Abstract: New antiviral nonaprenylamine derivatives represented by the following formula ##STR1## wherein R is 4 or 5 atoms selected from the group consisting of C and N so as to complete, with the non-R nitrogen, a 5- or 6-membered heterocyclic ring, and X is selected from the group consisting of H and hydroxy-lower alkyl and non-toxic, pharmaceutically acceptable acid addition salts thereof and a pharmaceutically acceptable carrier.

Abstract: A vaccine useful for the protection of poultry from colibacillosis infections which comprises as an active ingredient pre-inactivated and ultrasonicated E. coli cells, and a method for protecting poultry from colibacillosis infections which comprises inoculating said vaccine into poultry through cloaca.

Abstract: The transdermal penetration of N-(2-hydroxyethyl) nicotinamide nitrate useful for the treatment of angina pectoris is improved by the use of a mixed solvent comprising an alcohol of 2 to 7 carbon atoms and an aliphatic ester having a molecular weight of at least 180 in the formulation of the external preparations.

Abstract: 2-Alkylsulfinyl-4(3H)-quinazolinone derivatives of formula (I) are provided. ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl group, an aryl group, a substituted aryl group or an aralkyl group, R.sub.2 is a phenyl group, a substituted phenyl group or a 5- or 6-membered heterocyclic group containing one or more N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring, n is 1 or 2 and X is hydrogen, a C.sub.1 -C.sub.6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

Abstract: 4-Thioquinazoline derivatives of formula (I) are provided. ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 alkylamino group, a phenyl group, a substituted phenyl group or a 5- or 6-membered heterocyclic group containing one or two N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

Abstract: A jet air flow crusher has a guide face formed by the inside surface of an outer wall in which a flat and almost ellipsoidal internal space is defined to guide an ellipsoidal gas phase flow powder grains; a crushing zone in which flowing powder grains are crushed provided on one side of the internal space in the direction of the ellipsoidal major axis; a classifying zone at which flowing powder grains are discharged provided on the other side of the internal space in the direction of the ellipsoidal major axis; a gas phase flow passage defined in the crushing zone by the inside surface of the outer wall and a partition wall; nozzles installed in the outer wall and the partition wall at several locations in the direction of the powder grain flow in the crushing zone to jet out air in a direction substantially corresponding to the powder grain flow for carrying and crushing the powder grains, and flow resisting means for limiting the gas phase flow carrying the powder grains, arranged at least at one location b

Abstract: Extruded elongate pasta is disclosed, each pasta strand having at least one groove formed longitudinally in the pasta strand in such a manner that the total cross sectional area of the groove is 2 to 25% of the cross sectional area of the pasta strand, and the groove in the pasta strand is substantially closed after the elongate pasta is boiled or dipped in hot water.

Abstract: New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octane-3-on e, by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.

Abstract: New .alpha.-amylase inhibitor from wheat (WAI-53). The inhibitor is characterized especially by having molecular weight of 24,000 as determined by gel filtration, giving a single band at an electrophoretic mobility of 0.53 on polyacrylamide gel electrophoresis according to the Davis Disc Electrophoresis Method and producing saturation curves of WAI-53 with human salivary alpha-amylase and with human pancreatic alpha-amylase with a ratio of the amount of WAI-53 required to produce 50% inhibition of human salivary .alpha.-amylase to that of human pancreatic amylase above 1:250. The alpha-amylase inhibitor is used for quantitative analysis of alpha-amylase isozymes in body fluid.

Abstract: New processes for preparing new steroid derivatives including ergosta-1,5,7,22-tetraen-3.beta.-ol, 1.alpha.-hydroxyergosteryl diacetate, etc. which are useful intermediates in the synthesis of 1.alpha.-hydroxy vitamin D.sub.2. The processes include the new steps of reacting ergosta-1,4,6,22-tetraen-3-one with isopropenyl acetate in the presence of an acid catalyst followed by reduction to ergosta-1,5,7,22-tetraen-3.beta.-ol. The overall yield leading to 1.alpha.-hydroxy vitamin D.sub.2 is dramatically increased.

Abstract: 2,6-Dimethyl-4-(2- or 3-substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diesters, having vasodilating and blood pressure lowering effects, in the ester moiety at the 3-position of which a heterocyclic group is linked to an alkylene group through an ester bond (carbonyloxy group). The diesters are used for treatment of cardiac diseases, cerebrovascular diseases and hypertension.

Abstract: Nonyl prenyl-N heterocyclic compounds are prepared, useful as antivirals.

Abstract: Extruded elongate pasta is disclosed, each pasta strand having at least one groove formed longitudinally in the pasta strand in such a manner that the total cross sectional area of the groove is 2 to 25% of the cross sectional area of the pasta strand, and the groove in the pasta strand is substantially closed after the elongate pasta is boiled or dipped in hot water. A die structure for extruding the elongate pasta is also disclosed, the die structure being so arranged that a projection is projected toward the axis of a die hole from the inner surface of the die hole and that the coefficient of friction of the inner surface of the die hole is 0.4 or less. It is preferable that a tapered portion is formed on the upstream end of the projection. Further, an extruder for forming the elongate pastas which has a number of such die holes is also disclosed, in which projections of the die holes are projected perpendicularly to the aligning direction of the die holes.

Abstract: Disclosed herein are saturated and unsaturated aliphatic acids and esters of formula R--Z as defined in the specification which are antiulcer agents.

Abstract: An improved process for the preparation of 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine and acid addition salts thereof, which are useful as a medicine. This process comprises effecting reaction between 4,5,6,7-tetrahydrothieno[3,2-c]pyridine and 2-chlorobenzyl halide in the presence of a phase transfer catalyst.

Abstract: New compound, designated as leucanicidin, is now provided and is useful as insecticide. Leucanicidin is fermentatively produced by a microorganism Streptomyces halstedii No. 3002-14 (identifiable as FERM BP-493).

Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 and R.sub.3, taken together with the nitrogen atom to which they are bonded, form an N' hydroxylalkyl substituted piperazine, and (aklylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.

Abstract: New processes for preparing cholesta-1,5,7-trien-3-ol which is a key intermediate in the synthesis of 1.alpha.-hydroxyvitamin D.sub.3. The processes utilize the steps of reacting cholesta-1,4,6-trien-3-one with isopropenyl acetate in the presence of an acid catalyst followed by reduction of the resultant cholesta-1,3,5,7-tetraen-3-yl-acetate.

Abstract: This invention relates to isoprenylamine derivatives and acid addition salts thereof, which compounds are useful for controlling virus infection of vertebrate animals.

Abstract: A stabilized pharmaceutical composition containing 4-(3-tert.-butylamino-2-hydroxy)propoxy-2-methylisocarbostyril or an acid addition salt thereof as the active ingredient is now provided, in which the active ingredient compound is stabilized by addition of at least one of stabilizing agents selected from magnesium silicate, magnesium oxide, hydrotalcite and sodium hydrogen carbonate.