Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

Abstract: An alkyloxirane derivative represented by formula (1), wherein MH and ML calculated from a gel permeation chromatogram satisfy formula (2): Z—[O-(AO)n-H]x??(1) where Z represents a residual group of a compound having 1 to 22 carbon atoms and one to six hydroxyl groups and wherein all of the hydroxyl groups are excluded from said compound; x is 1 to 6; and AO represents an oxyalkylene group having 3 carbon atoms; and n is 25 or more; 0.35?ML/MH?0.75??(2) where MH represents a distance between point O and intersecting point P, and ML represents a distance between point Q and intersecting point P determined from the chromatogram.

Abstract: A lubricating oil composition including 100 mass parts of (A) an ester compound, 0.05 to 1.5 mass parts of (B) an amine salt of an acidic phosphoric ester and 0.01 to 0.50 mass parts of (C) a monoesterified compound, wherein (A) the ester compound is an ester compound of trimethylolpropane, a straight-chain saturated fatty acid having a carbon number of 8 to 10 and adipic acid; (B) the amine salt is an amine salt of an acidic phosphoric ester; and (C) the monoesterified compound is a monoesterified compound of an alkane diol having a carbon number of 3 to 8 and of succinic acid having an alkyl group having a carbon number of 8 to 18 or an alkenyl group having a carbon number of 8 to 18.

Abstract: A coating agent for preventing the adsorption of extracellular vesicles represented by exosomes to a tool has been developed. Adsorption of extracellular vesicles to a tool can be prevented by using a coating agent which contains a hydrophilic polymer having a weight average molecular weight of 10,000 or more and 1,000,000 or less, wherein a coated layer formed by the coating agent has a contact angle of 0 degree or more and 30 degrees or less.

Abstract: A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. It has been confirmed that a silicone contact lens including, on its surface, a graft polymer chain derived from a polyoxyethylene compound having a plurality of hydroxyl groups at a terminal thereof has surface hydrophilicity and surface lubricity.

Abstract: Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.

Abstract: A heterobifunctional monodispersed polyethylene glycol represented by the formula (1): wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule, the functional group contained in the atomic group X1 and the functional group contained in the atomic group Y1 are different from each other; R1 is a hydrocarbon group having from 1 to 7 carbon atoms or a hydrogen atom; n is an integer of 3 to 72; l is an integer of 2 to 72; and A1, B1 and C1 are as defined herein.

Abstract: The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Ya, Yb, Za, and Zb are as defined in the specification.

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Abstract: A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).

Abstract: Provided is a zwitterionic polymer that has a zwitterion that includes an effect of improving the stability of proteins. This zwitterionic polymer is a polymeric protein stabilizer that exhibits a protein stabilizing effect even at a small addition amount of addition, and at the same time has an antioxidant capability. Also provided is a method for producing this zwitterionic polymer. This problem is solved by a zwitterionic polymer containing a repeating unit represented by formula (1) and having a number-average molecular weight of 1,000 to 1,000,000. On formula (1), R1 and R2 are each independently selected from a hydrogen atom; linear, branched or cyclic alkyl groups having 1 to 6 carbons; aromatic groups having 6 to 20 carbons; or alkylene groups having 1 to 6 carbons and formed by linking R1 to R2. R3 represents a hydrogen atom or a methyl group).

Abstract: The invention aims to provide a constituent component of a liposome for a DDS carrier that does not show a membrane fusion promoting effect on viruses. In particular, the invention provides a sphingomyelin-derived lipid represented by the formula (1): wherein R1 is an alkyl group having 13-17 carbon atoms, and R2 is an acyl group having 12-24 carbon atoms, and a production method thereof.

Abstract: A branched monodispersed polyethylene glycol represented by the formula (1): wherein X1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L1 represents a single bond, —NH—, -L2-(CH2)m1— or -L2-(CH2)m1-L3-(CH2)2-, L2 represents an ether bond, an amide bond, an urethane bond or a single bond, L3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.

Abstract: A method for purifying a specific trityl group-containing monodispersed polyethylene glycol from a mixture containing the trityl group-containing monodispersed polyethylene glycol and a specific ditritylated impurity. The method includes performing steps (A), (B) and (C). Step (A): a step of esterifying the hydroxyl group of the trityl group-containing monodispersed polyethylene glycol by a specific method; Step (B): a step of extracting the esterified compound by a specific method; and Step (C): a step of hydrolyzing the esterified compound to obtain the trityl group-containing monodispersed polyethylene glycol.

Abstract: A polypropylene resin composition contains components (A), (B) and (C). A content of (A) is from 70 to 90 parts by weight, a content of (B) is from 10 to 30 parts by weight, and a content of (C) is from 1 to 5 parts by weight, when the total of the content of (A) and (B) is taken as 100 parts by weight. (A) polypropylene, (B) talc having an average particle diameter of 1 ?m to 8 ?m, (C) polyethylene glycol, wherein a molecular weight at the maximum point of refractive index intensity in a chromatogram obtained by gel permeation chromatography using a differential refractometer is from 2,000 to 4,000, and S2/S1 is from 1.3 to 2.0, where peak areas S2 and S1 are as defined herein.

Abstract: Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.

Abstract: A polypropylene resin composition contains components (A), (B) and (C). A content of (A) is from 70 to 90 parts by weight, a content of (B) is from 10 to 30 parts by weight, and a content of (C) is from 1 to 5 parts by weight, when the total of the content of (A) and (B) is taken as 100 parts by weight. (A) polypropylene, (B) talc having an average particle diameter of 1 ?m to 8 ?m, (C) polyethylene glycol, wherein a molecular weight at the maximum point of refractive index intensity in a chromatogram obtained by gel permeation chromatography using a differential refractometer is from 2,000 to 4,000, and S2/S1 is from 1.3 to 2.0, where peak areas S2 and S1 are as defined herein.

Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

Abstract: An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer: