Patents Assigned to Northwestern University
  • HIGHLY SOLUBLE BIS-BORATE AS BINUCLEAR CO-CATALYSTS FOR OLEFIN POLYMERIZATION
    Publication number: 20210108005
    Abstract: Embodiments are directed to catalyst systems comprising: a procatalyst; and a co-catalyst dissolved in a non-halogenated aprotic hydrocarbon solvent, the co-catalyst comprising: a non-coordinating borate dianion having the formula: (III) and two cations, each cation being independently chosen from a cation according to formula (I) or formula (II).
    Type: Application
    Filed: March 28, 2019
    Publication date: April 15, 2021
    Applicants: Dow Global Technologies LLC, Northwestern University
    Inventors: Tobin J. Marks, Yanshan Gao, Tracy L. Lohr, Matthew D. Christianson, Jerzy Klosin, Edmund M. Carnahan, Andrew J. Young
  • Anti-Polyethylene Glycol (PEG) Antibody Mouse Model for Rigorous Assessment of PEG-Based Therapies
    Publication number: 20210106697
    Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Helena Freire Haddad
  • Preventing service discrimination in a blockchain distribution network
    Patent number: 10977628
    Abstract: A server in a blockchain distribution network includes a processor and a transceiver operatively coupled to the processor. The transceiver is configured to receive bytes of an encrypted blockchain from a peer node in a peer-to-peer network, where the server is unable to identify a source node that generated the encrypted blockchain based on the received bytes. The transceiver is also configured to propagate the bytes of the encrypted blockchain to one or more additional peer nodes and to one or more additional servers in the blockchain distribution network.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 13, 2021
    Assignee: Northwestern University
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • Short interfering RNA templated lipoprotein particles (siRNA-TLP)
    Patent number: 10967072
    Abstract: Nanostructures for the systemic delivery of nucleic acids, such as RNA, are provided herein. The nanostructures include templated lipoprotein nanoparticles (TLPs) composed of a core decorated with proteins, a lipid bilayer and hydrophobic molecules that self-assemble with nucleic acids, such as RNA. The nanostructures are useful for research, therapeutic and diagnostic applications.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: April 6, 2021
    Assignee: Northwestern University
    Inventors: C. Shad Thaxton, Kaylin M. McMahon
  • Epidermal microfluidic sensor for sweat collection and analysis from aquatic athletes
    Patent number: 10969395
    Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: April 6, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: John A. Rogers, Jungil Choi, Johnathan T. Reeder
  • Blockchain distribution network with service transparency
    Patent number: 10970690
    Abstract: A peer node in a blockchain distribution network includes a processor and a transceiver operatively coupled to the processor. The processor is configured to generate an encrypted test block. The encrypted test block is indistinguishable from an encrypted blockchain in the blockchain distribution network. The transceiver is configured to transmit the encrypted test block to a server for distribution throughout the blockchain distribution network. The transceiver is also configured to receive a message from a second peer node in the blockchain distribution network, where the message indicates that the second peer node received the encrypted test block.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 6, 2021
    Assignee: Northwestern University
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • HIGH TEMPERATURE, CREEP-RESISTANT ALUMINUM ALLOY MICROALLOYED WITH MANGANESE, MOLYBDENUM AND TUNGSTEN
    Publication number: 20210095365
    Abstract: A high temperature creep-resistant aluminum alloy microalloyed with manganese and molybdenum and/or tungsten is provided. The aluminum alloy includes scandium, zirconium, erbium, silicon, at least one of molybdenum and tungsten, manganese and the balance aluminum and incidental impurities. The concentration of the alloying elements, in atom %, is greater than 0.0 and less than or equal to 0.15 scandium, greater than 0.0 and less than or equal to 0.35 zirconium, greater than 0.0 and less than or equal to 0.15 erbium, greater than 0.0 and less than or equal to 0.2 silicon, greater than 0.0 and less or equal to 0.75 molybdenum when included, greater than 0.0 and less than or equal to 0.35 tungsten when included, and greater than 0.0 and less than or equal to 1.5 manganese. And the total concentration of Zr+Er+Sc is greater than or equal to 0.1.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 1, 2021
    Applicants: Ford Global Technologies, LLC, Northwestern University
    Inventors: Anthony De Luca, David N. Seidman, David C. Dunand, James M. Boileau, Bita Ghaffari
  • Cycloaddition reactions using quantum dots
    Patent number: 10961178
    Abstract: Disclosed herein are methods in which colloidal quantum dots (QDs) can serve as visible-light chromophores, photocatalysts, and reusable scaffolds for homo- and hetero-intermolecular [2+2] photocycloadditions. The methods may lead to >90% tunable regioselectivity and up to 98% diastereoselectivity for previously minor syn-cyclobutane products, including the syn-head-to-tail cyclobutane.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: March 30, 2021
    Assignee: Northwestern University
    Inventors: Yishu Jiang, Cameron R. Rogers, Mohamad S. Kodaimati, Emily A. Weiss
  • COST EFFECTIVE CULTURE MEDIA AND PROTOCOL FOR HUMAN INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20210087525
    Abstract: A novel culture media formula that is thoroughly optimized to support high growth rate under low seeding density conditions, require minimal media exchanges, and at low cost, while maintaining differentiation reproducibility is provided. This formula is capable of supporting both human induced pluripotent stem cell (hiPSC) generation and culture for >100 passages. Generation of B8 supplement aliquots suitable for making 100 liters of media is simple for any research lab with basic equipment, with complete bottles of media costing ˜$12 USD per liter. Weekend free hiPSC cell culture methods are possible with this formulation.
    Type: Application
    Filed: September 18, 2020
    Publication date: March 25, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventor: Paul Burridge
  • Electronically abrupt borophene/organic lateral heterostructures and preparation thereof
    Patent number: 10954132
    Abstract: A method of preparing a boron allotrope-organic lateral heterostructural article includes providing an article comprising a substrate comprising a portion thereof coupled to a boron allotrope comprising an elemental boron layer; generating an organic compound vapor from a solid organic compound source, said organic compound vapor having a higher enthalpy of adsorption on said substrate compared to enthalpy of adsorption on said boron allotrope; and contacting said organic compound vapor with said article to selectively deposit said organic compound on a substrate portion not coupled to said boron allotrope to provide a heterostructural article comprising said organic compound and said boron allotrope laterally adjacent one to the other and providing a lateral interface one with the other.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: March 23, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Mark C. Hersam, Xiaolong Liu
  • 3-METHYLIDENEOXAN-4-ONE COMPOUNDS AND SUBSTITUTED DERIVATIVES THEREOF AS INHIBITORS OF TELOMERASE
    Publication number: 20210070725
    Abstract: Disclosed are 3-methylideneoxan-4-one compounds, derivatives thereof, and methods of their synthesis and methods of their use in treating a disease or disorder in a subject in need thereof, such as diseases and disorders that are associated with telomerase activity such as cancer. The disclosed compounds may be formulated in a pharmaceutical composition for treating diseases and disorders that are associated with telomerase activity such as cancer.
    Type: Application
    Filed: August 6, 2020
    Publication date: March 11, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Karl A. Scheidt, Rick C. Betori
  • Thermally activated memristors, fabricating methods and applications of same
    Patent number: 10944047
    Abstract: Thermally activated memristors from solution-processed two-dimensional (2D) semiconductors, fabricating methods and applications of the same. The memristor includes a semiconductor film formed on a nanoporous membrane, and at least two electrodes spatial-apart formed on the semiconductor film and electrically coupled with the semiconductor film to define a channel in the semiconductor film between the at least two electrodes, where the channel has one or more filaments, one or more dendrite, or a combination of them formed in the semiconductor film. The underlying switching mechanism applies generally to a range of 2D semiconductors including, but not limited to, MoS2, MoSe2, WS2, ReS2, InSe, or related 2D semiconductor materials.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 9, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Mark C. Hersam, Vinod K. Sangwan
  • SUPRAMOLECULAR TESSELLATION OF RIGID TRIANGULAR MACROCYCLES
    Publication number: 20210062365
    Abstract: Disclosed herein are crystalline compositions comprising tessellated rigid triangular macrocycles in a two-dimensional plane and methods of making the same.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 4, 2021
    Applicants: NORTHWESTERN UNIVERSITY, King Abdulaziz City for Science and Technology (KACST)
    Inventors: James Fraser Stoddart, Yassine Beldjoudi
  • THERAPEUTIC TARGETING OF THE BAP1 COMPLEX IN CANCER
    Publication number: 20210060001
    Abstract: Disclosed are methods for methods, compounds, and compositions for treating cancers characterized by therapeutic targeting of the BAP1 histone H2A deubiquitinase (DUB) complex, otherwise referred to herein as the BAP1 complex. In particular, the methods, compounds, and compositions disclosed herein relate to the use of therapeutic agents that inhibit the biological activity of the BAP1 complex for treating cancers such as myeloid neoplasms.
    Type: Application
    Filed: July 17, 2020
    Publication date: March 4, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Lu Wang, Ali Shilatifard
  • Magnetically controlled particle abrasion method for biofouling removal
    Patent number: 10933449
    Abstract: Methods of removing a film of a biological material from a surface are provided. In embodiments, such a method comprises applying magnetic particles to a surface contaminated with a film of a biological material; and exposing the magnetic particles to a changing magnetic field to move the magnetic particles relative to the contaminated surface, thereby removing the film from the surface.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: March 2, 2021
    Assignee: Northwestern University
    Inventors: Alex B. Gelber, Yuehan Yao, Morgan L. Petrovich, George F. Wells, Kyoo-Chul Park, Youhua Jiang
  • Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
    Patent number: 10934270
    Abstract: Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: March 2, 2021
    Assignee: Northwestern University
    Inventors: Dimitri Krainc, Richard B. Silverman, Jianbin Zheng
  • Use of trinucleotide repeat RNAs to treat cancer
    Patent number: 10934547
    Abstract: Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 2, 2021
    Assignee: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann
  • COMPOSITIONS AND METHODS OF USING PROPYLENE SULFIDE-BASED POLYMERS FOR TREATMENT OF CHAGAS DISEASE
    Publication number: 20210052498
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 25, 2021
    Applicant: Northwestern University
    Inventors: Evan A. Scott, Sijia Yi, Nicholas Karabin, Xiaomo Li
  • Peer auditing in a blockchain distribution network
    Patent number: 10929823
    Abstract: A system for use in a blockchain distribution network includes a plurality of peer-to-peer nodes and a plurality of central servers in communication with at least a portion of the plurality of peer-to-peer nodes. The plurality of peer-to-peer nodes includes a first peer node and a second peer node and the plurality of central servers includes a first central server. The first peer node includes a first transceiver that is configured to transmit a blockchain to the second peer node. The second peer node includes a second transceiver that is configured to relay the blockchain to the first central server such that the first central server is unable to identify an origin of the blockchain.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: February 23, 2021
    Assignee: Northwestern University
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • Systems, methods, and apparatus for equalization preference learning
    Patent number: RE48462
    Abstract: Systems, methods, and apparatus are provided for equalization preference learning for digital audio modification. A method for listener calibration of an audio signal includes modifying a reference sound using at least one equalization curve; playing the modified reference sound for a listener; accepting listener feedback regarding the modified reference sound; and generating a weighting function based on listener feedback. A listener audio configuration system includes an output providing a sound for listener review; an interface accepting listener feedback regarding the sound; and a processor programming an audio device based on listener feedback.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: March 9, 2021
    Assignee: Northwestern University
    Inventors: Andrew Todd Sabin, Bryan A. Pardo