Patents Assigned to Nodality, Inc.
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Publication number: 20130218474Abstract: Methods for determining a model that can characterize and distinguish normal cell from a diseased cell and methods for determining health or health-risk status of an individual based on a normal/health cell reference population of cells are described.Type: ApplicationFiled: January 25, 2013Publication date: August 22, 2013Applicant: Nodality, Inc.Inventor: Nodality, Inc.
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Publication number: 20130173618Abstract: In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.Type: ApplicationFiled: November 26, 2012Publication date: July 4, 2013Applicant: Nodality, Inc.Inventor: Nodality, Inc.
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Publication number: 20130130279Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: May 17, 2012Publication date: May 23, 2013Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Publication number: 20130129681Abstract: An embodiment of the present invention is useful for identifying tumor cells in bladder cancer washes, pleural effusions, biliary tumor cells and circulating tumor cells in whole blood. Subsequent analysis may identify therapeutic treatments based on a single cell analysis of activatable elements in cell signaling pathways. This analysis can be useful for diagnosis, prognosis, therapy selection and monitoring of solid tumor diseases.Type: ApplicationFiled: October 4, 2012Publication date: May 23, 2013Applicant: NODALITY, INC.Inventor: NODALITY, INC.
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Publication number: 20130124522Abstract: The present invention relates to methods for representing multidimensional data. The methods of the present invention are well suited but not limited to the representation of multidimensional data in such a way as to enable the comparison and differentiation of data sets. For example, the invention may be applied to the representation of flow cytometric data. The invention further relates to a program storage device having instructions for controlling a computer system to perform the methods, and to a program storage device containing data structures used in the practice of the methods.Type: ApplicationFiled: May 4, 2012Publication date: May 16, 2013Applicant: Nodality, Inc.Inventors: Allan Robert Moser, Wade Thomas Rogers, Herbert Alan Holyst
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Publication number: 20130122524Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens.Type: ApplicationFiled: November 8, 2012Publication date: May 16, 2013Applicant: Nodality, Inc.Inventor: Nodality, Inc.
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Publication number: 20130123131Abstract: A method is disclosed in which control processes are used to maintain consistency across a research or diagnostic series of steps. Some embodiments of the processes include the use of fresh or lyophilized cell lines, beads, surface or other markers. The use of quality control processes is intended to monitor data from the underlying methods in order to detect unacceptable variations and to allow for exclusion or normalization. Overlapping control processes allows for tighter control and for redundancy in the monitoring.Type: ApplicationFiled: November 9, 2012Publication date: May 16, 2013Applicant: Nodality, Inc.Inventor: Nodality, Inc.
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Publication number: 20130109050Abstract: Fluorescently labeled microsphere calibration and quality control particles for use in establishing standardized fluorescence detector setup, monitoring daily QC of flow cytometers and quantitative calibration of the fluorescence detectors in traceable units of measure (molecules equivalent soluble fluorescence; MESF).Type: ApplicationFiled: April 23, 2012Publication date: May 2, 2013Applicant: Nodality, Inc.Inventor: Norman Baylis Purvis, JR.
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Publication number: 20130096948Abstract: An embodiment of the present invention is a method of generating a report based on an association metric. The method involves identifying node state data associated with a sample, and generating an association metric based on the node state data.Type: ApplicationFiled: August 31, 2012Publication date: April 18, 2013Applicant: Nodality, Inc.Inventors: David Parkinson, Wendy J. Fantl, Alessandra Cesano, David Spellmeyer
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Publication number: 20130078621Abstract: The invention provides methods, kits, devices and compositions for detecting one or more target analytes. In some embodiments, the invention provides binding elements and labeling elements capable of being joined through a plurality of joining elements.Type: ApplicationFiled: September 25, 2012Publication date: March 28, 2013Applicant: NODALITY, INC.Inventor: NODALITY, INC.
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Patent number: 8399206Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: October 22, 2010Date of Patent: March 19, 2013Assignee: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
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Publication number: 20130035253Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.Type: ApplicationFiled: August 3, 2012Publication date: February 7, 2013Applicant: Nodality, Inc. A Delaware CorporationInventors: David B. Rosen, Santosh K. Putta, Brent Louie, Norman Purvis
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Publication number: 20130034862Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: August 28, 2012Publication date: February 7, 2013Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
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Publication number: 20130024177Abstract: The present invention provides various methods of generating and using models of biological events. The models can be used to classify individuals according to the biological event.Type: ApplicationFiled: March 24, 2011Publication date: January 24, 2013Applicant: Nodality, Inc.Inventor: Garry Nolan
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Publication number: 20120309029Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.Type: ApplicationFiled: June 11, 2012Publication date: December 6, 2012Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, Santosh K. Putta, Omar D. Perez, Helen L. Francis-Lang, Aileen C. Cohen
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Patent number: 8309306Abstract: The invention provides methods, kits, devices and compositions for detecting one or more target analytes. In some embodiments, the invention provides binding elements and labeling elements capable of being joined through a plurality of joining elements.Type: GrantFiled: November 12, 2009Date of Patent: November 13, 2012Assignee: Nodality, Inc.Inventors: Garry Nolan, Philip McGarrigle
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Publication number: 20120276558Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.Type: ApplicationFiled: July 9, 2012Publication date: November 1, 2012Applicant: Nodality, Inc.Inventors: David Soper, David Rosen, Todd Covey, Ying-Wen Huang, Wenday Fantl, Ralph Lin
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Patent number: 8273544Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: April 8, 2011Date of Patent: September 25, 2012Assignee: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, James R. Hackett, Michael Walker, Jing Shi
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Publication number: 20120215481Abstract: In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.Type: ApplicationFiled: February 17, 2012Publication date: August 23, 2012Applicant: Nodality, Inc.Inventors: Todd M. Covey, Darwin A. Farrow, Barton J. Friedland, Helen Francis-Lang, Malcolm Francis-Lang, Justin W. Mccarthy, Norman B. Purvis, JR., Santosh K. Putta, David B. Rosen, David M. Soper, David C. Spellmeyer
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Publication number: 20120215487Abstract: In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.Type: ApplicationFiled: February 17, 2012Publication date: August 23, 2012Applicant: Nodality, Inc.Inventors: Steven C. Banville, Santosh K. Putta, David C. Spellmeyer