Abstract: The present invention provides a cationic lipid that can be used as a nucleic acid delivery carrier with good intracellular dynamics, a lipid membrane structure containing the same, a nucleic acid-introducing agent and a pharmaceutical composition containing any of them, a method for introducing nucleic acid into cells or target cells, and a method for producing a cell medicine. A cationic lipid represented by the formula (1) (definitions of symbols in the formula are as described in the specification), a lipid membrane structure using the aforementioned cationic lipid, a nucleic acid-introducing agent and a pharmaceutical composition using the aforementioned cationic lipid or the aforementioned lipid membrane structure, a method for introducing nucleic acid into cells or target cells by using the aforementioned nucleic acid-introducing agent, and a method for producing a cell medicine by using the aforementioned nucleic acid-introducing agent.

Abstract: Provided is a copolymer that imparts hydrophilicity and antifouling properties to a contact lens by a simple method and maintains lasting effects thereof. A copolymer (P) comprises constituent units represented by formula (1a) and formula (1b), the molar ratio na:nb of the constituent units being 10-99: 1-90, and the weight average molecular weight being 10,000-2,000,000. (In formula (1a), R1 is a hydrogen atom or a methyl group, and W1 is O or NR2, where R2 is H or a C1-4 alkyl group.) (In formula (1b), R1 is a hydrogen atom or a methyl group, R2 is H or a C1-4 alkyl group, L1 is a C1-5 alkylene group, or a C1-5 alkylene group including one or more hydroxy groups, and m is an integer of 2 or 3.

Abstract: The present invention provides a method for producing nucleic acid-encapsulated lipid nanoparticles, which can encapsulate any nucleic acid with high efficiency and with ease. A method for producing nucleic acid-encapsulated lipid nanoparticles, including the following steps: a) a step of preparing a suspension of lipid nanoparticles not containing a nucleic acid, by mixing an alcohol solution containing ionic lipid, sterol and PEG lipid with an acidic buffer having a buffering action at pH 1 to 6.5, and b) a step of mixing, without lyophilization, the suspension of the lipid nanoparticles obtained in step a with an aqueous solution containing a nucleic acid and optionally containing 0 to 25 v/v % alcohol, and optionally incubating the mixture at 0 to 95° C. for 0 to 60 min to obtain nucleic acid-encapsulated lipid nanoparticles.

Abstract: The present invention provides lipid nanoparticles for delivering nucleic acid to peripheral blood mononuclear cells that can improve the efficiency of nucleic acid delivery to peripheral blood mononuclear cells, and a method for delivering nucleic acid to peripheral blood mononuclear cells by using same. Lipid nanoparticles for use in delivering a nucleic acid to a peripheral blood mononuclear cell, containing an ionic lipid represented by the formula (1), a phospholipid that is 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups have not less than 20 carbon atoms and at least one of the acyl groups is an alkenoyl group, cholesterol, and a dimyristoylglycerol PEG represented by the formula: CH2(OR6)—CH(OR7)—CH2(OR8) (symbols in the formula are as described in the specification), and a method for delivering a nucleic acids to a peripheral blood mononuclear cell by using same.

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

Abstract: The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i): (in the above-mentioned formula, each symbol is as described in the specification), and a pH-responsive transport carrier which is useful as a transport carrier for safely and efficiently performing delivery of low-molecular-weight drugs and the like to tumor tissues.

Abstract: Provided is an alkaline cleaning agent that does not tend to affect screen plates, and permitting easy removal of electroconductive paste adhered to the screen plate. One embodiment relates to a cleaning agent composition for electroconductive paste, the cleaning agent composition containing a compound (component (A)) represented by formula (1) and an aliphatic alcohol (component (B)) having 2-6 (inclusive) carbon atoms and a molecular weight of 40-120 (inclusive). The pH of the cleaning agent composition is 11.0 or more and less than 14.0. Relative to the total mass of the cleaning agent composition, the content of the component (A) is 0.1-5 mass % (inclusive) and the content of the component (B) is 5-40 mass % (inclusive). R1—O—(C2H4O)a-H??Formula (1) (In formula (1), R1 represents a C6-18 branched alkyl group and a, which is the average number of added mol of C2H4O groups, is a number 2-10 (inclusive).

Abstract: A wireless detonation system (1) includes a blasting operation device (40), a detonator (10), and a relay device (30). The blasting operation device (40) is disposed at a distance from a blasting face (71) and wirelessly transmits a first downstream signal at a first frequency. The detonator (10) is loaded in a blast hole (72) in the blasting face (71), and has a receiving coil (12) for wirelessly receiving a second downstream signal at a second frequency lower than the first frequency. A relay device (30) includes a first transmitting-receiving antenna (35) that wirelessly receives the first downstream signal, a relay processor (32) that wirelessly receives the first downstream signal and processes it into the second downstream signal to be wirelessly transmitted at the second frequency, and a second transmitting-receiving antenna (37) that transmits the second downstream signal.

Abstract: A release agent for a circuit board resin film being able to release a resin film formed on a circuit board in a short amount of time, having a high resin film fragmentation performance, and having a low environmental burden, is provided. The release agent contains a compound (component (A)) shown in formula (1) and a fatty alcohol (component (B)) having a carbon number of 1-6 and a molecular weight of 30-120, wherein the pH is 13.0-14.0, the content of component (A) is 0.1-5 mass %, and the content of component (B) is 5-40 mass %. Formula (1): R1—O-(A1O)a-H, wherein R1 represents a branched alkyl group having a carbon number of 6-10, A1O represents an oxyalkylene group having a carbon number of 2-3, and a, which is the average number of added moles of the oxyalkylene group, is from 2 to 15.

Abstract: An intermediate for production of a branched type hetero monodispersed polyethylene glycol which is represented by formula (2), the intermediate being represented by formula (3) or (40): where X1, L1, L3, Y1, Y2, and n are as defined herein.

Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.

Abstract: A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface.

Abstract: There is provided a protein stabilizer for stably storing a protein in a solution. The protein may be an enzyme, an antibody, an enzyme-labeled antibody, or the like for a biochemical assay, etc. There is further provided a protein stabilization reagent comprising a protein-containing solution and the protein stabilizer dissolved therein. The protein stabilizer comprises a copolymer prepared by copolymerizing a monomer (a) of the following formula (1), a monomer (b) of the following formula (2), and a monomer (c) of the following formula (3).

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

Abstract: Provided is a urethane curable composition including: a catalyst (a); a polyol (b) having two or more hydroxyl groups in one molecule; a polyisocyanate (c) having two or more isocyanate groups in one molecule; and silica particles (d) at a predetermined ratio, in which the catalyst (a) is a metal carboxylate represented by a formula (1): M(OCOR)n??(1) where M represents Li, Na, K, Rb, Cs, Mg, Ca, Sr, Ba, Mn, Fe, Co, Ni, Cu, Zn, or Pb; R represents any one of a saturated hydrocarbon group having 1 to 20 carbon atoms, a branched unsaturated hydrocarbon group, an alicyclic hydrocarbon group, and an aromatic hydrocarbon group; and n represents the same number as a valence of M.

Abstract: Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.

Abstract: Provided is a novel method of suppressing non-specific protein adsorption. The above-mentioned object can be achieved by treating a solid phase with a solid phase-treating liquid containing a phosphorylcholine group-containing polymer as a main component, and treating a specimen with a specimen-treating liquid containing, as a main component, a polymer having a phosphorylcholine group, a hydroxy group, and a hydrophobic group, followed by addition of the treated specimen to the treated solid phase.

Abstract: Provided is an ophthalmic solution of which preservative component, hexamethylene biguanide, contained therein is inhibited from being adsorbed on soft contact lenses and eye droppers. The ophthalmic solution contains, at a specific ratio, (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to the total amount of the hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of the hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s; (B) sodium chloride or potassium chloride; (C) hexamethylene biguanide or a salt thereof; (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer; and (E) water.

Abstract: Provided is a tear lipid layer stabilizer that is capable of stabilizing a tear lipid layer and allowing the tear lipid layer to sufficiently spread over a corneal surface, to thereby prevent the evaporation of a tear aqueous layer on the corneal surface, and hence is suitable for amelioration, alleviation, or treatment of evaporative dry eye symptoms caused by Meibomian gland dysfunction, an ophthalmic solution having blended therein the tear lipid layer stabilizer, and a tear lipid layer-stabilizing method using the tear lipid layer stabilizer. The tear lipid layer stabilizer includes a copolymer that has a weight-average molecular weight of from 10,000 to 5,000,000, and contains 10 mol % to 90 mol % of a constituent unit (A) based on 2-(meth)acryloyloxyethyl phosphorylcholine and 90 mol % to 10 mol % of a constituent unit (B) based on an alkyl group-containing (meth)acrylic monomer.

Abstract: Provided are: a fouling inhibitor that is capable of effectively inhibiting fouling of porous filtration membranes use as water purification membranes or the like, that has resistance to chemicals, such as alkali used when the membrane is fouled, and that is capable of maintaining such effects sufficiently even after chemical wash; a filtration membrane provided with the inhibitor; and a method for producing the same. The inhibitor contains: (A) a copolymer having a weight average molecular weight of 10000 to 300000 and contains a MPC unit (a1) and a BMA unit (a2), wherein the ratio of (a1) to (a2) ((a1)/(a2)) by mole is 10/90 to 70/30; and (B) PVA having a saponification degree of 72 to 93 mol % and a polymerization degree of 300 to 1000, wherein the ratio of component (A) to component (B) ((A)/(B)) by mass is 25/75 to 75/25.