Patents Assigned to NOF Corporation
  • Patent number: 10808050
    Abstract: An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer:
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: October 20, 2020
    Assignee: NOF CORPORATION
    Inventors: Takuma Tsubusaki, Yuji Yamamoto
  • Publication number: 20200308502
    Abstract: A lubricating oil composition including 100 mass parts of (A) an ester compound, 0.05 to 1.5 mass parts of (B) an amine salt of an acidic phosphoric ester and 0.01 to 0.50 mass parts of (C) a monoesterified compound, wherein (A) the ester compound is an ester compound of trimethylolpropane, a straight-chain saturated fatty acid having a carbon number of 8 to 10 and adipic acid; (B) the amine salt is an amine salt of an acidic phophoric ester; and (C) the monoesterified compound is a monoesterified compound of an alkane diol having a carbon number of 3 to 8 and of succinic acid having an alkyl group having a carbon number of 8 to 18 or an alkenyl group having a carbon number of 8 to 18.
    Type: Application
    Filed: June 7, 2017
    Publication date: October 1, 2020
    Applicant: NOF CORPORATION
    Inventors: Hideki KAWAMOTO, Shunsuke MONJIYAMA
  • Publication number: 20200289656
    Abstract: A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Yuji Yamamoto
  • Publication number: 20200291178
    Abstract: A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Yuji YAMAMOTO
  • Patent number: 10752732
    Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: August 25, 2020
    Assignee: NOF CORPORATION
    Inventors: Midori Hirai, Hiroki Yoshioka
  • Patent number: 10745518
    Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. The silicone contact lens includes, on its surface, a graft polymer chain derived from a branched polyoxyethylene compound represented by the formula (1): where n represents from 3 to 1,150, a represents 0 or 2, and R1 represents a hydrogen atom or a methyl group.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: August 18, 2020
    Assignee: NOF CORPORATION
    Inventors: Yoshihisa Shimamura, Yosuke Matsuoka
  • Publication number: 20200239613
    Abstract: Provided is a water repellent composition which does not use a fluorine-containing monomer, especially a fluoroalkyl group-containing monomer. A water repellent composition which contains (1) (a) a polymer which has a repeating unit derived from an amide group-containing monomer that is represented by formula: (wherein R1 represents an organic residue having an ethylenically unsaturated polymerizable group; R2 represents a hydrocarbon group having 7-30 carbon atoms; and R3 represents a hydrocarbon group having 1-5 carbon atoms) in an amount of 2-100% by weight relative to the polymer, and (2) a liquid medium.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 30, 2020
    Applicants: DAIKIN INDUSTRIES, LTD., NOF CORPORATION
    Inventors: Yuuki YAMAMOTO, Norimasa UESUGI, Ikuo YAMAMOTO, Kei-ichi MARUYAMA, Mitsuhiro FUKUSHIMA, Muneaki IIZUKA
  • Publication number: 20200230562
    Abstract: Heat-expandable microcapsules each having a core/shell structure which includes a core and a shell, wherein the core contains a volatile substance and the shell contains a polymer, the polymer being obtained by reacting a monomer mixture with an organic peroxide represented by general formula (1): wherein the R1 moieties each independently represent a C2-12 unsaturated hydrocarbon group, the unsaturated hydrocarbon group being optionally separated by one or more of —CO—O—, —O—CO—, and —O—.
    Type: Application
    Filed: September 5, 2018
    Publication date: July 23, 2020
    Applicant: NOF CORPORATION
    Inventors: Masaki HAYASHI, Keiji GOTO, Ryosuke ITOYAMA
  • Patent number: 10717942
    Abstract: A lubricant base oil composed of an ester. The ester includes a component (A) derived from trimethylolpropane in a molar percentage Amol % of 25 to 42 mol %; components (B) derived from monovalent straight-chain saturated fatty acids each having a carbon number of 8 to 12 in a molar percentage Bmol % of 33 to 55 mol %: and a component (C) derived from adipic acid in a molar ratio Cmol % of 12 to 34 mol %. The components (B) include lauric acid in a molar percentage of 5 to 50 mol %, and (BCOOH+CCOOH)/AOH is 0.90 to 1.02. AOH represents a hydroxyl equivalent of the component (A), BCOOH represents a carboxyl group equivalent of the components (B); and CCOOH represents a carboxyl group equivalent of the component (C).
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: July 21, 2020
    Assignee: NOF CORPORATION
    Inventors: Hideki Kawamoto, Shunsuke Monjiyama
  • Patent number: 10711217
    Abstract: A lubricant base oil which contains an ester. The ester constituting the lubricant base oil includes: a component (A) derived from pentaerythritol in a molar percentage Amol % of 20 to 30 mol %; a component (B) derived from a straight-chain fatty acid having a carbon number of 14 to 22 in a molar percentage Bmol % of 55 to 79 mol %; and a component (C) derived from adipic acid in a molar percentage Cmol % of 1 to 15 mol %. A molar ratio (Cmol/Cmol) of the component (C) derived from adipic acid and the component (B) derived from the straight-chain fatty acid having a carbon number of 14 to 22 is 0.02 to 0.25, and the ester has a hydroxyl value of 10 to 100 mgKOH/g.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: July 14, 2020
    Assignee: NOF CORPORATION
    Inventors: Shunsuke Monjiyama, Hideki Kawamoto
  • Publication number: 20200190260
    Abstract: An alkyloxirane derivative represented by formula (1), wherein MH and ML calculated from a gel permeation chromatogram satisfy formula (2): Z—[O-(AO)n-H]x??(1) where Z represents a residual group of a compound having 1 to 22 carbon atoms and one to six hydroxyl groups and wherein all of the hydroxyl groups are excluded from said compound; x is 1 to 6; and AO represents an oxyalkylene group having 3 carbon atoms; and n is 25 or more; 0.35?ML/MH?0.75??(2) where MH represents a distance between point O and intersecting point P, and ML represents a distance between point Q and intersecting point P determined from the chromatogram.
    Type: Application
    Filed: August 4, 2017
    Publication date: June 18, 2020
    Applicant: NOF CORPORATION
    Inventors: Yusuke HARA, Kazuaki WAKITA, Mitsushi KUSUMOTO, Megumi NAGAYAMA, Shunsuke MONJIYAMA, Aiko YAMANAKA, Hideki KAWAMOTO
  • Patent number: 10633489
    Abstract: A hydrophilic polymer derivative having a benzylidene acetal linker whose hydrolysis rate at the pH of a weakly acidic environment in the living body can be accurately controlled. A hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by the following formula (1): wherein R1 is a hydrogen atom or a hydrocarbon group; R2, R3, R4, R5, and R6 are each independently a hydrogen atom or a substituent and at least one of R3, R4, and R5 is an electron-withdrawing substituent or at least one of R2 and R6 represents a substituent; X1 is a chemically reactive functional group; P is a hydrophilic polymer; w is an integer of 1 to 8; and Z1 and Z2 are an independently selected divalent spacer.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: April 28, 2020
    Assignee: NOF CORPORATION
    Inventors: Takuma Tsubusaki, Yuji Yamamoto
  • Patent number: 10626217
    Abstract: A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1): wherein, R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Z1 and Z2 are each independently a selected divalent spacer.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 21, 2020
    Assignee: NOF CORPORATION
    Inventors: Masaki Ota, Takuma Tsubusaki, Yuji Yamamoto
  • Patent number: 10620177
    Abstract: A protein adsorption inhibitor includes a compound of Formula (1) as an active ingredient. The protein adsorption inhibitor is capable of highly inhibiting non-specific adsorption of a protein such as an antibody or an enzyme to a surface of a base body such as an immune reaction vessel or an assay instrument. Also provided is a coating layer-formed base body having a coating layer containing the protein adsorption inhibitor on the base body. The coating layer-formed base body has an excellent protein adsorption-inhibiting function. A method for inhibiting the adsorption of the protein to the base body is provided. The method includes forming the coating layer containing the protein adsorption inhibitor on the surface of the base body: wherein, X is a hydrogen atom or a methyl group and n is an integer of 9 to 15.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 14, 2020
    Assignee: NOF CORPORATION
    Inventors: Fumio Nakashima, Satoshi Yamada, Tomozumi Noda, Masaru Matsuda
  • Publication number: 20200079905
    Abstract: A purification method of a polyethylene glycol compound having one carboxyl group. In the method, an aqueous solution of the compound having a pH of 8 to 11 is prepared, the aqueous solution and a mixed organic solvent are mixed at a temperature of 15° C. or more and 50° C. or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of solvent I is from 25 to 60% by mass, and a ratio of solvent II is from 75 to 40% by mass. Solvent I is a hydrocarbon, solvent II is a halogenated hydrocarbon, a mixing ratio Y (organic solvent I/organic solvent II), a temperature T (° C.) at mixing and a weight average molecular weight M of the compound satisfy a relationship of 3.11×10?6M+0.084?Y?0.0135T??1.77×10?6M+0.404.
    Type: Application
    Filed: March 22, 2018
    Publication date: March 12, 2020
    Applicant: NOF CORPORATION
    Inventors: Midori HIRAI, Hiroki Yoshioka
  • Publication number: 20200079903
    Abstract: A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.
    Type: Application
    Filed: March 22, 2018
    Publication date: March 12, 2020
    Applicant: NOF CORPORATION
    Inventors: Hiroki YOSHIOKA, Yuji YAMAMOTO
  • Patent number: 10584949
    Abstract: A wireless detonator (10) includes a detonation side receiving antenna (11), a detonation side transmitting antenna (18), an initiator (14) and a detonation side electronic circuit. The detonation side receiving antenna (11) receives energy for driving the detonation side electronic circuit, a control signal and an initiation signal. The detonation side electronic circuit receives the energy, the control signal and the initiation signal via the detonation side receiving antenna (11), transmits a response signal via the detonation side transmitting antenna (18) and ignites the initiator (14) in accordance with the initiation signal. A response frequency of the response signal is set to be greater than or equal to 100 MHz and less than or equal to 1 GHz.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: March 10, 2020
    Assignees: NOF CORPORATION, FUTABA CORPORATION
    Inventors: Yoji Tasaki, Satoshi Hikone, Shinya Tanaka, Kohichi Shimazaki, Kazuhito Watanabe, Michihiro Takayasu
  • Patent number: 10577477
    Abstract: Provided is a urethane curable composition including: a catalyst (a); a polyol (b) having two or more hydroxyl groups in one molecule; a polyisocyanate (c) having two or more isocyanate groups in one molecule; and silica particles (d) at a predetermined ratio, in which the catalyst (a) is a metal carboxylate represented by a formula (1): M(OCOR)n??(1) where M represents Li, Na, K, Rb, Cs, Mg, Ca, Sr, Ba, Mn, Fe, Co, Ni, Cu, Zn, or Pb; R represents any one of a saturated hydrocarbon group having 1 to 20 carbon atoms, a branched unsaturated hydrocarbon group, an alicyclic hydrocarbon group, and an aromatic hydrocarbon group; and n represents the same number as a valence of M.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: March 3, 2020
    Assignee: NOF Corporation
    Inventors: Shingo Kataoka, Yasushi Sugihara, Yuto Ichihara
  • Publication number: 20200024391
    Abstract: To provide a degradable polyethylene glycol derivative in which polyethylene glycol chains are linked by a disulfide linker capable of accurately controlling the degradation rate under different reductive environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body is able to be accurately controlled. A degradable polyethylene glycol derivative represented by formula (1). R1, R2, R3 and R4 represent each independently a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms, and at least one of R1, R2, R3 and R4 is the hydrocarbon group; P1 is a straight-chain or branched polyethylene glycol chain having a number of ethylene glycol units of 3 or more; P2 is a straight-chain polyethylene glycol chain having a number of ethylene glycol units of 3 or more; w is an integer of 1 to 8; u is an integer of 1 to 10; X1 is a chemically reactive functional group; and Z1, Z2 and Z3 are each independently a selected divalent spacer.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 23, 2020
    Applicant: NOF CORPORATION
    Inventors: Kota TANGE, Hiroki YOSHIOKA, Takuma TSUBUSAKI, Masaki KAMIYA
  • Publication number: 20200010620
    Abstract: To provide a hydrophilic polymer derivative having a novel linker technique which is able to from a hydrophilic polymer pro-drug of a drug containing an amino group or the like in order to overcome the restrictions of conventional hydrophilic polymer pro-drugs.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 9, 2020
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Shinya TAMAGAWA