof and/or an effective amount of a monounsaturated fatty acid having 20 carbons or a salt or an ester thereof.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: August 13, 2019
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Zhi-hong Yang, Hiroko Miyahara, Shuhei Takemura, Akimasa Hatanaka
  • Publication number: 20190216059
    Abstract: An aquacultured shrimp contains carotenoid and does not have a broken 2nd antenna.
    Type: Application
    Filed: February 15, 2019
    Publication date: July 18, 2019
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hiroshi MINAMI, Kosuke MATSUOKA
  • Publication number: 20190119689
    Abstract: A microbial oil is obtained from Labyrinthulomycetes in which a gene for fatty acid biosynthesis has been disrupted or an expression of the gene has been inhibited to highly accumulate the fatty acid. The microbial oil typically contains: (a) 1.5% or more of arachidonic acid (AA) based on a total amount of fatty acid; (b) 0.2% or more of dihomo-?-linolenic acid (DGLA) based on the total amount of fatty acid; (c) 0.04% or more of eicosatetraenoic acid (ETA) based on the total amount of fatty acid; (d) 3.8% or more of eicosapentaenoic acid (EPA) based on the total amount of fatty acid; (e) 13.7% or less of n-6 docosapentaenoic acid (n-6DPA) based on the total amount of fatty acid; and (f) 43.9% or less of docosahexaenoic acid (DHA) based on the total amount of fatty acid.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 25, 2019
    Applicants: KYUSHU UNIVERSITY, NAT'L UNIVERSITY CORPORATION, UNIVERSITY OF MIYAZAKI, KONAN GAKUEN, NIPPON SUISAN KAISHA, LTD.
    Inventors: Keishi Sakaguchi, Rie Hamaguchi, Takanori Matsuda, Makoto Ito, Naoki Nagano, Masahiro Hayashi, Yuji Okita, Shinichi Sugimoto, Daisuke Honda
  • Patent number: 10138502
    Abstract: A method for lowering saturated fatty acid content, the method comprising concentrating polyunsaturated fatty acid using a lipase having low reactivity for the polyunsaturated fatty acid to react with a glyceride containing a polyunsaturated fatty acid; wherein the lipase reaction is performed at a temperature of not more than 25° C.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: November 27, 2018
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideo Ikemoto, Nobushige Doisaki, Yasuo Umehara
  • Publication number: 20180320208
    Abstract: A Labyrinthulid microorganism capable of producing a PUFA only through the elongase-desaturase pathway. A Labyrinthulid microorganism which has no ability of producing a PUFA through the endogenous PUFA-PKS pathway or has the ability at an extremely weak level and which has an ability of producing a PUFA through the endogenous elongase-desaturase pathway. The Labyrinthulid microorganism is a microorganism belonging to the genus Parietichytrium or Parietichytrium.
    Type: Application
    Filed: July 4, 2016
    Publication date: November 8, 2018
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KONAN GAKUEN, NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuji Okita, Makoto Ito, Rie Hamaguchi, Hatsumi Goda, Seiya Mochinaga, Daisuke Honda
  • Patent number: 10105340
    Abstract: Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Ton or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: October 23, 2018
    Assignees: NIPPON SUISAN KAISHA, LTD., MOCHIDA PHARMACEUTICAL CO., LTD.
    Inventors: Nobushige Doisaki, Shingo Arato, Takuro Fukae
  • Publication number: 20180273877
    Abstract: Docosahexaenoic acid-containing oil containing docosahexaenoic acid in a concentration of 40 wt. % or more of the total weight of fatty acids in the oil, and having an endothermic peak temperature determined by differential scanning calorimetry (DSC) of 15° C. or lower; a biomass including the same; and a method for producing docosahexaenoic acid-containing oil including obtaining a biomass by culturing microorganisms of the genus Aurantiochytrium capable of producing this docosahexaenoic acid-containing oil, recovering the biomass after culture, and extracting the oil from the biomass after recovery.
    Type: Application
    Filed: May 31, 2018
    Publication date: September 27, 2018
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventors: Takayoshi SEKIGUCHI, Yuji OKITA, Yumiko NISHIZAWA
  • Publication number: 20180195021
    Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.
    Type: Application
    Filed: February 27, 2018
    Publication date: July 12, 2018
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Yuhei KOSUGE, Hideaki YAMAGUCHI, Nobushige DOISAKI
  • Publication number: 20180187126
    Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.
    Type: Application
    Filed: February 27, 2018
    Publication date: July 5, 2018
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Hideaki YAMAGUCHI, Nobushige DOISAKI, Seizo SATO, Yuhei KOSUGE
  • Patent number: 9961924
    Abstract: This invention provides a feed for fish farming which is excellent in terms of stability of feed supply and feed shelf life and which has excellent feed intake and feed efficiency. The feed for fish farming has an outer layer and an inner layer, characterized in that a composition constituting the outer layer has a breaking stress of 5×104 to 1×106 N/m2, a cohesiveness (30%) of 0.4 to 1.0, and a breaking strain of 30 to 80%. The feed for fish farming is characterized by having an outer layer constructed from a heat-induced gel which comprises a protein and/or a starch, and an inner layer comprising a composition which contains nutrient ingredients having fish meal and an oil as essential ingredients.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: May 8, 2018
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Tsuyoshi Goto, Yasuhiro Fukuda, Itaru Shioya, Hideki Nikaido, Yosuke Tanaka, Taeko Kousaka
  • Publication number: 20180077909
    Abstract: Provided are a method of maintaining the ovaries of marine fish, and a method of obtaining fertilized egg. Provided is a method of maintaining ovaries in which the ovaries are removed from marine fish and the ovaries or fragmented ovaries are cultured in a culture solution. Also, provided is a method of obtaining fertilized eggs of marine fish, the method including allowing ovaries, which have been maintained after removal to ovulate and performing artificial insemination. Further, the present invention relates to a method of maintaining the fertilization capability of ovulated eggs of marine fish by using the culture solution. According to the present invention, fertilized eggs of marine fish can be easily obtained and seed can be efficiently produced.
    Type: Application
    Filed: January 19, 2016
    Publication date: March 22, 2018
    Applicant: Nippon Suisan Kaisha, Ltd.
    Inventors: Taku ENDO, Naoki KUMAKURA, Shinji ADACHI
  • Patent number: 9918953
    Abstract: Provided are: an eicosapentaenoic acid alkyl ester-ontaining composition which comprises 96-99 area % of an eicosapentaenoic acid alkyl ester, wherein the content of an arachidonic acid alkyl ester is 0.7 area % or less, and the content of mono-trans forms of the eicosapentaenoic acid alkyl ester is 2.5 area % or less; a method for producing a high-concentration eicosapentaenoic acid alkyl ester-containing composition, which comprises performing rectification on an eicosapentaenoic acid alkyl ester-containing composition with the degree of vacuum being 0.2 Torr or less and at a whole-column temperature 190° C. or less, and performing a concentration treatment on the rectified composition using chromatography, the eicosapentaenoic acid alkyl ester-containing composition being obtained by alkyl esterifying a feed oil containing eicosapentaenoic acid.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: March 20, 2018
    Assignees: NIPPON SUISAN KAISHA, LTD., MOCHIDA PHARMACEUTICAL CO., LTD.
    Inventors: Nobushige Doisaki, Shingo Arato, Takuro Fukae
  • Publication number: 20180042230
    Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.
    Type: Application
    Filed: October 25, 2017
    Publication date: February 15, 2018
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Seizo SATO, Takuro FUKAE, Naomi OHTSUKA, Hideaki YAMAGUCHI, Rie IKEDA
  • Patent number: 9820484
    Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: November 21, 2017
    Assignee: NIPPON SUISAN KAISHA, LTD.
    Inventors: Seizo Sato, Takuro Fukae, Naomi Ohtsuka, Hideaki Yamaguchi, Rie Ikeda