Patents Assigned to Nisshin Flour Milling Co., Ltd.
  • Patent number: 4659833
    Abstract: Four different optical isomers of a new compound, 1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy)-2-p ropanol are now provided as new substances. These four optical isomers are now named as (2R, 1'S)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, (2S, 1'S)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, (2S, 1'R)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, and (2R, 1'R)-1-[2'-(o-methoxyphenoxy)-1'-methylethylamino]-3-(4"-isocarbostyriloxy )-2-propanol, respectively. These four optical isomers have different activities for their .beta.-adrenergic-blocking effect and .alpha.-adrenergic-blocking effect and are useful as valuable agents for therapeutic treatment of various cardiovascular diseases, as compared to an optically inactive racemic mixture of said isomer compounds.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: April 21, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Toshihiro Takahashi, Noriyoshi Sueda, Masahiro Tsuji, Yoshiyuki Tahara, Hiroyasu Koyama, Yoshikuni Suzuki, Masao Nagase, Toshiji Sugai
  • Patent number: 4658063
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 is a hydrogen atom, R.sub.3 is a lower alkyl group, and (alkylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: April 14, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Patent number: 4649135
    Abstract: Mycotrienin-related compounds called the T-23-X, -XI, -XII, -XIII and -XIV. These compounds are isolated and characterized by structural formula and other identifying data. They are useful in the treatment of tumors.
    Type: Grant
    Filed: April 15, 1986
    Date of Patent: March 10, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Shigeru Hiramoto
  • Patent number: 4645862
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.3 each is benzyl or substituted with up to 3 methoxy groups, R.sub.2 is a hydrogen atom and (alkylene) is lower alkyl and the compounds are useful for controlling viral infections.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: February 24, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Patent number: 4642314
    Abstract: An antiulcer composition, containing, as active ingredient, an antiulcer effective amount of an isoprene derivative as herein defined, is described.
    Type: Grant
    Filed: November 14, 1984
    Date of Patent: February 10, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Michiko Nagai, Katsura Kogure, Shigeo Kawase, Teruhito Yamaguchi
  • Patent number: 4621154
    Abstract: An improved process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid which is useful as anti-inflammatory and analgesic agents. The process comprises reacting biphenyl with succinic anhydride in chlorobenzene in the presence of anhydrous aluminum chloride. No 4-(4-chlorophenyl)-4-oxo-butanoic acid is produced as by-product.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: November 4, 1986
    Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Chemicals Co., Ltd.
    Inventor: Haruhiko Kikuchi
  • Patent number: 4610828
    Abstract: L-carnitine and salts thereof are resolved from DL-carnitine by the use as a resolving agent of dibenzoyl-L(+)tartaric acid. L-carnitine is known as vitamin B.sub.T and is useful as a medicine.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: September 9, 1986
    Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Chemicals Co., Ltd.
    Inventor: Haruhiko Kikuchi
  • Patent number: 4604192
    Abstract: In a powder classifier of the kind having a turbine-like horizontally rotating classifying rotor which is arranged to have air diametrically flow into radial passages and to cause the coarse powder portion of a powder material supplied to the inside of the radial passages to move to a circular passage encompassing the outer circumference of the rotor and the fine powder portion of the powder material to move diametrically toward the inside of the rotor, the circular passage has a discharge port formed in a part of the outer circumferential wall thereof. To the discharge port is connected a coarse powder discharge duct which approximately tangentially extends from the discharge port of the circular passage to a chute part arranged above a coarse powder recovering device; a powder return duct is connected to the chute part and extends approximately tangentially relative to the circular passage from the chute part to an opening provided in the outer circumferential wall of the circular passage.
    Type: Grant
    Filed: May 10, 1984
    Date of Patent: August 5, 1986
    Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Engineering Co., Ltd.
    Inventors: Yukiyoshi Yamada, Shin Doi, Masayuki Yasuguchi
  • Patent number: 4600587
    Abstract: Disclosed is a process of producing a frozen yeast fermented dough which involves first emulsifying the total amount of water required for the dough with fat or oil before mixing with other dough ingredients.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: July 15, 1986
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Satoshi Nomura, Shinji Ishigami
  • Patent number: 4596497
    Abstract: A powder disperser comprises a nozzle having a narrow discharge port for discharging a powder. A high speed air flow discharge port forms a narrow air port encompassing the outer circumference of the discharge port of the nozzle and is inwardly slanting at an acute angle relative to the discharge direction of a powder flow from the nozzle. A powder dispersing passage is narrowly formed on the downstream side of the nozzle in a circular tube like shape or in a radial shape along the outer wall surface continuing from the outer wall of the high speed air flow discharge port. The powder discharge passage is connected to the powder supply port of a classifier located downstream next to the disperser.
    Type: Grant
    Filed: May 3, 1984
    Date of Patent: June 24, 1986
    Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Engineering Co., Ltd.
    Inventors: Yukiyoshi Yamada, Shin Doi, Masayuki Yasuguchi
  • Patent number: 4587237
    Abstract: Mycotrienin-related compounds called the T-23-VIII and T-23-IX substances. These substances are isolated and characterized by structural formula and other identifying data. These substances are useful in the treatment of tumors.
    Type: Grant
    Filed: September 6, 1985
    Date of Patent: May 6, 1986
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Shigeru Hiramoto
  • Patent number: 4579746
    Abstract: A new method of preparing a cooked and frozen noodle product capable of being re-cooked to the "ready-to-eat" state uniformly in its texture with recovering the original, good chewiness of the non-frozen, cooked noodle product, is now provided, which method comprises applying water onto the outer, exposing surfaces of the noodles cooked and frozen in a clump form, followed by freezing the applied water on the noodle surfaces.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: April 1, 1986
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventor: Akio Hirose
  • Patent number: 4568765
    Abstract: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful as medicines for controlling virus infection of vertebrate animals, or the intermediates therefor.
    Type: Grant
    Filed: May 12, 1982
    Date of Patent: February 4, 1986
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Patent number: 4562078
    Abstract: Barm for bakery and pastry products is produced by mixing an alcohol-freed beer solution with Koji and incubating the mixture at a temperature of 20.degree.-30.degree. C. The Koji is prepared by inoculating steamed rice with Aspergillus oryzae.
    Type: Grant
    Filed: June 21, 1983
    Date of Patent: December 31, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Rikiichi Kizawa, Shinji Ishigami
  • Patent number: 4560471
    Abstract: A powder classifier having two stages of classification blades which are arranged to intersect the radial directions of the powder classifier.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: December 24, 1985
    Assignees: Nisshin Flour Milling Co. Ltd., Nisshin Engineering Co., Ltd.
    Inventors: Yukiyoshi Yamada, Masayuki Yasuguchi
  • Patent number: 4555365
    Abstract: Compounds of the formula R.sub.1 --CO--NH.sub.2 wherein R.sub.1 is ##STR1## are described. The compounds are useful in the treatment of hypertension and hyperlipidemia.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: November 26, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Toshihiro Takahashi, Hiroyasu Koyama, Yoshikuni Suzuki, Masatoshi Yasuda
  • Patent number: 4526893
    Abstract: Compounds of the structure ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as herein defined, effective as .beta.-blockers and hypotensive agents, are described.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: July 2, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Toshihiro Takahashi, Noriyoshi Sueda, Masahiro Tsuji, Yoshiyuki Tahara, Hiroyasu Koyama, Yoshikuni Suzuki, Masao Nagase, Toshiji Sugai
  • Patent number: 4521339
    Abstract: The disclosure describes a microbiological process for the preparation of mycotrien-related compounds.The compounds are isolated and characterized by structural formula and other identifying data.The compounds are useful in the treatment of tumors.
    Type: Grant
    Filed: November 24, 1982
    Date of Patent: June 4, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Yohei Natori, Noriyoshi Sueda
  • Patent number: 4517365
    Abstract: Isocarbostyrils of the formula ##STR1## wherein R is a branched alkyl of 3 to 4 carbon atoms, and the acid addition salts thereof, having .beta.-adrenergic blocking activity, are described.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: May 14, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Hiroyasu Koyama, Masahiro Tsuji, Yoshikuni Suzuki
  • Patent number: 4514573
    Abstract: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful for controlling virus infection of vertebrate animals.
    Type: Grant
    Filed: May 12, 1982
    Date of Patent: April 30, 1985
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi